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Protein

Protein FAM98A

Gene

Fam98a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Positively stimulates PRMT1-induced protein arginine methylation (By similarity). Involved in skeletal homeostasis (PubMed:27777970). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:27777970).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM98A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fam98a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1919972 Fam98a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001871851 – 515Protein FAM98AAdd BLAST515

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q3TJZ6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3TJZ6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3TJZ6

PeptideAtlas

More...
PeptideAtlasi
Q3TJZ6

PRoteomics IDEntifications database

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PRIDEi
Q3TJZ6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3TJZ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3TJZ6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q3TJZ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000002017 Expressed in 291 organ(s), highest expression level in ear vesicle

CleanEx database of gene expression profiles

More...
CleanExi
MM_2810405J04RIK

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3TJZ6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N- and C-terminus) with DDX1 (By similarity). Interacts (via N- and C-terminus) with C14orf166 (By similarity). Interacts with FAM98B (By similarity). Interacts with PLEKHM1 (via N- and C-terminus) (PubMed:27777970).By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
215533, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q3TJZ6, 5 interactors

Molecular INTeraction database

More...
MINTi
Q3TJZ6

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000108126

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q3TJZ6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi109 – 112Poly-Leu4
Compositional biasi314 – 317Poly-Pro4
Compositional biasi334 – 510Gly-richAdd BLAST177

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM98 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3973 Eukaryota
ENOG4111GTB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000037341

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231951

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054060

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q3TJZ6

Identification of Orthologs from Complete Genome Data

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OMAi
RMLCVNT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0EOM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3TJZ6

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018797 FAM98

The PANTHER Classification System

More...
PANTHERi
PTHR31353 PTHR31353, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10239 DUF2465, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3TJZ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MECDLMETDI LESLEDLGYK GPLLDDGALL QAVSAGAASP EFTKLCAWLV
60 70 80 90 100
SELRVLCKLE ENVQATNSPS EAEEFQLEVS GLLGEMNCPY PSLTSGDVTK
110 120 130 140 150
RLLVEKNCLL LLTYLISELE AARMLCVNAP PKKAQEGGGS EVFQELKGIC
160 170 180 190 200
IALGMSKPPA NITMFQFFSG IEKKLKETLA KVPPNHVGKP LLKKPMGPAH
210 220 230 240 250
WEKIEAINQA IANEYEVRRK LLIKRLDVTV QSFGWSDRAK SQTDKLAKVY
260 270 280 290 300
QPKRSLLSPK GKVSVAHLLA ARQDLSKILR TSSGSIREKT ACAINKVLMG
310 320 330 340 350
RVPDRGGRPN EIEPPPPEMP PWQKRQDGPQ QQAGGRGGGR GGYEHSSYGG
360 370 380 390 400
RGGHEQGGRG GRGSYDHGGR GGGRGNKHQG GWTDGGSGSG GGYQDGAYRD
410 420 430 440 450
SGFQPGGYHG GHSGGYQAGG YGGFQTSSYT GSGYQGGGYQ QDNRYQDGGH
460 470 480 490 500
HGERGSGRGG RGGRGGRGGR GSQGGGWGGR GSQTYHQGGQ FEQHFQHGGY
510
QYSHSGFGQG RHYTS
Length:515
Mass (Da):55,055
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB985739E8F3270B
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH04626 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK167224 mRNA Translation: BAE39349.1
BC004626 mRNA Translation: AAH04626.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS28974.2

NCBI Reference Sequences

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RefSeqi
NP_598508.2, NM_133747.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.24641

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000112507; ENSMUSP00000108126; ENSMUSG00000002017

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
72722

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:72722

UCSC genome browser

More...
UCSCi
uc008doq.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK167224 mRNA Translation: BAE39349.1
BC004626 mRNA Translation: AAH04626.1 Different initiation.
CCDSiCCDS28974.2
RefSeqiNP_598508.2, NM_133747.2
UniGeneiMm.24641

3D structure databases

SMRiQ3TJZ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215533, 2 interactors
IntActiQ3TJZ6, 5 interactors
MINTiQ3TJZ6
STRINGi10090.ENSMUSP00000108126

PTM databases

iPTMnetiQ3TJZ6
PhosphoSitePlusiQ3TJZ6
SwissPalmiQ3TJZ6

Proteomic databases

EPDiQ3TJZ6
MaxQBiQ3TJZ6
PaxDbiQ3TJZ6
PeptideAtlasiQ3TJZ6
PRIDEiQ3TJZ6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112507; ENSMUSP00000108126; ENSMUSG00000002017
GeneIDi72722
KEGGimmu:72722
UCSCiuc008doq.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25940
MGIiMGI:1919972 Fam98a

Phylogenomic databases

eggNOGiKOG3973 Eukaryota
ENOG4111GTB LUCA
GeneTreeiENSGT00440000037341
HOGENOMiHOG000231951
HOVERGENiHBG054060
InParanoidiQ3TJZ6
OMAiRMLCVNT
OrthoDBiEOG091G0EOM
PhylomeDBiQ3TJZ6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Fam98a mouse

Protein Ontology

More...
PROi
PR:Q3TJZ6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000002017 Expressed in 291 organ(s), highest expression level in ear vesicle
CleanExiMM_2810405J04RIK
GenevisibleiQ3TJZ6 MM

Family and domain databases

InterProiView protein in InterPro
IPR018797 FAM98
PANTHERiPTHR31353 PTHR31353, 1 hit
PfamiView protein in Pfam
PF10239 DUF2465, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA98A_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3TJZ6
Secondary accession number(s): Q99KJ2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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