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Protein

Histone H2A.V

Gene

H2afv

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity).By similarity

GO - Molecular functioni

  • DNA binding Source: GO_Central
  • protein heterodimerization activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-171306 Packaging Of Telomere Ends
R-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-212300 PRC2 methylates histones and DNA
R-MMU-2299718 Condensation of Prophase Chromosomes
R-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence
R-MMU-3214858 RMTs methylate histone arginines
R-MMU-427359 SIRT1 negatively regulates rRNA expression
R-MMU-427413 NoRC negatively regulates rRNA expression
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5578749 Transcriptional regulation by small RNAs
R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-MMU-73728 RNA Polymerase I Promoter Opening
R-MMU-73777 RNA Polymerase I Chain Elongation
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A.V
Alternative name(s):
H2A.F/Z
Gene namesi
Name:H2afv
Synonyms:H2av
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1924855 H2afv

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCurated
ChainiPRO_00002390692 – 128Histone H2A.VAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5N6-acetyllysine1 Publication1
Modified residuei8N6-acetyllysine1 Publication1
Modified residuei12N6-acetyllysine1 Publication1

Post-translational modificationi

Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.By similarity
Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.1 Publication

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

EPDiQ3THW5
MaxQBiQ3THW5
PaxDbiQ3THW5
PRIDEiQ3THW5

PTM databases

iPTMnetiQ3THW5
PhosphoSitePlusiQ3THW5

Expressioni

Gene expression databases

BgeeiENSMUSG00000041126 Expressed in 291 organ(s), highest expression level in floor plate of midbrain
CleanExiMM_H2AFV
ExpressionAtlasiQ3THW5 baseline and differential
GenevisibleiQ3THW5 MM

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFV forms a heterodimer with H2B (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi218792, 1 interactor
IntActiQ3THW5, 1 interactor
STRINGi10090.ENSMUSP00000105359

Structurei

3D structure databases

ProteinModelPortaliQ3THW5
SMRiQ3THW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1757 Eukaryota
COG5262 LUCA
GeneTreeiENSGT00900000140979
HOGENOMiHOG000234652
HOVERGENiHBG009342
InParanoidiQ3THW5
KOiK11251
OMAiIHRYLMN
OrthoDBiEOG091G0XGD
PhylomeDBiQ3THW5
TreeFamiTF354232

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3THW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGGKAGKDS GKAKAKAVSR SQRAGLQFPV GRIHRHLKTR TTSHGRVGAT
60 70 80 90 100
AAVYSAAILE YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL
110 120
IKATIAGGGV IPHIHKSLIG KKGQQKTA
Length:128
Mass (Da):13,509
Last modified:January 23, 2007 - v3
Checksum:i1F3C388F6854041C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8R029Q8R029_MOUSE
Histone H2A
H2afv mCG_121516
90Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2A → VA in CAI26006 (PubMed:19468303).Curated1
Sequence conflicti27Q → E in BAE40081 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021267 mRNA Translation: BAB32354.1
AK155105 mRNA Translation: BAE33050.1
AK168110 mRNA Translation: BAE40081.1
AL646020 Genomic DNA Translation: CAI26006.1
CCDSiCCDS48750.1
RefSeqiNP_084214.1, NM_029938.1
UniGeneiMm.27624

Genome annotation databases

EnsembliENSMUST00000109737; ENSMUSP00000105359; ENSMUSG00000041126
GeneIDi77605
KEGGimmu:77605
UCSCiuc007hyp.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021267 mRNA Translation: BAB32354.1
AK155105 mRNA Translation: BAE33050.1
AK168110 mRNA Translation: BAE40081.1
AL646020 Genomic DNA Translation: CAI26006.1
CCDSiCCDS48750.1
RefSeqiNP_084214.1, NM_029938.1
UniGeneiMm.27624

3D structure databases

ProteinModelPortaliQ3THW5
SMRiQ3THW5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218792, 1 interactor
IntActiQ3THW5, 1 interactor
STRINGi10090.ENSMUSP00000105359

PTM databases

iPTMnetiQ3THW5
PhosphoSitePlusiQ3THW5

Proteomic databases

EPDiQ3THW5
MaxQBiQ3THW5
PaxDbiQ3THW5
PRIDEiQ3THW5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109737; ENSMUSP00000105359; ENSMUSG00000041126
GeneIDi77605
KEGGimmu:77605
UCSCiuc007hyp.2 mouse

Organism-specific databases

CTDi94239
MGIiMGI:1924855 H2afv

Phylogenomic databases

eggNOGiKOG1757 Eukaryota
COG5262 LUCA
GeneTreeiENSGT00900000140979
HOGENOMiHOG000234652
HOVERGENiHBG009342
InParanoidiQ3THW5
KOiK11251
OMAiIHRYLMN
OrthoDBiEOG091G0XGD
PhylomeDBiQ3THW5
TreeFamiTF354232

Enzyme and pathway databases

ReactomeiR-MMU-171306 Packaging Of Telomere Ends
R-MMU-201722 Formation of the beta-catenin:TCF transactivating complex
R-MMU-212300 PRC2 methylates histones and DNA
R-MMU-2299718 Condensation of Prophase Chromosomes
R-MMU-2559580 Oxidative Stress Induced Senescence
R-MMU-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-MMU-2559586 DNA Damage/Telomere Stress Induced Senescence
R-MMU-3214858 RMTs methylate histone arginines
R-MMU-427359 SIRT1 negatively regulates rRNA expression
R-MMU-427413 NoRC negatively regulates rRNA expression
R-MMU-5250924 B-WICH complex positively regulates rRNA expression
R-MMU-5578749 Transcriptional regulation by small RNAs
R-MMU-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-MMU-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-MMU-73728 RNA Polymerase I Promoter Opening
R-MMU-73777 RNA Polymerase I Chain Elongation
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-9018519 Estrogen-dependent gene expression

Miscellaneous databases

ChiTaRSiH2afv mouse
PROiPR:Q3THW5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041126 Expressed in 291 organ(s), highest expression level in floor plate of midbrain
CleanExiMM_H2AFV
ExpressionAtlasiQ3THW5 baseline and differential
GenevisibleiQ3THW5 MM

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH2AV_MOUSE
AccessioniPrimary (citable) accession number: Q3THW5
Secondary accession number(s): Q5NC92, Q6ZWU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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