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UniProtKB - Q3TKR3 (NAL4C_MOUSE)

Entry version 123 (02 Dec 2020)
Sequence version 1 (11 Oct 2005)
Previous versions | rss
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Protein

NACHT, LRR and PYD domains-containing protein 4C

Gene

Nlrp4c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi154 – 161ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processInflammatory response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-3134975, Regulation of innate immune responses to cytosolic DNA
R-MMU-3270619, IRF3-mediated induction of type I IFN

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NACHT, LRR and PYD domains-containing protein 4C
Alternative name(s):
NALP-alpha
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nlrp4c
Synonyms:Nalp4c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1890518, Nlrp4c

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002863311 – 982NACHT, LRR and PYD domains-containing protein 4CAdd BLAST982

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q3TKR3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q3TKR3

PRoteomics IDEntifications database

More...PRIDEi		Q3TKR3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q3TKR3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q3TKR3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000034690, Expressed in brain and 54 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q3TKR3, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000046503

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q3TKR3, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 93PyrinPROSITE-ProRule annotationAdd BLAST93
Domaini148 – 471NACHTPROSITE-ProRule annotationAdd BLAST324
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati594 – 617LRR 1Add BLAST24
Repeati689 – 716LRR 2Add BLAST28
Repeati746 – 773LRR 3Add BLAST28
Repeati802 – 825LRR 4Add BLAST24
Repeati827 – 844LRR 5Add BLAST18
Repeati859 – 882LRR 6Add BLAST24
Repeati916 – 940LRR 7Add BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NLRP family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SGVH, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162284

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002274_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q3TKR3

Identification of Orthologs from Complete Genome Data

More...OMAi		LMLAFCH

Database of Orthologous Groups

More...OrthoDBi		114368at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q3TKR3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004020, DAPIN
IPR011029, DEATH-like_dom_sf
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR007111, NACHT_NTPase
IPR041267, NLRP_HD2
IPR041075, NOD2_WH
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13516, LRR_6, 3 hits
PF05729, NACHT, 1 hit
PF17776, NLRC4_HD2, 1 hit
PF17779, NOD2_WH, 1 hit
PF02758, PYRIN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01289, PYRIN, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47986, SSF47986, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50824, DAPIN, 1 hit
PS51450, LRR, 3 hits
PS50837, NACHT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3TKR3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASFFSDFGL MWYLEELNKK EFMKFKEFLK QEILQLRLKQ ISWTEVKKAS 
        60         70         80         90        100
REDLANLLLK HYEEKKAWDM TFKIFQKMNR KDLMERAGRE IAGHSKLYQA 
       110        120        130        140        150
HLKKKLTHDY ARKFNIKVQD FSKQKFTQDD YDRFENFLIS KVTAKKPHMV 
       160        170        180        190        200
FLQGAAGIGK SLMLTKLMLA WSEGMVFQNK FSYIFYFCCQ DVKKMKRASL 
       210        220        230        240        250
AELISKEWPK TSAPIEDILS QPEKLLFVID NLEVMECDMS ERESELCDTC 
       260        270        280        290        300
TEKQPVRILL SSLLRRKMLP KSSFLISATP ETFEKMEGRV ECTNVKIVTG 
       310        320        330        340        350
FNESNIKMYF RSLFQDKTKT QEIFSLVKEN QQLFTVCQVP VLCWMVATCL 
       360        370        380        390        400
KKEIEKGRDL VSVCRRTTSL YTTHIFNLFI PQSAQYPSKE SQAQLQSLCS 
       410        420        430        440        450
LAAEGMWTDT FVFGEEALRR NGIMDSDIPT LLDVRILEKS KKSEKSYIFL 
       460        470        480        490        500
HPSIQEVCAA IFYLLKSHMD HPSQDVKSIE ALIFTFLKKV KVQWIFFGSF 
       510        520        530        540        550
IFGLLHESEQ KKLEAFFGHQ LSQEIKRQLY QCLETISGNE ELQEQVDGMK 
       560        570        580        590        600
LFYCLFEMDD EAFLAQAMNC MEQINFVAKD YSDVIVAAHC LQHCSTLKKL 
       610        620        630        640        650
SLSTQNVLSE GQEHSYTEKL LMCWHHMCSV LISSKDIYIL QVKNTNLNET 
       660        670        680        690        700
ASLVLYSHLM YPSCTLKALV VNNVTFLCDN RLFFELIQNQ CLQHLDLNLT 
       710        720        730        740        750
FLSHGDVKLL CDVLSQEECN IEKLMVAACN LSPDDCKVFA SVLISSKMLK 
       760        770        780        790        800
HLNLSSNNLD KGISSLSKAL CHPDCVLKNL VLVNCSLSEQ CWDYLSEVLR 
       810        820        830        840        850
RNKTLNHLDI SSNDLKDEGL KVLCGALSLP DSVLKSLSVR YCLITTSGCQ 
       860        870        880        890        900
DLAEVLRKNQ NLRNLQVSNN KIEDAGVKLL CDAIKHPNCH LENIGLEACA 
       910        920        930        940        950
LTGACCEDLA SAFTHCKTLW GINLQENALD HSGLIVLFEA LKQQQCTLHV 
       960        970        980 
LGLRITDFDK ETQELLMAEE EKNPHLSILS SV
Length:982
Mass (Da):112,674
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i612D76CC6F0D4398
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti892E → Q in AAU06315 (PubMed:15317747).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY596194 mRNA Translation: AAU06315.1
AK166817 mRNA Translation: BAE39043.1
AK166869 mRNA Translation: BAE39081.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS51988.1

NCBI Reference Sequences

More...RefSeqi		NP_113566.2, NM_031389.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000037728; ENSMUSP00000046503; ENSMUSG00000034690
ENSMUST00000121583; ENSMUSP00000113824; ENSMUSG00000034690
ENSMUST00000208360; ENSMUSP00000146613; ENSMUSG00000034690

Database of genes from NCBI RefSeq genomes

More...GeneIDi		83564

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:83564

UCSC genome browser

More...UCSCi		uc009fan.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596194 mRNA Translation: AAU06315.1
AK166817 mRNA Translation: BAE39043.1
AK166869 mRNA Translation: BAE39081.1
CCDSiCCDS51988.1
RefSeqiNP_113566.2, NM_031389.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046503

PTM databases

iPTMnetiQ3TKR3
PhosphoSitePlusiQ3TKR3

Proteomic databases

MaxQBiQ3TKR3
PaxDbiQ3TKR3
PRIDEiQ3TKR3

Genome annotation databases

EnsembliENSMUST00000037728; ENSMUSP00000046503; ENSMUSG00000034690
ENSMUST00000121583; ENSMUSP00000113824; ENSMUSG00000034690
ENSMUST00000208360; ENSMUSP00000146613; ENSMUSG00000034690
GeneIDi83564
KEGGimmu:83564
UCSCiuc009fan.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		83564
MGIiMGI:1890518, Nlrp4c

Phylogenomic databases

eggNOGiENOG502SGVH, Eukaryota
GeneTreeiENSGT00940000162284
HOGENOMiCLU_002274_2_1_1
InParanoidiQ3TKR3
OMAiLMLAFCH
OrthoDBi114368at2759
PhylomeDBiQ3TKR3

Enzyme and pathway databases

ReactomeiR-MMU-3134975, Regulation of innate immune responses to cytosolic DNA
R-MMU-3270619, IRF3-mediated induction of type I IFN

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		83564, 2 hits in 17 CRISPR screens

Protein Ontology

More...PROi		PR:Q3TKR3
RNActiQ3TKR3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000034690, Expressed in brain and 54 other tissues
GenevisibleiQ3TKR3, MM

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR004020, DAPIN
IPR011029, DEATH-like_dom_sf
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR007111, NACHT_NTPase
IPR041267, NLRP_HD2
IPR041075, NOD2_WH
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF13516, LRR_6, 3 hits
PF05729, NACHT, 1 hit
PF17776, NLRC4_HD2, 1 hit
PF17779, NOD2_WH, 1 hit
PF02758, PYRIN, 1 hit
SMARTiView protein in SMART
SM01289, PYRIN, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50824, DAPIN, 1 hit
PS51450, LRR, 3 hits
PS50837, NACHT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAL4C_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3TKR3
Secondary accession number(s): Q66X27
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 11, 2005
Last modified: December 2, 2020
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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