UniProtKB - Q3TIW4 (Q3TIW4_MOUSE)
Protein
FERM domain-containing protein
Gene
Nf2
Organism
Mus musculus (Mouse)
Status
Names & Taxonomyi
Protein namesi | Recommended name: FERM domain-containing proteinInterPro annotation |
Gene namesi | Name:Nf2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:97307, Nf2 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Other locations
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Cytoskeleton
- cytoskeleton Source: InterPro
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cell projection Source: UniProtKB-KW
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cell membraneARBA annotation, Cell projectionARBA annotation, CytoplasmARBA annotation, MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 133 | FERMInterPro annotationAdd BLAST | 133 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 382 – 402 | DisorderedSequence analysisAdd BLAST | 21 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 135 – 251 | Sequence analysisAdd BLAST | 117 | |
Coiled coili | 263 – 300 | Sequence analysisAdd BLAST | 38 | |
Coiled coili | 340 – 381 | Sequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 388 – 402 | PolarSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
OrthoDBi | 627741at2759 |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit cd13194, FERM_C_ERM, 1 hit |
Gene3Di | 1.25.40.1020, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011259, ERM_C_dom IPR041789, ERM_FERM_C IPR000798, Ez/rad/moesin-like IPR035963, FERM_2 IPR019748, FERM_central IPR019747, FERM_CS IPR000299, FERM_domain IPR018980, FERM_PH-like_C IPR008954, Moesin_tail_sf IPR011993, PH-like_dom_sf |
Pfami | View protein in Pfam PF00769, ERM, 1 hit PF09380, FERM_C, 1 hit PF00373, FERM_M, 1 hit |
PRINTSi | PR00661, ERMFAMILY |
SMARTi | View protein in SMART SM01196, FERM_C, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF48678, SSF48678, 1 hit |
PROSITEi | View protein in PROSITE PS00661, FERM_2, 1 hit PS50057, FERM_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3TIW4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTPEMWEERI TAWYAEHRGR ARDEAEMEYL KIAQDLEMYG VNYFTIRNKK
60 70 80 90 100
GTELLLGVDA LGLHIYDPEN RLTPKISFPW NEIRNISYSD KEFTIKPLDK
110 120 130 140 150
KIDVFKFNSS KLRVNKLILQ LCIGNHDLFM RRRKADSLEV QQMKAQAREE
160 170 180 190 200
KARKQMERQR LAREKQMREE AERTRDELER RLLQMKEEAT MANEALMRSE
210 220 230 240 250
ETADLLAEKA QITEEEAKLL AQKAAEAEQE MQRIKATAIR TEEEKRLMEQ
260 270 280 290 300
KVLEAEVLAL KMAEESERRA KEADQLKQDL QEAREAERRA KQKLLEIATK
310 320 330 340 350
PTYPPMNPIP PPLPPDIPSF DIIADSLSFD FKDTDMKRLS MEIEKEKVEY
360 370 380 390 400
MEKSKHLQEQ LNELKTEIEA LKLKERETAL DVLHSESSDR GGPSSKHNTI
410
KKLTLQSAKS RVAFFEEL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK167685 mRNA Translation: BAE39732.1 |
RefSeqi | NP_035028.2, NM_010898.4 |
Genome annotation databases
GeneIDi | 18016 |
KEGGi | mmu:18016 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK167685 mRNA Translation: BAE39732.1 |
RefSeqi | NP_035028.2, NM_010898.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | Q3TIW4 |
PeptideAtlasi | Q3TIW4 |
Genome annotation databases
GeneIDi | 18016 |
KEGGi | mmu:18016 |
Organism-specific databases
CTDi | 4771 |
MGIi | MGI:97307, Nf2 |
Phylogenomic databases
OrthoDBi | 627741at2759 |
Miscellaneous databases
BioGRID-ORCSi | 18016, 7 hits in 22 CRISPR screens |
ChiTaRSi | Nf2, mouse |
SOURCEi | Search... |
Gene expression databases
Genevisiblei | Q3TIW4, MM |
Family and domain databases
CDDi | cd14473, FERM_B-lobe, 1 hit cd13194, FERM_C_ERM, 1 hit |
Gene3Di | 1.25.40.1020, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011259, ERM_C_dom IPR041789, ERM_FERM_C IPR000798, Ez/rad/moesin-like IPR035963, FERM_2 IPR019748, FERM_central IPR019747, FERM_CS IPR000299, FERM_domain IPR018980, FERM_PH-like_C IPR008954, Moesin_tail_sf IPR011993, PH-like_dom_sf |
Pfami | View protein in Pfam PF00769, ERM, 1 hit PF09380, FERM_C, 1 hit PF00373, FERM_M, 1 hit |
PRINTSi | PR00661, ERMFAMILY |
SMARTi | View protein in SMART SM01196, FERM_C, 1 hit |
SUPFAMi | SSF47031, SSF47031, 1 hit SSF48678, SSF48678, 1 hit |
PROSITEi | View protein in PROSITE PS00661, FERM_2, 1 hit PS50057, FERM_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3TIW4_MOUSE | |
Accessioni | Q3TIW4Primary (citable) accession number: Q3TIW4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |