UniProtKB - Q3TJD7 (PDLI7_MOUSE)
PDZ and LIM domain protein 7
Pdlim7
Functioni
GO - Molecular functioni
- actin binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- muscle alpha-actinin binding Source: GO_Central
GO - Biological processi
- actin cytoskeleton organization Source: MGI
- cell differentiation Source: UniProtKB-KW
- heart development Source: GO_Central
- muscle structure development Source: GO_Central
- ossification Source: UniProtKB-KW
- positive regulation of osteoblast differentiation Source: MGI
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Osteogenesis |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-8853659, RET signaling |
Names & Taxonomyi
Protein namesi | Recommended name: PDZ and LIM domain protein 7Alternative name(s): LIM mineralization protein Short name: LMP Protein enigma |
Gene namesi | Name:Pdlim7 Synonyms:Enigma |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914649, Pdlim7 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytoskeleton
- cytoskeleton By similarity
Note: Colocalizes with RET to the cell periphery and in some cytoskeletal components. Colocalizes with TPM2 near the Z line in muscle. Colocalizes with TBX4 and TBX5 to actin filaments (By similarity).By similarity
Cytoskeleton
- actin cytoskeleton Source: MGI
- filamentous actin Source: GO_Central
- stress fiber Source: MGI
Nucleus
- nucleoplasm Source: MGI
Other locations
- adherens junction Source: MGI
- cytoplasm Source: MGI
- focal adhesion Source: MGI
- ruffle Source: MGI
- Z disc Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000075882 | 1 – 457 | PDZ and LIM domain protein 7Add BLAST | 457 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 78 | PhosphoserineBy similarity | 1 | |
Modified residuei | 96 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 103 | Asymmetric dimethylarginineBy similarity | 1 | |
Modified residuei | 111 | PhosphoserineBy similarity | 1 | |
Modified residuei | 247 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q3TJD7 |
jPOSTi | Q3TJD7 |
MaxQBi | Q3TJD7 |
PaxDbi | Q3TJD7 |
PeptideAtlasi | Q3TJD7 |
PRIDEi | Q3TJD7 |
ProteomicsDBi | 287992 [Q3TJD7-1] 287993 [Q3TJD7-2] 287994 [Q3TJD7-3] |
PTM databases
iPTMneti | Q3TJD7 |
PhosphoSitePlusi | Q3TJD7 |
Expressioni
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000021493, Expressed in hindlimb stylopod muscle and 250 other tissues |
Genevisiblei | Q3TJD7, MM |
Interactioni
Subunit structurei
Specifically binds via its LIM zinc-binding 3 domain (LIM 3) domain to endocytic codes of INSR, but not with those of IGF1R, LDLR, TFRC, or EGFR.
Interacts with various PKC isoforms through the LIM zinc-binding domains. Binds to RET in a phosphorylation-independent manner via its LIM zinc-binding domain 2 (LIM 2). Probably part of a complex with SHC and the RET dimer.
Interacts with TPM2, TBX4 and TBX5 (By similarity).
By similarityGO - Molecular functioni
- actin binding Source: GO_Central
- muscle alpha-actinin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 212162, 4 interactors |
STRINGi | 10090.ENSMUSP00000047173 |
Miscellaneous databases
RNActi | Q3TJD7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 85 | PDZPROSITE-ProRule annotationAdd BLAST | 85 | |
Domaini | 280 – 338 | LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST | 59 | |
Domaini | 339 – 398 | LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 399 – 457 | LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST | 59 |
Domaini
Keywords - Domaini
LIM domain, RepeatPhylogenomic databases
eggNOGi | KOG1703, Eukaryota |
GeneTreei | ENSGT00940000159626 |
HOGENOMi | CLU_001357_8_1_1 |
InParanoidi | Q3TJD7 |
OMAi | HQCHKII |
OrthoDBi | 1013114at2759 |
PhylomeDBi | Q3TJD7 |
TreeFami | TF106408 |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00412, LIM, 3 hits PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00132, LIM, 3 hits SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 3 hits PS50106, PDZ, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDSFKVVLEG PAPWGFRLQG GKDFNVPLSI SRLTPGGKAA QAGVAVGDWV
60 70 80 90 100
LNIDGENAGS LTHIEAQNKI RACGERLSLG LSRAQPVQSK PQKALTPPAD
110 120 130 140 150
PPRYTFAPSA SLNKTARPFG APPPTDSTLR QNGQLLRQPV PDASKQRLME
160 170 180 190 200
DTEDWRPRPG TGQSRSFRIL AHLTGTEFMQ DPDEEFMKKS SQVPRTEAPA
210 220 230 240 250
PASTIPQESW PGPTTPSPTS RPPWAVDPAF AERYAPDKTS TVLTRHSQPA
260 270 280 290 300
TPTPLQNRTS IVQAAAGGGT GGGSNNGKTP VCHQCHKIIR GRYLVALGHA
310 320 330 340 350
YHPEEFVCSQ CGKVLEEGGF FEEKGAIFCP SCYDVRYAPN CAKCKKKITG
360 370 380 390 400
EIMHALKMTW HVHCFTCAAC KTPIRNRAFY MEEGAPYCER DYEKMFGTKC
410 420 430 440 450
RGCDFKIDAG DRFLEALGFS WHDTCFVCAI CQINLEGKTF YSKKDKPLCK
SHAFSHV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8BVJ7 | Q8BVJ7_MOUSE | PDZ and LIM domain protein 7 | Pdlim7 | 222 | Annotation score: | ||
B8JJB2 | B8JJB2_MOUSE | PDZ and LIM domain protein 7 | Pdlim7 | 124 | Annotation score: | ||
B8JJB3 | B8JJB3_MOUSE | PDZ and LIM domain protein 7 | Pdlim7 | 219 | Annotation score: | ||
B8JJB1 | B8JJB1_MOUSE | PDZ and LIM domain protein 7 | Pdlim7 | 58 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 85 | Q → P in BAB22725 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 151 | D → G in AAH49565 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016517 | 94 – 133 | ALTPP…LRQNG → VQTSDK in isoform 2. 2 PublicationsAdd BLAST | 40 | |
Alternative sequenceiVSP_016518 | 134 – 153 | QLLRQ…MEDTE → CRPLTNSCSDSRSPMPASSG in isoform 3. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_016519 | 154 – 457 | Missing in isoform 3. 1 PublicationAdd BLAST | 304 | |
Alternative sequenceiVSP_016520 | 191 – 222 | SQVPR…PTSRP → REKYVLELQSPRYTRLRDWH HQRSAHVLNVQS in isoform 2. 2 PublicationsAdd BLAST | 32 | |
Alternative sequenceiVSP_016521 | 223 – 457 | Missing in isoform 2. 2 PublicationsAdd BLAST | 235 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK003338 mRNA Translation: BAB22725.1 AK010141 mRNA Translation: BAB26726.1 AK003019 mRNA Translation: BAC25017.1 AK167476 mRNA Translation: BAE39558.1 BC045528 mRNA Translation: AAH45528.1 BC049565 mRNA Translation: AAH49565.1 |
CCDSi | CCDS26547.1 [Q3TJD7-2] CCDS49275.1 [Q3TJD7-1] |
RefSeqi | NP_001107560.1, NM_001114088.2 [Q3TJD7-1] NP_080407.3, NM_026131.4 [Q3TJD7-2] |
Genome annotation databases
Ensembli | ENSMUST00000046246; ENSMUSP00000047173; ENSMUSG00000021493 [Q3TJD7-1] ENSMUST00000069929; ENSMUSP00000064219; ENSMUSG00000021493 [Q3TJD7-2] ENSMUST00000155098; ENSMUSP00000120465; ENSMUSG00000021493 [Q3TJD7-1] |
GeneIDi | 67399 |
KEGGi | mmu:67399 |
UCSCi | uc007qrg.3, mouse [Q3TJD7-1] uc007qri.3, mouse [Q3TJD7-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK003338 mRNA Translation: BAB22725.1 AK010141 mRNA Translation: BAB26726.1 AK003019 mRNA Translation: BAC25017.1 AK167476 mRNA Translation: BAE39558.1 BC045528 mRNA Translation: AAH45528.1 BC049565 mRNA Translation: AAH49565.1 |
CCDSi | CCDS26547.1 [Q3TJD7-2] CCDS49275.1 [Q3TJD7-1] |
RefSeqi | NP_001107560.1, NM_001114088.2 [Q3TJD7-1] NP_080407.3, NM_026131.4 [Q3TJD7-2] |
3D structure databases
SMRi | Q3TJD7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 212162, 4 interactors |
STRINGi | 10090.ENSMUSP00000047173 |
PTM databases
iPTMneti | Q3TJD7 |
PhosphoSitePlusi | Q3TJD7 |
Proteomic databases
EPDi | Q3TJD7 |
jPOSTi | Q3TJD7 |
MaxQBi | Q3TJD7 |
PaxDbi | Q3TJD7 |
PeptideAtlasi | Q3TJD7 |
PRIDEi | Q3TJD7 |
ProteomicsDBi | 287992 [Q3TJD7-1] 287993 [Q3TJD7-2] 287994 [Q3TJD7-3] |
Protocols and materials databases
Antibodypediai | 17442, 138 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000046246; ENSMUSP00000047173; ENSMUSG00000021493 [Q3TJD7-1] ENSMUST00000069929; ENSMUSP00000064219; ENSMUSG00000021493 [Q3TJD7-2] ENSMUST00000155098; ENSMUSP00000120465; ENSMUSG00000021493 [Q3TJD7-1] |
GeneIDi | 67399 |
KEGGi | mmu:67399 |
UCSCi | uc007qrg.3, mouse [Q3TJD7-1] uc007qri.3, mouse [Q3TJD7-2] |
Organism-specific databases
CTDi | 9260 |
MGIi | MGI:1914649, Pdlim7 |
Phylogenomic databases
eggNOGi | KOG1703, Eukaryota |
GeneTreei | ENSGT00940000159626 |
HOGENOMi | CLU_001357_8_1_1 |
InParanoidi | Q3TJD7 |
OMAi | HQCHKII |
OrthoDBi | 1013114at2759 |
PhylomeDBi | Q3TJD7 |
TreeFami | TF106408 |
Enzyme and pathway databases
Reactomei | R-MMU-8853659, RET signaling |
Miscellaneous databases
BioGRID-ORCSi | 67399, 1 hit in 51 CRISPR screens |
ChiTaRSi | Pdlim7, mouse |
PROi | PR:Q3TJD7 |
RNActi | Q3TJD7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021493, Expressed in hindlimb stylopod muscle and 250 other tissues |
Genevisiblei | Q3TJD7, MM |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf IPR001781, Znf_LIM |
Pfami | View protein in Pfam PF00412, LIM, 3 hits PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00132, LIM, 3 hits SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 3 hits PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PDLI7_MOUSE | |
Accessioni | Q3TJD7Primary (citable) accession number: Q3TJD7 Secondary accession number(s): Q80ZY6 Q9CRA1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | April 7, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot