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UniProtKB - Q3T9Z9 (ZUP1_MOUSE)

Entry version 114 (10 Feb 2021)
Sequence version 2 (27 Jun 2006)
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Protein

Zinc finger-containing ubiquitin peptidase 1

Gene

Zup1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).By similarity EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei359NucleophileBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei486Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion holeBy similarity1
Active sitei490Proton acceptorBy similarity1
Active sitei511By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri2 – 24C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri29 – 52C2H2-type 2; atypicalBy similarityAdd BLAST24
Zinc fingeri153 – 176C2H2-type 3; atypicalBy similarityAdd BLAST24
Zinc fingeri192 – 214C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger-containing ubiquitin peptidase 1Curated (EC:3.4.19.12By similarity)
Alternative name(s):
Lys-63-specific deubiquitinase ZUFSP
Short name:
DUB
Zinc finger with UFM1-specific peptidase domain protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zup1Imported
Synonyms:Zufsp
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1919830, Zup1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002443381 – 577Zinc finger-containing ubiquitin peptidase 1Add BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei261N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q3T9Z9

PeptideAtlas

More...PeptideAtlasi		Q3T9Z9

PRoteomics IDEntifications database

More...PRIDEi		Q3T9Z9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q3T9Z9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q3T9Z9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000039531, Expressed in oocyte and 278 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q3T9Z9, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RPA1 and RPA2.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		215450, 3 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000037121

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q3T9Z9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q3T9Z9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni225 – 247MIUBy similarityAdd BLAST23
Regioni248 – 273zUBD/ZHABy similarityAdd BLAST26

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The motif interacting with ubiquitin (MIU) and ZUFSP ubiquitin-binding domain (zUBD, also called ZUFSP helical arm ZHA) are responsible for binding the distal (outgoing) ubiquitin units S1 and S2 respectively.By similarity
C2H2-type zinc finger 4 is a ubiquitin-binding zinc finger (UBZ) and required for polyubiquitin binding, possibly binding the proximal ubiqutin, and for catalytic activity. C2H2-type zinc fingers 1-3 are required for localization to sites of DNA damage.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C78 family. ZUFSP subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2 – 24C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri29 – 52C2H2-type 2; atypicalBy similarityAdd BLAST24
Zinc fingeri153 – 176C2H2-type 3; atypicalBy similarityAdd BLAST24
Zinc fingeri192 – 214C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4696, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008232

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_017060_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q3T9Z9

Identification of Orthologs from Complete Genome Data

More...OMAi		EYHKRKA

Database of Orthologous Groups

More...OrthoDBi		788957at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q3T9Z9

TreeFam database of animal gene trees

More...TreeFami		TF323699

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012462, Peptidase_C78_UfSP1/2
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07910, Peptidase_C78, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3T9Z9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSCNICGET VNSEPDMKAH LIVHMENEII CPFCKLSGIN YNEICFHIET 
        60         70         80         90        100
VHFEQNAPEK NSEKLAAVQY GHSDRKNTNL QSTAEVTSGI HSACASSFPK 
       110        120        130        140        150
ESSESLPKDR TVKHEAFYTE NITESRKYQK SREKKPGLSE AQGSIYETTY 
       160        170        180        190        200
SPPECPFCGK IEGCSQDMEI HVKTKHASLL ESPLKDCHQP LYDCPMCGLV 
       210        220        230        240        250
CTNYHILQEH VDLHLEESSF QQGMDRVQCS SDRELAHRLQ QEEDRKRKSE 
       260        270        280        290        300
ESRQEREEFQ KLQRQYGLDN SGGYKQQQLR HMELEVNRGR MHPSEFHSRK 
       310        320        330        340        350
ADMLESIAIG IDDGKTKTSG IIEALHRYYQ NTATDVRCVW LSTVVDHFHS 
       360        370        380        390        400
SFGDKGWGCG YRNFQMLLSS LLQSDVYGDC LKGMAVPCIP KIQSMIEDAW 
       410        420        430        440        450
NEGFDPQGAS QLNNKLQGTK AWIGACEIYT LLTSLRVKCR IIDFHKSTGP 
       460        470        480        490        500
LGTHPRLFEW ILNYYSSETE GTPKIVCTSK PPIYLQHQGH SRTVVGIEEK 
       510        520        530        540        550
KNRTLCLLVF DPGCPSREMQ KLLKQDMEAS SLRQLRKSVG NLKHKQYQIV 
       560        570 
AVEGVLSPEE KVARKQASQV FTAEKIP
Length:577
Mass (Da):65,593
Last modified:June 27, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i711B6DE1629DFD01
GO
Isoform 2 (identifier: Q3T9Z9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     563-577: ARKQASQVFTAEKIP → VSIG

Show »
Length:566
Mass (Da):64,294
Checksum:i434BE6D94791CD0A
GO
Isoform 3 (identifier: Q3T9Z9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     529-562: Missing.

Show »
Length:543
Mass (Da):61,819
Checksum:i8C74D689D1E4DDD5
GO
Isoform 4 (identifier: Q3T9Z9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     264-279: RQYGLDNSGGYKQQQL → ELLKPSIGIIRTLPQM
     280-577: Missing.

Show »
Length:279
Mass (Da):31,895
Checksum:iAFA1E1DD4A76603E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P7K8A0A1W2P7K8_MOUSE
Lys-63-specific deubiquitinase ZUFS...
Zup1
551Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P6E9A0A1W2P6E9_MOUSE
Zinc finger-containing ubiquitin pe...
Zup1
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P714A0A1W2P714_MOUSE
Zinc finger-containing ubiquitin pe...
Zup1
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2P761A0A1W2P761_MOUSE
Zinc finger-containing ubiquitin pe...
Zup1
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC36984 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5N → D in BAE42871 (PubMed:16141072).Curated1
Sequence conflicti50T → A in AAH89514 (PubMed:15489334).Curated1
Sequence conflicti182S → I in BAC36739 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_019534264 – 279RQYGL…KQQQL → ELLKPSIGIIRTLPQM in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_019535280 – 577Missing in isoform 4. 1 PublicationAdd BLAST298
Alternative sequenceiVSP_019536529 – 562Missing in isoform 3. 1 PublicationAdd BLAST34
Alternative sequenceiVSP_019537563 – 577ARKQA…AEKIP → VSIG in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK012263 mRNA Translation: BAB28126.1
AK046191 mRNA Translation: BAC32628.1
AK052071 mRNA Translation: BAC34846.1
AK077304 mRNA Translation: BAC36739.1
AK077730 mRNA Translation: BAC36984.1 Frameshift.
AK172184 mRNA Translation: BAE42871.1
BC067065 mRNA Translation: AAH67065.1
BC089514 mRNA Translation: AAH89514.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS23772.1 [Q3T9Z9-2]
CCDS87987.1 [Q3T9Z9-1]

NCBI Reference Sequences

More...RefSeqi		NP_082563.1, NM_028287.2 [Q3T9Z9-2]
XP_006512930.1, XM_006512867.3
XP_006512931.1, XM_006512868.3 [Q3T9Z9-1]
XP_006512932.1, XM_006512869.3 [Q3T9Z9-1]
XP_006512933.1, XM_006512870.3 [Q3T9Z9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000048222; ENSMUSP00000037121; ENSMUSG00000039531 [Q3T9Z9-2]
ENSMUST00000218055; ENSMUSP00000151811; ENSMUSG00000039531 [Q3T9Z9-1]
ENSMUST00000218275; ENSMUSP00000151484; ENSMUSG00000039531 [Q3T9Z9-4]
ENSMUST00000219457; ENSMUSP00000151455; ENSMUSG00000039531 [Q3T9Z9-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		72580

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:72580

UCSC genome browser

More...UCSCi		uc007euj.1, mouse [Q3T9Z9-3]
uc007euk.1, mouse [Q3T9Z9-1]
uc007eum.1, mouse [Q3T9Z9-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012263 mRNA Translation: BAB28126.1
AK046191 mRNA Translation: BAC32628.1
AK052071 mRNA Translation: BAC34846.1
AK077304 mRNA Translation: BAC36739.1
AK077730 mRNA Translation: BAC36984.1 Frameshift.
AK172184 mRNA Translation: BAE42871.1
BC067065 mRNA Translation: AAH67065.1
BC089514 mRNA Translation: AAH89514.1
CCDSiCCDS23772.1 [Q3T9Z9-2]
CCDS87987.1 [Q3T9Z9-1]
RefSeqiNP_082563.1, NM_028287.2 [Q3T9Z9-2]
XP_006512930.1, XM_006512867.3
XP_006512931.1, XM_006512868.3 [Q3T9Z9-1]
XP_006512932.1, XM_006512869.3 [Q3T9Z9-1]
XP_006512933.1, XM_006512870.3 [Q3T9Z9-1]

3D structure databases

SMRiQ3T9Z9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi215450, 3 interactors
STRINGi10090.ENSMUSP00000037121

PTM databases

iPTMnetiQ3T9Z9
PhosphoSitePlusiQ3T9Z9

Proteomic databases

PaxDbiQ3T9Z9
PeptideAtlasiQ3T9Z9
PRIDEiQ3T9Z9

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32518, 109 antibodies

Genome annotation databases

EnsembliENSMUST00000048222; ENSMUSP00000037121; ENSMUSG00000039531 [Q3T9Z9-2]
ENSMUST00000218055; ENSMUSP00000151811; ENSMUSG00000039531 [Q3T9Z9-1]
ENSMUST00000218275; ENSMUSP00000151484; ENSMUSG00000039531 [Q3T9Z9-4]
ENSMUST00000219457; ENSMUSP00000151455; ENSMUSG00000039531 [Q3T9Z9-4]
GeneIDi72580
KEGGimmu:72580
UCSCiuc007euj.1, mouse [Q3T9Z9-3]
uc007euk.1, mouse [Q3T9Z9-1]
uc007eum.1, mouse [Q3T9Z9-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		221302
MGIiMGI:1919830, Zup1

Phylogenomic databases

eggNOGiKOG4696, Eukaryota
GeneTreeiENSGT00390000008232
HOGENOMiCLU_017060_1_1_1
InParanoidiQ3T9Z9
OMAiEYHKRKA
OrthoDBi788957at2759
PhylomeDBiQ3T9Z9
TreeFamiTF323699

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		72580, 0 hits in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Zufsp, mouse

Protein Ontology

More...PROi		PR:Q3T9Z9
RNActiQ3T9Z9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000039531, Expressed in oocyte and 278 other tissues
GenevisibleiQ3T9Z9, MM

Family and domain databases

InterProiView protein in InterPro
IPR012462, Peptidase_C78_UfSP1/2
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF07910, Peptidase_C78, 1 hit
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 4 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 2 hits
PS50157, ZINC_FINGER_C2H2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZUP1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3T9Z9
Secondary accession number(s): Q5FWB1
, Q6NXI1, Q8BJZ1, Q8BK40, Q8BKH3, Q8BL75, Q9CSP5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: February 10, 2021
This is version 114 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Peptidase families
    Classification of peptidase families and list of entries
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