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Protein

Spliceosome-associated protein CWC27 homolog

Gene

Cwc27

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.By similarity

Caution

Despite the fact that it belongs to the cyclophilin-type PPIase family, it has probably no peptidyl-prolyl cis-trans isomerase activity.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Spliceosome-associated protein CWC27 homologCurated
Alternative name(s):
Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homologBy similarity
Short name:
PPIase CWC27By similarity
Gene namesi
Name:Cwc27Imported
Synonyms:Sdccag10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1914535 Cwc27

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Knockout mice manifest significant embryonic lethality. Growth retardation, lack of neural tube closure, and absence of limb buds are observed at embryonic day 12.5. Surviving mice show growth retardation and retinal dystrophic changes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003136492 – 469Spliceosome-associated protein CWC27 homologAdd BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ3TKY6
MaxQBiQ3TKY6
PaxDbiQ3TKY6
PeptideAtlasiQ3TKY6
PRIDEiQ3TKY6

PTM databases

iPTMnetiQ3TKY6
PhosphoSitePlusiQ3TKY6

Expressioni

Gene expression databases

BgeeiENSMUSG00000021715 Expressed in 247 organ(s), highest expression level in embryonic stem cell
CleanExiMM_SDCCAG10
ExpressionAtlasiQ3TKY6 baseline and differential
GenevisibleiQ3TKY6 MM

Interactioni

Subunit structurei

Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed at least of 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Recruited during early steps of activated spliceosome B maturation, it is probably one of the first proteins released from this complex as he matures to the spliceosome C complex.By similarity

Protein-protein interaction databases

IntActiQ3TKY6, 1 interactor
MINTiQ3TKY6
STRINGi10090.ENSMUSP00000022228

Structurei

3D structure databases

ProteinModelPortaliQ3TKY6
SMRiQ3TKY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 166PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST156

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili206 – 229Sequence analysisAdd BLAST24
Coiled coili309 – 371Sequence analysisAdd BLAST63

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0885 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00760000119072
HOGENOMiHOG000161443
HOVERGENiHBG097993
InParanoidiQ3TKY6
KOiK12737
OMAiSENHYIN
OrthoDBiEOG091G0BVF
PhylomeDBiQ3TKY6
TreeFamiTF105935

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3TKY6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNIYIQEPP TNGKVLLKTT AGDIDIELWS KEAPKACRNF IQLCLEAYYD
60 70 80 90 100
NTIFHRVVPG FIVQGGDPTG TGTGGESIYG APFKDEFHSR LRFNRRGLVA
110 120 130 140 150
MANAGPHDNG SQFFFTLGRA DELNNKHTIF GKVTGDTVYN MLRLTEVDID
160 170 180 190 200
DEERPRNPHR IKSCEVLFNP FDDITPREIK KPKNEKPEEE VKKLKPKGTK
210 220 230 240 250
NFSLLSFGEE AEEEEEEVNR VSQSMKGRSK SSHDLLKDDP HLSSVPAVES
260 270 280 290 300
EKDDATGDLE DDGEDDSAER DEYMEDDEKN LMRERIAKRL KKDASASVKS
310 320 330 340 350
AGDGEKKPAS RSEELRKEAR QLKRELLAAK QKKETAIKVE EGREEEEAAP
360 370 380 390 400
DGAVAEYRRE KQKYEALRKQ QPKKGTSRED QTLALLSQFK SKLTQAITET
410 420 430 440 450
PENSVPEAEV EDDEGWMSHV LQFEDKTRKV KDASMQDSDT FEIYDPRNPV
460
NKRRREESKK LLREKKERR
Length:469
Mass (Da):53,543
Last modified:October 11, 2005 - v1
Checksum:iF0AF5A6E650BE7A3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z2U3D3Z2U3_MOUSE
Peptidyl-prolyl cis-trans isomerase
Cwc27
83Annotation score:

Sequence cautioni

The sequence AAH25437 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB29120 differs from that shown. Reason: Frameshift at position 90.Curated
The sequence BAC36042 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC37003 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti261D → DLLQ in BAB29120 (PubMed:16141072).Curated1
Sequence conflicti337I → T in AAH25437 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014025 mRNA Translation: BAB29120.1 Frameshift.
AK075902 mRNA Translation: BAC36042.1 Different initiation.
AK077779 mRNA Translation: BAC37003.1 Different initiation.
AK166770 mRNA Translation: BAE39007.1
BC025437 mRNA Translation: AAH25437.1 Different initiation.
CCDSiCCDS26752.1
RefSeqiNP_080348.1, NM_026072.1
UniGeneiMm.235398

Genome annotation databases

EnsembliENSMUST00000022228; ENSMUSP00000022228; ENSMUSG00000021715
GeneIDi67285
KEGGimmu:67285
UCSCiuc007rtj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014025 mRNA Translation: BAB29120.1 Frameshift.
AK075902 mRNA Translation: BAC36042.1 Different initiation.
AK077779 mRNA Translation: BAC37003.1 Different initiation.
AK166770 mRNA Translation: BAE39007.1
BC025437 mRNA Translation: AAH25437.1 Different initiation.
CCDSiCCDS26752.1
RefSeqiNP_080348.1, NM_026072.1
UniGeneiMm.235398

3D structure databases

ProteinModelPortaliQ3TKY6
SMRiQ3TKY6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3TKY6, 1 interactor
MINTiQ3TKY6
STRINGi10090.ENSMUSP00000022228

PTM databases

iPTMnetiQ3TKY6
PhosphoSitePlusiQ3TKY6

Proteomic databases

EPDiQ3TKY6
MaxQBiQ3TKY6
PaxDbiQ3TKY6
PeptideAtlasiQ3TKY6
PRIDEiQ3TKY6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022228; ENSMUSP00000022228; ENSMUSG00000021715
GeneIDi67285
KEGGimmu:67285
UCSCiuc007rtj.1 mouse

Organism-specific databases

CTDi10283
MGIiMGI:1914535 Cwc27

Phylogenomic databases

eggNOGiKOG0885 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00760000119072
HOGENOMiHOG000161443
HOVERGENiHBG097993
InParanoidiQ3TKY6
KOiK12737
OMAiSENHYIN
OrthoDBiEOG091G0BVF
PhylomeDBiQ3TKY6
TreeFamiTF105935

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

ChiTaRSiCwc27 mouse
PROiPR:Q3TKY6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021715 Expressed in 247 organ(s), highest expression level in embryonic stem cell
CleanExiMM_SDCCAG10
ExpressionAtlasiQ3TKY6 baseline and differential
GenevisibleiQ3TKY6 MM

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCWC27_MOUSE
AccessioniPrimary (citable) accession number: Q3TKY6
Secondary accession number(s): Q8BG42, Q8R158, Q9CXT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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