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Entry version 101 (12 Aug 2020)
Sequence version 2 (13 Nov 2007)
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Protein

Protein dispatched homolog 1

Gene

Disp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.6.9.2, the resistance-nodulation-cell division (rnd) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein dispatched homolog 1
Alternative name(s):
Mdispa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Disp1
Synonyms:Disp, Dispa, Icb, Icbins
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1916147, Disp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Transmembranei499 – 519HelicalSequence analysisAdd BLAST21
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Transmembranei548 – 568HelicalSequence analysisAdd BLAST21
Transmembranei603 – 623HelicalSequence analysisAdd BLAST21
Transmembranei637 – 657HelicalSequence analysisAdd BLAST21
Transmembranei717 – 737HelicalSequence analysisAdd BLAST21
Transmembranei986 – 1006HelicalSequence analysisAdd BLAST21
Transmembranei1008 – 1028HelicalSequence analysisAdd BLAST21
Transmembranei1038 – 1058HelicalSequence analysisAdd BLAST21
Transmembranei1081 – 1101HelicalSequence analysisAdd BLAST21
Transmembranei1109 – 1129HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Death at or soon after 9.5 dpc probably due to abnormal embryonic turning and looping of the heart. Embryos also display defects in development of the forebrain and branchial arches.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi571 – 572DD → AA: Loss of function; when associated with A-1049. 1 Publication2
Mutagenesisi571 – 572DD → NN: Loss of function; when associated with N-1049. 1 Publication2
Mutagenesisi829C → F in icb; loss of function. 1 Publication1
Mutagenesisi1049D → A: Loss of function; when associated with 571-A-A-572. 1 Publication1
Mutagenesisi1049D → N: Loss of function; when associated with 571-N-N-572. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003106941 – 1521Protein dispatched homolog 1Add BLAST1521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi14N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi581N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1455N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3TDN0

PRoteomics IDEntifications database

More...
PRIDEi
Q3TDN0

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q3TDN0, 5 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3TDN0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3TDN0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression overlaps with the one of SHH and IHH being restricted to tissues that require Hh signaling. PubMed:12372301, reported a more ubiquitous expression which is detected throughout the embryo at 7.5 dpc and is maintained during embryonic development.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030768, Expressed in oocyte and 203 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3TDN0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SHH; via the cholesterol anchor of the dually lipid-modified SHH (ShhNp) (PubMed:22902404).

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000003035

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3TDN0, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini485 – 657SSDPROSITE-ProRule annotationAdd BLAST173

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dispatched family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3664, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157407

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004076_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3TDN0

Identification of Orthologs from Complete Genome Data

More...
OMAi
YYHVLAR

Database of Orthologous Groups

More...
OrthoDBi
1156918at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3TDN0

TreeFam database of animal gene trees

More...
TreeFami
TF324144

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003392, Ptc/Disp
IPR000731, SSD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02460, Patched, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50156, SSD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3TDN0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVISGSDSV LLSNGSISTS TSNPSPLSPS DGDLPAQHLG PRETPRTKAS
60 70 80 90 100
PNGCLQLNGT VKSSFLPLDN QRTPQTPTQC CHPCPYHHPV SSHSNHQECH
110 120 130 140 150
PEAGLAASPA LASCRMQPHS EYSASLCPNH SPVYQAAHCL QPSPSFCLHH
160 170 180 190 200
PWPDHFQHQP VRQHLTIIRP SRPFKFPRSY AALLADWPVV VLGMCTLLIV
210 220 230 240 250
VCALVGVLVP ELPDFSDPLL GFEPRGTTIG QRLVTWNNMM RNTGYKATLA
260 270 280 290 300
NYPYKYAEEQ ARSHRDDRWS DDHHERERRE VDWNFQKDSF FCDVPSDGYS
310 320 330 340 350
RVVFASAGGE TLWNLPAIKS MCDVDNSRIR SHPQFSDLCQ RTTAVSCCPS
360 370 380 390 400
WTLGNYIAIL NNRSSCQKIV ERDVSHTLKL LRTCAKHYQN GTLGPDCWDK
410 420 430 440 450
AARRKDQLKC TNVPRKCTKY NAVYQILHYL VDKDFMTPKT ADYAVPALKY
460 470 480 490 500
SMLFSPTEKG ESMMNIYLDN FENWNSSDGI TTVTGIEFGI KHSLFQDYLL
510 520 530 540 550
MDTVYPAIAI AIVLLIMCVY TKSMFITLMT MFAIISSLIV SYFLYRVVFN
560 570 580 590 600
FEFFPFMNLT ALIILVGIGA DDAFVLCDVW NYTKFDKPRA ETSEAVSVTL
610 620 630 640 650
QHAALSMFVT SFTTAAAFYA NYVSNITAIR CFGVYAGTAI LVNYVLMVTW
660 670 680 690 700
LPAVIVLHER YLLNIFTCFR KPQPQAYDKS CWAVLCQKCR RVLFAVSEAS
710 720 730 740 750
RIFFEKVLPC IVIKFRYLWL IWFLALTVGG AYIVCVNPKM KLPSLELSEF
760 770 780 790 800
QVFRSSHPFE RYDAEFKKLF MFERVHHGEE LHMPITVIWG VSPEDSGDPL
810 820 830 840 850
NPKSKGELTL DSTFNIASPA SQAWILHFCQ KLRNQTFFHQ TEQQDFTSCF
860 870 880 890 900
IETFKQWMEN QDCDEPALYP CCSHCSFPYK QEVFELCIKK AIMELDRSTG
910 920 930 940 950
YHLNNKTPGP RFDINDTIRA VVLEFQSTFL FTLAYEKMQQ FYKEVDSWIS
960 970 980 990 1000
HELSSAPEGL SRGWFVSNLE FYDLQDSLSD GTLIAMGLSV AVAFSVMLLT
1010 1020 1030 1040 1050
TWNIIISLYA IVSIAGTIFV TVGSLVLLGW ELNVLESVTI SVAVGLSVDF
1060 1070 1080 1090 1100
AVHYGVAYRL APDPDREGKV IFSLSRMGSA IAMAALTTFV AGAMMMPSTV
1110 1120 1130 1140 1150
LAYTQLGTFM MLVMCVSWAF ATFFFQCLCR CLGPQGTCGQ IPFPTKLQCS
1160 1170 1180 1190 1200
PFSHTLSARP GDRGPSKTHA ASAYSVDARG QKSQLEHEFY ELQPLASHSC
1210 1220 1230 1240 1250
TSSEKTTYEE PHTCSEFFNG QAKNLRMPVP AAYSSELTKS PSSEPGSALL
1260 1270 1280 1290 1300
QSCLEQDTVC HFSLNPRCNC RDAYTHLQYG LPEIHCQQMG DSLCHKCAST
1310 1320 1330 1340 1350
AGGFVQIQSS VAPLKASHQA AEGLLHPAQH MLPPGMQNSR PRNFFLHSVQ
1360 1370 1380 1390 1400
HFQAQENLGR TSTHSTDERL PRTAELSPPP SDSRSTESFQ RACCHPENNQ
1410 1420 1430 1440 1450
RRLCKSRDPG DTEGSGGTKS KVSGLPNQTD KEEKQVEPSL LQTDETVNSE
1460 1470 1480 1490 1500
HLNHNESNFT FSHLPGEAGC RSCPNSPQSC RSIMRSKCGT EDCQTPNLEA
1510 1520
NVPAVPTHSD LSGESLLIKT L
Length:1,521
Mass (Da):170,130
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B1E9A0F7873BB30
GO
Isoform 2 (identifier: Q3TDN0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     329-345: IRSHPQFSDLCQRTTAV → VCKTQLKSIQHNKVMLR
     346-1521: Missing.

Show »
Length:345
Mass (Da):38,420
Checksum:i9CF7B836F0B954E8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YWR7A0A0A6YWR7_MOUSE
Protein dispatched homolog 1
Disp1
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti292C → W in BAE23607 (PubMed:16141072).Curated1
Sequence conflicti688K → M in AAN52161 (PubMed:12372301).Curated1
Sequence conflicti949I → V in BAE23607 (PubMed:16141072).Curated1
Sequence conflicti1309S → N in AAN52161 (PubMed:12372301).Curated1
Sequence conflicti1309S → N in AAN64660 (PubMed:12421714).Curated1
Sequence conflicti1431K → E in AAN52161 (PubMed:12372301).Curated1
Sequence conflicti1431K → E in AAN64660 (PubMed:12421714).Curated1
Sequence conflicti1431K → E in BAE41571 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029322329 – 345IRSHP…RTTAV → VCKTQLKSIQHNKVMLR in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_029323346 – 1521Missing in isoform 2. 1 PublicationAdd BLAST1176

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY150698 mRNA Translation: AAN52161.1
AY150577 mRNA Translation: AAN64660.1
AK004521 mRNA Translation: BAB23344.1
AK138276 mRNA Translation: BAE23607.1
AK170113 mRNA Translation: BAE41571.1
BC043102 mRNA Translation: AAH43102.1
BC059225 mRNA Translation: AAH59225.1
AY144589 mRNA Translation: AAN08631.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS56661.1 [Q3TDN0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001265147.1, NM_001278218.1 [Q3TDN0-1]
NP_001265148.1, NM_001278219.1 [Q3TDN0-1]
NP_001265149.1, NM_001278220.1 [Q3TDN0-1]
NP_081142.3, NM_026866.3 [Q3TDN0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000003035; ENSMUSP00000003035; ENSMUSG00000030768 [Q3TDN0-1]
ENSMUST00000171366; ENSMUSP00000126742; ENSMUSG00000030768 [Q3TDN0-1]
ENSMUST00000195372; ENSMUSP00000141747; ENSMUSG00000030768 [Q3TDN0-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
68897

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:68897

UCSC genome browser

More...
UCSCi
uc008ick.2, mouse [Q3TDN0-1]
uc008ico.2, mouse [Q3TDN0-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY150698 mRNA Translation: AAN52161.1
AY150577 mRNA Translation: AAN64660.1
AK004521 mRNA Translation: BAB23344.1
AK138276 mRNA Translation: BAE23607.1
AK170113 mRNA Translation: BAE41571.1
BC043102 mRNA Translation: AAH43102.1
BC059225 mRNA Translation: AAH59225.1
AY144589 mRNA Translation: AAN08631.1
CCDSiCCDS56661.1 [Q3TDN0-1]
RefSeqiNP_001265147.1, NM_001278218.1 [Q3TDN0-1]
NP_001265148.1, NM_001278219.1 [Q3TDN0-1]
NP_001265149.1, NM_001278220.1 [Q3TDN0-1]
NP_081142.3, NM_026866.3 [Q3TDN0-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003035

Protein family/group databases

TCDBi2.A.6.9.2, the resistance-nodulation-cell division (rnd) superfamily

PTM databases

GlyGeniQ3TDN0, 5 sites
iPTMnetiQ3TDN0
PhosphoSitePlusiQ3TDN0

Proteomic databases

PaxDbiQ3TDN0
PRIDEiQ3TDN0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
34633, 140 antibodies

Genome annotation databases

EnsembliENSMUST00000003035; ENSMUSP00000003035; ENSMUSG00000030768 [Q3TDN0-1]
ENSMUST00000171366; ENSMUSP00000126742; ENSMUSG00000030768 [Q3TDN0-1]
ENSMUST00000195372; ENSMUSP00000141747; ENSMUSG00000030768 [Q3TDN0-1]
GeneIDi68897
KEGGimmu:68897
UCSCiuc008ick.2, mouse [Q3TDN0-1]
uc008ico.2, mouse [Q3TDN0-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84976
MGIiMGI:1916147, Disp1

Phylogenomic databases

eggNOGiKOG3664, Eukaryota
GeneTreeiENSGT00940000157407
HOGENOMiCLU_004076_1_0_1
InParanoidiQ3TDN0
OMAiYYHVLAR
OrthoDBi1156918at2759
PhylomeDBiQ3TDN0
TreeFamiTF324144

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
68897, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Disp1, mouse

Protein Ontology

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PROi
PR:Q3TDN0
RNActiQ3TDN0, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030768, Expressed in oocyte and 203 other tissues
GenevisibleiQ3TDN0, MM

Family and domain databases

InterProiView protein in InterPro
IPR003392, Ptc/Disp
IPR000731, SSD
PfamiView protein in Pfam
PF02460, Patched, 2 hits
PROSITEiView protein in PROSITE
PS50156, SSD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDISP1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3TDN0
Secondary accession number(s): Q3UUL8
, Q80ZZ8, Q8CGS3, Q8CIP6, Q8CIQ9, Q9CT62
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: August 12, 2020
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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