Nlrp4c

Functionⁱ

May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	154 – 161	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

inflammatory response Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Inflammatory response
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3134975 Regulation of innate immune responses to cytosolic DNA R-MMU-3270619 IRF3-mediated induction of type I IFN

Reactomeⁱ

R-MMU-3134975 Regulation of innate immune responses to cytosolic DNA
R-MMU-3270619 IRF3-mediated induction of type I IFN

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: NACHT, LRR and PYD domains-containing protein 4C Alternative name(s): NALP-alpha
Gene namesⁱ	Name:Nlrp4c Synonyms:Nalp4c
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1890518 Nlrp4c

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000286331	1 – 982	NACHT, LRR and PYD domains-containing protein 4CAdd BLAST		982

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3TKR3
PaxDbⁱ	Q3TKR3
PRIDEⁱ	Q3TKR3

PTM databases

iPTMnetⁱ	Q3TKR3
PhosphoSitePlusⁱ	Q3TKR3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000034690 Expressed in 40 organ(s), highest expression level in brain
CleanExⁱ	MM_NLRP4C
Genevisibleⁱ	Q3TKR3 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000046503

STRINGⁱ

10090.ENSMUSP00000046503

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3TKR3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 93	PyrinPROSITE-ProRule annotationAdd BLAST	93
Domainⁱ	148 – 471	NACHTPROSITE-ProRule annotationAdd BLAST	324
Repeatⁱ	594 – 617	LRR 1Add BLAST	24
Repeatⁱ	689 – 716	LRR 2Add BLAST	28
Repeatⁱ	746 – 773	LRR 3Add BLAST	28
Repeatⁱ	802 – 825	LRR 4Add BLAST	24
Repeatⁱ	827 – 844	LRR 5Add BLAST	18
Repeatⁱ	859 – 882	LRR 6Add BLAST	24
Repeatⁱ	916 – 940	LRR 7Add BLAST	25

Sequence similaritiesⁱ

Belongs to the NLRP family.Curated

Keywords - Domainⁱ

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG4308 Eukaryota ENOG410ZBX3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140813
HOGENOMⁱ	HOG000294064
HOVERGENⁱ	HBG063656
InParanoidⁱ	Q3TKR3
KEGG Orthology (KO) More...KOⁱ	K22265
OMAⁱ	HYEEQQA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01CG
PhylomeDBⁱ	Q3TKR3

Family and domain databases

Gene3Dⁱ	3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR004020 DAPIN IPR011029 DEATH-like_dom_sf IPR001611 Leu-rich_rpt IPR032675 LRR_dom_sf IPR007111 NACHT_NTPase IPR027417 P-loop_NTPase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13516 LRR_6, 3 hits PF05729 NACHT, 1 hit PF02758 PYRIN, 1 hit
SMARTⁱ	View protein in SMART SM01289 PYRIN, 1 hit
SUPFAMⁱ	SSF47986 SSF47986, 1 hit SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS50824 DAPIN, 1 hit PS51450 LRR, 3 hits PS50837 NACHT, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3TKR3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASFFSDFGL MWYLEELNKK EFMKFKEFLK QEILQLRLKQ ISWTEVKKAS 
        60         70         80         90        100
REDLANLLLK HYEEKKAWDM TFKIFQKMNR KDLMERAGRE IAGHSKLYQA 
       110        120        130        140        150
HLKKKLTHDY ARKFNIKVQD FSKQKFTQDD YDRFENFLIS KVTAKKPHMV 
       160        170        180        190        200
FLQGAAGIGK SLMLTKLMLA WSEGMVFQNK FSYIFYFCCQ DVKKMKRASL 
       210        220        230        240        250
AELISKEWPK TSAPIEDILS QPEKLLFVID NLEVMECDMS ERESELCDTC 
       260        270        280        290        300
TEKQPVRILL SSLLRRKMLP KSSFLISATP ETFEKMEGRV ECTNVKIVTG 
       310        320        330        340        350
FNESNIKMYF RSLFQDKTKT QEIFSLVKEN QQLFTVCQVP VLCWMVATCL 
       360        370        380        390        400
KKEIEKGRDL VSVCRRTTSL YTTHIFNLFI PQSAQYPSKE SQAQLQSLCS 
       410        420        430        440        450
LAAEGMWTDT FVFGEEALRR NGIMDSDIPT LLDVRILEKS KKSEKSYIFL 
       460        470        480        490        500
HPSIQEVCAA IFYLLKSHMD HPSQDVKSIE ALIFTFLKKV KVQWIFFGSF 
       510        520        530        540        550
IFGLLHESEQ KKLEAFFGHQ LSQEIKRQLY QCLETISGNE ELQEQVDGMK 
       560        570        580        590        600
LFYCLFEMDD EAFLAQAMNC MEQINFVAKD YSDVIVAAHC LQHCSTLKKL 
       610        620        630        640        650
SLSTQNVLSE GQEHSYTEKL LMCWHHMCSV LISSKDIYIL QVKNTNLNET 
       660        670        680        690        700
ASLVLYSHLM YPSCTLKALV VNNVTFLCDN RLFFELIQNQ CLQHLDLNLT 
       710        720        730        740        750
FLSHGDVKLL CDVLSQEECN IEKLMVAACN LSPDDCKVFA SVLISSKMLK 
       760        770        780        790        800
HLNLSSNNLD KGISSLSKAL CHPDCVLKNL VLVNCSLSEQ CWDYLSEVLR 
       810        820        830        840        850
RNKTLNHLDI SSNDLKDEGL KVLCGALSLP DSVLKSLSVR YCLITTSGCQ 
       860        870        880        890        900
DLAEVLRKNQ NLRNLQVSNN KIEDAGVKLL CDAIKHPNCH LENIGLEACA 
       910        920        930        940        950
LTGACCEDLA SAFTHCKTLW GINLQENALD HSGLIVLFEA LKQQQCTLHV 
       960        970        980 
LGLRITDFDK ETQELLMAEE EKNPHLSILS SV

Length:982

Mass (Da):112,674

Last modified:October 11, 2005 - v1

Checksum:ⁱ612D76CC6F0D4398

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	892	E → Q in AAU06315 (PubMed:15317747).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY596194 mRNA Translation: AAU06315.1 AK166817 mRNA Translation: BAE39043.1 AK166869 mRNA Translation: BAE39081.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS51988.1
NCBI Reference Sequences More...RefSeqⁱ	NP_113566.2, NM_031389.2
UniGeneⁱ	Mm.247765

Genome annotation databases

Ensemblⁱ	ENSMUST00000037728; ENSMUSP00000046503; ENSMUSG00000034690 ENSMUST00000121583; ENSMUSP00000113824; ENSMUSG00000034690 ENSMUST00000208360; ENSMUSP00000146613; ENSMUSG00000034690
GeneIDⁱ	83564
KEGGⁱ	mmu:83564
UCSC genome browser More...UCSCⁱ	uc009fan.2 mouse

Protein	Similar proteins		Species	Score	Length	Source
Q3TKR3	Nlrp4c protein		MOUSE		748	UniRef100_Q3TKR3

Protein	Similar proteins		Species	Score	Length	Source
Q3TKR3	Nlrp4c protein		MOUSE		748	UniRef90_Q3TKR3

Protein	Similar proteins		Species	Score	Length	Source
Q3TKR3	Isoform 2 of NACHT, LRR and PYD domains-containing protein 4		HUMAN		503	UniRef50_Q96MN2-2
NACHT, LRR and PYD domains-containing protein 4E		MOUSE		978
NACHT, LRR and PYD domains-containing protein 4		FUKDA		984
NLRP4 isoform 3		PANTR		919
NLRP4 isoform 2		PONAB		919
+59

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY596194 mRNA Translation: AAU06315.1 AK166817 mRNA Translation: BAE39043.1 AK166869 mRNA Translation: BAE39081.1
CCDSⁱ	CCDS51988.1
RefSeqⁱ	NP_113566.2, NM_031389.2
UniGeneⁱ	Mm.247765

3D structure databases

ProteinModelPortalⁱ	Q3TKR3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000046503

STRINGⁱ

10090.ENSMUSP00000046503

PTM databases

iPTMnetⁱ	Q3TKR3
PhosphoSitePlusⁱ	Q3TKR3

Proteomic databases

MaxQBⁱ	Q3TKR3
PaxDbⁱ	Q3TKR3
PRIDEⁱ	Q3TKR3

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000037728; ENSMUSP00000046503; ENSMUSG00000034690 ENSMUST00000121583; ENSMUSP00000113824; ENSMUSG00000034690 ENSMUST00000208360; ENSMUSP00000146613; ENSMUSG00000034690
GeneIDⁱ	83564
KEGGⁱ	mmu:83564
UCSCⁱ	uc009fan.2 mouse

Organism-specific databases

CTDⁱ	83564
MGIⁱ	MGI:1890518 Nlrp4c

Phylogenomic databases

eggNOGⁱ	KOG4308 Eukaryota ENOG410ZBX3 LUCA
GeneTreeⁱ	ENSGT00900000140813
HOGENOMⁱ	HOG000294064
HOVERGENⁱ	HBG063656
InParanoidⁱ	Q3TKR3
KOⁱ	K22265
OMAⁱ	HYEEQQA
OrthoDBⁱ	EOG091G01CG
PhylomeDBⁱ	Q3TKR3

Enzyme and pathway databases

Reactomeⁱ	R-MMU-3134975 Regulation of innate immune responses to cytosolic DNA R-MMU-3270619 IRF3-mediated induction of type I IFN

Reactomeⁱ

R-MMU-3134975 Regulation of innate immune responses to cytosolic DNA
R-MMU-3270619 IRF3-mediated induction of type I IFN

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q3TKR3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000034690 Expressed in 40 organ(s), highest expression level in brain
CleanExⁱ	MM_NLRP4C
Genevisibleⁱ	Q3TKR3 MM

Family and domain databases

Gene3Dⁱ	3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR004020 DAPIN IPR011029 DEATH-like_dom_sf IPR001611 Leu-rich_rpt IPR032675 LRR_dom_sf IPR007111 NACHT_NTPase IPR027417 P-loop_NTPase
Pfamⁱ	View protein in Pfam PF13516 LRR_6, 3 hits PF05729 NACHT, 1 hit PF02758 PYRIN, 1 hit
SMARTⁱ	View protein in SMART SM01289 PYRIN, 1 hit
SUPFAMⁱ	SSF47986 SSF47986, 1 hit SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS50824 DAPIN, 1 hit PS51450 LRR, 3 hits PS50837 NACHT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NAL4C_MOUSE
Accessionⁱ	Q3TKR3Primary (citable) accession number: Q3TKR3 Secondary accession number(s): Q66X27
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
	Last sequence update:	October 11, 2005
	Last modified:	November 7, 2018
	This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3TKR3 (NAL4C_MOUSE)

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NACHT, LRR and PYD domains-containing protein 4C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ