Lpcat1

Functionⁱ

Possesses both acyltransferase and acetyltransferase activities (PubMed:16704971). Activity is calcium-independent (PubMed:18285344). Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (PubMed:16704971, PubMed:18156367). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (PubMed:16704971, PubMed:18285344). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (PubMed:16704971). Involved in the regulation of lipid droplet number and size (By similarity).By similarity3 Publications

Catalytic activityⁱ

Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine.1 Publication

Acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine = CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine.1 Publication

Activity regulationⁱ

Not activated by inflammatory stimulation. Inhibited by Cu²⁺ and Fe²⁺. Activity is not affected by Co²⁺, Mg²⁺ or Mn²⁺.1 Publication

Kineticsⁱ

pH dependenceⁱ

Optimum pH is 7.5.2 Publications

Pathwayⁱ: phospholipid metabolism

This protein is involved in the pathway phospholipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway phospholipid metabolism and in Lipid metabolism.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	392 – 403	1PROSITE-ProRule annotationAdd BLAST		12

GO - Molecular functionⁱ

1-acylglycerophosphocholine O-acyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16704971
1-alkenylglycerophosphocholine O-acyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16704971
1-alkylglycerophosphocholine O-acetyltransferase activity Source: UniProtKB-EC
1-alkylglycerophosphocholine O-acyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16704971
calcium ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of phosphatidylcholine biosynthetic process
Source: MGI
Inferred from direct assayⁱ
- 20018880
phosphatidylcholine acyl-chain remodeling Source: MGI
phospholipid biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 16704971
positive regulation of protein catabolic process
Source: MGI
Inferred from direct assayⁱ
- 20018880
retina development in camera-type eye
Source: MGI
Inferred from mutant phenotypeⁱ
- 21052544
surfactant homeostasis
Source: MGI
Inferred from direct assayⁱ
- 20018880

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Acyltransferase, Transferase
Biological process	Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
Ligand	Calcium, Metal-binding

Enzyme and pathway databases

BRENDAⁱ	2.3.1.23 3474 2.3.1.67 3474
Reactomeⁱ	R-MMU-1482788 Acyl chain remodelling of PC R-MMU-1482925 Acyl chain remodelling of PG R-MMU-1483166 Synthesis of PA R-MMU-1483191 Synthesis of PC R-MMU-6798695 Neutrophil degranulation
UniPathwayⁱ	UPA00085

Chemistry databases

SwissLipidsⁱ	SLP:000000297

SwissLipidsⁱ

SLP:000000297

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lysophosphatidylcholine acyltransferase 1 (EC:2.3.1.23) Short name: LPC acyltransferase 1 Short name: LPCAT-1 Short name: LysoPC acyltransferase 1 Short name: mLPCAT1 Alternative name(s): 1-acylglycerophosphocholine O-acyltransferase 1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67) Acetyl-CoA:lyso-platelet-activating factor acetyltransferase Short name: Acetyl-CoA:lyso-PAF acetyltransferase Short name: Lyso-PAF acetyltransferase Short name: LysoPAFAT Acyltransferase-like 2
Gene namesⁱ	Name:Lpcat1 Synonyms:Aytl2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 13

Organism-specific databases

MGIⁱ	MGI:2384812 Lpcat1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 57	CytoplasmicSequence analysisAdd BLAST	57
Transmembraneⁱ	58 – 78	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	79 – 534	LumenalSequence analysisAdd BLAST	456

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Golgi apparatus, Lipid droplet, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	135 – 140	Missing : Abolishes activity. 1 Publication	6
Mutagenesisⁱ	135	H → A: Loss of activity. 1 Publication	1
Mutagenesisⁱ	140	D → A: Loss of activity. 1 Publication	1
Mutagenesisⁱ	160	I → A: No effect on activity for acetyl-CoA. Reduced activity for palmitoyl-CoA. 1 Publication	1
Mutagenesisⁱ	162	I → A: Greatly reduced activity. 1 Publication	1
Mutagenesisⁱ	163	W → A: Greatly reduced activity. 1 Publication	1
Mutagenesisⁱ	164 – 177	Missing : Abolishes activity. 1 PublicationAdd BLAST	14
Mutagenesisⁱ	164	G → A: Slightly increased activity. 1 Publication	1
Mutagenesisⁱ	166	L → A: Greatly reduced activity. 1 Publication	1
Mutagenesisⁱ	167	I → A: Slightly reduced activity. 1 Publication	1
Mutagenesisⁱ	168	R → A: Reduced activity. 1 Publication	1
Mutagenesisⁱ	169	Y → A: Slightly reduced activity. 1 Publication	1
Mutagenesisⁱ	170	I → A: Slightly reduced activity. 1 Publication	1
Mutagenesisⁱ	171	R → A: Reduced activity. 1 Publication	1
Mutagenesisⁱ	173	V → A: Greatly reduced activity. 1 Publication	1
Mutagenesisⁱ	174	F → A: Loss of lyso-PAFAT activity. LPCAT activity is partially reduced. 1 Publication	1
Mutagenesisⁱ	175	V → A: No activity for acetyl-CoA. Activity for palmitoyl-CoA decreased. 1 Publication	1
Mutagenesisⁱ	177	R → A: Loss of lyso-PAFAT activity. LPCAT activity is partially reduced. 1 Publication	1
Mutagenesisⁱ	203 – 209	Missing : Abolishes activity. 1 Publication	7
Mutagenesisⁱ	208	E → A: Loss of activity. 1 Publication	1
Mutagenesisⁱ	209	G → A: Reduced activity. 1 Publication	1
Mutagenesisⁱ	227 – 233	Missing : Abolishes activity. 1 Publication	7
Mutagenesisⁱ	227	P → A: Reduced activity. 1 Publication	1
Mutagenesisⁱ	230	P → A: Reduced activity. 1 Publication	1
Mutagenesisⁱ	233	P → A: Reduced activity. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000247065	1 – 534	Lysophosphatidylcholine acyltransferase 1Add BLAST		534

Proteomic databases

EPDⁱ	Q3TFD2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3TFD2
PaxDbⁱ	Q3TFD2
PeptideAtlas More...PeptideAtlasⁱ	Q3TFD2
PRIDEⁱ	Q3TFD2

PTM databases

iPTMnetⁱ	Q3TFD2
PhosphoSitePlusⁱ	Q3TFD2

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in lung where it is enriched in alveolar type II cells. Expressed at lower levels in spleen and brain. Also detected in erythroleukemic cells and reticulocytes. Weakly or not expressed in other tissues.3 Publications

Developmental stageⁱ

Expression increases steadily throughout embryogenesis and decreases slightly in the adult.1 Publication

Inductionⁱ

Constitutively expressed. Not induced by inflammatory stimulation.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000021608 Expressed in 283 organ(s), highest expression level in primary oocyte
CleanExⁱ	MM_LPCAT1
ExpressionAtlasⁱ	Q3TFD2 baseline and differential
Genevisibleⁱ	Q3TFD2 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	229195, 1 interactor
IntActⁱ	Q3TFD2, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q3TFD2
STRINGⁱ	10090.ENSMUSP00000022099

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3TFD2
SMRⁱ	Q3TFD2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	379 – 414	EF-hand 1PROSITE-ProRule annotationAdd BLAST		36
Domainⁱ	451 – 486	EF-hand 2PROSITE-ProRule annotationAdd BLAST		36

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	135 – 140	HXXXXD motif		6
Motifⁱ	531 – 534	Di-lysine motif		4

Domainⁱ

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine.By similarity

The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.By similarity

Sequence similaritiesⁱ

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.Curated

Keywords - Domainⁱ

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4666 Eukaryota ENOG410XSIQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004914
HOGENOMⁱ	HOG000234374
HOVERGENⁱ	HBG060273
InParanoidⁱ	Q3TFD2
KEGG Orthology (KO) More...KOⁱ	K13510
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09LH
PhylomeDBⁱ	Q3TFD2
TreeFamⁱ	TF323244

Family and domain databases

InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR002123 Plipid/glycerol_acylTrfase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01553 Acyltransferase, 1 hit PF13833 EF-hand_8, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 3 hits SM00563 PlsC, 1 hit
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 1 hit PS50222 EF_HAND_2, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q3TFD2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLRGRGPRA APSSSSGAGD ARRLAPPGRN PFVHELRLSA LQKAQVAFMT 
        60         70         80         90        100
LTLFPIRLLF AAFMMLLAWP FALLASLGPP DKEPEQPLAL WRKVVDFLLK 
       110        120        130        140        150
AIMRTMWFAG GFHRVAVKGR QALPTEAAIL TLAPHSSYFD AIPVTMTMSS 
       160        170        180        190        200
IVMKAESRDI PIWGTLIRYI RPVFVSRSDQ DSRRKTVEEI KRRAQSNGKW 
       210        220        230        240        250
PQIMIFPEGT CTNRTCLITF KPGAFIPGVP VQPVVLRYPN KLDTITWTWQ 
       260        270        280        290        300
GPGALKILWL TLCQFQNQVE IEFLPVYCPS EEEKRNPALY ASNVRRVMAK 
       310        320        330        340        350
ALGVSVTDYT FEDCQLALAE GQLRLPADTC LLEFARLVRG LGLKPENLEK 
       360        370        380        390        400
DLDKYSESAR MKRGEKIRLP EFAAYLEVPV SDALEDMFSL FDESGGGEID 
       410        420        430        440        450
LREYVVALSV VCRPSQTLAT IQLAFKMYGS PEDGSIDEAN LSCILKTALG 
       460        470        480        490        500
VSELTVTDLF QAIDQEDKGR ITFDDFCGFA EMYPDYAEDY LYPDQTHFDS 
       510        520        530 
CAQTPPAPTP NGFCIDFSPE NSDFGRKNSC KKAD

Length:534

Mass (Da):59,744

Last modified:October 11, 2005 - v1

Checksum:ⁱ50C1EF4A5D494DF2

GO

Isoform 2 (identifier: Q3TFD2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-48: Missing.

« Hide

        10         20         30         40         50
MTLTLFPIRL LFAAFMMLLA WPFALLASLG PPDKEPEQPL ALWRKVVDFL 
        60         70         80         90        100
LKAIMRTMWF AGGFHRVAVK GRQALPTEAA ILTLAPHSSY FDAIPVTMTM 
       110        120        130        140        150
SSIVMKAESR DIPIWGTLIR YIRPVFVSRS DQDSRRKTVE EIKRRAQSNG 
       160        170        180        190        200
KWPQIMIFPE GTCTNRTCLI TFKPGAFIPG VPVQPVVLRY PNKLDTITWT 
       210        220        230        240        250
WQGPGALKIL WLTLCQFQNQ VEIEFLPVYC PSEEEKRNPA LYASNVRRVM 
       260        270        280        290        300
AKALGVSVTD YTFEDCQLAL AEGQLRLPAD TCLLEFARLV RGLGLKPENL 
       310        320        330        340        350
EKDLDKYSES ARMKRGEKIR LPEFAAYLEV PVSDALEDMF SLFDESGGGE 
       360        370        380        390        400
IDLREYVVAL SVVCRPSQTL ATIQLAFKMY GSPEDGSIDE ANLSCILKTA 
       410        420        430        440        450
LGVSELTVTD LFQAIDQEDK GRITFDDFCG FAEMYPDYAE DYLYPDQTHF 
       460        470        480 
DSCAQTPPAP TPNGFCIDFS PENSDFGRKN SCKKAD

Note: No experimental confirmation available.

Show »

Length:486

Mass (Da):54,650

Checksum:ⁱ058873866F2736C6

GO

Isoform 3 (identifier: Q3TFD2-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-203: Missing.

« Hide

        10         20         30         40         50
MIFPEGTCTN RTCLITFKPG AFIPGVPVQP VVLRYPNKLD TITWTWQGPG 
        60         70         80         90        100
ALKILWLTLC QFQNQVEIEF LPVYCPSEEE KRNPALYASN VRRVMAKALG 
       110        120        130        140        150
VSVTDYTFED CQLALAEGQL RLPADTCLLE FARLVRGLGL KPENLEKDLD 
       160        170        180        190        200
KYSESARMKR GEKIRLPEFA AYLEVPVSDA LEDMFSLFDE SGGGEIDLRE 
       210        220        230        240        250
YVVALSVVCR PSQTLATIQL AFKMYGSPED GSIDEANLSC ILKTALGVSE 
       260        270        280        290        300
LTVTDLFQAI DQEDKGRITF DDFCGFAEMY PDYAEDYLYP DQTHFDSCAQ 
       310        320        330 
TPPAPTPNGF CIDFSPENSD FGRKNSCKKA D

Note: No experimental confirmation available.

Show »

Length:331

Mass (Da):36,982

Checksum:ⁱ2B9F5AA5431F7DBA

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RFA8	D6RFA8_MOUSE	Acyltransferase like 2, isoform CRA... Acyltransferase like 2, isoform CRA_b (Lysophosphatidylcholine acyltransferase 1)	Lpcat1 Aytl2, mCG_10024	46	Annotation score:
D6RE48	D6RE48_MOUSE	Lysophosphatidylcholine acyltransfe... Lysophosphatidylcholine acyltransferase 1	Lpcat1	77	Annotation score:

Sequence cautionⁱ

The sequence AAH05662 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAC32594 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAC32760 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	25	A → T in BAC38353 (PubMed:16141072).Curated	1
Sequence conflictⁱ	101	A → T in AAH66809 (PubMed:15489334).Curated	1
Sequence conflictⁱ	232	Q → R in BAE42540 (PubMed:16141072).Curated	1
Sequence conflictⁱ	272	E → G in AAH66809 (PubMed:15489334).Curated	1
Sequence conflictⁱ	338	V → M in BAC32594 (PubMed:16141072).Curated	1
Sequence conflictⁱ	338	V → M in BAC32760 (PubMed:16141072).Curated	1
Sequence conflictⁱ	442	S → P in AAH66809 (PubMed:15489334).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_019913	1 – 203	Missing in isoform 3. 1 PublicationAdd BLAST		203
Alternative sequenceⁱVSP_019914	1 – 48	Missing in isoform 2. 1 PublicationAdd BLAST		48

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB244717 mRNA Translation: BAE94687.2 AK046079 mRNA Translation: BAC32594.1 Different initiation. AK046507 mRNA Translation: BAC32760.1 Different initiation. AK081865 mRNA Translation: BAC38353.1 AK155286 mRNA Translation: BAE33166.1 AK169190 mRNA Translation: BAE40966.1 AK170723 mRNA Translation: BAE41980.1 AK171582 mRNA Translation: BAE42540.1 BC005662 mRNA Translation: AAH05662.1 Different initiation. BC066809 mRNA Translation: AAH66809.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36726.1 [Q3TFD2-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_663351.3, NM_145376.5 [Q3TFD2-1]
UniGeneⁱ	Mm.284649

Genome annotation databases

Ensemblⁱ	ENSMUST00000022099; ENSMUSP00000022099; ENSMUSG00000021608 [Q3TFD2-1] ENSMUST00000223060; ENSMUSP00000152190; ENSMUSG00000021608 [Q3TFD2-2]
GeneIDⁱ	210992
KEGGⁱ	mmu:210992
UCSC genome browser More...UCSCⁱ	uc007rdk.1 mouse [Q3TFD2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q3TFD2	Isoform 2 of Lysophosphatidylcholine acyltransferase 1		MOUSE		486	UniRef100_Q3TFD2
Isoform 3 of Lysophosphatidylcholine acyltransferase 1		MOUSE		331
UPI0003D72482		MOUSE		432

Protein	Similar proteins		Species	Score	Length	Source
Q3TFD2	Lysophosphatidylcholine acyltransferase 1		RAT		534	UniRef90_Q3TFD2
Isoform 2 of Lysophosphatidylcholine acyltransferase 1		MOUSE		486
Lysophosphatidylcholine acyltransferase 1		CASCN		534
UPI000A317EDA		MUSCR		534
UPI000A312306		MUSPA		534
+9

Protein	Similar proteins		Species	Score	Length	Source
Q3TFD2	Lysophosphatidylcholine acyltransferase 1		RAT		534	UniRef50_Q3TFD2
Isoform 2 of Lysophosphatidylcholine acyltransferase 1		MOUSE		486
Lysophosphatidylcholine acyltransferase 1		CASCN		534
Uncharacterized protein		MONDO		547
Lysophosphatidylcholine acyltransferase 1		SARHA		486
+32

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB244717 mRNA Translation: BAE94687.2 AK046079 mRNA Translation: BAC32594.1 Different initiation. AK046507 mRNA Translation: BAC32760.1 Different initiation. AK081865 mRNA Translation: BAC38353.1 AK155286 mRNA Translation: BAE33166.1 AK169190 mRNA Translation: BAE40966.1 AK170723 mRNA Translation: BAE41980.1 AK171582 mRNA Translation: BAE42540.1 BC005662 mRNA Translation: AAH05662.1 Different initiation. BC066809 mRNA Translation: AAH66809.1
CCDSⁱ	CCDS36726.1 [Q3TFD2-1]
RefSeqⁱ	NP_663351.3, NM_145376.5 [Q3TFD2-1]
UniGeneⁱ	Mm.284649

3D structure databases

ProteinModelPortalⁱ	Q3TFD2
SMRⁱ	Q3TFD2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	229195, 1 interactor
IntActⁱ	Q3TFD2, 1 interactor
MINTⁱ	Q3TFD2
STRINGⁱ	10090.ENSMUSP00000022099

Chemistry databases

SwissLipidsⁱ	SLP:000000297

SwissLipidsⁱ

SLP:000000297

PTM databases

iPTMnetⁱ	Q3TFD2
PhosphoSitePlusⁱ	Q3TFD2

Proteomic databases

EPDⁱ	Q3TFD2
MaxQBⁱ	Q3TFD2
PaxDbⁱ	Q3TFD2
PeptideAtlasⁱ	Q3TFD2
PRIDEⁱ	Q3TFD2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000022099; ENSMUSP00000022099; ENSMUSG00000021608 [Q3TFD2-1] ENSMUST00000223060; ENSMUSP00000152190; ENSMUSG00000021608 [Q3TFD2-2]
GeneIDⁱ	210992
KEGGⁱ	mmu:210992
UCSCⁱ	uc007rdk.1 mouse [Q3TFD2-1]

Organism-specific databases

CTDⁱ	79888
MGIⁱ	MGI:2384812 Lpcat1

Phylogenomic databases

eggNOGⁱ	KOG4666 Eukaryota ENOG410XSIQ LUCA
GeneTreeⁱ	ENSGT00390000004914
HOGENOMⁱ	HOG000234374
HOVERGENⁱ	HBG060273
InParanoidⁱ	Q3TFD2
KOⁱ	K13510
OrthoDBⁱ	EOG091G09LH
PhylomeDBⁱ	Q3TFD2
TreeFamⁱ	TF323244

Enzyme and pathway databases

UniPathwayⁱ	UPA00085
BRENDAⁱ	2.3.1.23 3474 2.3.1.67 3474
Reactomeⁱ	R-MMU-1482788 Acyl chain remodelling of PC R-MMU-1482925 Acyl chain remodelling of PG R-MMU-1483166 Synthesis of PA R-MMU-1483191 Synthesis of PC R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q3TFD2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000021608 Expressed in 283 organ(s), highest expression level in primary oocyte
CleanExⁱ	MM_LPCAT1
ExpressionAtlasⁱ	Q3TFD2 baseline and differential
Genevisibleⁱ	Q3TFD2 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom IPR002123 Plipid/glycerol_acylTrfase
Pfamⁱ	View protein in Pfam PF01553 Acyltransferase, 1 hit PF13833 EF-hand_8, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 3 hits SM00563 PlsC, 1 hit
SUPFAMⁱ	SSF47473 SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 1 hit PS50222 EF_HAND_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PCAT1_MOUSE
Accessionⁱ	Q3TFD2Primary (citable) accession number: Q3TFD2 Secondary accession number(s): Q3TAX4 , Q6NXZ6, Q8BG23, Q8BUX7, Q99JU6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
	Last sequence update:	October 11, 2005
	Last modified:	November 7, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways

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Supporting data

UniProtKB - Q3TFD2 (PCAT1_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Lysophosphatidylcholine acyltransferase 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

pH dependencei

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phospholipid metabolism

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Endoplasmic reticulum

Other locations

Endoplasmic reticulum

Golgi apparatus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Kineticsⁱ

pH dependenceⁱ

Pathwayⁱ: phospholipid metabolism

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ