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Protein

Synembryn-A

Gene

Ric8a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Synembryn-A
Alternative name(s):
Protein Ric-8A
Gene namesi
Name:Ric8a
Synonyms:Ric8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2141866 Ric8a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

Death during early embryonic development. Heterozygous mice exhibit impaired spatial memory and decreased anxiety.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002358921 – 530Synembryn-AAdd BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei435PhosphoserineCombined sources1
Modified residuei440PhosphothreonineCombined sources1
Modified residuei442PhosphothreonineCombined sources1
Modified residuei501PhosphoserineBy similarity1
Modified residuei522PhosphoserineBy similarity1
Modified residuei523PhosphoserineBy similarity1
Modified residuei527PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3TIR3
MaxQBiQ3TIR3
PaxDbiQ3TIR3
PeptideAtlasiQ3TIR3
PRIDEiQ3TIR3

PTM databases

iPTMnetiQ3TIR3
PhosphoSitePlusiQ3TIR3
SwissPalmiQ3TIR3

Expressioni

Tissue specificityi

Expressed in neurons and neurites of the CA1 and CA2 subregions of the hippocampus (at protein level). In adult brain, it is expressed in the neocortex, hippocampus and cerebellum as well as in the pineal gland and ependymal layer.2 Publications

Developmental stagei

During the early development (E9.5-E12.0) it is expressed in the developing nervous system such as the cranial ganglia, neural tube, sympathetic chain and dorsal root ganglia. Also found in the lens, vomeronasal organ and endolymphatic sac.1 Publication

Gene expression databases

BgeeiENSMUSG00000025485 Expressed in 285 organ(s), highest expression level in supraoptic nucleus
ExpressionAtlasiQ3TIR3 baseline and differential
GenevisibleiQ3TIR3 MM

Interactioni

Subunit structurei

Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. Interacts (via C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active GTP-bound form of GNAI1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221670, 2 interactors
IntActiQ3TIR3, 1 interactor
STRINGi10090.ENSMUSP00000026558

Structurei

3D structure databases

ProteinModelPortaliQ3TIR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the synembryn family.Curated

Phylogenomic databases

eggNOGiKOG4464 Eukaryota
ENOG410XSCJ LUCA
GeneTreeiENSGT00390000014700
HOGENOMiHOG000236345
HOVERGENiHBG054867
InParanoidiQ3TIR3
OMAiGMSPRGH
OrthoDBiEOG091G07N6
PhylomeDBiQ3TIR3
TreeFamiTF314907

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR019318 Gua_nucleotide_exch_fac_Ric8
IPR008376 Synembryn
PANTHERiPTHR12425 PTHR12425, 1 hit
PfamiView protein in Pfam
PF10165 Ric8, 1 hit
PRINTSiPR01802 SYNEMBRYN
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q3TIR3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPRAVADAL ETGEEDAVTE ALRSFNREHS QSFTFDDAQQ EDRKRLAKLL
60 70 80 90 100
VSVLEQGLSP KHRVTWLQTI RILSRDRSCL DSFASRQSLH ALACYADITV
110 120 130 140 150
SEEPIPQSPD MDVLLESLKC LCNLVLSSPT AQMLAAEARL VVRLAERVGL
160 170 180 190 200
YRKRSYPHEV QFFDLRLLFL LTALRTDVRQ QLFQELHGVR LLTDALELTL
210 220 230 240 250
GVAPKENPPV MLPAQETERA MEILKVLFNI TFDSVKREVD EEDAALYRYL
260 270 280 290 300
GTLLRHCVMV EAAGDRTEEF HGHTVNLLGN LPLKCLDVLL ALELHEGSLE
310 320 330 340 350
FMGVNMDVIS ALLAFLEKRL HQTHRLKECV APVLNVLTEC ARMHRPARKF
360 370 380 390 400
LKAQVLPPLR DVRTRPEVGD LLRNKLVRLM THLDTDVKRV AAEFLFVLCS
410 420 430 440 450
ESVPRFIKYT GYGNAAGLLA ARGLMAGGRP EGQYSEDEDT DTEEYREAKA
460 470 480 490 500
SINPVTGRVE EKPPNPMEGM TEEQKEHEAM KLVNMFDKLS RHRVIQPMGM
510 520 530
SPRGHLTSLQ DAMCETMEGQ LSSDPDSDPD
Length:530
Mass (Da):59,847
Last modified:May 16, 2006 - v2
Checksum:iD23AFC0442CCC815
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GSI8A0A1B0GSI8_MOUSE
Synembryn-A
Ric8a
328Annotation score:
A0A1B0GS30A0A1B0GS30_MOUSE
Synembryn-A
Ric8a
160Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87Q → R in BAE41115 (PubMed:16141072).Curated1
Sequence conflicti274T → A in BAE39783 (PubMed:16141072).Curated1
Sequence conflicti449K → E in BAE39783 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288813 mRNA Translation: AAG10200.1
AK031466 mRNA Translation: BAC27418.1
AK080192 mRNA Translation: BAC37844.1
AK155282 mRNA Translation: BAE33163.1
AK167746 mRNA Translation: BAE39783.1
AK169367 mRNA Translation: BAE41115.1
BC022917 mRNA Translation: AAH22917.1
CCDSiCCDS21988.1
RefSeqiNP_444424.1, NM_053194.4
UniGeneiMm.281916

Genome annotation databases

EnsembliENSMUST00000026558; ENSMUSP00000026558; ENSMUSG00000025485
GeneIDi101489
KEGGimmu:101489
UCSCiuc009kij.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF288813 mRNA Translation: AAG10200.1
AK031466 mRNA Translation: BAC27418.1
AK080192 mRNA Translation: BAC37844.1
AK155282 mRNA Translation: BAE33163.1
AK167746 mRNA Translation: BAE39783.1
AK169367 mRNA Translation: BAE41115.1
BC022917 mRNA Translation: AAH22917.1
CCDSiCCDS21988.1
RefSeqiNP_444424.1, NM_053194.4
UniGeneiMm.281916

3D structure databases

ProteinModelPortaliQ3TIR3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221670, 2 interactors
IntActiQ3TIR3, 1 interactor
STRINGi10090.ENSMUSP00000026558

PTM databases

iPTMnetiQ3TIR3
PhosphoSitePlusiQ3TIR3
SwissPalmiQ3TIR3

Proteomic databases

EPDiQ3TIR3
MaxQBiQ3TIR3
PaxDbiQ3TIR3
PeptideAtlasiQ3TIR3
PRIDEiQ3TIR3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026558; ENSMUSP00000026558; ENSMUSG00000025485
GeneIDi101489
KEGGimmu:101489
UCSCiuc009kij.1 mouse

Organism-specific databases

CTDi60626
MGIiMGI:2141866 Ric8a

Phylogenomic databases

eggNOGiKOG4464 Eukaryota
ENOG410XSCJ LUCA
GeneTreeiENSGT00390000014700
HOGENOMiHOG000236345
HOVERGENiHBG054867
InParanoidiQ3TIR3
OMAiGMSPRGH
OrthoDBiEOG091G07N6
PhylomeDBiQ3TIR3
TreeFamiTF314907

Miscellaneous databases

PROiPR:Q3TIR3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025485 Expressed in 285 organ(s), highest expression level in supraoptic nucleus
ExpressionAtlasiQ3TIR3 baseline and differential
GenevisibleiQ3TIR3 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR019318 Gua_nucleotide_exch_fac_Ric8
IPR008376 Synembryn
PANTHERiPTHR12425 PTHR12425, 1 hit
PfamiView protein in Pfam
PF10165 Ric8, 1 hit
PRINTSiPR01802 SYNEMBRYN
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRIC8A_MOUSE
AccessioniPrimary (citable) accession number: Q3TIR3
Secondary accession number(s): Q3TEY3, Q99JW0, Q9ERR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: November 7, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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