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UniProtKB - Q3TA88 (Q3TA88_MOUSE)

Entry version 119 (07 Apr 2021)
Sequence version 1 (11 Oct 2005)
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Protein
Submitted name:

Uncharacterized protein

Gene

Sh3kbp1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sh3kbp1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1889583, Sh3kbp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmARBA annotation, MembraneARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation, Ubl conjugationARBA annotation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q3TA88

PeptideAtlas

More...PeptideAtlasi		Q3TA88

PRoteomics IDEntifications database

More...PRIDEi		Q3TA88

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000040990, Expressed in cardiac ventricle and 286 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q3TA88, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q3TA88, MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q3TA88

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 58SH3InterPro annotationAdd BLAST58
Domaini98 – 157SH3InterPro annotationAdd BLAST60
Domaini267 – 328SH3InterPro annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni159 – 203DisorderedSequence analysisAdd BLAST45
Regioni245 – 265DisorderedSequence analysisAdd BLAST21
Regioni328 – 441DisorderedSequence analysisAdd BLAST114
Regioni467 – 606DisorderedSequence analysisAdd BLAST140

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili609 – 654Sequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi162 – 200PolarSequence analysisAdd BLAST39
Compositional biasi353 – 390PolyampholyteSequence analysisAdd BLAST38
Compositional biasi470 – 507PolarSequence analysisAdd BLAST38
Compositional biasi509 – 531PolyampholyteSequence analysisAdd BLAST23
Compositional biasi532 – 550PolarSequence analysisAdd BLAST19
Compositional biasi560 – 593PolarSequence analysisAdd BLAST34

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_024255_1_0_1

Family and domain databases

Conserved Domains Database

More...CDDi		cd12052, SH3_CIN85_1, 1 hit
cd12055, SH3_CIN85_2, 1 hit
cd12057, SH3_CIN85_3, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035770, CIN85_SH3_1
IPR035771, CIN85_SH3_2
IPR035772, CIN85_SH3_3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR028506, Sorbin_SH3

The PANTHER Classification System

More...PANTHERi		PTHR14167:SF6, PTHR14167:SF6, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14604, SH3_9, 3 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00326, SH3, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50044, SSF50044, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50002, SH3, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3TA88-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVEAIVEFDY QAQHDDELTI SVGEVITNIR KEDGGWWEGQ INGRRGLFPD 
        60         70         80         90        100
NFVREIKKDM KKDLLSNKAP EKPMHDVSSG NALLSSETIL RTNKRGERRR 
       110        120        130        140        150
RRCQVAFSYL PQNDDELELK VGDIIEVVGE VEEGWWEGVL NGKTGMFPSN 
       160        170        180        190        200
FIKELSGESD ELGISQDEQL SKSSLRETTG SESDGGDSSS TKSEGANGTM 
       210        220        230        240        250
ATAAIQPKKV KGVGFGDIFK DKPIKLRPRS IEVENDFLPV EKTIGKKLPP 
       260        270        280        290        300
ATSTPDPSKT EMDSRTKTKD YCKVIFPYEA QNDDELTIKE GDIVTLINKD 
       310        320        330        340        350
CIDVGWWEGE LNGRRGVFPD NFVKLLPSDF DKEGNRPKKP PPPSAPVVKQ 
       360        370        380        390        400
GAGTTERKHE IKKIPPERPE TLPNRTEEKE RPEREPKLDL QKPSVPAIPP 
       410        420        430        440        450
KKPRPPKTNS LNRPGALPPR RPERPVGPLT HTRGDSPKID LAGSALSGIL 
       460        470        480        490        500
DKDLSDRSND IDLEGFDSVI SSTEKLSHPT TSRPKATGRR PPSQSLTSSS 
       510        520        530        540        550
LSSPDIFDSP SPEEDKEEHI SLAHRGIDVS KKTSKTVTIS QVSDNKTSLP 
       560        570        580        590        600
PKPGTMAAAS SGPASLSSVA SSPMSSSLGT AGQRASSPSL FSTEGKPKME 
       610        620        630        640        650
PAVSSQAAIE ELKMQVRELR TIIETMKDQQ KREIKQLLSE LDEEKKIRLR 
       660 
LQMEVNDIKK ALQSK
Length:665
Mass (Da):73,328
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i724607807A66B043
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK172022 mRNA Translation: BAE42781.1

NCBI Reference Sequences

More...RefSeqi		NP_001129199.1, NM_001135727.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		58194

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:58194

UCSC genome browser

More...UCSCi		uc009ust.3, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172022 mRNA Translation: BAE42781.1
RefSeqiNP_001129199.1, NM_001135727.2

3D structure databases

SMRiQ3TA88
ModBaseiSearch...

Proteomic databases

EPDiQ3TA88
PeptideAtlasiQ3TA88
PRIDEiQ3TA88

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		521, 208 antibodies

The DNASU plasmid repository

More...DNASUi		58194

Genome annotation databases

GeneIDi58194
KEGGimmu:58194
UCSCiuc009ust.3, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		30011
MGIiMGI:1889583, Sh3kbp1

Phylogenomic databases

HOGENOMiCLU_024255_1_0_1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		58194, 1 hit in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Sh3kbp1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000040990, Expressed in cardiac ventricle and 286 other tissues
ExpressionAtlasiQ3TA88, baseline and differential
GenevisibleiQ3TA88, MM

Family and domain databases

CDDicd12052, SH3_CIN85_1, 1 hit
cd12055, SH3_CIN85_2, 1 hit
cd12057, SH3_CIN85_3, 1 hit
InterProiView protein in InterPro
IPR035770, CIN85_SH3_1
IPR035771, CIN85_SH3_2
IPR035772, CIN85_SH3_3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR028506, Sorbin_SH3
PANTHERiPTHR14167:SF6, PTHR14167:SF6, 2 hits
PfamiView protein in Pfam
PF14604, SH3_9, 3 hits
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00326, SH3, 3 hits
SUPFAMiSSF50044, SSF50044, 3 hits
PROSITEiView protein in PROSITE
PS50002, SH3, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3TA88_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3TA88
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 7, 2021
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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