UniProtKB - Q3TFD2 (PCAT1_MOUSE)
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>sp|Q3TFD2|PCAT1_MOUSE Lysophosphatidylcholine acyltransferase 1 OS=Mus musculus OX=10090 GN=Lpcat1 PE=1 SV=1 MRLRGRGPRAAPSSSSGAGDARRLAPPGRNPFVHELRLSALQKAQVAFMTLTLFPIRLLF AAFMMLLAWPFALLASLGPPDKEPEQPLALWRKVVDFLLKAIMRTMWFAGGFHRVAVKGR QALPTEAAILTLAPHSSYFDAIPVTMTMSSIVMKAESRDIPIWGTLIRYIRPVFVSRSDQ DSRRKTVEEIKRRAQSNGKWPQIMIFPEGTCTNRTCLITFKPGAFIPGVPVQPVVLRYPN KLDTITWTWQGPGALKILWLTLCQFQNQVEIEFLPVYCPSEEEKRNPALYASNVRRVMAK ALGVSVTDYTFEDCQLALAEGQLRLPADTCLLEFARLVRGLGLKPENLEKDLDKYSESAR MKRGEKIRLPEFAAYLEVPVSDALEDMFSLFDESGGGEIDLREYVVALSVVCRPSQTLAT IQLAFKMYGSPEDGSIDEANLSCILKTALGVSELTVTDLFQAIDQEDKGRITFDDFCGFA EMYPDYAEDYLYPDQTHFDSCAQTPPAPTPNGFCIDFSPENSDFGRKNSCKKADCommunity curation ()Add a publicationFeedback
Lysophosphatidylcholine acyltransferase 1
Lpcat1
Annotation score:5 out of 5
<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>Select a section on the left to see content.
<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni
<p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More...</a></p> Manual assertion inferred from sequence similarity toi
3 Publications<p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More...</a></p> Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233. - Ref.6"Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes."
Soupene E., Fyrst H., Kuypers F.A.
Proc. Natl. Acad. Sci. U.S.A. 105:88-93(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi
- a 1-acyl-sn-glycero-3-phosphocholineEC:2.3.1.23
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Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233. - Ref.6"Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes."
Soupene E., Fyrst H., Kuypers F.A.
Proc. Natl. Acad. Sci. U.S.A. 105:88-93(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
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Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233. - Ref.6"Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes."
Soupene E., Fyrst H., Kuypers F.A.
Proc. Natl. Acad. Sci. U.S.A. 105:88-93(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Source: Rhea- Search for this reaction in UniProtKB.
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a 1-acyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+an acyl-CoA- Search proteins in UniProtKB for this molecule.
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=a 1,2-diacyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- 1-O-alkyl-sn-glycero-3-phosphocholineEC:2.3.1.67
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Manual assertion based on experiment ini
- Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
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Manual assertion based on experiment ini
- Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
Source: Rhea- Search for this reaction in UniProtKB.
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1-O-alkyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+acetyl-CoA- Search proteins in UniProtKB for this molecule.
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=a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- a 1-acyl-sn-glycero-3-phosphateEC:2.3.1.51
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Manual assertion inferred from sequence similarity toi
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Manual assertion inferred from sequence similarity toi
Source: Rhea- Search for this reaction in UniProtKB.
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a 1-acyl-sn-glycero-3-phosphate- Search proteins in UniProtKB for this molecule.
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+an acyl-CoA- Search proteins in UniProtKB for this molecule.
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=a 1,2-diacyl-sn-glycero-3-phosphate- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholineEC:2.3.1.25
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Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
Source: Rhea- Search for this reaction in UniProtKB.
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1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+an acyl-CoA- Search proteins in UniProtKB for this molecule.
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=1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)
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Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
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Manual assertion inferred from sequence similarity toi
direction.Source: Rhea- Search for this reaction in UniProtKB.
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1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)- Search proteins in UniProtKB for this molecule.
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+an acyl-CoA- Search proteins in UniProtKB for this molecule.
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=1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- 1-hexadecanoyl-sn-glycero-3-phosphocholine
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Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
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<p>Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.</p> <p><a href="/manual/evidences#ECO:0000305">More...</a></p> Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Source: Rhea- Search for this reaction in UniProtKB.
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1-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+hexadecanoyl-CoA- Search proteins in UniProtKB for this molecule.
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=1,2-dihexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- 1-O-hexadecyl-sn-glycero-3-phosphocholine
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Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
1-O-hexadecyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
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+hexadecanoyl-CoA- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
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=1-O-hexadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine
- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
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+hexadecanoyl-CoA- Search proteins in UniProtKB for this molecule.
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=1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)- Search proteins in UniProtKB for this molecule.
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+hexadecanoyl-CoA- Search proteins in UniProtKB for this molecule.
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=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- 1-dodecanoyl-sn-glycero-3-phosphocholine
- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
1-dodecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+hexadecanoyl-CoA- Search proteins in UniProtKB for this molecule.
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=1-dodecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- 1-tetradecanoyl-sn-glycero-3-phosphocholine
- Search proteins in UniProtKB for this molecule.
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- Search proteins in UniProtKB for this molecule.
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- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
1-tetradecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
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+hexadecanoyl-CoA- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
zoom
=1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- 1-O-octadecyl-sn-glycero-3-phosphocholine
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
1-O-octadecyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
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+hexadecanoyl-CoA- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
zoom
=1-O-octadecyl-2-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
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zoom
+CoA- Search proteins in UniProtKB for this molecule.
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- 1-octadecanoyl-sn-glycero-3-phosphocholine
- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
1-octadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+hexadecanoyl-CoA- Search proteins in UniProtKB for this molecule.
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zoom
=1-octadecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
a 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
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+hexadecanoyl-CoA- Search proteins in UniProtKB for this molecule.
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=1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- 1-eicosanoyl-sn-glycero-3-phosphocholine
- Search proteins in UniProtKB for this molecule.
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- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
1-eicosanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+hexadecanoyl-CoA- Search proteins in UniProtKB for this molecule.
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=1-eicosanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
1-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+hexanoyl-CoA- Search proteins in UniProtKB for this molecule.
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=1-hexadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- 1-hexadecanoyl-sn-glycero-3-phosphocholine
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
1-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+octanoyl-CoA- Search proteins in UniProtKB for this molecule.
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=1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- 1-hexadecanoyl-sn-glycero-3-phosphocholine
- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
1-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+decanoyl-CoA- Search proteins in UniProtKB for this molecule.
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=1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- 1-hexadecanoyl-sn-glycero-3-phosphocholine
- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
1-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+dodecanoyl-CoA- Search proteins in UniProtKB for this molecule.
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=1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine
- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
1-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+tetradecanoyl-CoA- Search proteins in UniProtKB for this molecule.
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=1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
- (9Z)-octadecenoyl-CoA
- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
(9Z)-octadecenoyl-CoA- Search proteins in UniProtKB for this molecule.
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+1-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- (9Z,12Z)-octadecadienoyl-CoA
- Search proteins in UniProtKB for this molecule.
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- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
(9Z,12Z)-octadecadienoyl-CoA- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
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+1-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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=1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA
- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA- Search proteins in UniProtKB for this molecule.
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+1-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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=1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- 1-hexadecanoyl-sn-glycero-3-phosphocholine
- Search proteins in UniProtKB for this molecule.
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- Search proteins in UniProtKB for this molecule.
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Manual assertion based on experiment ini
- Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
Source: Rhea- Search for this reaction in UniProtKB.
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1-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+acetyl-CoA- Search proteins in UniProtKB for this molecule.
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=1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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- 1-hexadecanoyl-sn-glycero-3-phosphocholine
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- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
Source: Rhea- Search for this reaction in UniProtKB.
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1-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+eicosanoyl-CoA- Search proteins in UniProtKB for this molecule.
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=1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- 1-O-hexadecyl-sn-glycero-3-phosphocholine
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- Search proteins in UniProtKB for this molecule.
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- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
Manual assertion based on experiment ini
- Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred by curator fromi
- Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
1-O-hexadecyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+acetyl-CoA- Search proteins in UniProtKB for this molecule.
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=1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- a 1-acyl-sn-glycero-3-phosphocholine
- Search proteins in UniProtKB for this molecule.
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- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred from sequence similarity toi
direction.Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
a 1-acyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+hexadecanoyl-CoA- Search proteins in UniProtKB for this molecule.
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=1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- a 1-acyl-sn-glycero-3-phosphate
- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
- Search chemical reactions in Rhea for this molecule.
- See the description of this molecule in ChEBI.
Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred from sequence similarity toi
direction.Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
a 1-acyl-sn-glycero-3-phosphate- Search proteins in UniProtKB for this molecule.
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+hexadecanoyl-CoA- Search proteins in UniProtKB for this molecule.
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=1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate- Search proteins in UniProtKB for this molecule.
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+CoA- Search proteins in UniProtKB for this molecule.
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- 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)
- Search proteins in UniProtKB for this molecule.
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- Search proteins in UniProtKB for this molecule.
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- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
- Search proteins in UniProtKB for this molecule.
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- See the description of this molecule in ChEBI.
Manual assertion inferred from sequence similarity toi
This reaction proceeds in the forward- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
Manual assertion inferred from sequence similarity toi
direction.Source: Rhea- Search for this reaction in UniProtKB.
- See the description of this reaction in Rhea.
1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)- Search proteins in UniProtKB for this molecule.
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+hexadecanoyl-CoA- Search proteins in UniProtKB for this molecule.
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=1-acyl-2-hexadecanoyl-sn-glycero-3-phospho-(1ʼ-sn-glycerol)- Search proteins in UniProtKB for this molecule.
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<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi
Manual assertion based on experiment ini
- Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233. - Ref.6"Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes."
Soupene E., Fyrst H., Kuypers F.A.
Proc. Natl. Acad. Sci. U.S.A. 105:88-93(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi
- KM=2.3 µM for 1-palmitoyl-LPC2 Publications
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
- KM=3 µM for palmitoyl-CoA2 Publications
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
pH dependencei
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phospholipid metabolism
This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi | 392 – 403 | 1PROSITE-ProRule annotation <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesi Add BLAST | 12 |
<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni
- 1-acylglycerol-3-phosphate O-acyltransferase activity Source: UniProtKB
- 1-acylglycerophosphocholine O-acyltransferase activity Source: UniProtKB
<p>Inferred from Direct Assay</p>
<p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p>
<p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p>
Inferred from direct assayi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.6"Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes."
Soupene E., Fyrst H., Kuypers F.A.
Proc. Natl. Acad. Sci. U.S.A. 105:88-93(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. - Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
- 1-alkenylglycerophosphocholine O-acyltransferase activity Source: UniProtKBInferred from direct assayi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
- 1-alkylglycerophosphocholine O-acetyltransferase activity Source: UniProtKBInferred from direct assayi
- Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
- 1-alkylglycerophosphocholine O-acyltransferase activity Source: UniProtKBInferred from direct assayi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
- calcium ion binding Source: InterPro
- plasmalogen synthase activity Source: UniProtKB-EC
GO - Biological processi
- negative regulation of phosphatidylcholine biosynthetic process Source: MGIInferred from direct assayi
- "Cross-talk between remodeling and de novo pathways maintains phospholipid balance through ubiquitination."
Butler P.L., Mallampalli R.K.
J Biol Chem 285:6246-6258(2010) [PubMed] [Europe PMC] [Abstract]
- phosphatidylcholine acyl-chain remodeling Source: MGI
- phospholipid biosynthetic process Source: UniProtKBInferred from direct assayi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
- positive regulation of protein catabolic process Source: MGIInferred from direct assayi
- "Cross-talk between remodeling and de novo pathways maintains phospholipid balance through ubiquitination."
Butler P.L., Mallampalli R.K.
J Biol Chem 285:6246-6258(2010) [PubMed] [Europe PMC] [Abstract]
- retina development in camera-type eye Source: MGI
<p>Inferred from Mutant Phenotype</p>
<p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p>
<p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p>
Inferred from mutant phenotypei
- "Mouse model resources for vision research."
Won J., Shi L.Y., Hicks W., Wang J., Hurd R., Naggert J.K., Chang B., Nishina P.M.
J Ophthalmol 2011:391384-391384(2011) [PubMed] [Europe PMC] [Abstract]
- surfactant homeostasis Source: MGIInferred from direct assayi
- "Cross-talk between remodeling and de novo pathways maintains phospholipid balance through ubiquitination."
Butler P.L., Mallampalli R.K.
J Biol Chem 285:6246-6258(2010) [PubMed] [Europe PMC] [Abstract]
<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDA Comprehensive Enzyme Information System More...BRENDAi | 2.3.1.23, 3474 2.3.1.67, 3474 |
Reactome - a knowledgebase of biological pathways and processes More...Reactomei | R-MMU-1482788, Acyl chain remodelling of PC R-MMU-1482925, Acyl chain remodelling of PG R-MMU-1483166, Synthesis of PA R-MMU-1483191, Synthesis of PC R-MMU-6798695, Neutrophil degranulation |
UniPathway: a resource for the exploration and annotation of metabolic pathways More...UniPathwayi | UPA00085 |
Chemistry databases
SwissLipids knowledge resource for lipid biology More...SwissLipidsi | SLP:000000297 |
<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi | Recommended name: Lysophosphatidylcholine acyltransferase 1 (EC:2.3.1.23
Manual assertion based on experiment ini
Short name: LPC acyltransferase 1 Short name: LPCAT-1 Short name: LysoPC acyltransferase 1 Short name: mLPCAT1 Alternative name(s): 1-acylglycerol-3-phosphate O-acyltransferase (EC:2.3.1.51
Manual assertion inferred from sequence similarity toi )1-acylglycerophosphocholine O-acyltransferase 1-alkenylglycerophosphocholine O-acyltransferase (EC:2.3.1.25
Manual assertion based on experiment ini
1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67
Manual assertion based on experiment ini
Acetyl-CoA:lyso-platelet-activating factor acetyltransferase Short name: Acetyl-CoA:lyso-PAF acetyltransferase Short name: Lyso-PAF acetyltransferase Short name: LysoPAFAT Acyltransferase-like 2 |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi | Name:Lpcat1 Synonyms:Aytl2 |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>Organismi | Mus musculus (Mouse) |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri | 10090 [NCBI] |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineagei | cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi |
|
Organism-specific databases
Mouse genome database (MGD) from Mouse Genome Informatics (MGI) More...MGIi | MGI:2384812, Lpcat1 |
<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Manual assertion inferred from sequence similarity toi
- Endoplasmic reticulum membrane 1 Publication
Plasma membrane
- Cell membrane 1 Publication
Manual assertion inferred by curator fromi
- Ref.6"Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes."
Soupene E., Fyrst H., Kuypers F.A.
Proc. Natl. Acad. Sci. U.S.A. 105:88-93(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Manual assertion inferred from sequence similarity toi
- Cell membrane 1 Publication
Golgi apparatus
- Golgi apparatus membrane 1 Publication
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Manual assertion inferred from sequence similarity toi
- Golgi apparatus membrane 1 Publication
Other locations
- Lipid droplet By similarity
Manual assertion inferred from sequence similarity toi
Note: May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm.By similarity- Lipid droplet By similarity
Manual assertion inferred from sequence similarity toi
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKBInferred from direct assayi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
- endoplasmic reticulum Source: UniProtKBInferred from direct assayi
Golgi apparatus
- Golgi apparatus Source: UniProtKBInferred from direct assayi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
- Golgi membrane Source: UniProtKB-SubCell
- Golgi apparatus Source: UniProtKBInferred from direct assayi
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- lipid droplet Source: MGI
- membrane Source: UniProtKBInferred from direct assayi
- Ref.6"Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes."
Soupene E., Fyrst H., Kuypers F.A.
Proc. Natl. Acad. Sci. U.S.A. 105:88-93(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini | 1 – 57 | CytoplasmicSequence analysisAdd BLAST | 57 | |
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei | 58 – 78 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 79 – 534 | LumenalSequence analysisAdd BLAST | 456 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, Golgi apparatus, Lipid droplet, Membrane<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi | 135 – 140 | Missing : Abolishes activity. 1 Publication Manual assertion based on experiment ini
| 6 | |
Mutagenesisi | 135 | H → A: Loss of activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 140 | D → A: Loss of activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 160 | I → A: No effect on activity for acetyl-CoA. Reduced activity for palmitoyl-CoA. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 162 | I → A: Greatly reduced activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 163 | W → A: Greatly reduced activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 164 – 177 | Missing : Abolishes activity. 1 Publication Manual assertion based on experiment ini
| 14 | |
Mutagenesisi | 164 | G → A: Slightly increased activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 166 | L → A: Greatly reduced activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 167 | I → A: Slightly reduced activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 168 | R → A: Reduced activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 169 | Y → A: Slightly reduced activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 170 | I → A: Slightly reduced activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 171 | R → A: Reduced activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 173 | V → A: Greatly reduced activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 174 | F → A: Loss of lyso-PAFAT activity. LPCAT activity is partially reduced. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 175 | V → A: No activity for acetyl-CoA. Activity for palmitoyl-CoA decreased. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 177 | R → A: Loss of lyso-PAFAT activity. LPCAT activity is partially reduced. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 203 – 209 | Missing : Abolishes activity. 1 Publication Manual assertion based on experiment ini
| 7 | |
Mutagenesisi | 208 | E → A: Loss of activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 209 | G → A: Reduced activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 227 – 233 | Missing : Abolishes activity. 1 Publication Manual assertion based on experiment ini
| 7 | |
Mutagenesisi | 227 | P → A: Reduced activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 230 | P → A: Reduced activity. 1 Publication Manual assertion based on experiment ini
| 1 | |
Mutagenesisi | 233 | P → A: Reduced activity. 1 Publication Manual assertion based on experiment ini
| 1 |
<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000247065 | 1 – 534 | Lysophosphatidylcholine acyltransferase 1Add BLAST | 534 |
Proteomic databases
Encyclopedia of Proteome Dynamics More...EPDi | Q3TFD2 |
MaxQB - The MaxQuant DataBase More...MaxQBi | Q3TFD2 |
PaxDb, a database of protein abundance averages across all three domains of life More...PaxDbi | Q3TFD2 |
PeptideAtlas More...PeptideAtlasi | Q3TFD2 |
PRoteomics IDEntifications database More...PRIDEi | Q3TFD2 |
PTM databases
iPTMnet integrated resource for PTMs in systems biology context More...iPTMneti | Q3TFD2 |
Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat. More...PhosphoSitePlusi | Q3TFD2 |
SwissPalm database of S-palmitoylation events More...SwissPalmi | Q3TFD2 |
<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni
<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi
Manual assertion based on experiment ini
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF. - Ref.2"Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells."
Chen X., Hyatt B.A., Mucenski M.L., Mason R.J., Shannon J.M.
Proc. Natl. Acad. Sci. U.S.A. 103:11724-11729(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. - Ref.6"Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes."
Soupene E., Fyrst H., Kuypers F.A.
Proc. Natl. Acad. Sci. U.S.A. 105:88-93(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei
Manual assertion based on experiment ini
- Ref.2"Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells."
Chen X., Hyatt B.A., Mucenski M.L., Mason R.J., Shannon J.M.
Proc. Natl. Acad. Sci. U.S.A. 103:11724-11729(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni
Manual assertion based on experiment ini
- Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
Gene expression databases
Bgee dataBase for Gene Expression Evolution More...Bgeei | ENSMUSG00000021608, Expressed in primary oocyte and 297 other tissues |
Genevisible search portal to normalized and curated expression data from Genevestigator More...Genevisiblei | Q3TFD2, MM |
<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni
Protein-protein interaction databases
The Biological General Repository for Interaction Datasets (BioGRID) More...BioGRIDi | 229195, 6 interactors |
Protein interaction database and analysis system More...IntActi | Q3TFD2, 1 interactor |
Molecular INTeraction database More...MINTi | Q3TFD2 |
STRING: functional protein association networks More...STRINGi | 10090.ENSMUSP00000022099 |
Miscellaneous databases
RNAct, Protein-RNA interaction predictions for model organisms. More...RNActi | Q3TFD2, protein |
<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei
3D structure databases
SWISS-MODEL Repository - a database of annotated 3D protein structure models More...SMRi | Q3TFD2 |
Database of comparative protein structure models More...ModBasei | Search... |
<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini | 379 – 414 | EF-hand 1PROSITE-ProRule annotation Manual assertion according to rulesi Add BLAST | 36 | |
Domaini | 451 – 486 | EF-hand 2PROSITE-ProRule annotation Manual assertion according to rulesi Add BLAST | 36 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi | 135 – 140 | HXXXXD motif1 Publication Manual assertion based on experiment ini
| 6 | |
Motifi | 531 – 534 | Di-lysine motif1 Publication Manual assertion inferred by curator fromi
| 4 |
<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini
Manual assertion inferred by curator fromi
- Ref.1"Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production."
Nakanishi H., Shindou H., Hishikawa D., Harayama T., Ogasawara R., Suwabe A., Taguchi R., Shimizu T.
J. Biol. Chem. 281:20140-20147(2006) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DI-LYSINE MOTIF.
Manual assertion based on experiment ini
- Ref.5"Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor."
Harayama T., Shindou H., Ogasawara R., Suwabe A., Shimizu T.
J. Biol. Chem. 283:11097-11106(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, MUTAGENESIS OF 135-HIS--ASP-140; HIS-135; ASP-140; ILE-160; ILE-162; TRP-163; 164-GLY--ARG-177; GLY-164; LEU-166; ILE-167; ARG-168; TYR-169; ILE-170; ARG-171; VAL-173; PHE-174; VAL-175; ARG-177; 203-ILE--GLY-209; GLU-208; GLY-209; 227-PRO--PRO-233; PRO-227; PRO-230 AND PRO-233.
<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi
Keywords - Domaini
Repeat, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
evolutionary genealogy of genes: Non-supervised Orthologous Groups More...eggNOGi | KOG4666, Eukaryota |
Ensembl GeneTree More...GeneTreei | ENSGT01000000214580 |
The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms More...HOGENOMi | CLU_025017_0_1_1 |
InParanoid: Eukaryotic Ortholog Groups More...InParanoidi | Q3TFD2 |
Database of Orthologous Groups More...OrthoDBi | 1266853at2759 |
Database for complete collections of gene phylogenies More...PhylomeDBi | Q3TFD2 |
TreeFam database of animal gene trees More...TreeFami | TF323244 |
Family and domain databases
Integrated resource of protein families, domains and functional sites More...InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR002123, Plipid/glycerol_acylTrfase |
Pfam protein domain database More...Pfami | View protein in Pfam PF01553, Acyltransferase, 1 hit PF13833, EF-hand_8, 1 hit |
Simple Modular Architecture Research Tool; a protein domain database More...SMARTi | View protein in SMART SM00054, EFh, 3 hits SM00563, PlsC, 1 hit |
Superfamily database of structural and functional annotation More...SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITE; a protein domain and family database More...PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits |
<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i
<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.
This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basketAdded to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MRLRGRGPRA APSSSSGAGD ARRLAPPGRN PFVHELRLSA LQKAQVAFMT
60 70 80 90 100
LTLFPIRLLF AAFMMLLAWP FALLASLGPP DKEPEQPLAL WRKVVDFLLK
110 120 130 140 150
AIMRTMWFAG GFHRVAVKGR QALPTEAAIL TLAPHSSYFD AIPVTMTMSS
160 170 180 190 200
IVMKAESRDI PIWGTLIRYI RPVFVSRSDQ DSRRKTVEEI KRRAQSNGKW
210 220 230 240 250
PQIMIFPEGT CTNRTCLITF KPGAFIPGVP VQPVVLRYPN KLDTITWTWQ
260 270 280 290 300
GPGALKILWL TLCQFQNQVE IEFLPVYCPS EEEKRNPALY ASNVRRVMAK
310 320 330 340 350
ALGVSVTDYT FEDCQLALAE GQLRLPADTC LLEFARLVRG LGLKPENLEK
360 370 380 390 400
DLDKYSESAR MKRGEKIRLP EFAAYLEVPV SDALEDMFSL FDESGGGEID
410 420 430 440 450
LREYVVALSV VCRPSQTLAT IQLAFKMYGS PEDGSIDEAN LSCILKTALG
460 470 480 490 500
VSELTVTDLF QAIDQEDKGR ITFDDFCGFA EMYPDYAEDY LYPDQTHFDS
510 520 530
CAQTPPAPTP NGFCIDFSPE NSDFGRKNSC KKAD
The sequence of this isoform differs from the canonical sequence as follows:
1-48: Missing.
10 20 30 40 50
MTLTLFPIRL LFAAFMMLLA WPFALLASLG PPDKEPEQPL ALWRKVVDFL
60 70 80 90 100
LKAIMRTMWF AGGFHRVAVK GRQALPTEAA ILTLAPHSSY FDAIPVTMTM
110 120 130 140 150
SSIVMKAESR DIPIWGTLIR YIRPVFVSRS DQDSRRKTVE EIKRRAQSNG
160 170 180 190 200
KWPQIMIFPE GTCTNRTCLI TFKPGAFIPG VPVQPVVLRY PNKLDTITWT
210 220 230 240 250
WQGPGALKIL WLTLCQFQNQ VEIEFLPVYC PSEEEKRNPA LYASNVRRVM
260 270 280 290 300
AKALGVSVTD YTFEDCQLAL AEGQLRLPAD TCLLEFARLV RGLGLKPENL
310 320 330 340 350
EKDLDKYSES ARMKRGEKIR LPEFAAYLEV PVSDALEDMF SLFDESGGGE
360 370 380 390 400
IDLREYVVAL SVVCRPSQTL ATIQLAFKMY GSPEDGSIDE ANLSCILKTA
410 420 430 440 450
LGVSELTVTD LFQAIDQEDK GRITFDDFCG FAEMYPDYAE DYLYPDQTHF
460 470 480
DSCAQTPPAP TPNGFCIDFS PENSDFGRKN SCKKAD
The sequence of this isoform differs from the canonical sequence as follows:
1-203: Missing.
10 20 30 40 50
MIFPEGTCTN RTCLITFKPG AFIPGVPVQP VVLRYPNKLD TITWTWQGPG
60 70 80 90 100
ALKILWLTLC QFQNQVEIEF LPVYCPSEEE KRNPALYASN VRRVMAKALG
110 120 130 140 150
VSVTDYTFED CQLALAEGQL RLPADTCLLE FARLVRGLGL KPENLEKDLD
160 170 180 190 200
KYSESARMKR GEKIRLPEFA AYLEVPVSDA LEDMFSLFDE SGGGEIDLRE
210 220 230 240 250
YVVALSVVCR PSQTLATIQL AFKMYGSPED GSIDEANLSC ILKTALGVSE
260 270 280 290 300
LTVTDLFQAI DQEDKGRITF DDFCGFAEMY PDYAEDYLYP DQTHFDSCAQ
310 320 330
TPPAPTPNGF CIDFSPENSD FGRKNSCKKA D
<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketEntry | Entry name | Protein names | Gene names | Length | Annotation | ||
---|---|---|---|---|---|---|---|
D6RE48 | D6RE48_MOUSE | Lysophosphatidylcholine acyltransfe... Lysophosphatidylcholine acyltransferase 1 | Lpcat1 | 77 | Annotation score: Annotation score:1 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> | ||
D6RFA8 | D6RFA8_MOUSE | Lysophosphatidylcholine acyltransfe... Lysophosphatidylcholine acyltransferase 1 | Lpcat1 | 46 | Annotation score: Annotation score:1 out of 5 <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p> |
<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti | 25 | A → T in BAC38353 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 101 | A → T in AAH66809 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 232 | Q → R in BAE42540 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 272 | E → G in AAH66809 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 338 | V → M in BAC32594 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 338 | V → M in BAC32760 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 442 | S → P in AAH66809 (PubMed:15489334).Curated | 1 |
Alternative sequence
Sequence databases
Select the link destinations: EMBL nucleotide sequence database More...EMBLiGenBank nucleotide sequence database More...GenBankiDNA Data Bank of Japan; a nucleotide sequence database More...DDBJiLinks Updated | AB244717 mRNA Translation: BAE94687.2 AK046079 mRNA Translation: BAC32594.1 Different initiation. AK046507 mRNA Translation: BAC32760.1 Different initiation. AK081865 mRNA Translation: BAC38353.1 AK155286 mRNA Translation: BAE33166.1 AK169190 mRNA Translation: BAE40966.1 AK170723 mRNA Translation: BAE41980.1 AK171582 mRNA Translation: BAE42540.1 BC005662 mRNA Translation: AAH05662.1 Different initiation. BC066809 mRNA Translation: AAH66809.1 |
The Consensus CDS (CCDS) project More...CCDSi | CCDS36726.1 [Q3TFD2-1] |
NCBI Reference Sequences More...RefSeqi | NP_663351.3, NM_145376.5 [Q3TFD2-1] |
Genome annotation databases
Ensembl eukaryotic genome annotation project More...Ensembli | ENSMUST00000022099; ENSMUSP00000022099; ENSMUSG00000021608 [Q3TFD2-1] ENSMUST00000223060; ENSMUSP00000152190; ENSMUSG00000021608 [Q3TFD2-2] |
Database of genes from NCBI RefSeq genomes More...GeneIDi | 210992 |
KEGG: Kyoto Encyclopedia of Genes and Genomes More...KEGGi | mmu:210992 |
UCSC genome browser More...UCSCi | uc007rdk.1, mouse [Q3TFD2-1] |
Keywords - Coding sequence diversityi
Alternative splicing<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi
Protein | Similar proteins | Species | Score | Length | Source | |
---|---|---|---|---|---|---|
Q3TFD2 | Isoform 2 of Lysophosphatidylcholine acyltransferase 1 | 486 | UniRef100_Q3TFD2 | |||
Isoform 3 of Lysophosphatidylcholine acyltransferase 1 | 331 | |||||
Uncharacterized protein (Fragment) | 48 | |||||
+1 |
Protein | Similar proteins | Species | Score | Length | Source | |
---|---|---|---|---|---|---|
Q3TFD2 | Lysophosphatidylcholine acyltransferase 1 | 534 | UniRef90_Q3TFD2 | |||
Isoform 2 of Lysophosphatidylcholine acyltransferase 1 | 486 | |||||
lysophosphatidylcholine acyltransferase 1 isoform X1 | 534 | |||||
lysophosphatidylcholine acyltransferase 1 | 534 | |||||
lysophosphatidylcholine acyltransferase 1 | 534 | |||||
+15 |
Protein | Similar proteins | Species | Score | Length | Source | |
---|---|---|---|---|---|---|
Q3TFD2 | Lysophosphatidylcholine acyltransferase 1 | 534 | UniRef50_Q3TFD2 | |||
Lysophosphatidylcholine acyltransferase 1 | 534 | |||||
Lysophosphatidylcholine acyltransferase 1 | 517 | |||||
Isoform 2 of Lysophosphatidylcholine acyltransferase 1 | 486 | |||||
lysophosphatidylcholine acyltransferase 1 | 534 | |||||
+504 |
<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB244717 mRNA Translation: BAE94687.2 AK046079 mRNA Translation: BAC32594.1 Different initiation. AK046507 mRNA Translation: BAC32760.1 Different initiation. AK081865 mRNA Translation: BAC38353.1 AK155286 mRNA Translation: BAE33166.1 AK169190 mRNA Translation: BAE40966.1 AK170723 mRNA Translation: BAE41980.1 AK171582 mRNA Translation: BAE42540.1 BC005662 mRNA Translation: AAH05662.1 Different initiation. BC066809 mRNA Translation: AAH66809.1 |
CCDSi | CCDS36726.1 [Q3TFD2-1] |
RefSeqi | NP_663351.3, NM_145376.5 [Q3TFD2-1] |
3D structure databases
SMRi | Q3TFD2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 229195, 6 interactors |
IntActi | Q3TFD2, 1 interactor |
MINTi | Q3TFD2 |
STRINGi | 10090.ENSMUSP00000022099 |
Chemistry databases
SwissLipidsi | SLP:000000297 |
PTM databases
iPTMneti | Q3TFD2 |
PhosphoSitePlusi | Q3TFD2 |
SwissPalmi | Q3TFD2 |
Proteomic databases
EPDi | Q3TFD2 |
MaxQBi | Q3TFD2 |
PaxDbi | Q3TFD2 |
PeptideAtlasi | Q3TFD2 |
PRIDEi | Q3TFD2 |
Protocols and materials databases
Antibodypedia a portal for validated antibodies More...Antibodypediai | 1587, 213 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000022099; ENSMUSP00000022099; ENSMUSG00000021608 [Q3TFD2-1] ENSMUST00000223060; ENSMUSP00000152190; ENSMUSG00000021608 [Q3TFD2-2] |
GeneIDi | 210992 |
KEGGi | mmu:210992 |
UCSCi | uc007rdk.1, mouse [Q3TFD2-1] |
Organism-specific databases
Comparative Toxicogenomics Database More...CTDi | 79888 |
MGIi | MGI:2384812, Lpcat1 |
Phylogenomic databases
eggNOGi | KOG4666, Eukaryota |
GeneTreei | ENSGT01000000214580 |
HOGENOMi | CLU_025017_0_1_1 |
InParanoidi | Q3TFD2 |
OrthoDBi | 1266853at2759 |
PhylomeDBi | Q3TFD2 |
TreeFami | TF323244 |
Enzyme and pathway databases
UniPathwayi | UPA00085 |
BRENDAi | 2.3.1.23, 3474 2.3.1.67, 3474 |
Reactomei | R-MMU-1482788, Acyl chain remodelling of PC R-MMU-1482925, Acyl chain remodelling of PG R-MMU-1483166, Synthesis of PA R-MMU-1483191, Synthesis of PC R-MMU-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID ORCS database of CRISPR phenotype screens More...BioGRID-ORCSi | 210992, 3 hits in 19 CRISPR screens |
ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data More...ChiTaRSi | Lpcat1, mouse |
Protein Ontology More...PROi | PR:Q3TFD2 |
RNActi | Q3TFD2, protein |
The Stanford Online Universal Resource for Clones and ESTs More...SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021608, Expressed in primary oocyte and 297 other tissues |
Genevisiblei | Q3TFD2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR002123, Plipid/glycerol_acylTrfase |
Pfami | View protein in Pfam PF01553, Acyltransferase, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits SM00563, PlsC, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits |
ProtoNet; Automatic hierarchical classification of proteins More...ProtoNeti | Search... |
MobiDB: a database of protein disorder and mobility annotations More...MobiDBi | Search... |
<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi
<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei | PCAT1_MOUSE | |
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>Accessioni | Q3TFD2Primary (citable) accession number: Q3TFD2 Secondary accession number(s): Q3TAX4 , Q6NXZ6, Q8BG23, Q8BUX7, Q99JU6 | |
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2006 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families