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Entry version 112 (07 Apr 2021)
Sequence version 1 (11 Oct 2005)
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Protein
Submitted name:

Egg permeability glycoprotein

Gene

ABCB1

Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi470 – 477ATPPROSITE-ProRule annotation8
Nucleotide bindingi1121 – 1128ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.201.15, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Egg permeability glycoproteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCB1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStrongylocentrotus purpuratus (Purple sea urchin)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7668 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaCamarodontaEchinideaStrongylocentrotidaeStrongylocentrotus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007110 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei101 – 125HelicalSequence analysisAdd BLAST25
Transmembranei160 – 183HelicalSequence analysisAdd BLAST24
Transmembranei233 – 252HelicalSequence analysisAdd BLAST20
Transmembranei258 – 280HelicalSequence analysisAdd BLAST23
Transmembranei337 – 360HelicalSequence analysisAdd BLAST24
Transmembranei375 – 393HelicalSequence analysisAdd BLAST19
Transmembranei759 – 782HelicalSequence analysisAdd BLAST24
Transmembranei802 – 822HelicalSequence analysisAdd BLAST21
Transmembranei883 – 904HelicalSequence analysisAdd BLAST22
Transmembranei910 – 930HelicalSequence analysisAdd BLAST21
Transmembranei985 – 1005HelicalSequence analysisAdd BLAST21
Transmembranei1025 – 1043HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7668.SPU_001752-tr

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini105 – 401ABC transmembrane type-1InterPro annotationAdd BLAST297
Domaini435 – 671ABC transporterInterPro annotationAdd BLAST237
Domaini763 – 1051ABC transmembrane type-1InterPro annotationAdd BLAST289
Domaini1086 – 1324ABC transporterInterPro annotationAdd BLAST239

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 82DisorderedSequence analysisAdd BLAST82
Regioni675 – 738DisorderedSequence analysisAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili311 – 331Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi65 – 82PolyampholyteSequence analysisAdd BLAST18
Compositional biasi685 – 700AcidicSequence analysisAdd BLAST16

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0055, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_17_2_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
TGYKPDH

Database of Orthologous Groups

More...
OrthoDBi
186078at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR027417, P-loop_NTPase
IPR039421, Type_1_exporter

The PANTHER Classification System

More...
PANTHERi
PTHR24221, PTHR24221, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q3T7C8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVEGDPPAVG FSNGNGTVQM NGNGASFDGP AVIDVSPVHE DAPSAKHARD
60 70 80 90 100
SPPPAYNDVD GTKEQENGGS VEGEGGEKEE KKETKVVGTF EVFRFATGLD
110 120 130 140 150
VVFILLALVI SLCHGVALPA VLLLFGEVTD SFITTASVNV TDNLAAFEES
160 170 180 190 200
VDSIITFSIY YSYLGCGVLA LAYFQVVLWD VAAERQIHKV RLRFFHAILR
210 220 230 240 250
QEIAWFDVHK GGELNTRLAD DIDKIRNGIG DKLGIMLQYT ATFVAGITIG
260 270 280 290 300
FVKSWKLTLV ILAVSLILIV PLVGSTSVII QRMTKQALDA YAKAGAIAGE
310 320 330 340 350
VFSGIRTVVA FNGEEKEMVR YSSNLDQAKS KTVKKDFATL LAQGFLFFSM
360 370 380 390 400
FSSYAIAFWY GTVLYLDNEI TPGDILTTFL AVLFGAFAIG QAGPNYSDFT
410 420 430 440 450
TARAAASSIW EVIDQIPTID CFSTDGKKEK ITGQVTFEGV HFSYPSRASV
460 470 480 490 500
KVLNGINLKV DVGKTVAMVG SSGCGKSTCI QLIQRFYDVA EGSIKIDGID
510 520 530 540 550
IRDLNVSWLR DHIGVVSQEP ILFATTIEEN IRYGRLDVTQ VEIEKAAEEA
560 570 580 590 600
NAHEFISKLP EGYSTLVGER GAQLSGGQKQ RIAIARALVR NPTILLLDEA
610 620 630 640 650
TSALDTESEA TVQLALEKAQ HGRTTLVIAH RLSTIFNSDL ICAFKEGIIS
660 670 680 690 700
EQGTHEELMK NEGGVYHTLV MKQGMKKEEE EEKKENEVPL DDDDDEEDDS
710 720 730 740 750
QGEKVYRAGS GKKKLTRVLS RTQSQMSGDE EKQDEDEYEK ELEKHFSMMR
760 770 780 790 800
VWKLNTPECG FILLGCIGAA INGAVQPGFA VVFSKILGAY SITDRAALFD
810 820 830 840 850
EVTIYCVLFA ALGLLSLLAS IIQGVGFGKS GGELTLRLRN MMFRAILRQN
860 870 880 890 900
ISFFDDKRNG TGALTTKLAT DVSLIQGVTG VRLGMIFEVL FNIGVGIVIS
910 920 930 940 950
FVYSWQIACL LLFAFLPILS LAGMIGWKIL QGNSIGTAGS QAEVGKLVSE
960 970 980 990 1000
CIENIRTVQS LNRGQTFHLK YCELQNPPYK QGIKGAFAAG LAFGFSQATI
1010 1020 1030 1040 1050
FFAYSATFRL GAHLVGTGDL TFPDVFLSFS ALMFGAFGLG RAAGSVPDFS
1060 1070 1080 1090 1100
KAKVATGELF YLVDRSPDID TFSDDGEKPA SYGGSVSLNN VRFRYPTRPD
1110 1120 1130 1140 1150
VPVLRGLSVS VDPGETLALV GSSGCGKSTT IQLMERFYDP HSGTVMFDSH
1160 1170 1180 1190 1200
DASLLNTRWQ RAQVGLVSQE PCLFDMSIAE NIKYGDNSRE VSIEDCIEAA
1210 1220 1230 1240 1250
KKSNIHDFVD SLPMKYDTNV GSKGTQLSGG QKQRIAIARA LVRNPKVLLL
1260 1270 1280 1290 1300
DEATSALDTE SERVVQDALD EAKKGRTCIT IAHRLSTIHN AEKIAVIREG
1310 1320
KLAEFGKHEE LMAMKQQYYS LYTAQSMQH
Length:1,329
Mass (Da):144,825
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9ADE31BE2ECC8C3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A7M7HPM5A0A7M7HPM5_STRPU
Uncharacterized protein
1,328Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7M7LW81A0A7M7LW81_STRPU
Uncharacterized protein
1,349Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY701853 mRNA Translation: AAW28777.1

NCBI Reference Sequences

More...
RefSeqi
NP_001029122.1, NM_001033950.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
NM_001033950; NP_001029122; GeneID_591668

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
591668

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spu:591668

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY701853 mRNA Translation: AAW28777.1
RefSeqiNP_001029122.1, NM_001033950.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7668.SPU_001752-tr

Protein family/group databases

TCDBi3.A.1.201.15, the atp-binding cassette (abc) superfamily

Genome annotation databases

EnsemblMetazoaiNM_001033950; NP_001029122; GeneID_591668
GeneIDi591668
KEGGispu:591668

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5243

Phylogenomic databases

eggNOGiKOG0055, Eukaryota
HOGENOMiCLU_000604_17_2_1
OMAiTGYKPDH
OrthoDBi186078at2759

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR027417, P-loop_NTPase
IPR039421, Type_1_exporter
PANTHERiPTHR24221, PTHR24221, 1 hit
PfamiView protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3T7C8_STRPU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3T7C8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 7, 2021
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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