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Entry version 115 (22 Apr 2020)
Sequence version 1 (11 Oct 2005)
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Protein

Heterochromatin protein 1-binding protein 3

Gene

Hp1bp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. May play a role in hypoxia-induced oncogenesis.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heterochromatin protein 1-binding protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hp1bp3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109369 Hp1bp3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003396432 – 554Heterochromatin protein 1-binding protein 3Add BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei6PhosphoserineBy similarity1
Modified residuei51PhosphothreonineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki64Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei85PhosphothreonineBy similarity1
Cross-linki97Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei144PhosphoserineBy similarity1
Modified residuei157PhosphoserineBy similarity1
Modified residuei158PhosphoserineBy similarity1
Modified residuei192N6-acetyllysineCombined sources1
Modified residuei249PhosphoserineBy similarity1
Cross-linki258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei443PhosphoserineBy similarity1
Modified residuei444PhosphoserineBy similarity1
Modified residuei447PhosphoserineBy similarity1
Isoform 2 (identifier: Q3TEA8-2)
Modified residuei72PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3TEA8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3TEA8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3TEA8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3TEA8

PeptideAtlas

More...
PeptideAtlasi
Q3TEA8

PRoteomics IDEntifications database

More...
PRIDEi
Q3TEA8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3TEA8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3TEA8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028759 Expressed in ear and 287 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3TEA8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3TEA8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via PxVxL motif) with CBX5 (via Trp-174).

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
200401, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q3TEA8, 6 interactors

Molecular INTeraction database

More...
MINTi
Q3TEA8

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000101453

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3TEA8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3TEA8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini159 – 234H15 1PROSITE-ProRule annotationAdd BLAST76
Domaini255 – 330H15 2PROSITE-ProRule annotationAdd BLAST76
Domaini337 – 413H15 3PROSITE-ProRule annotationAdd BLAST77

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi255 – 259PxVxL motifBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi59 – 128Glu-richAdd BLAST70
Compositional biasi432 – 441Poly-Asp10
Compositional biasi455 – 554Lys-richAdd BLAST100

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

A central region that included the first H15 (linker histone H1/H5 globular) domain binds at the entry/exit site of the nucleosomal DNA.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4012 Eukaryota
ENOG4112541 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155314

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_035727_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3TEA8

Identification of Orthologs from Complete Genome Data

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OMAi
ASGTFQX

Database of Orthologous Groups

More...
OrthoDBi
903215at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3TEA8

TreeFam database of animal gene trees

More...
TreeFami
TF106395

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00073 H15, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR005819 Histone_H5
IPR033061 HP1BP3
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

The PANTHER Classification System

More...
PANTHERi
PTHR15832:SF1 PTHR15832:SF1, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00538 Linker_histone, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00624 HISTONEH5

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00526 H15, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51504 H15, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3TEA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATDMSQGEL IHPKALPLIV GAQLIHADKL GEKAEDTTMP IRRAVNSTRE
60 70 80 90 100
TPPKSKLAEG EEEKPEPDGS SEESISTVEE QENETPPATS SEAEQPKGEP
110 120 130 140 150
ESGEKEENNN KSAEEPKKDE KDQSKEKEKK VKKTIPAWAT LSASQLARAQ
160 170 180 190 200
RQTPMASSPR PKMDAILTEA IKACFQKTGA SVVAIRKYII HKYPSLGLER
210 220 230 240 250
RGYLLKQALK RELNRGVIRQ VKGKGASGSF VVVQKSKPPQ KSKNRKKGSA
260 270 280 290 300
LDPEPQVKLE DVLPLAFTRL CEPKEASYSL IRKYVSQYYP KLRVDIRPQL
310 320 330 340 350
LKNALQRAVE RGQLEQITGK GASGTFQLKK SGEKPLLGGS LMEYAILSAI
360 370 380 390 400
AAMNEPKTCS TTALKKYVLE NHPGANSNYQ MHLLKKTLQK CEKNGWLEQI
410 420 430 440 450
SGKGFSGTFQ LSFPYYPSPG VLFPKKESGG SDDEDEDDDD DESSEDSEDE
460 470 480 490 500
EPPPKRSLQK KTPAKSQGKT ASMKQRGSKP ARKVPAAQRG KVRPLPKKAP
510 520 530 540 550
PKAKTPARKA RPSPSVIKKP SGSSSRKPIA SARKEAKLPG KGKSAMKKSF

KTKK
Length:554
Mass (Da):60,867
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA49C4F7C42D1BE64
GO
Isoform 2 (identifier: Q3TEA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-79: Missing.

Show »
Length:541
Mass (Da):59,548
Checksum:i2F19451E819E2EB7
GO
Isoform 3 (identifier: Q3TEA8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.

Show »
Length:516
Mass (Da):56,841
Checksum:i95FCF9348F2868BE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AM63A2AM63_MOUSE
Heterochromatin protein 1-binding p...
Hp1bp3
208Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AM65A2AM65_MOUSE
Heterochromatin protein 1-binding p...
Hp1bp3
292Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YKA3Z4YKA3_MOUSE
Heterochromatin protein 1-binding p...
Hp1bp3
516Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Z4YKB8Z4YKB8_MOUSE
Heterochromatin protein 1-binding p...
Hp1bp3
554Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AM62A2AM62_MOUSE
Heterochromatin protein 1-binding p...
Hp1bp3
165Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AM69A2AM69_MOUSE
Heterochromatin protein 1-binding p...
Hp1bp3
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AM70A2AM70_MOUSE
Heterochromatin protein 1-binding p...
Hp1bp3
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC35912 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti68D → N in BAE36164 (PubMed:16141072).Curated1
Sequence conflicti110N → S in CAA67961 (PubMed:8978696).Curated1
Sequence conflicti110N → S in AAH20024 (PubMed:15489334).Curated1
Sequence conflicti111K → E in BAB23683 (PubMed:16141072).Curated1
Sequence conflicti174C → S in CAM18860 (PubMed:19468303).Curated1
Sequence conflicti174C → S in CAM18863 (PubMed:19468303).Curated1
Sequence conflicti197G → D in CAA67961 (PubMed:8978696).Curated1
Sequence conflicti197G → D in AAH04053 (PubMed:15489334).Curated1
Sequence conflicti197G → D in AAH20024 (PubMed:15489334).Curated1
Sequence conflicti219R → K in CAA67961 (PubMed:8978696).Curated1
Sequence conflicti219R → K in AAH04053 (PubMed:15489334).Curated1
Sequence conflicti219R → K in AAH20024 (PubMed:15489334).Curated1
Sequence conflicti247Missing in BAC25794 (PubMed:16141072).Curated1
Sequence conflicti403K → R in BAE38604 (PubMed:16141072).Curated1
Sequence conflicti436E → D in AAH04053 (PubMed:15489334).Curated1
Sequence conflicti436E → D in AAH20024 (PubMed:15489334).Curated1
Sequence conflicti440 – 441Missing in AAH04053 (PubMed:15489334).Curated2
Sequence conflicti547K → E in BAE36164 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0341741 – 38Missing in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_03417567 – 79Missing in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK004938 mRNA Translation: BAB23683.1
AK028181 mRNA Translation: BAC25794.1
AK043260 mRNA Translation: BAC31507.1
AK075725 mRNA Translation: BAC35912.1 Frameshift.
AK161041 mRNA Translation: BAE36164.1
AK166161 mRNA Translation: BAE38604.1
AK169740 mRNA Translation: BAE41340.1
AL807249 Genomic DNA Translation: CAM18860.1
AL807249 Genomic DNA Translation: CAM18863.1
BC004053 mRNA Translation: AAH04053.1
BC020024 mRNA Translation: AAH20024.1
X99642 mRNA Translation: CAA67961.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS38927.1 [Q3TEA8-1]
CCDS51334.1 [Q3TEA8-3]

NCBI Reference Sequences

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RefSeqi
NP_001116368.1, NM_001122896.2 [Q3TEA8-3]
NP_001116369.1, NM_001122897.2 [Q3TEA8-1]
NP_001272407.1, NM_001285478.1 [Q3TEA8-1]
NP_001272408.1, NM_001285479.1
NP_001272409.1, NM_001285480.1
NP_001272410.1, NM_001285481.1 [Q3TEA8-2]
NP_034600.2, NM_010470.3 [Q3TEA8-1]
XP_006538631.1, XM_006538568.3 [Q3TEA8-1]
XP_006538633.1, XM_006538570.2 [Q3TEA8-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000030541; ENSMUSP00000030541; ENSMUSG00000028759 [Q3TEA8-1]
ENSMUST00000097836; ENSMUSP00000095447; ENSMUSG00000028759 [Q3TEA8-3]
ENSMUST00000165861; ENSMUSP00000132614; ENSMUSG00000028759 [Q3TEA8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
15441

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:15441

UCSC genome browser

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UCSCi
uc008vkg.3 mouse [Q3TEA8-1]
uc008vki.3 mouse [Q3TEA8-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004938 mRNA Translation: BAB23683.1
AK028181 mRNA Translation: BAC25794.1
AK043260 mRNA Translation: BAC31507.1
AK075725 mRNA Translation: BAC35912.1 Frameshift.
AK161041 mRNA Translation: BAE36164.1
AK166161 mRNA Translation: BAE38604.1
AK169740 mRNA Translation: BAE41340.1
AL807249 Genomic DNA Translation: CAM18860.1
AL807249 Genomic DNA Translation: CAM18863.1
BC004053 mRNA Translation: AAH04053.1
BC020024 mRNA Translation: AAH20024.1
X99642 mRNA Translation: CAA67961.1
CCDSiCCDS38927.1 [Q3TEA8-1]
CCDS51334.1 [Q3TEA8-3]
RefSeqiNP_001116368.1, NM_001122896.2 [Q3TEA8-3]
NP_001116369.1, NM_001122897.2 [Q3TEA8-1]
NP_001272407.1, NM_001285478.1 [Q3TEA8-1]
NP_001272408.1, NM_001285479.1
NP_001272409.1, NM_001285480.1
NP_001272410.1, NM_001285481.1 [Q3TEA8-2]
NP_034600.2, NM_010470.3 [Q3TEA8-1]
XP_006538631.1, XM_006538568.3 [Q3TEA8-1]
XP_006538633.1, XM_006538570.2 [Q3TEA8-3]

3D structure databases

SMRiQ3TEA8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi200401, 10 interactors
IntActiQ3TEA8, 6 interactors
MINTiQ3TEA8
STRINGi10090.ENSMUSP00000101453

PTM databases

iPTMnetiQ3TEA8
PhosphoSitePlusiQ3TEA8

Proteomic databases

EPDiQ3TEA8
jPOSTiQ3TEA8
MaxQBiQ3TEA8
PaxDbiQ3TEA8
PeptideAtlasiQ3TEA8
PRIDEiQ3TEA8

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
29832 80 antibodies

Genome annotation databases

EnsembliENSMUST00000030541; ENSMUSP00000030541; ENSMUSG00000028759 [Q3TEA8-1]
ENSMUST00000097836; ENSMUSP00000095447; ENSMUSG00000028759 [Q3TEA8-3]
ENSMUST00000165861; ENSMUSP00000132614; ENSMUSG00000028759 [Q3TEA8-1]
GeneIDi15441
KEGGimmu:15441
UCSCiuc008vkg.3 mouse [Q3TEA8-1]
uc008vki.3 mouse [Q3TEA8-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
50809
MGIiMGI:109369 Hp1bp3

Phylogenomic databases

eggNOGiKOG4012 Eukaryota
ENOG4112541 LUCA
GeneTreeiENSGT00940000155314
HOGENOMiCLU_035727_1_0_1
InParanoidiQ3TEA8
OMAiASGTFQX
OrthoDBi903215at2759
PhylomeDBiQ3TEA8
TreeFamiTF106395

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Hp1bp3 mouse

Protein Ontology

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PROi
PR:Q3TEA8
RNActiQ3TEA8 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028759 Expressed in ear and 287 other tissues
ExpressionAtlasiQ3TEA8 baseline and differential
GenevisibleiQ3TEA8 MM

Family and domain databases

CDDicd00073 H15, 1 hit
Gene3Di1.10.10.10, 3 hits
InterProiView protein in InterPro
IPR005818 Histone_H1/H5_H15
IPR005819 Histone_H5
IPR033061 HP1BP3
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR15832:SF1 PTHR15832:SF1, 1 hit
PfamiView protein in Pfam
PF00538 Linker_histone, 3 hits
PRINTSiPR00624 HISTONEH5
SMARTiView protein in SMART
SM00526 H15, 3 hits
SUPFAMiSSF46785 SSF46785, 3 hits
PROSITEiView protein in PROSITE
PS51504 H15, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHP1B3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3TEA8
Secondary accession number(s): A2AM64
, A2AM68, Q3TM38, Q3TU07, Q61688, Q8BT17, Q8C6H2, Q8C911, Q8VE06, Q99KR0, Q9DBI1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 11, 2005
Last modified: April 22, 2020
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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