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Entry version 116 (16 Oct 2019)
Sequence version 2 (29 Apr 2008)
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Protein

Rho GTPase-activating protein 45

Gene

Arhgap45

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri699 – 744Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST46

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-194840 Rho GTPase cycle
R-MMU-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 45Imported
Alternative name(s):
Minor histocompatibility protein HA-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arhgap45Imported
Synonyms:Hmha1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1917969 Arhgap45

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003303141 – 1116Rho GTPase-activating protein 45Add BLAST1116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei23PhosphoserineCombined sources1
Modified residuei72PhosphoserineBy similarity1
Modified residuei92PhosphoserineBy similarity1
Modified residuei98PhosphoserineBy similarity1
Modified residuei568PhosphoserineCombined sources1
Modified residuei577PhosphoserineCombined sources1
Modified residuei591PhosphoserineCombined sources1
Modified residuei618PhosphoserineCombined sources1
Modified residuei946PhosphoserineBy similarity1
Modified residuei1017PhosphoserineCombined sources1
Modified residuei1020PhosphoserineCombined sources1
Modified residuei1022PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3TBD2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3TBD2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3TBD2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3TBD2

PeptideAtlas

More...
PeptideAtlasi
Q3TBD2

PRoteomics IDEntifications database

More...
PRIDEi
Q3TBD2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3TBD2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3TBD2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000035697 Expressed in 121 organ(s), highest expression level in thymus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3TBD2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3TBD2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
214219, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q3TBD2, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000097100

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3TBD2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini268 – 538F-BARPROSITE-ProRule annotationAdd BLAST271
Domaini758 – 971Rho-GAPPROSITE-ProRule annotationAdd BLAST214

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili375 – 498Sequence analysisAdd BLAST124

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Rho-GAP domain is able to regulate RhoGTPase activity, actin cytoskeleton and cell spreading. However N-terminally BAR domain plays an autoinhibitory role.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri699 – 744Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST46

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1453 Eukaryota
ENOG410YM3I LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183110

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3TBD2

KEGG Orthology (KO)

More...
KOi
K20644

Identification of Orthologs from Complete Genome Data

More...
OMAi
QYDFEPY

Database of Orthologous Groups

More...
OrthoDBi
1300981at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3TBD2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029 C1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
1.20.1270.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR002219 PE/DAG-bd
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00620 RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109 C1, 1 hit
SM00055 FCH, 1 hit
SM00324 RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103657 SSF103657, 1 hit
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51741 F_BAR, 1 hit
PS50238 RHOGAP, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3TBD2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFSRKKRELM KTPSISKKNR AGSPNPQSSS GELPRKDWTE APGLEPPATS
60 70 80 90 100
LSTVAKGTGT LKRPTSLSRH ASAAGFPLSG TATWTLVRGY RSPLSAASPA
110 120 130 140 150
ELPTEGAFPD GVEDISTLLA DVARFAEGLE KLKECVLQDD LLEARRPLAH
160 170 180 190 200
ECLGEALRVM RQVISRYPLL NTVETLTAAG TLIAKVKAFH YECNNESDKR
210 220 230 240 250
EFEKALETIA VSFSCTVSEF LLGEVDSSTL LAVPPGDPSQ SMENLYGAGT
260 270 280 290 300
EGPPHNVEEC EEGCLPPEEV DMLLQRCEGG VDAALQYAKD MARYMKDLIS
310 320 330 340 350
YLEKRTTLEM EFAKGLQKVV HNCRQSVTHE PHMPLLSIYS LALEQDLEFG
360 370 380 390 400
HGMVQAAGTL QTQTFMQPLT LRRLEHERRR KEIKESWHRA QRKLQEAEAN
410 420 430 440 450
LRKAKQGYKQ RCEDHDKARL QVAKAEEEQQ GTGPGAGTAA SKALDKRRRL
460 470 480 490 500
EEEAKNKAEE AMATYRTCVA DAKTQKQELE DTKVTALRQI QEVIRQSDQT
510 520 530 540 550
IKSATISYYQ LMHMQTAPLP VNFQMLCESS KLYDPGQQYA SHVRQLQRGE
560 570 580 590 600
EPDVRYDFEP YVSNNSWSPI MRTRKGSFNP GDASGPEAAG SPPEEGGTSE
610 620 630 640 650
AAPNKDHRGG RGHQVHKSWP ISISDTEVGL DTSSGDLKKF DRTSSSGTMS
660 670 680 690 700
SSEELGDQEA GLVASAFDSA DLNGMDPELP VAMPSGPFRH VGLSKAARTH
710 720 730 740 750
RLRKLRTPAK CRECNSYVYF QGAECEECCL ACHKKCLETL AIQCGHKKLQ
760 770 780 790 800
GRLQLFGQDF SQAALSTPDG VPFIVKKCVC EIERRALHTK GIYRVNGVKT
810 820 830 840 850
RVEKLCQAFE NGKELVELSQ ASPHDISNVL KLYLRQLPEP LISFRFYHEL
860 870 880 890 900
VGLAKDSLKA EAEAKAASRG RQGGSESEAA TLAMVGRLRE LMQDLPAENR
910 920 930 940 950
ATLLYLLKHL RRIVEMEQDN KMTPGNLGIV FGPTLLRPRP TDATVSLSSL
960 970 980 990 1000
VDYPHQARVI ETLIVHYGLV FEEEPEEAPG SQEGASTQCG QLESAEGIVF
1010 1020 1030 1040 1050
PLQEEAEDGS RESHAASNDS DSELEDASDP LSSSDASALH RLSFLEQTEA
1060 1070 1080 1090 1100
GLEEGPQSHS GSEEQLEGED GAPGPWLCHF NTNQSNNTSR APLPTMRLRG
1110
GQITGGTSQE RQPQFV
Length:1,116
Mass (Da):122,902
Last modified:April 29, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE3F52D0364F19E96
GO
Isoform 2 (identifier: Q3TBD2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     117-139: TLLADVARFAEGLEKLKECVLQD → MCVCGTLHPALDHDPLCCQTRAR

Show »
Length:1,000
Mass (Da):110,690
Checksum:i2E8F552F6F0D55E3
GO
Isoform 3 (identifier: Q3TBD2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-309: Missing.

Show »
Length:807
Mass (Da):89,341
Checksum:i21C2C7C28239509A
GO
Isoform 4 (identifier: Q3TBD2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-461: Missing.

Show »
Length:655
Mass (Da):71,921
Checksum:i19CB353B6752CCBC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z7R7D3Z7R7_MOUSE
Rho GTPase-activating protein 45
Arhgap45 Hmha1
1,127Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3X9Q3G3X9Q3_MOUSE
Histocompatibility (Minor) HA-1, is...
Arhgap45 Hmha1, mCG_13376
1,116Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti87V → G in BAE34889 (PubMed:16141072).Curated1
Sequence conflicti87V → G in BAE41670 (PubMed:16141072).Curated1
Sequence conflicti587E → K in BAE21986 (PubMed:16141072).Curated1
Sequence conflicti710K → E in BAE34889 (PubMed:16141072).Curated1
Sequence conflicti979P → H in BAB31085 (PubMed:16141072).Curated1
Sequence conflicti1047Q → R in BAE41670 (PubMed:16141072).Curated1
Sequence conflicti1047Q → R in BAE42381 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0330291 – 461Missing in isoform 4. 1 PublicationAdd BLAST461
Alternative sequenceiVSP_0330301 – 309Missing in isoform 3. 1 PublicationAdd BLAST309
Alternative sequenceiVSP_0330311 – 116Missing in isoform 2. 2 PublicationsAdd BLAST116
Alternative sequenceiVSP_033032117 – 139TLLAD…CVLQD → MCVCGTLHPALDHDPLCCQT RAR in isoform 2. 2 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK018130 mRNA Translation: BAB31085.1
AK044860 mRNA Translation: BAC32124.1
AK134029 mRNA Translation: BAE21986.1
AK159194 mRNA Translation: BAE34889.1
AK161766 mRNA Translation: BAE36565.1
AK170262 mRNA Translation: BAE41670.1
AK171304 mRNA Translation: BAE42381.1
BC053750 mRNA Translation: AAH53750.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24005.1 [Q3TBD2-2]
CCDS48624.1 [Q3TBD2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001136173.1, NM_001142701.1
NP_001334003.1, NM_001347074.1
NP_081797.1, NM_027521.3 [Q3TBD2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000043311; ENSMUSP00000041019; ENSMUSG00000035697 [Q3TBD2-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
70719

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:70719

UCSC genome browser

More...
UCSCi
uc007gbe.2 mouse [Q3TBD2-1]
uc007gbg.2 mouse [Q3TBD2-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018130 mRNA Translation: BAB31085.1
AK044860 mRNA Translation: BAC32124.1
AK134029 mRNA Translation: BAE21986.1
AK159194 mRNA Translation: BAE34889.1
AK161766 mRNA Translation: BAE36565.1
AK170262 mRNA Translation: BAE41670.1
AK171304 mRNA Translation: BAE42381.1
BC053750 mRNA Translation: AAH53750.1
CCDSiCCDS24005.1 [Q3TBD2-2]
CCDS48624.1 [Q3TBD2-1]
RefSeqiNP_001136173.1, NM_001142701.1
NP_001334003.1, NM_001347074.1
NP_081797.1, NM_027521.3 [Q3TBD2-2]

3D structure databases

SMRiQ3TBD2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi214219, 2 interactors
IntActiQ3TBD2, 3 interactors
STRINGi10090.ENSMUSP00000097100

PTM databases

iPTMnetiQ3TBD2
PhosphoSitePlusiQ3TBD2

Proteomic databases

EPDiQ3TBD2
jPOSTiQ3TBD2
MaxQBiQ3TBD2
PaxDbiQ3TBD2
PeptideAtlasiQ3TBD2
PRIDEiQ3TBD2

Genome annotation databases

EnsembliENSMUST00000043311; ENSMUSP00000041019; ENSMUSG00000035697 [Q3TBD2-2]
GeneIDi70719
KEGGimmu:70719
UCSCiuc007gbe.2 mouse [Q3TBD2-1]
uc007gbg.2 mouse [Q3TBD2-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23526
MGIiMGI:1917969 Arhgap45

Phylogenomic databases

eggNOGiKOG1453 Eukaryota
ENOG410YM3I LUCA
GeneTreeiENSGT00950000183110
InParanoidiQ3TBD2
KOiK20644
OMAiQYDFEPY
OrthoDBi1300981at2759
PhylomeDBiQ3TBD2

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Arhgap45 mouse

Protein Ontology

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PROi
PR:Q3TBD2

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000035697 Expressed in 121 organ(s), highest expression level in thymus
ExpressionAtlasiQ3TBD2 baseline and differential
GenevisibleiQ3TBD2 MM

Family and domain databases

CDDicd00029 C1, 1 hit
Gene3Di1.10.555.10, 1 hit
1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR002219 PE/DAG-bd
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00055 FCH, 1 hit
SM00324 RhoGAP, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50238 RHOGAP, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMHA1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3TBD2
Secondary accession number(s): Q3TDD2
, Q3TSW0, Q3TXM6, Q3UZ72, Q8BI83, Q9CU46
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: October 16, 2019
This is version 116 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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