UniProtKB - Q3TB92 (MILR1_MOUSE)
Protein
Allergin-1
Gene
Milr1
Organism
Mus musculus (Mouse)
Status
Functioni
Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction.1 Publication
GO - Molecular functioni
- transmembrane signaling receptor activity Source: GO_Central
GO - Biological processi
- cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
- cell surface receptor signaling pathway Source: GO_Central
- mast cell degranulation Source: UniProtKB
- negative regulation of mast cell activation Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Allergin-1Alternative name(s): Allergy inhibitory receptor 1 Mast cell antigen 32 Short name: MCA-32 Short name: Mast cell Ag-32 Mast cell immunoglobulin-like receptor 1 |
Gene namesi | Name:Milr1 Synonyms:Gm885, Mca32 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2685731, Milr1 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 34 – 150 | ExtracellularSequence analysisAdd BLAST | 117 | |
Transmembranei | 151 – 171 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 172 – 246 | CytoplasmicSequence analysisAdd BLAST | 75 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Disruption phenotypei
Enhanced IgE-mediated, mast cell-dependent passive systemic anaphylaxis. No effect on differentiation of hematopoietic cells, including mast cells.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 216 | Y → F: Abolishes interaction with PTPN6 and PTPN11. Loss of function; when associated with F-241. 1 Publication | 1 | |
Mutagenesisi | 241 | Y → F: Abolishes interaction with PTPN6 and PTPN11. Loss of function; when associated with F-216. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | Sequence analysisAdd BLAST | 33 | |
ChainiPRO_0000307365 | 34 – 246 | Allergin-1Add BLAST | 213 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 68 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 73 ↔ 120 | PROSITE-ProRule annotation | ||
Modified residuei | 216 | PhosphotyrosineCombined sources1 Publication | 1 | |
Modified residuei | 241 | PhosphotyrosineCombined sources1 Publication | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | Q3TB92 |
PaxDbi | Q3TB92 |
PeptideAtlasi | Q3TB92 |
PRIDEi | Q3TB92 |
ProteomicsDBi | 290081 [Q3TB92-1] 290082 [Q3TB92-2] |
PTM databases
GlyGeni | Q3TB92, 1 site |
iPTMneti | Q3TB92 |
PhosphoSitePlusi | Q3TB92 |
Expressioni
Tissue specificityi
Expressed in myeloid cells (dendritic cells, macrophages and neutrophils but not in T-cells, B-cells or natural killer cells) and mast cells (at protein level).1 Publication
Gene expression databases
Bgeei | ENSMUSG00000040528, Expressed in granulocyte and 112 other tissues |
ExpressionAtlasi | Q3TB92, baseline and differential |
Genevisiblei | Q3TB92, MM |
Interactioni
Subunit structurei
Monomer (Probable).
Interacts (tyrosine-phosphorylated) with PTPN6, PTPN11 and INPP5D.
Curated1 PublicationProtein-protein interaction databases
DIPi | DIP-62112N |
STRINGi | 10090.ENSMUSP00000083538 |
Miscellaneous databases
RNActi | Q3TB92, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 52 – 131 | Ig-like C2-typeAdd BLAST | 80 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 214 – 219 | ITIM motif | 6 | |
Motifi | 239 – 244 | ITIM motif | 6 |
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S5BW, Eukaryota |
GeneTreei | ENSGT01020000230339 |
InParanoidi | Q3TB92 |
OMAi | CENQAGK |
OrthoDBi | 1405395at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR029626, Allergin-1 IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub |
PANTHERi | PTHR11481:SF58, PTHR11481:SF58, 2 hits |
Pfami | View protein in Pfam PF13895, Ig_2, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q3TB92-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGDGDSPMCL SAVSFKGIRC WLDKLLLWAL TISITLQNAA VDCTRVENNE
60 70 80 90 100
LPSPNLNSSM NVVRMGQNVS LSCSTKNTSV DITYSLFWGT KYLESKRRRG
110 120 130 140 150
GAVDFHLRIS NANESGPYKC KVNVSNLMKY SQDFNFTMAK DESCPSCRLS
160 170 180 190 200
LLLPGLLLGI LVIVLVLAYL IHLKYKKGKK TQREDQSKGS GDAPAQDELY
210 220 230 240
VNACKTQTEQ PQEIHYATPV FKEMAPMEEE GGTDGKADYI YSELTH
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A140T8Q6 | A0A140T8Q6_MOUSE | Allergin-1 | Milr1 | 245 | Annotation score: | ||
B7ZP19 | B7ZP19_MOUSE | Allergin-1 | Milr1 Gm885 | 246 | Annotation score: | ||
S4R1V2 | S4R1V2_MOUSE | Allergin-1 | Milr1 | 143 | Annotation score: | ||
A0A0B4J1N6 | A0A0B4J1N6_MOUSE | Allergin-1 | Milr1 | 178 | Annotation score: |
Sequence cautioni
The sequence BAE32051 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | V → F in BAE32051 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 104 | D → E in BAE30712 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 140 – 141 | KD → N in BAE42422 (PubMed:16141072).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028742 | 140 – 178 | KDESC…KYKKG → R in isoform 2. 2 PublicationsAdd BLAST | 39 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB542953 mRNA Translation: BAJ08254.1 AK136488 mRNA Translation: BAE23003.1 AK151814 mRNA Translation: BAE30712.1 AK153506 mRNA Translation: BAE32051.1 Different initiation. AK169925 mRNA Translation: BAE41463.1 AK170947 mRNA Translation: BAE42134.1 AK171381 mRNA Translation: BAE42422.1 BC139224 mRNA Translation: AAI39225.1 BC139225 mRNA Translation: AAI39226.1 BC145580 mRNA Translation: AAI45581.1 |
CCDSi | CCDS25560.1 [Q3TB92-1] CCDS70335.1 [Q3TB92-2] |
RefSeqi | NP_001028607.1, NM_001033435.3 [Q3TB92-1] NP_001258301.1, NM_001271372.1 NP_001258302.1, NM_001271373.1 NP_001258303.1, NM_001271374.1 [Q3TB92-2] NP_001258304.1, NM_001271375.1 [Q3TB92-2] XP_006533711.1, XM_006533648.3 [Q3TB92-1] XP_006533712.1, XM_006533649.3 [Q3TB92-2] XP_011247406.1, XM_011249104.2 [Q3TB92-1] |
Genome annotation databases
Ensembli | ENSMUST00000086353; ENSMUSP00000083538; ENSMUSG00000040528 [Q3TB92-1] ENSMUST00000147326; ENSMUSP00000138742; ENSMUSG00000040528 [Q3TB92-1] ENSMUST00000182908; ENSMUSP00000138678; ENSMUSG00000040528 [Q3TB92-2] ENSMUST00000183111; ENSMUSP00000138513; ENSMUSG00000040528 [Q3TB92-2] |
GeneIDi | 380732 |
KEGGi | mmu:380732 |
UCSCi | uc007lzj.2, mouse [Q3TB92-1] uc007lzl.2, mouse [Q3TB92-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB542953 mRNA Translation: BAJ08254.1 AK136488 mRNA Translation: BAE23003.1 AK151814 mRNA Translation: BAE30712.1 AK153506 mRNA Translation: BAE32051.1 Different initiation. AK169925 mRNA Translation: BAE41463.1 AK170947 mRNA Translation: BAE42134.1 AK171381 mRNA Translation: BAE42422.1 BC139224 mRNA Translation: AAI39225.1 BC139225 mRNA Translation: AAI39226.1 BC145580 mRNA Translation: AAI45581.1 |
CCDSi | CCDS25560.1 [Q3TB92-1] CCDS70335.1 [Q3TB92-2] |
RefSeqi | NP_001028607.1, NM_001033435.3 [Q3TB92-1] NP_001258301.1, NM_001271372.1 NP_001258302.1, NM_001271373.1 NP_001258303.1, NM_001271374.1 [Q3TB92-2] NP_001258304.1, NM_001271375.1 [Q3TB92-2] XP_006533711.1, XM_006533648.3 [Q3TB92-1] XP_006533712.1, XM_006533649.3 [Q3TB92-2] XP_011247406.1, XM_011249104.2 [Q3TB92-1] |
3D structure databases
SMRi | Q3TB92 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-62112N |
STRINGi | 10090.ENSMUSP00000083538 |
PTM databases
GlyGeni | Q3TB92, 1 site |
iPTMneti | Q3TB92 |
PhosphoSitePlusi | Q3TB92 |
Proteomic databases
MaxQBi | Q3TB92 |
PaxDbi | Q3TB92 |
PeptideAtlasi | Q3TB92 |
PRIDEi | Q3TB92 |
ProteomicsDBi | 290081 [Q3TB92-1] 290082 [Q3TB92-2] |
Protocols and materials databases
Antibodypediai | 68852, 106 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000086353; ENSMUSP00000083538; ENSMUSG00000040528 [Q3TB92-1] ENSMUST00000147326; ENSMUSP00000138742; ENSMUSG00000040528 [Q3TB92-1] ENSMUST00000182908; ENSMUSP00000138678; ENSMUSG00000040528 [Q3TB92-2] ENSMUST00000183111; ENSMUSP00000138513; ENSMUSG00000040528 [Q3TB92-2] |
GeneIDi | 380732 |
KEGGi | mmu:380732 |
UCSCi | uc007lzj.2, mouse [Q3TB92-1] uc007lzl.2, mouse [Q3TB92-2] |
Organism-specific databases
CTDi | 284021 |
MGIi | MGI:2685731, Milr1 |
Phylogenomic databases
eggNOGi | ENOG502S5BW, Eukaryota |
GeneTreei | ENSGT01020000230339 |
InParanoidi | Q3TB92 |
OMAi | CENQAGK |
OrthoDBi | 1405395at2759 |
Miscellaneous databases
BioGRID-ORCSi | 380732, 0 hits in 52 CRISPR screens |
PROi | PR:Q3TB92 |
RNActi | Q3TB92, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000040528, Expressed in granulocyte and 112 other tissues |
ExpressionAtlasi | Q3TB92, baseline and differential |
Genevisiblei | Q3TB92, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR029626, Allergin-1 IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub |
PANTHERi | PTHR11481:SF58, PTHR11481:SF58, 2 hits |
Pfami | View protein in Pfam PF13895, Ig_2, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MILR1_MOUSE | |
Accessioni | Q3TB92Primary (citable) accession number: Q3TB92 Secondary accession number(s): B2RTB7 Q3U9F5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | October 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot