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Entry version 130 (10 Apr 2019)
Sequence version 1 (11 Oct 2005)
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Protein

GON-4-like protein

Gene

GON4L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GON-4-like protein
Alternative name(s):
GON-4 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GON4L
Synonyms:GON4, KIAA1606
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000116580.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25973 GON4L

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610393 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3T8J9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54856

Open Targets

More...
OpenTargetsi
ENSG00000116580

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671723

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GON4L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
84029264

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001971091 – 2241GON-4-like proteinAdd BLAST2241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei206PhosphoserineCombined sources1
Modified residuei346PhosphoserineCombined sources1
Modified residuei775PhosphoserineBy similarity1
Modified residuei1268PhosphoserineCombined sources1
Modified residuei1426PhosphoserineCombined sources1
Modified residuei1896PhosphoserineCombined sources1
Modified residuei1902PhosphoserineCombined sources1
Modified residuei1977PhosphoserineCombined sources1
Modified residuei2107PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3T8J9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3T8J9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3T8J9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3T8J9

PeptideAtlas

More...
PeptideAtlasi
Q3T8J9

PRoteomics IDEntifications database

More...
PRIDEi
Q3T8J9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61875
61876 [Q3T8J9-2]
61877 [Q3T8J9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3T8J9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3T8J9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116580 Expressed in 202 organ(s), highest expression level in small intestine Peyer's patch

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q3T8J9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3T8J9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006986
HPA057305
HPA074504

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a complex with YY1, SIN3A and HDAC1.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120206, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q3T8J9, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357315

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q3T8J9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3T8J9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1624 – 1696PAH 1PROSITE-ProRule annotationAdd BLAST73
Domaini1706 – 1777PAH 2PROSITE-ProRule annotationAdd BLAST72
Domaini2148 – 2201Myb-likePROSITE-ProRule annotationAdd BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni600 – 1339Required for interaction with YY1, SIN3A AND HDAC1, and transcriptional repression activityBy similarityAdd BLAST740

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi245 – 248Poly-Lys4
Compositional biasi448 – 454Poly-Pro7
Compositional biasi517 – 576Asp-richAdd BLAST60
Compositional biasi1449 – 1569Glu-richAdd BLAST121

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHDM Eukaryota
ENOG410XS4M LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016256

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081563

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3T8J9

Identification of Orthologs from Complete Genome Data

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OMAi
QESWLPS

Database of Orthologous Groups

More...
OrthoDBi
49443at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3T8J9

TreeFam database of animal gene trees

More...
TreeFami
TF343327

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033277 GON-4-like
IPR009057 Homeobox-like_sf
IPR017877 Myb-like_dom
IPR003822 PAH
IPR036600 PAH_sf

The PANTHER Classification System

More...
PANTHERi
PTHR16088:SF11 PTHR16088:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02671 PAH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit
SSF47762 SSF47762, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50090 MYB_LIKE, 1 hit
PS51477 PAH, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3T8J9-1) [UniParc]FASTAAdd to basket
Also known as: Isoform A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPCKKRRTT VTESLQHKGN QEENNVDLES AVKPESDQVK DLSSVSLSWD
60 70 80 90 100
PSHGRVAGFE VQSLQDAGNQ LGMEDTSLSS GMLTQNTNVP ILEGVDVAIS
110 120 130 140 150
QGITLPSLES FHPLNIHIGK GKLHATGSKR GKKMTLRPGP VTQEDRCDHL
160 170 180 190 200
TLKEPFSGEP SEEVKEEGGK PQMNSEGEIP SLPSGSQSAK PVSQPRKSTQ
210 220 230 240 250
PDVCASPQEK PLRTLFHQPE EEIEDGGLFI PMEEQDNEES EKRRKKKKGT
260 270 280 290 300
KRKRDGRGQE GTLAYDLKLD DMLDRTLEDG AKQHNLTAVN VRNILHEVIT
310 320 330 340 350
NEHVVAMMKA AISETEDMPM FEPKMTRSKL KEVVEKGVVI PTWNISPIKK
360 370 380 390 400
ANEIKPPQFV DIHLEEDDSS DEEYQPDDEE EDETAEESLL ESDVESTASS
410 420 430 440 450
PRGAKKSRLR QSSEMTETDE ESGILSEAEK VTTPAIRHIS AEVVPMGPPP
460 470 480 490 500
PPKPKQTRDS TFMEKLHAVD EELASSPVCM DSFQPMDDSL IAFRTRSKMP
510 520 530 540 550
LKDVPLGQLE AELQAPDITP DMYDPNTADD EDWKMWLGGL MNDDVGNEDE
560 570 580 590 600
ADDDDDPEYN FLEDLDEPDT EDFRTDRAVR ITKKEVNELM EELFETFQDE
610 620 630 640 650
MGFSNMEDDG PEEEECVAEP RPNFNTPQAL RFEEPLANLL NEQHRTVKEL
660 670 680 690 700
FEQLKMKKSS AKQLQEVEKV KPQSEKVHQT LILDPAQRKR LQQQMQQHVQ
710 720 730 740 750
LLTQIHLLAT CNPNLNPEAT TTRIFLKELG TFAQSSIALH HQYNPKFQTL
760 770 780 790 800
FQPCNLMGAM QLIEDFSTHV SIDCSPHKTV KKTANEFPCL PKQVAWILAT
810 820 830 840 850
SKVFMYPELL PVCSLKAKNP QDKIVFTKAE DNLLALGLKH FEGTEFPNPL
860 870 880 890 900
ISKYLLTCKT AHQLTVRIKN LNMNRAPDNI IKFYKKTKQL PVLGKCCEEI
910 920 930 940 950
QPHQWKPPIE REEHRLPFWL KASLPSIQEE LRHMADGARE VGNMTGTTEI
960 970 980 990 1000
NSDRSLEKDN LELGSESRYP LLLPKGVVLK LKPVATRFPR KAWRQKRSSV
1010 1020 1030 1040 1050
LKPLLIQPSP SLQPSFNPGK TPARSTHSEA PPSKMVLRIP HPIQPATVLQ
1060 1070 1080 1090 1100
TVPGVPPLGV SGGESFESPA ALPAVPPEAR TSFPLSESQT LLSSAPVPKV
1110 1120 1130 1140 1150
MLPSLAPSKF RKPYVRRRPS KRRGVKASPC MKPAPVIHHP ASVIFTVPAT
1160 1170 1180 1190 1200
TVKIVSLGGG CNMIQPVNAA VAQSPQTIPI TTLLVNPTSF PCPLNQSLVA
1210 1220 1230 1240 1250
SSVSPLIVSG NSVNLPIPST PEDKAHVNVD IACAVADGEN AFQGLEPKLE
1260 1270 1280 1290 1300
PQELSPLSAT VFPKVEHSPG PPLADAECQE GLSENSACRW TVVKTEEGRQ
1310 1320 1330 1340 1350
ALEPLPQGIQ ESLNNPTPGD LEEIVKMEPE EAREEISGSP ERDICDDIKV
1360 1370 1380 1390 1400
EHAVELDTGA PSEELSSAGE VTKQTVLQKE EERSQPTKTP SSSQEPPDEG
1410 1420 1430 1440 1450
TSGTDVNKGS SKNALSSMDP EVRLSSPPGK PEDSSSVDGQ SVGTPVGPET
1460 1470 1480 1490 1500
GGEKNGPEEE EEEDFDDLTQ DEEDEMSSAS EESVLSVPEL QETMEKLTWL
1510 1520 1530 1540 1550
ASERRMSQEG ESEEENSQEE NSEPEEEEEE EAEGMESLQK EDEMTDEAVG
1560 1570 1580 1590 1600
DSAEKPPTFA SPETAPEVET SRTPPGESIK AAGKGRNNHR ARNKRGSRAR
1610 1620 1630 1640 1650
ASKDTSKLLL LYDEDILERD PLREQKDLAF AQAYLTRVRE ALQHIPGKYE
1660 1670 1680 1690 1700
DFLQVIYEFE SSTQRRTAVD LYKSLQILLQ DWPQLLKDFA AFLLPEQALA
1710 1720 1730 1740 1750
CGLFEEQQAF EKSRKFLRQL EICFAENPSH HQKIIKVLQG CADCLPQEIT
1760 1770 1780 1790 1800
ELKTQMWQLL KGHDHLQDEF SIFFDHLRPA ASRMGDFEEI NWTEEKEYEF
1810 1820 1830 1840 1850
DGFEEVALPD VEEEEEPPKI PTASKNKRKK EIGVQNHDKE TEWPDGAKDC
1860 1870 1880 1890 1900
ACSCHEGGPD SKLKKSKRRS CSHCSSKVCD SKSYKSKEPH ELVGSSPHRE
1910 1920 1930 1940 1950
ASPMPGAKEA GQGKDMMEEE APEERESTEA TQSRTVRTTR KGEMPVSAGL
1960 1970 1980 1990 2000
AVGSTLPSPR EVTVTERLLL DGPPPHSPET PQFPPTTGAV LYTVKRNQVG
2010 2020 2030 2040 2050
PEVRSCPKAS PRLQKEREGQ KAVSESEALM LVWDASETEK LPGTVEPPAS
2060 2070 2080 2090 2100
FLSPVSSKTR DAGRRHVSGK PDTQERWLPS SRARVKTRDR TCPVHESPSG
2110 2120 2130 2140 2150
IDTSETSPKA PRGGLAKDSG TQAKGPEGEQ QPKAAEATVC ANNSKVSSTG
2160 2170 2180 2190 2200
EKVVLWTREA DRVILTMCQE QGAQPQTFNI ISQQLGNKTP AEVSHRFREL
2210 2220 2230 2240
MQLFHTACEA SSEDEDDATS TSNADQLSDH GDLLSEEELD E
Length:2,241
Mass (Da):248,620
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i07959F5B5E832DC7
GO
Isoform 2 (identifier: Q3T8J9-2) [UniParc]FASTAAdd to basket
Also known as: Isoform B

The sequence of this isoform differs from the canonical sequence as follows:
     1492-1529: ETMEKLTWLA...ENSEPEEEEE → VRAGEYSQVF...TMDSPKIICI
     1530-2241: Missing.

Show »
Length:1,529
Mass (Da):169,107
Checksum:i3813E51701483286
GO
Isoform 3 (identifier: Q3T8J9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1948-1948: Missing.

Show »
Length:2,240
Mass (Da):248,549
Checksum:iF9278C03C9382D21
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A4PB68A4PB68_HUMAN
GON-4-like protein
GON4L
970Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WUE6A0A087WUE6_HUMAN
GON-4-like protein
GON4L
1,542Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD97829 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAH10549 differs from that shown. Reason: Erroneous termination at position 1114. Translated as Tyr.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti433T → A in AAR01262 (Ref. 1) Curated1
Sequence conflicti433T → A in CAD97829 (PubMed:11230166).Curated1
Sequence conflicti626T → A in CAH10549 (PubMed:11230166).Curated1
Sequence conflicti988F → S in AAR01262 (Ref. 1) Curated1
Sequence conflicti988F → S in CAD97829 (PubMed:11230166).Curated1
Sequence conflicti1150T → S in CAH10549 (PubMed:11230166).Curated1
Sequence conflicti1299R → G in CAH10549 (PubMed:11230166).Curated1
Sequence conflicti1382E → G in AAR01262 (Ref. 1) Curated1
Sequence conflicti1382E → G in CAD97829 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_056169150L → F. Corresponds to variant dbSNP:rs3738586Ensembl.1
Natural variantiVAR_056170416T → A. Corresponds to variant dbSNP:rs34939643Ensembl.1
Natural variantiVAR_0561711197S → P. Corresponds to variant dbSNP:rs676814Ensembl.1
Natural variantiVAR_0243201418M → V1 PublicationCorresponds to variant dbSNP:rs2297775Ensembl.1
Natural variantiVAR_0561721539Q → E. Corresponds to variant dbSNP:rs607790Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0165801492 – 1529ETMEK…EEEEE → VRAGEYSQVFRGLSNMYHLL ICHLLACCTMDSPKIICI in isoform 2. 3 PublicationsAdd BLAST38
Alternative sequenceiVSP_0165811530 – 2241Missing in isoform 2. 3 PublicationsAdd BLAST712
Alternative sequenceiVSP_0165821948Missing in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY335490 mRNA Translation: AAR01260.1
AY335491 mRNA Translation: AAR01261.1
AY335492 mRNA Translation: AAR01262.1
AL136565 mRNA Translation: CAB66500.2
BX537764 mRNA Translation: CAD97829.1 Different initiation.
BX648043 mRNA Translation: CAH10549.1 Different termination.
AL139128 Genomic DNA No translation available.
AL162734 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53029.1
CH471121 Genomic DNA Translation: EAW53030.1
BC036740 mRNA Translation: AAH36740.2
BC064933 mRNA Translation: AAH64933.1
BC114629 mRNA Translation: AAI14630.1
AB046826 mRNA Translation: BAB13432.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1121.1 [Q3T8J9-2]
CCDS44242.1 [Q3T8J9-3]
CCDS60296.1 [Q3T8J9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001269785.1, NM_001282856.1 [Q3T8J9-1]
NP_001269787.1, NM_001282858.1 [Q3T8J9-3]
NP_001269789.1, NM_001282860.1 [Q3T8J9-1]
NP_001269790.1, NM_001282861.1 [Q3T8J9-2]
NP_115668.4, NM_032292.5 [Q3T8J9-2]
XP_006711456.1, XM_006711393.3 [Q3T8J9-3]
XP_006711457.1, XM_006711394.3 [Q3T8J9-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.656361

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000271883; ENSP00000271883; ENSG00000116580 [Q3T8J9-3]
ENST00000361040; ENSP00000354322; ENSG00000116580 [Q3T8J9-2]
ENST00000368331; ENSP00000357315; ENSG00000116580 [Q3T8J9-1]
ENST00000437809; ENSP00000396117; ENSG00000116580 [Q3T8J9-3]
ENST00000615926; ENSP00000483100; ENSG00000116580 [Q3T8J9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54856

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54856

UCSC genome browser

More...
UCSCi
uc001flz.4 human [Q3T8J9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

GON4L entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY335490 mRNA Translation: AAR01260.1
AY335491 mRNA Translation: AAR01261.1
AY335492 mRNA Translation: AAR01262.1
AL136565 mRNA Translation: CAB66500.2
BX537764 mRNA Translation: CAD97829.1 Different initiation.
BX648043 mRNA Translation: CAH10549.1 Different termination.
AL139128 Genomic DNA No translation available.
AL162734 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53029.1
CH471121 Genomic DNA Translation: EAW53030.1
BC036740 mRNA Translation: AAH36740.2
BC064933 mRNA Translation: AAH64933.1
BC114629 mRNA Translation: AAI14630.1
AB046826 mRNA Translation: BAB13432.1
CCDSiCCDS1121.1 [Q3T8J9-2]
CCDS44242.1 [Q3T8J9-3]
CCDS60296.1 [Q3T8J9-1]
RefSeqiNP_001269785.1, NM_001282856.1 [Q3T8J9-1]
NP_001269787.1, NM_001282858.1 [Q3T8J9-3]
NP_001269789.1, NM_001282860.1 [Q3T8J9-1]
NP_001269790.1, NM_001282861.1 [Q3T8J9-2]
NP_115668.4, NM_032292.5 [Q3T8J9-2]
XP_006711456.1, XM_006711393.3 [Q3T8J9-3]
XP_006711457.1, XM_006711394.3 [Q3T8J9-3]
UniGeneiHs.656361

3D structure databases

ProteinModelPortaliQ3T8J9
SMRiQ3T8J9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120206, 9 interactors
IntActiQ3T8J9, 2 interactors
STRINGi9606.ENSP00000357315

PTM databases

iPTMnetiQ3T8J9
PhosphoSitePlusiQ3T8J9

Polymorphism and mutation databases

BioMutaiGON4L
DMDMi84029264

Proteomic databases

EPDiQ3T8J9
jPOSTiQ3T8J9
MaxQBiQ3T8J9
PaxDbiQ3T8J9
PeptideAtlasiQ3T8J9
PRIDEiQ3T8J9
ProteomicsDBi61875
61876 [Q3T8J9-2]
61877 [Q3T8J9-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271883; ENSP00000271883; ENSG00000116580 [Q3T8J9-3]
ENST00000361040; ENSP00000354322; ENSG00000116580 [Q3T8J9-2]
ENST00000368331; ENSP00000357315; ENSG00000116580 [Q3T8J9-1]
ENST00000437809; ENSP00000396117; ENSG00000116580 [Q3T8J9-3]
ENST00000615926; ENSP00000483100; ENSG00000116580 [Q3T8J9-1]
GeneIDi54856
KEGGihsa:54856
UCSCiuc001flz.4 human [Q3T8J9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54856
DisGeNETi54856
EuPathDBiHostDB:ENSG00000116580.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GON4L

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0001135
HIX0028547
HGNCiHGNC:25973 GON4L
HPAiHPA006986
HPA057305
HPA074504
MIMi610393 gene
neXtProtiNX_Q3T8J9
OpenTargetsiENSG00000116580
PharmGKBiPA142671723

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHDM Eukaryota
ENOG410XS4M LUCA
GeneTreeiENSGT00390000016256
HOVERGENiHBG081563
InParanoidiQ3T8J9
OMAiQESWLPS
OrthoDBi49443at2759
PhylomeDBiQ3T8J9
TreeFamiTF343327

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GON4L human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GON4L

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54856

Protein Ontology

More...
PROi
PR:Q3T8J9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116580 Expressed in 202 organ(s), highest expression level in small intestine Peyer's patch
ExpressionAtlasiQ3T8J9 baseline and differential
GenevisibleiQ3T8J9 HS

Family and domain databases

InterProiView protein in InterPro
IPR033277 GON-4-like
IPR009057 Homeobox-like_sf
IPR017877 Myb-like_dom
IPR003822 PAH
IPR036600 PAH_sf
PANTHERiPTHR16088:SF11 PTHR16088:SF11, 1 hit
PfamiView protein in Pfam
PF02671 PAH, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47762 SSF47762, 2 hits
PROSITEiView protein in PROSITE
PS50090 MYB_LIKE, 1 hit
PS51477 PAH, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGON4L_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3T8J9
Secondary accession number(s): B7ZBL4
, Q14C93, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 11, 2005
Last modified: April 10, 2019
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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