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Entry version 95 (08 May 2019)
Sequence version 1 (11 Oct 2005)
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Protein

Endonuclease/exonuclease/phosphatase family domain-containing protein 1

Gene

Eepd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endonuclease/exonuclease/phosphatase family domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Eepd1
Synonyms:Kiaa1706
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914734 Eepd1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003172622 – 569Endonuclease/exonuclease/phosphatase family domain-containing protein 1Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycineBy similarity1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei16PhosphoserineBy similarity1
Modified residuei25PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei160PhosphoserineBy similarity1
Modified residuei173PhosphoserineCombined sources1
Modified residuei265PhosphothreonineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3TGW2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3TGW2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3TGW2

PeptideAtlas

More...
PeptideAtlasi
Q3TGW2

PRoteomics IDEntifications database

More...
PRIDEi
Q3TGW2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3TGW2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3TGW2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q3TGW2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036611 Expressed in 208 organ(s), highest expression level in brown adipose tissue

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3TGW2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000047083

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 67HhHAdd BLAST30

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KDV5 Eukaryota
COG1555 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009677

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112330

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3TGW2

Identification of Orthologs from Complete Genome Data

More...
OMAi
KFCAELN

Database of Orthologous Groups

More...
OrthoDBi
814192at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3TGW2

TreeFam database of animal gene trees

More...
TreeFami
TF328735

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004509 Competence_ComEA_HhH
IPR036691 Endo/exonu/phosph_ase_sf
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR010994 RuvA_2-like

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00278 HhH1, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47781 SSF47781, 2 hits
SSF56219 SSF56219, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00426 TIGR00426, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q3TGW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSTLGCHRS IPRDPSDLSH NRKFSAACNF SNILVNQERL NINTATEEEL
60 70 80 90 100
MTLPGVTRAV ARSIVEYREY IGGFKKVEDL ALVSGVGATK LEQVKFEICV
110 120 130 140 150
SSKGNSAQHS PSSLRRDLLA EQQPHHLTTT VPLTPRVNIN TATLAQLMSV
160 170 180 190 200
RGLSEKMALS IVDYRREHGP FRSVEDLVRM DGINAAFLDR IRHQVFAERS
210 220 230 240 250
RPPSTHTNGG LTFTAKPHPS PTSLSLQSED LDLPPGGPTQ IISMRPSVEA
260 270 280 290 300
FGGMRDGRPV FRLATWNLQG CSVEKANNPG VREVVCMTLL ENSIKLLAVQ
310 320 330 340 350
ELLDKEALEK FCTELNQPIL PNIRKWKGSR GCWRSIVAEK PSNQLQKGPC
360 370 380 390 400
YSGFLWDTAA NVELRDIPGR ESSPSNGHAK AVGPSPFLAR FKVGSNDLTL
410 420 430 440 450
VNLQLTALAL PGAENSSKNH SDGHRLLNFA LTLQETLKGE KDVVILGDFG
460 470 480 490 500
QGPDSNDYDI LRREKFHHLV PAHTFTNIST RNPQGSKSVD NIWISKSLKK
510 520 530 540 550
VFTGHWAVVR EGLTNPWIPD NWSWGGVASE HCPVLAELYM EKDWSKKEVP
560
RNGNGVTLEP SEANIKHER
Length:569
Mass (Da):62,953
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B4A49C082A3715F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32517 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30F → L in BAB26125 (PubMed:16141072).Curated1
Sequence conflicti389A → T in AAH25571 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK173239 mRNA Translation: BAD32517.1 Different initiation.
AK009180 mRNA Translation: BAB26125.1
AK168564 mRNA Translation: BAE40436.1
BC025571 mRNA Translation: AAH25571.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS22935.1

NCBI Reference Sequences

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RefSeqi
NP_080465.3, NM_026189.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000040677; ENSMUSP00000047083; ENSMUSG00000036611

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
67484

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:67484

UCSC genome browser

More...
UCSCi
uc009opn.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173239 mRNA Translation: BAD32517.1 Different initiation.
AK009180 mRNA Translation: BAB26125.1
AK168564 mRNA Translation: BAE40436.1
BC025571 mRNA Translation: AAH25571.1
CCDSiCCDS22935.1
RefSeqiNP_080465.3, NM_026189.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047083

PTM databases

iPTMnetiQ3TGW2
PhosphoSitePlusiQ3TGW2
SwissPalmiQ3TGW2

Proteomic databases

jPOSTiQ3TGW2
MaxQBiQ3TGW2
PaxDbiQ3TGW2
PeptideAtlasiQ3TGW2
PRIDEiQ3TGW2

Genome annotation databases

EnsembliENSMUST00000040677; ENSMUSP00000047083; ENSMUSG00000036611
GeneIDi67484
KEGGimmu:67484
UCSCiuc009opn.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80820
MGIiMGI:1914734 Eepd1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG410KDV5 Eukaryota
COG1555 LUCA
GeneTreeiENSGT00390000009677
HOGENOMiHOG000112330
InParanoidiQ3TGW2
OMAiKFCAELN
OrthoDBi814192at2759
PhylomeDBiQ3TGW2
TreeFamiTF328735

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q3TGW2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036611 Expressed in 208 organ(s), highest expression level in brown adipose tissue
GenevisibleiQ3TGW2 MM

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR004509 Competence_ComEA_HhH
IPR036691 Endo/exonu/phosph_ase_sf
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR010994 RuvA_2-like
SMARTiView protein in SMART
SM00278 HhH1, 3 hits
SUPFAMiSSF47781 SSF47781, 2 hits
SSF56219 SSF56219, 1 hit
TIGRFAMsiTIGR00426 TIGR00426, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEEPD1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3TGW2
Secondary accession number(s): Q69ZC7, Q8K3B5, Q9D7J3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 11, 2005
Last modified: May 8, 2019
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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