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Protein

NACHT, LRR and PYD domains-containing protein 4C

Gene

Nlrp4c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi154 – 161ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processInflammatory response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-3134975 Regulation of innate immune responses to cytosolic DNA
R-MMU-3270619 IRF3-mediated induction of type I IFN

Names & Taxonomyi

Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 4C
Alternative name(s):
NALP-alpha
Gene namesi
Name:Nlrp4c
Synonyms:Nalp4c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1890518 Nlrp4c

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002863311 – 982NACHT, LRR and PYD domains-containing protein 4CAdd BLAST982

Proteomic databases

MaxQBiQ3TKR3
PaxDbiQ3TKR3
PRIDEiQ3TKR3

PTM databases

iPTMnetiQ3TKR3
PhosphoSitePlusiQ3TKR3

Expressioni

Gene expression databases

BgeeiENSMUSG00000034690 Expressed in 40 organ(s), highest expression level in brain
CleanExiMM_NLRP4C
GenevisibleiQ3TKR3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046503

Structurei

3D structure databases

ProteinModelPortaliQ3TKR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 93PyrinPROSITE-ProRule annotationAdd BLAST93
Domaini148 – 471NACHTPROSITE-ProRule annotationAdd BLAST324
Repeati594 – 617LRR 1Add BLAST24
Repeati689 – 716LRR 2Add BLAST28
Repeati746 – 773LRR 3Add BLAST28
Repeati802 – 825LRR 4Add BLAST24
Repeati827 – 844LRR 5Add BLAST18
Repeati859 – 882LRR 6Add BLAST24
Repeati916 – 940LRR 7Add BLAST25

Sequence similaritiesi

Belongs to the NLRP family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4308 Eukaryota
ENOG410ZBX3 LUCA
GeneTreeiENSGT00900000140813
HOGENOMiHOG000294064
HOVERGENiHBG063656
InParanoidiQ3TKR3
KOiK22265
OMAiHYEEQQA
OrthoDBiEOG091G01CG
PhylomeDBiQ3TKR3

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF13516 LRR_6, 3 hits
PF05729 NACHT, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS51450 LRR, 3 hits
PS50837 NACHT, 1 hit

Sequencei

Sequence statusi: Complete.

Q3TKR3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASFFSDFGL MWYLEELNKK EFMKFKEFLK QEILQLRLKQ ISWTEVKKAS
60 70 80 90 100
REDLANLLLK HYEEKKAWDM TFKIFQKMNR KDLMERAGRE IAGHSKLYQA
110 120 130 140 150
HLKKKLTHDY ARKFNIKVQD FSKQKFTQDD YDRFENFLIS KVTAKKPHMV
160 170 180 190 200
FLQGAAGIGK SLMLTKLMLA WSEGMVFQNK FSYIFYFCCQ DVKKMKRASL
210 220 230 240 250
AELISKEWPK TSAPIEDILS QPEKLLFVID NLEVMECDMS ERESELCDTC
260 270 280 290 300
TEKQPVRILL SSLLRRKMLP KSSFLISATP ETFEKMEGRV ECTNVKIVTG
310 320 330 340 350
FNESNIKMYF RSLFQDKTKT QEIFSLVKEN QQLFTVCQVP VLCWMVATCL
360 370 380 390 400
KKEIEKGRDL VSVCRRTTSL YTTHIFNLFI PQSAQYPSKE SQAQLQSLCS
410 420 430 440 450
LAAEGMWTDT FVFGEEALRR NGIMDSDIPT LLDVRILEKS KKSEKSYIFL
460 470 480 490 500
HPSIQEVCAA IFYLLKSHMD HPSQDVKSIE ALIFTFLKKV KVQWIFFGSF
510 520 530 540 550
IFGLLHESEQ KKLEAFFGHQ LSQEIKRQLY QCLETISGNE ELQEQVDGMK
560 570 580 590 600
LFYCLFEMDD EAFLAQAMNC MEQINFVAKD YSDVIVAAHC LQHCSTLKKL
610 620 630 640 650
SLSTQNVLSE GQEHSYTEKL LMCWHHMCSV LISSKDIYIL QVKNTNLNET
660 670 680 690 700
ASLVLYSHLM YPSCTLKALV VNNVTFLCDN RLFFELIQNQ CLQHLDLNLT
710 720 730 740 750
FLSHGDVKLL CDVLSQEECN IEKLMVAACN LSPDDCKVFA SVLISSKMLK
760 770 780 790 800
HLNLSSNNLD KGISSLSKAL CHPDCVLKNL VLVNCSLSEQ CWDYLSEVLR
810 820 830 840 850
RNKTLNHLDI SSNDLKDEGL KVLCGALSLP DSVLKSLSVR YCLITTSGCQ
860 870 880 890 900
DLAEVLRKNQ NLRNLQVSNN KIEDAGVKLL CDAIKHPNCH LENIGLEACA
910 920 930 940 950
LTGACCEDLA SAFTHCKTLW GINLQENALD HSGLIVLFEA LKQQQCTLHV
960 970 980
LGLRITDFDK ETQELLMAEE EKNPHLSILS SV
Length:982
Mass (Da):112,674
Last modified:October 11, 2005 - v1
Checksum:i612D76CC6F0D4398
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti892E → Q in AAU06315 (PubMed:15317747).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596194 mRNA Translation: AAU06315.1
AK166817 mRNA Translation: BAE39043.1
AK166869 mRNA Translation: BAE39081.1
CCDSiCCDS51988.1
RefSeqiNP_113566.2, NM_031389.2
UniGeneiMm.247765

Genome annotation databases

EnsembliENSMUST00000037728; ENSMUSP00000046503; ENSMUSG00000034690
ENSMUST00000121583; ENSMUSP00000113824; ENSMUSG00000034690
ENSMUST00000208360; ENSMUSP00000146613; ENSMUSG00000034690
GeneIDi83564
KEGGimmu:83564
UCSCiuc009fan.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596194 mRNA Translation: AAU06315.1
AK166817 mRNA Translation: BAE39043.1
AK166869 mRNA Translation: BAE39081.1
CCDSiCCDS51988.1
RefSeqiNP_113566.2, NM_031389.2
UniGeneiMm.247765

3D structure databases

ProteinModelPortaliQ3TKR3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046503

PTM databases

iPTMnetiQ3TKR3
PhosphoSitePlusiQ3TKR3

Proteomic databases

MaxQBiQ3TKR3
PaxDbiQ3TKR3
PRIDEiQ3TKR3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037728; ENSMUSP00000046503; ENSMUSG00000034690
ENSMUST00000121583; ENSMUSP00000113824; ENSMUSG00000034690
ENSMUST00000208360; ENSMUSP00000146613; ENSMUSG00000034690
GeneIDi83564
KEGGimmu:83564
UCSCiuc009fan.2 mouse

Organism-specific databases

CTDi83564
MGIiMGI:1890518 Nlrp4c

Phylogenomic databases

eggNOGiKOG4308 Eukaryota
ENOG410ZBX3 LUCA
GeneTreeiENSGT00900000140813
HOGENOMiHOG000294064
HOVERGENiHBG063656
InParanoidiQ3TKR3
KOiK22265
OMAiHYEEQQA
OrthoDBiEOG091G01CG
PhylomeDBiQ3TKR3

Enzyme and pathway databases

ReactomeiR-MMU-3134975 Regulation of innate immune responses to cytosolic DNA
R-MMU-3270619 IRF3-mediated induction of type I IFN

Miscellaneous databases

PROiPR:Q3TKR3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034690 Expressed in 40 organ(s), highest expression level in brain
CleanExiMM_NLRP4C
GenevisibleiQ3TKR3 MM

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF13516 LRR_6, 3 hits
PF05729 NACHT, 1 hit
PF02758 PYRIN, 1 hit
SMARTiView protein in SMART
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS51450 LRR, 3 hits
PS50837 NACHT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNAL4C_MOUSE
AccessioniPrimary (citable) accession number: Q3TKR3
Secondary accession number(s): Q66X27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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