Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acid sphingomyelinase-like phosphodiesterase

Gene

Smpdl3b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi28Zinc 1UniRule annotation1
Metal bindingi30Zinc 1UniRule annotation1
Metal bindingi93Zinc 1UniRule annotation1
Metal bindingi93Zinc 2UniRule annotation1
Metal bindingi134Zinc 2UniRule annotation1
Metal bindingi236Zinc 2UniRule annotation1
Metal bindingi277Zinc 2UniRule annotation1
Metal bindingi279Zinc 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Acid sphingomyelinase-like phosphodiesteraseUniRule annotation
Gene namesi
Name:Smpdl3bImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1916022 Smpdl3b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18UniRule annotationAdd BLAST18
ChainiPRO_501421250219 – 456Acid sphingomyelinase-like phosphodiesteraseUniRule annotationAdd BLAST438

Proteomic databases

MaxQBiQ3TLX9

Expressioni

Gene expression databases

BgeeiENSMUSG00000028885
ExpressionAtlasiQ3TLX9 baseline and differential

Structurei

3D structure databases

SMRiQ3TLX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 280MetallophosInterPro annotationAdd BLAST259

Sequence similaritiesi

Belongs to the acid sphingomyelinase family.UniRule annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiENOG410ISVB Eukaryota
ENOG410XRWF LUCA
HOVERGENiHBG050594
KOiK01128
OMAiDPLQVCP
OrthoDBiEOG091G080M

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR017064 ASM-like_Pdiesterase_prd
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PIRSFiPIRSF036767 ASM-like_PDE, 1 hit

Sequencei

Sequence statusi: Complete.

Q3TLX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLLGWLIFL APWGVAGAQL GRFWHISDLH LDPNYTVSKD PLQVCPSAGS
60 70 80 90 100
QPVLNAGPWG DYLCDSPWAL INSSLYAMKE IEPKPDFILW TGDDTPHVPN
110 120 130 140 150
ESLGEAAVLA IVERLTNLIK EVFPDTKVYA ALGNHDFHPK NQFPAQSNRI
160 170 180 190 200
YNQVAELWRP WLSNESYALF KRGAFYSEKL PGPSRAGRVV VLNTNLYYSN
210 220 230 240 250
NEQTAGMADP GEQFRWLGDV LSNASRDGEM VYVIGHVPPG FFEKTQNKAW
260 270 280 290 300
FRESFNEEYL KVIQKHHRVI AGQFFGHHHT DSFRMFYDNT GAPINVMFLT
310 320 330 340 350
PGVTPWKTTL PGVVDGANNP GIRIFEYDRA TLNLKDLVTY FLNLRQANVQ
360 370 380 390 400
ETPRWEQEYR LTEAYQVPDA SVSSMHTALT RIASEPHILQ RYYVYNSVSY
410 420 430 440 450
NHLTCEDSCR IEHVCAIQHV AFNTYATCLH GLGAKLVPGF LLILTLLPSL

HVLEVL
Length:456
Mass (Da):51,600
Last modified:October 11, 2005 - v1
Checksum:i11BD6AF4806FD990
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154599 mRNA Translation: BAE32702.1
AK166253 mRNA Translation: BAE38663.1
RefSeqiNP_598649.1, NM_133888.2
UniGeneiMm.287187

Genome annotation databases

GeneIDi100340
KEGGimmu:100340

Similar proteinsi

Entry informationi

Entry nameiQ3TLX9_MOUSE
AccessioniPrimary (citable) accession number: Q3TLX9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health