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Entry version 107 (02 Jun 2021)
Sequence version 3 (09 Jan 2013)
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Protein

Protein PRRC2C

Gene

Prrc2c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for efficient formation of stress granules.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein PRRC2C
Alternative name(s):
BAT2 domain-containing protein 1
HLA-B-associated transcript 2-like 2
Proline-rich and coiled-coil-containing protein 2C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Prrc2c
Synonyms:Bat2d, Bat2d1, Bat2l2, Kiaa1096
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1913754, Prrc2c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003492401 – 2846Protein PRRC2CAdd BLAST2846

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei27N6-acetyllysineBy similarity1
Modified residuei102PhosphoserineCombined sources1
Modified residuei189PhosphoserineBy similarity1
Modified residuei192PhosphoserineCombined sources1
Modified residuei243Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei243Omega-N-methylarginine; alternateCombined sources1
Modified residuei256Asymmetric dimethylarginineBy similarity1
Modified residuei267Asymmetric dimethylarginineBy similarity1
Modified residuei280Omega-N-methylarginineCombined sources1
Modified residuei282Omega-N-methylarginineCombined sources1
Modified residuei336PhosphoserineBy similarity1
Modified residuei393N6-acetyllysineBy similarity1
Modified residuei501PhosphoserineBy similarity1
Modified residuei755PhosphoserineBy similarity1
Modified residuei761PhosphoserineBy similarity1
Modified residuei777PhosphoserineBy similarity1
Modified residuei853PhosphoserineCombined sources1
Modified residuei904PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1215PhosphoserineBy similarity1
Modified residuei1219PhosphoserineBy similarity1
Modified residuei1221PhosphoserineBy similarity1
Modified residuei1222PhosphoserineBy similarity1
Modified residuei1236PhosphoserineBy similarity1
Modified residuei1238PhosphothreonineCombined sources1
Modified residuei1240PhosphothreonineBy similarity1
Modified residuei1516PhosphoserineBy similarity1
Modified residuei1917PhosphothreonineBy similarity1
Modified residuei1935PhosphoserineCombined sources1
Modified residuei1938PhosphoserineCombined sources1
Modified residuei1965PhosphoserineBy similarity1
Modified residuei2057PhosphoserineBy similarity1
Modified residuei2095PhosphoserineBy similarity1
Modified residuei2212PhosphoserineBy similarity1
Modified residuei2625PhosphothreonineCombined sources1
Modified residuei2634PhosphothreonineBy similarity1
Modified residuei2638PhosphoserineBy similarity1
Modified residuei2646PhosphoserineBy similarity1
Modified residuei2766Omega-N-methylarginineCombined sources1
Modified residuei2775Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei2775Omega-N-methylarginine; alternateCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3TLH4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3TLH4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3TLH4

PeptideAtlas

More...
PeptideAtlasi
Q3TLH4

PRoteomics IDEntifications database

More...
PRIDEi
Q3TLH4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
289396 [Q3TLH4-1]
289397 [Q3TLH4-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3TLH4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3TLH4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q3TLH4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040225, Expressed in dorsal pancreas and 275 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3TLH4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
230531, 23 interactors

Protein interaction database and analysis system

More...
IntActi
Q3TLH4, 6 interactors

Molecular INTeraction database

More...
MINTi
Q3TLH4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000138433

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3TLH4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3TLH4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 212DisorderedSequence analysisAdd BLAST167
Regioni264 – 705DisorderedSequence analysisAdd BLAST442
Regioni777 – 1619DisorderedSequence analysisAdd BLAST843
Regioni1642 – 1742DisorderedSequence analysisAdd BLAST101
Regioni1762 – 1803DisorderedSequence analysisAdd BLAST42
Regioni1866 – 1938DisorderedSequence analysisAdd BLAST73
Regioni1960 – 1996DisorderedSequence analysisAdd BLAST37
Regioni2025 – 2108DisorderedSequence analysisAdd BLAST84
Regioni2209 – 2249DisorderedSequence analysisAdd BLAST41
Regioni2269 – 2293DisorderedSequence analysisAdd BLAST25
Regioni2617 – 2655DisorderedSequence analysisAdd BLAST39
Regioni2778 – 2846DisorderedSequence analysisAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili995 – 1026Sequence analysisAdd BLAST32
Coiled coili1655 – 1681Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi87 – 101Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi124 – 149Polar residuesSequence analysisAdd BLAST26
Compositional biasi187 – 212Polar residuesSequence analysisAdd BLAST26
Compositional biasi298 – 315Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi358 – 372Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi402 – 439Pro residuesSequence analysisAdd BLAST38
Compositional biasi442 – 582Basic and acidic residuesSequence analysisAdd BLAST141
Compositional biasi592 – 621Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi644 – 679Polar residuesSequence analysisAdd BLAST36
Compositional biasi680 – 696Pro residuesSequence analysisAdd BLAST17
Compositional biasi803 – 821Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi829 – 862Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi863 – 920Polar residuesSequence analysisAdd BLAST58
Compositional biasi929 – 1032Basic and acidic residuesSequence analysisAdd BLAST104
Compositional biasi1033 – 1060Pro residuesSequence analysisAdd BLAST28
Compositional biasi1061 – 1075Polar residuesSequence analysisAdd BLAST15
Compositional biasi1106 – 1168Basic and acidic residuesSequence analysisAdd BLAST63
Compositional biasi1183 – 1329Basic and acidic residuesSequence analysisAdd BLAST147
Compositional biasi1355 – 1421Basic and acidic residuesSequence analysisAdd BLAST67
Compositional biasi1423 – 1441Polar residuesSequence analysisAdd BLAST19
Compositional biasi1449 – 1471Polar residuesSequence analysisAdd BLAST23
Compositional biasi1473 – 1492Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1518 – 1538Polar residuesSequence analysisAdd BLAST21
Compositional biasi1570 – 1589Polar residuesSequence analysisAdd BLAST20
Compositional biasi1595 – 1618Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1657 – 1680Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1687 – 1720Polar residuesSequence analysisAdd BLAST34
Compositional biasi1769 – 1803Polar residuesSequence analysisAdd BLAST35
Compositional biasi1872 – 1893Polar residuesSequence analysisAdd BLAST22
Compositional biasi1894 – 1908Pro residuesSequence analysisAdd BLAST15
Compositional biasi1909 – 1938Polar residuesSequence analysisAdd BLAST30
Compositional biasi1974 – 1996Polar residuesSequence analysisAdd BLAST23
Compositional biasi2029 – 2043Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi2056 – 2088Basic and acidic residuesSequence analysisAdd BLAST33
Compositional biasi2216 – 2249Polar residuesSequence analysisAdd BLAST34
Compositional biasi2629 – 2655Polar residuesSequence analysisAdd BLAST27
Compositional biasi2778 – 2805Polar residuesSequence analysisAdd BLAST28

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4817, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183161

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000586_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3TLH4

Database of Orthologous Groups

More...
OrthoDBi
17901at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009738, BAT2_N
IPR033184, PRRC2

The PANTHER Classification System

More...
PANTHERi
PTHR14038, PTHR14038, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07001, BAT2_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3TLH4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEKSGQSTK AKDGKKYATL SLFNTYKGKS LETQKTTVAA RHGLQSLGKV
60 70 80 90 100
GISRRMPPPA NLPSLKAENK GNDPNVNIVP KDGTGWASKQ EQHEEEKAPE
110 120 130 140 150
VSPAQPKPGV AAPPEVAPAP KSWASNKQGG QGDGIQVNSQ FQQEFPSLQA
160 170 180 190 200
AGDQEKKEKE ANDENYGPGP SLRPPNVACW RDGGKSAGSP SSDQDEKQLG
210 220 230 240 250
QDESTAITSE QNDILKVVEK RIACGPPQAK LNGQQPALAS QYRAMMPPYM
260 270 280 290 300
FQQYPRMAYP PLHGPMRFPP SLSEANKSLR GRGPPPSWAS EPERPSILSA
310 320 330 340 350
SELKELDKFD NLDAEADEGW AGAQMEVDYT EQLNFSDDDE QGSTSPKESS
360 370 380 390 400
SEDQTAKTPE STENRKEVDE ASSTKSSSQI PAQPPVTKSP YGKGPPFNQE
410 420 430 440 450
RGPSSHLPPP PKLLAQQHPP PPDRQIPGRQ GPFPSKPPVP DNDEIWKQRR
460 470 480 490 500
KQQSEISAAV ERARKRREEE ERRMEEQRKA ACAEKLKQLD EKLGIIEKQP
510 520 530 540 550
SPEELRERER EKERERELEK EKERELEKEQ EKQREMERAR QQEKELEQQR
560 570 580 590 600
EKEQELQRLR EQEKEGEPKE QEKEEKVEPQ EPVVEPATEN QESENNCKKE
610 620 630 640 650
EEPIFTRQDS NRSEKETTQV VQEAEPESGA QPRPGYFKQF QKSLPPRFQR
660 670 680 690 700
QQEQMKQQQW QQQQQQQQQG VLPQTVPSQP SNGSVPPPPH RPLYQPMQPH
710 720 730 740 750
PQHLASMGFD PRWLMMQSYM DPRMISGRPA MDIPPIHPGM IPPKPLIRRD
760 770 780 790 800
QMEGSPNSSE SFEHIARSAR DHGISLSEPR MMWGSDPYHA EPQQAATPKS
810 820 830 840 850
AEETGDARPE TAMDHEHMTA AYPVEHSQLE THSKTDVARD STETEEQKFL
860 870 880 890 900
SRSLEDVKPR HVDTNTQSAC FDVIDQKSLP TSAEERISAL ESQPARKRSV
910 920 930 940 950
SHGSNHAQNA EEQRNEPSVS IPKVINRCMD SKETVEKPEE KPRKDGFLRS
960 970 980 990 1000
SEGPKPEKVY KSKSETRWGP RPSSNRREEG NDRPVRRSGP IKKPVLRDMK
1010 1020 1030 1040 1050
EEREQRKEKE GEKLEKVTEK VVKAEKPEKK DLPLPLPPPA PAQPQPQPLV
1060 1070 1080 1090 1100
SPPVQPEPEK PPSTETSTLT QKPSQDEKPL EPVGSVQVEP VVKTVNQQSV
1110 1120 1130 1140 1150
AAPTVKEEKP PEKVINKDVG IERSRPDSRL AVKKDSSLPT RTYWKEARDR
1160 1170 1180 1190 1200
DWFPDQGYRG RGRGEYYSRG RSYRGSYGGR GRGGRGHTRE YPQYRDNKPR
1210 1220 1230 1240 1250
TEHVPSGPLR QREESETRSE SSDFEVVPKR RRQRGSETDT DSEVHESASD
1260 1270 1280 1290 1300
KDSVSKGKLP KREERPENKK PVKPQSSFKP ENHVRIDNRP LEKPYIREED
1310 1320 1330 1340 1350
KSKPGFLPKG EPTRRGRGGT FRRGGRDPGG RPSRPATLRR PAYRDNQWNT
1360 1370 1380 1390 1400
RQAEPPKPED GEPPRRHEQF MPIPADKRPP KFERKFDPAR ERPRRQRPTR
1410 1420 1430 1440 1450
PPRQDKPPRF RRLREREAAS KTSEVLVPSN GTANNVVQEP VNPPADISGN
1460 1470 1480 1490 1500
KTPDLSNQNS SDQANEEWET ASESSDFNER RERDEKKNAD KSSQAVVKAG
1510 1520 1530 1540 1550
ESVLPPKREI AKRSFSSQRP GVDRQNRRGN NGPPKSGRNF SGPRNERRNG
1560 1570 1580 1590 1600
PPSKGGKRGP FDDQASGTAG ADPVSGNSAH HQEGVPNGAG QKNSKDAAGK
1610 1620 1630 1640 1650
KREDTKPGPK KPKEKVDALS QFDLNNYASV VIIDDHPEVT VIEDPQSNLN
1660 1670 1680 1690 1700
DDGFTEVVSK KQQKRLQDEE RRKKEEQVVQ VWSKKNIGEK GRSQTSKLPP
1710 1720 1730 1740 1750
RFAKKQATGT QQIQAPPSAP VPVSSSAPGL TAPAAAAPAS TPAPVPILAS
1760 1770 1780 1790 1800
ATALVPVSTP APVLTSCPAP VPTSASAPVP ASTSSPVTAS SSSQPSVPAP
1810 1820 1830 1840 1850
TPVLASASTT VSVPILTSAS IPILASALAP ATVSSPTPVV SATAVPSIST
1860 1870 1880 1890 1900
PAVPASAPTA SVPLAPASAA STVPPPASTV QTQTQTQTHK PVQSPLPPSA
1910 1920 1930 1940 1950
PSSKQPPPSI RLPSAQTSNG TDFVAAGKSM PTSQSHGSLT AELWDSKVAA
1960 1970 1980 1990 2000
PAVLNDISKK LGPISPPQPP SVSAWNKPLT SFGSATSSEG TRNGQESGVE
2010 2020 2030 2040 2050
IGIDTIQFGA PASNGNENEV VPVLSEKATD KVPEPKEQRQ KQPRAGPIKA
2060 2070 2080 2090 2100
QKLPDLSLVE NKEHKPGPIG KERSLKNRKV KDAQQVEPEG QEKPSPAVVR
2110 2120 2130 2140 2150
STDPETAKET KAVSEMSAEI GAMISVSSAE YGSDAKESVT DYTTPSSSLP
2160 2170 2180 2190 2200
NTVATNNAKM EDTLVNNVPL PNTLPLPKRE TIQQSSSLTS VPPTTFSLTF
2210 2220 2230 2240 2250
KMESARKAWE NSPNLREKGS PVTSTAPPIV SGVSSSASGP STANYSSFSS
2260 2270 2280 2290 2300
ASMPQIPVAS VTPTASLSGA GTYTTSSLST KSTTTSDPPN ICKVKPQQLQ
2310 2320 2330 2340 2350
TSSLPSASHF SQLSCMPSLI AQQQQSPQVY VSQSAAAQIP AFYMDTSHLF
2360 2370 2380 2390 2400
NTQHARLAPP SLAQQQGFQP GLSQPTSVQQ IPIPIYAPLQ GQHQAQLSLG
2410 2420 2430 2440 2450
AGPAVSQAQE LFSSSIQPYR SQPAFMQSSL SQPSVVLSGT AIHNFPAVQH
2460 2470 2480 2490 2500
QELAKAQSGL AFQQTSNPQP IPILYDHQLG QASGLGSSQL IDTHLLQARA
2510 2520 2530 2540 2550
NLTQASNLYS GQVQQPGQTN FYNTAQSPSA LQQVTVPLPA SQLSLTNFGS
2560 2570 2580 2590 2600
TGQPLIALPQ TLQPQLQHTT PQAQAQSLSR PAQVSQPFRG LIPAGTQHSM
2610 2620 2630 2640 2650
MATTGKMSEM ELKAFGSGID IKPGTPPIGG RSTTPTSSPF RATSTSPNSQ
2660 2670 2680 2690 2700
SSKMNSVVYQ KQFQSAPATV RMAQPFPAQF APQILSQPNL VPPLVRAPHT
2710 2720 2730 2740 2750
NTFPAPVQRP PMALASQMPP PLTTGLMSHA RLPHVARGPC GSLSGVRGNQ
2760 2770 2780 2790 2800
AQAALKAEQD LKAKQRAEVL QSTQRFFSEQ QQNKQIGGKT QRVDSDTSNP
2810 2820 2830 2840
ETLSDPPGTC PEKVEEKPPP APTITTKPVR TGPIKPQAIK TEETKS
Length:2,846
Mass (Da):310,892
Last modified:January 9, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2AEFFE844FBC60C8
GO
Isoform 5 (identifier: Q3TLH4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2684-2762: Missing.

Show »
Length:2,767
Mass (Da):302,606
Checksum:iA23A9945F3F383F2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R294S4R294_MOUSE
Protein PRRC2C
Prrc2c
2,724Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2J9S4R2J9_MOUSE
Protein PRRC2C
Prrc2c
2,765Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQ79A0A0A0MQ79_MOUSE
Protein PRRC2C
Prrc2c
2,844Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2E2S4R2E2_MOUSE
Protein PRRC2C
Prrc2c
564Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2L9S4R2L9_MOUSE
Protein PRRC2C
Prrc2c
1,276Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R298S4R298_MOUSE
Protein PRRC2C
Prrc2c
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R209S4R209_MOUSE
Protein PRRC2C
Prrc2c
1,515Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH06723 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH21412 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH37745 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH80672 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH99612 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC25414 differs from that shown. Reason: Frameshift.Curated
The sequence BAC65723 differs from that shown. Reason: Frameshift.Curated
The sequence BAE22468 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti38 – 39Missing in AAH80672 (PubMed:16141072).Curated2
Sequence conflicti38 – 39Missing in BAC25414 (PubMed:16141072).Curated2
Sequence conflicti38 – 39Missing in BAE38818 (PubMed:16141072).Curated2
Sequence conflicti38 – 39Missing in BAE39192 (PubMed:16141072).Curated2
Sequence conflicti186S → C in BAE38818 (PubMed:16141072).Curated1
Sequence conflicti264G → V in BAC25414 (PubMed:16141072).Curated1
Sequence conflicti347K → E in BAC25414 (PubMed:16141072).Curated1
Sequence conflicti376 – 378SSS → IIF in BAC25414 (PubMed:16141072).Curated3
Sequence conflicti382A → T in BAE38818 (PubMed:16141072).Curated1
Sequence conflicti563E → K in AAH64009 (PubMed:15489334).Curated1
Sequence conflicti846E → G in BAE38818 (PubMed:16141072).Curated1
Sequence conflicti1362E → G in BAC65723 (PubMed:12693553).Curated1
Sequence conflicti1491K → M in BAC65723 (PubMed:12693553).Curated1
Sequence conflicti1686N → K in AAH50871 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0352552684 – 2762Missing in isoform 5. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC118643 Genomic DNA No translation available.
AC132867 Genomic DNA No translation available.
AK013732 mRNA Translation: BAC25414.1 Frameshift.
AK030766 mRNA Translation: BAC27127.1
AK135245 mRNA Translation: BAE22468.1 Sequence problems.
AK166509 mRNA Translation: BAE38818.1
AK167018 mRNA Translation: BAE39192.1
BC006723 mRNA Translation: AAH06723.1 Sequence problems.
BC021412 mRNA Translation: AAH21412.1 Sequence problems.
BC037745 mRNA Translation: AAH37745.1 Sequence problems.
BC050871 mRNA Translation: AAH50871.1
BC064009 mRNA Translation: AAH64009.1
BC080672 mRNA Translation: AAH80672.1 Sequence problems.
BC099612 mRNA Translation: AAH99612.1 Sequence problems.
AK122441 Transcribed RNA Translation: BAC65723.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35749.1 [Q3TLH4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001074759.1, NM_001081290.1 [Q3TLH4-1]
XP_011237086.1, XM_011238784.2 [Q3TLH4-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000182660; ENSMUSP00000138433; ENSMUSG00000040225 [Q3TLH4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
226562

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:226562

UCSC genome browser

More...
UCSCi
uc007dgr.1, mouse [Q3TLH4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118643 Genomic DNA No translation available.
AC132867 Genomic DNA No translation available.
AK013732 mRNA Translation: BAC25414.1 Frameshift.
AK030766 mRNA Translation: BAC27127.1
AK135245 mRNA Translation: BAE22468.1 Sequence problems.
AK166509 mRNA Translation: BAE38818.1
AK167018 mRNA Translation: BAE39192.1
BC006723 mRNA Translation: AAH06723.1 Sequence problems.
BC021412 mRNA Translation: AAH21412.1 Sequence problems.
BC037745 mRNA Translation: AAH37745.1 Sequence problems.
BC050871 mRNA Translation: AAH50871.1
BC064009 mRNA Translation: AAH64009.1
BC080672 mRNA Translation: AAH80672.1 Sequence problems.
BC099612 mRNA Translation: AAH99612.1 Sequence problems.
AK122441 Transcribed RNA Translation: BAC65723.1 Frameshift.
CCDSiCCDS35749.1 [Q3TLH4-1]
RefSeqiNP_001074759.1, NM_001081290.1 [Q3TLH4-1]
XP_011237086.1, XM_011238784.2 [Q3TLH4-5]

3D structure databases

SMRiQ3TLH4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi230531, 23 interactors
IntActiQ3TLH4, 6 interactors
MINTiQ3TLH4
STRINGi10090.ENSMUSP00000138433

PTM databases

iPTMnetiQ3TLH4
PhosphoSitePlusiQ3TLH4
SwissPalmiQ3TLH4

Proteomic databases

jPOSTiQ3TLH4
MaxQBiQ3TLH4
PaxDbiQ3TLH4
PeptideAtlasiQ3TLH4
PRIDEiQ3TLH4
ProteomicsDBi289396 [Q3TLH4-1]
289397 [Q3TLH4-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
20552, 27 antibodies

Genome annotation databases

EnsembliENSMUST00000182660; ENSMUSP00000138433; ENSMUSG00000040225 [Q3TLH4-1]
GeneIDi226562
KEGGimmu:226562
UCSCiuc007dgr.1, mouse [Q3TLH4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23215
MGIiMGI:1913754, Prrc2c

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG4817, Eukaryota
GeneTreeiENSGT00950000183161
HOGENOMiCLU_000586_0_0_1
InParanoidiQ3TLH4
OrthoDBi17901at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
226562, 7 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Prrc2c, mouse

Protein Ontology

More...
PROi
PR:Q3TLH4
RNActiQ3TLH4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040225, Expressed in dorsal pancreas and 275 other tissues
GenevisibleiQ3TLH4, MM

Family and domain databases

InterProiView protein in InterPro
IPR009738, BAT2_N
IPR033184, PRRC2
PANTHERiPTHR14038, PTHR14038, 1 hit
PfamiView protein in Pfam
PF07001, BAT2_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRC2C_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3TLH4
Secondary accession number(s): E9QKG5
, Q05CS4, Q05DM5, Q3TKF3, Q3UXU5, Q4FZE4, Q66K03, Q6P3F4, Q80TK3, Q80YR0, Q8BMJ4, Q8C1K7, Q8CGH3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: January 9, 2013
Last modified: June 2, 2021
This is version 107 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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