UniProtKB - Q3TGR2 (Q3TGR2_MOUSE)
Protein
Fibrinogen beta chain
Gene
Fgb
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- cell adhesion molecule binding Source: Ensembl
- chaperone binding Source: Ensembl
- signaling receptor binding Source: Ensembl
- structural molecule activity Source: Ensembl
GO - Biological processi
- blood coagulation, fibrin clot formation Source: Ensembl
- cell-matrix adhesion Source: Ensembl
- cellular response to interleukin-1 Source: Ensembl
- cellular response to leptin stimulus Source: Ensembl
- fibrinolysis Source: Ensembl
- induction of bacterial agglutination Source: Ensembl
- negative regulation of endothelial cell apoptotic process Source: Ensembl
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
- plasminogen activation Source: Ensembl
- platelet aggregation Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- positive regulation of exocytosis Source: Ensembl
- positive regulation of heterotypic cell-cell adhesion Source: Ensembl
- positive regulation of peptide hormone secretion Source: Ensembl
- positive regulation of protein secretion Source: Ensembl
- positive regulation of vasoconstriction Source: Ensembl
- protein polymerization Source: Ensembl
- response to calcium ion Source: Ensembl
Keywordsi
Biological process | Blood coagulationARBA annotation, Hemostasis |
Names & Taxonomyi
Protein namesi | Recommended name: Fibrinogen beta chainARBA annotationAlternative name(s): Fibrinopeptide BARBA annotation |
Gene namesi | Name:FgbImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:99501, Fgb |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: Ensembl
Extracellular region or secreted
- blood microparticle Source: Ensembl
- fibrinogen complex Source: Ensembl
Plasma Membrane
- external side of plasma membrane Source: Ensembl
Other locations
- platelet alpha granule Source: Ensembl
Keywords - Cellular componenti
SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_5014309133 | 20 – 481 | Fibrinogen beta chainSequence analysisAdd BLAST | 462 |
Keywords - PTMi
Disulfide bondARBA annotationProteomic databases
EPDi | Q3TGR2 |
PeptideAtlasi | Q3TGR2 |
PRIDEi | Q3TGR2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000033831, Expressed in liver and 96 other tissues |
Interactioni
GO - Molecular functioni
- cell adhesion molecule binding Source: Ensembl
- chaperone binding Source: Ensembl
- signaling receptor binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 222 – 478 | Fibrinogen C-terminalInterPro annotationAdd BLAST | 257 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 22 – 81 | DisorderedSequence analysisAdd BLAST | 60 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 185 – 212 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 29 – 48 | PolyampholyteSequence analysisAdd BLAST | 20 |
Keywords - Domaini
Coiled coilSequence analysis, SignalSequence analysisPhylogenomic databases
HOGENOMi | CLU_038628_13_0_1 |
OMAi | VYPDAGG |
OrthoDBi | 357340at2759 |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
InterProi | View protein in InterPro IPR036056, Fibrinogen-like_C IPR002181, Fibrinogen_a/b/g_C_dom IPR012290, Fibrinogen_a/b/g_coil_dom IPR037580, Fibrinogen_beta IPR020837, Fibrinogen_CS |
PANTHERi | PTHR19143:SF332, PTHR19143:SF332, 1 hit |
Pfami | View protein in Pfam PF08702, Fib_alpha, 1 hit PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit SM01212, Fib_alpha, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3TGR2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRHLWLLLLL CVFSVQTQAA DDDYDEPTDS LDARGHRPVD RRKEEPPSLR
60 70 80 90 100
PAPPPISGGG YRARPAKATA NQKKVERRPP DAGGCLHADT DMGVLCPTGC
110 120 130 140 150
TLQQTLLNQE RPIKSSIAEL NNNIQSVSDT SSVTFQYLTL LKDMWKKKQA
160 170 180 190 200
QVKENENVIN EYSSILEDQR LYIDETVNDN IPLNLRVLRS ILEDLRSKIQ
210 220 230 240 250
KLESDISAQM EYCRTPCTVS CNIPVVSGKE CEEIIRKGGE TSEMYLIQPD
260 270 280 290 300
TSIKPYRVYC DMKTENGGWT VIQNRQDGSV DFGRKWDPYK KGFGNIATNE
310 320 330 340 350
DAKKYCGLPG EYWLGNDKIS QLTRMGPTEL LIEMEDWKGD KVKAHYGGFT
360 370 380 390 400
VQNEASKYQV SVNKYKGTAG NALMDGASQL VGENRTMTIH NGMFFSTYDR
410 420 430 440 450
DNDGWVTTDP RKQCSKEDGG GWWYNRCHAA NPNGRYYWGG LYSWDMSKHG
460 470 480
TDDGVVWMNW KGSWYSMRRM SMKIRPFFPQ Q
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK146960 mRNA Translation: BAE27567.1 AK168626 mRNA Translation: BAE40486.1 |
RefSeqi | NP_862897.1, NM_181849.3 |
Genome annotation databases
GeneIDi | 110135 |
KEGGi | mmu:110135 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK146960 mRNA Translation: BAE27567.1 AK168626 mRNA Translation: BAE40486.1 |
RefSeqi | NP_862897.1, NM_181849.3 |
3D structure databases
SMRi | Q3TGR2 |
ModBasei | Search... |
Proteomic databases
EPDi | Q3TGR2 |
PeptideAtlasi | Q3TGR2 |
PRIDEi | Q3TGR2 |
Protocols and materials databases
Antibodypediai | 855, 570 antibodies |
Genome annotation databases
GeneIDi | 110135 |
KEGGi | mmu:110135 |
Organism-specific databases
CTDi | 2244 |
MGIi | MGI:99501, Fgb |
Phylogenomic databases
HOGENOMi | CLU_038628_13_0_1 |
OMAi | VYPDAGG |
OrthoDBi | 357340at2759 |
Miscellaneous databases
BioGRID-ORCSi | 110135, 1 hit in 17 CRISPR screens |
ChiTaRSi | Fgb, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000033831, Expressed in liver and 96 other tissues |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
InterProi | View protein in InterPro IPR036056, Fibrinogen-like_C IPR002181, Fibrinogen_a/b/g_C_dom IPR012290, Fibrinogen_a/b/g_coil_dom IPR037580, Fibrinogen_beta IPR020837, Fibrinogen_CS |
PANTHERi | PTHR19143:SF332, PTHR19143:SF332, 1 hit |
Pfami | View protein in Pfam PF08702, Fib_alpha, 1 hit PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit SM01212, Fib_alpha, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3TGR2_MOUSE | |
Accessioni | Q3TGR2Primary (citable) accession number: Q3TGR2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |