UniProtKB - Q3TKR3 (NAL4C_MOUSE)
Protein
NACHT, LRR and PYD domains-containing protein 4C
Gene
Nlrp4c
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 154 – 161 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- inflammatory response Source: UniProtKB-KW
Keywordsi
Biological process | Inflammatory response |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-3134975, Regulation of innate immune responses to cytosolic DNA R-MMU-3270619, IRF3-mediated induction of type I IFN |
Names & Taxonomyi
Protein namesi | Recommended name: NACHT, LRR and PYD domains-containing protein 4CAlternative name(s): NALP-alpha |
Gene namesi | Name:Nlrp4c Synonyms:Nalp4c |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1890518, Nlrp4c |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286331 | 1 – 982 | NACHT, LRR and PYD domains-containing protein 4CAdd BLAST | 982 |
Proteomic databases
MaxQBi | Q3TKR3 |
PaxDbi | Q3TKR3 |
PRIDEi | Q3TKR3 |
PTM databases
iPTMneti | Q3TKR3 |
PhosphoSitePlusi | Q3TKR3 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000034690, Expressed in brain and 54 other tissues |
Genevisiblei | Q3TKR3, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000046503 |
Miscellaneous databases
RNActi | Q3TKR3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 93 | PyrinPROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 148 – 471 | NACHTPROSITE-ProRule annotationAdd BLAST | 324 | |
Repeati | 594 – 617 | LRR 1Add BLAST | 24 | |
Repeati | 689 – 716 | LRR 2Add BLAST | 28 | |
Repeati | 746 – 773 | LRR 3Add BLAST | 28 | |
Repeati | 802 – 825 | LRR 4Add BLAST | 24 | |
Repeati | 827 – 844 | LRR 5Add BLAST | 18 | |
Repeati | 859 – 882 | LRR 6Add BLAST | 24 | |
Repeati | 916 – 940 | LRR 7Add BLAST | 25 |
Sequence similaritiesi
Belongs to the NLRP family.Curated
Keywords - Domaini
Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | ENOG502SGVH, Eukaryota |
GeneTreei | ENSGT00940000162284 |
HOGENOMi | CLU_002274_2_1_1 |
InParanoidi | Q3TKR3 |
OMAi | LMLAFCH |
OrthoDBi | 114368at2759 |
PhylomeDBi | Q3TKR3 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR004020, DAPIN IPR011029, DEATH-like_dom_sf IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR007111, NACHT_NTPase IPR041267, NLRP_HD2 IPR041075, NOD2_WH IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF13516, LRR_6, 3 hits PF05729, NACHT, 1 hit PF17776, NLRC4_HD2, 1 hit PF17779, NOD2_WH, 1 hit PF02758, PYRIN, 1 hit |
SMARTi | View protein in SMART SM01289, PYRIN, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50824, DAPIN, 1 hit PS51450, LRR, 3 hits PS50837, NACHT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3TKR3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASFFSDFGL MWYLEELNKK EFMKFKEFLK QEILQLRLKQ ISWTEVKKAS
60 70 80 90 100
REDLANLLLK HYEEKKAWDM TFKIFQKMNR KDLMERAGRE IAGHSKLYQA
110 120 130 140 150
HLKKKLTHDY ARKFNIKVQD FSKQKFTQDD YDRFENFLIS KVTAKKPHMV
160 170 180 190 200
FLQGAAGIGK SLMLTKLMLA WSEGMVFQNK FSYIFYFCCQ DVKKMKRASL
210 220 230 240 250
AELISKEWPK TSAPIEDILS QPEKLLFVID NLEVMECDMS ERESELCDTC
260 270 280 290 300
TEKQPVRILL SSLLRRKMLP KSSFLISATP ETFEKMEGRV ECTNVKIVTG
310 320 330 340 350
FNESNIKMYF RSLFQDKTKT QEIFSLVKEN QQLFTVCQVP VLCWMVATCL
360 370 380 390 400
KKEIEKGRDL VSVCRRTTSL YTTHIFNLFI PQSAQYPSKE SQAQLQSLCS
410 420 430 440 450
LAAEGMWTDT FVFGEEALRR NGIMDSDIPT LLDVRILEKS KKSEKSYIFL
460 470 480 490 500
HPSIQEVCAA IFYLLKSHMD HPSQDVKSIE ALIFTFLKKV KVQWIFFGSF
510 520 530 540 550
IFGLLHESEQ KKLEAFFGHQ LSQEIKRQLY QCLETISGNE ELQEQVDGMK
560 570 580 590 600
LFYCLFEMDD EAFLAQAMNC MEQINFVAKD YSDVIVAAHC LQHCSTLKKL
610 620 630 640 650
SLSTQNVLSE GQEHSYTEKL LMCWHHMCSV LISSKDIYIL QVKNTNLNET
660 670 680 690 700
ASLVLYSHLM YPSCTLKALV VNNVTFLCDN RLFFELIQNQ CLQHLDLNLT
710 720 730 740 750
FLSHGDVKLL CDVLSQEECN IEKLMVAACN LSPDDCKVFA SVLISSKMLK
760 770 780 790 800
HLNLSSNNLD KGISSLSKAL CHPDCVLKNL VLVNCSLSEQ CWDYLSEVLR
810 820 830 840 850
RNKTLNHLDI SSNDLKDEGL KVLCGALSLP DSVLKSLSVR YCLITTSGCQ
860 870 880 890 900
DLAEVLRKNQ NLRNLQVSNN KIEDAGVKLL CDAIKHPNCH LENIGLEACA
910 920 930 940 950
LTGACCEDLA SAFTHCKTLW GINLQENALD HSGLIVLFEA LKQQQCTLHV
960 970 980
LGLRITDFDK ETQELLMAEE EKNPHLSILS SV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 892 | E → Q in AAU06315 (PubMed:15317747).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY596194 mRNA Translation: AAU06315.1 AK166817 mRNA Translation: BAE39043.1 AK166869 mRNA Translation: BAE39081.1 |
CCDSi | CCDS51988.1 |
RefSeqi | NP_113566.2, NM_031389.2 |
Genome annotation databases
Ensembli | ENSMUST00000037728; ENSMUSP00000046503; ENSMUSG00000034690 ENSMUST00000121583; ENSMUSP00000113824; ENSMUSG00000034690 ENSMUST00000208360; ENSMUSP00000146613; ENSMUSG00000034690 |
GeneIDi | 83564 |
KEGGi | mmu:83564 |
UCSCi | uc009fan.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY596194 mRNA Translation: AAU06315.1 AK166817 mRNA Translation: BAE39043.1 AK166869 mRNA Translation: BAE39081.1 |
CCDSi | CCDS51988.1 |
RefSeqi | NP_113566.2, NM_031389.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000046503 |
PTM databases
iPTMneti | Q3TKR3 |
PhosphoSitePlusi | Q3TKR3 |
Proteomic databases
MaxQBi | Q3TKR3 |
PaxDbi | Q3TKR3 |
PRIDEi | Q3TKR3 |
Genome annotation databases
Ensembli | ENSMUST00000037728; ENSMUSP00000046503; ENSMUSG00000034690 ENSMUST00000121583; ENSMUSP00000113824; ENSMUSG00000034690 ENSMUST00000208360; ENSMUSP00000146613; ENSMUSG00000034690 |
GeneIDi | 83564 |
KEGGi | mmu:83564 |
UCSCi | uc009fan.2, mouse |
Organism-specific databases
CTDi | 83564 |
MGIi | MGI:1890518, Nlrp4c |
Phylogenomic databases
eggNOGi | ENOG502SGVH, Eukaryota |
GeneTreei | ENSGT00940000162284 |
HOGENOMi | CLU_002274_2_1_1 |
InParanoidi | Q3TKR3 |
OMAi | LMLAFCH |
OrthoDBi | 114368at2759 |
PhylomeDBi | Q3TKR3 |
Enzyme and pathway databases
Reactomei | R-MMU-3134975, Regulation of innate immune responses to cytosolic DNA R-MMU-3270619, IRF3-mediated induction of type I IFN |
Miscellaneous databases
BioGRID-ORCSi | 83564, 2 hits in 17 CRISPR screens |
PROi | PR:Q3TKR3 |
RNActi | Q3TKR3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000034690, Expressed in brain and 54 other tissues |
Genevisiblei | Q3TKR3, MM |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR004020, DAPIN IPR011029, DEATH-like_dom_sf IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR007111, NACHT_NTPase IPR041267, NLRP_HD2 IPR041075, NOD2_WH IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF13516, LRR_6, 3 hits PF05729, NACHT, 1 hit PF17776, NLRC4_HD2, 1 hit PF17779, NOD2_WH, 1 hit PF02758, PYRIN, 1 hit |
SMARTi | View protein in SMART SM01289, PYRIN, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50824, DAPIN, 1 hit PS51450, LRR, 3 hits PS50837, NACHT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NAL4C_MOUSE | |
Accessioni | Q3TKR3Primary (citable) accession number: Q3TKR3 Secondary accession number(s): Q66X27 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families