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Protein

U4/U6.U5 tri-snRNP-associated protein 2

Gene

Usp39

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin-specific peptidase activity.By similarity

Caution

Lacks the conserved His and Cys residues that are essential for the activity of de-ubiquitinating enzymes. Lacks ubiquitin C-terminal hydrolase activity.By similarityCurated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri121 – 182UBP-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, mRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Protein family/group databases

MEROPSiC19.972

Names & Taxonomyi

Protein namesi
Recommended name:
U4/U6.U5 tri-snRNP-associated protein 2
Alternative name(s):
Inactive ubiquitin-specific peptidase 39
Gene namesi
Name:Usp39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107622 Usp39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002239631 – 564U4/U6.U5 tri-snRNP-associated protein 2Add BLAST564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei46PhosphoserineBy similarity1
Cross-linki51Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei81PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ3TIX9
MaxQBiQ3TIX9
PaxDbiQ3TIX9
PeptideAtlasiQ3TIX9
PRIDEiQ3TIX9

PTM databases

iPTMnetiQ3TIX9
PhosphoSitePlusiQ3TIX9

Expressioni

Gene expression databases

BgeeiENSMUSG00000056305 Expressed in 291 organ(s), highest expression level in primary oocyte
CleanExiMM_USP39
ExpressionAtlasiQ3TIX9 baseline and differential
GenevisibleiQ3TIX9 MM

Interactioni

Subunit structurei

The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8.By similarity

Protein-protein interaction databases

BioGridi205726, 2 interactors
IntActiQ3TIX9, 3 interactors
MINTiQ3TIX9
STRINGi10090.ENSMUSP00000064515

Structurei

3D structure databases

ProteinModelPortaliQ3TIX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini224 – 554USPAdd BLAST331

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 102Arg-richAdd BLAST99

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri121 – 182UBP-typePROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2026 Eukaryota
ENOG410XS41 LUCA
GeneTreeiENSGT00390000007992
HOGENOMiHOG000188754
HOVERGENiHBG079718
InParanoidiQ3TIX9
KOiK12847
OMAiCNVVLHA
OrthoDBiEOG091G06U0
PhylomeDBiQ3TIX9
TreeFamiTF300610

Family and domain databases

CDDicd02669 Peptidase_C19M, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR033809 USP39
IPR028889 USP_dom
IPR013083 Znf_RING/FYVE/PHD
IPR001607 Znf_UBP
PANTHERiPTHR43985 PTHR43985, 1 hit
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PF02148 zf-UBP, 1 hit
SMARTiView protein in SMART
SM00290 ZnF_UBP, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50235 USP_3, 1 hit
PS50271 ZF_UBP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3TIX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSRSKRQSH GSTRGKRESE SRGSSGRIKK ERDREKEPEA ASSRGSPVRV
60 70 80 90 100
KREAEPAARE VPAPALPVVR VKREREADED SEPEREVRAK NGRVDSEDRR
110 120 130 140 150
SRHCPYLDTI NRSVLDFDFE KLCSISLSHI NAYACLVCGK YFQGRGLKSH
160 170 180 190 200
AYIHSVQFSH HVFLNLHTLK FYCLPDNYEI IDSSLEDITY VLKPTFTKQQ
210 220 230 240 250
IANLDKQAKL SRAYDGTTYL PGIVGLNNIK ANDYANAVLQ ALSNVPPLRN
260 270 280 290 300
YFLEEDNYKN IKRPPGDIMF LLVQRFGELM RKLWNPRNFK AHVSPHEMLQ
310 320 330 340 350
AVVLCSKKTF QITKQGDGVD FLSWFLNALH SALGGTKKKK KTIVNDVFQG
360 370 380 390 400
SMRIFTKKLP HPDLPAEEKE QLLHNDEYQE TMVESTFMYL TLDLPTAPLY
410 420 430 440 450
KDEKEQLIIP QVPLFNILAK FNGITEKEYK TYKENFLKRF QLTKLPPYLI
460 470 480 490 500
FCIKRFTKNN FFVEKNPTIV NFPITNVDLR EYLSEEVQAV HKNTTYDLIA
510 520 530 540 550
NIVHDGKPSE GSYRIHVLHH GTGKWYELQD LQVTDILPQM ITLSEAYIQI
560
WKRRDNDETN QQGA
Length:564
Mass (Da):65,146
Last modified:February 21, 2006 - v2
Checksum:i67A84B80FEE5AB71
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RP18A0A0U1RP18_MOUSE
U4/U6.U5 tri-snRNP-associated prote...
Usp39
65Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3S → T in BAC32203 (PubMed:16141072).Curated1
Sequence conflicti14R → S in BAE39991 (PubMed:16141072).Curated1
Sequence conflicti334G → V in BAC28153 (PubMed:16141072).Curated1
Sequence conflicti465K → E in AAH26983 (PubMed:16141072).Curated1
Sequence conflicti465K → E in BAE39717 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010443 mRNA Translation: BAB26944.1
AK018595 mRNA Translation: BAB31299.1
AK033105 mRNA Translation: BAC28153.1
AK045062 mRNA Translation: BAC32203.1
AK167668 mRNA Translation: BAE39717.1
AK165625 mRNA Translation: BAE38302.1
AK168003 mRNA Translation: BAE39991.1
AK088354 mRNA Translation: BAC40299.1
BC026983 mRNA Translation: AAH26983.1
CCDSiCCDS20238.1
RefSeqiNP_613058.1, NM_138592.4
UniGeneiMm.281900

Genome annotation databases

EnsembliENSMUST00000070345; ENSMUSP00000064515; ENSMUSG00000056305
ENSMUST00000193449; ENSMUSP00000141203; ENSMUSG00000104250
GeneIDi28035
KEGGimmu:28035
UCSCiuc009cif.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010443 mRNA Translation: BAB26944.1
AK018595 mRNA Translation: BAB31299.1
AK033105 mRNA Translation: BAC28153.1
AK045062 mRNA Translation: BAC32203.1
AK167668 mRNA Translation: BAE39717.1
AK165625 mRNA Translation: BAE38302.1
AK168003 mRNA Translation: BAE39991.1
AK088354 mRNA Translation: BAC40299.1
BC026983 mRNA Translation: AAH26983.1
CCDSiCCDS20238.1
RefSeqiNP_613058.1, NM_138592.4
UniGeneiMm.281900

3D structure databases

ProteinModelPortaliQ3TIX9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205726, 2 interactors
IntActiQ3TIX9, 3 interactors
MINTiQ3TIX9
STRINGi10090.ENSMUSP00000064515

Protein family/group databases

MEROPSiC19.972

PTM databases

iPTMnetiQ3TIX9
PhosphoSitePlusiQ3TIX9

Proteomic databases

EPDiQ3TIX9
MaxQBiQ3TIX9
PaxDbiQ3TIX9
PeptideAtlasiQ3TIX9
PRIDEiQ3TIX9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070345; ENSMUSP00000064515; ENSMUSG00000056305
ENSMUST00000193449; ENSMUSP00000141203; ENSMUSG00000104250
GeneIDi28035
KEGGimmu:28035
UCSCiuc009cif.1 mouse

Organism-specific databases

CTDi10713
MGIiMGI:107622 Usp39

Phylogenomic databases

eggNOGiKOG2026 Eukaryota
ENOG410XS41 LUCA
GeneTreeiENSGT00390000007992
HOGENOMiHOG000188754
HOVERGENiHBG079718
InParanoidiQ3TIX9
KOiK12847
OMAiCNVVLHA
OrthoDBiEOG091G06U0
PhylomeDBiQ3TIX9
TreeFamiTF300610

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway

Miscellaneous databases

PROiPR:Q3TIX9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056305 Expressed in 291 organ(s), highest expression level in primary oocyte
CleanExiMM_USP39
ExpressionAtlasiQ3TIX9 baseline and differential
GenevisibleiQ3TIX9 MM

Family and domain databases

CDDicd02669 Peptidase_C19M, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR033809 USP39
IPR028889 USP_dom
IPR013083 Znf_RING/FYVE/PHD
IPR001607 Znf_UBP
PANTHERiPTHR43985 PTHR43985, 1 hit
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PF02148 zf-UBP, 1 hit
SMARTiView protein in SMART
SM00290 ZnF_UBP, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50235 USP_3, 1 hit
PS50271 ZF_UBP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNUT2_MOUSE
AccessioniPrimary (citable) accession number: Q3TIX9
Secondary accession number(s): Q3TI55
, Q8BLI5, Q8BZZ5, Q9CQR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 21, 2006
Last modified: November 7, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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