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Entry version 113 (02 Dec 2020)
Sequence version 1 (11 Oct 2005)
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Protein

Condensin-2 complex subunit D3

Gene

Ncapd3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, DNA condensationUniRule annotationARBA annotation, MitosisUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Condensin-2 complex subunit D3UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ncapd3Imported
Synonyms:LOC315508Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

Rat genome database

More...
RGDi
1562176, Ncapd3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3T1H0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3T1H0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000008932, Expressed in thymus and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the condensin-2 complex.

UniRule annotation

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini950 – 1126Cnd1InterPro annotationAdd BLAST177

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni154 – 195DisorderedSequence analysisAdd BLAST42
Regioni1305 – 1328DisorderedSequence analysisAdd BLAST24
Regioni1371 – 1398DisorderedSequence analysisAdd BLAST28
Regioni1456 – 1494DisorderedSequence analysisAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1242 – 1262Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi162 – 180BasicSequence analysisAdd BLAST19
Compositional biasi1371 – 1394PolarSequence analysisAdd BLAST24
Compositional biasi1460 – 1478PolarSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002301_0_0_1

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3T1H0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR026971, CND1/NCAPD3
IPR032682, Cnd1_C
IPR012371, NCAPD3

The PANTHER Classification System

More...
PANTHERi
PTHR14222, PTHR14222, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12717, Cnd1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036508, Condns_HCP-6, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3T1H0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALKDLGRDL QPWCPLDLSL EWVNTVWDLD FTETEPLDPS VVAEILETGR
60 70 80 90 100
DAFTKLYGSL FPFATDESGS LESVWSFFTE NSISSNTLVA LFCHFVQEAH
110 120 130 140 150
KKSASVQYRE YGLRAAGLYF LLLEIPGSVV NQVFHPVMFD KCIQILKKSW
160 170 180 190 200
PQESNLTQKR KKEHSKSSKA NYRRSRKRGK PPRKEDYQVD ELSREEEEEE
210 220 230 240 250
EEEIYFSVRD LSQIRDAIFN LLKNFLRLLP KFSLKEKPQS IQTCIEVFVA
260 270 280 290 300
LTSFEPIPHK FLISQARNLS EVKHISELAY YGLYLLCSPV HGEGNKVIGS
310 320 330 340 350
IFHQMLNVIL MLEVGEGSRC APLAITSHVI NCRNQAVQFV SSLVDELQES
360 370 380 390 400
VFPILGTLLQ HICAKVVDKA EYRTYAAQSL VQLLSKLPSK EYATFIAWLY
410 420 430 440 450
KYSRSSKIPH RVFTLDVALA LLELPERLLD DTVLLEHQKF LKHKFFVQEI
460 470 480 490 500
IFDRCLDKAP TVRSKALSSF AQCLELSTSN TSENTLEIFI NSTVTGIHSH
510 520 530 540 550
FGTSLRPSTV LTSQSCRSVQ SSTHDSDEQT PPGERRFMTM LRKRTKDEKI
560 570 580 590 600
NVRKSALQVL MSILKHCDIL SMEEDLLILQ DHCRDPAISV RKQALQSLTE
610 620 630 640 650
LVMAKPTCVP VQKAWLMGVI PVVMDYESTV QEKALECLDQ LLLQNIKHHR
660 670 680 690 700
KFHSEDRSQV LAWALLALLT VESQDLSRYL NKAFHIWSKK DKFSSTFINS
710 720 730 740 750
VISHTDTERS APAWMLLSKI TCSSPKLDYT KIMESWEKLS REQSPNSNTL
760 770 780 790 800
GYMLCVIGHI AKHLPKSTQD KITGVIKAKL NGFQWSLELI SLSVDTLQGL
810 820 830 840 850
CRASAKTLRE EQELLKRVCG DVLSTCEQHL SNILLKEDGT GNMDEDLVVK
860 870 880 890 900
CIFTLGDIAQ LCPALVEKRV FLLIQSILAS SAHADHLPSS QGTTDLASQL
910 920 930 940 950
PFQARSSALP SVIRAHAIIT LGKLCLQHED LAKKSIPALV RELEVCEDVA
960 970 980 990 1000
VRNNVIIVMC DLCIRYTVMV DNYIPNISIC LKDSDPFIRK QTLILLTNLL
1010 1020 1030 1040 1050
QEEYVKWKGS LFFRFVSTLV DSHPDIASLG EFCLAHLLLK RNPTMFFQHF
1060 1070 1080 1090 1100
IECIFHFNSY EKHGQYNKFS QSERGKPLFL LKGKTNKEKR MRIYKFLLEH
1110 1120 1130 1140 1150
FTDEQRFNVT SKICLNILAC FTDGVLPVDM EASELLSDTF DILSSKEIKL
1160 1170 1180 1190 1200
LAMRAQASKE LLEEDDVALA NVVMQEAQMK IISQVQKRNF IENIIPIIIS
1210 1220 1230 1240 1250
LKTVLEKNKI PALRELMNYL REVMQDYRDE IKDFFAVDRQ LASELEYDMK
1260 1270 1280 1290 1300
KYTEQLAQEQ ALTEHANATN VPADGDRVPS QQVAPDLQAV PGAAAAAGAG
1310 1320 1330 1340 1350
QADANMPLPL AQSQPSAPGS SFTPTLPPIC EKGPLKIMSS TRPMSLSTIA
1360 1370 1380 1390 1400
ILNSVKKAVA SKSRTRSLGA LSFNMENGSP ENPSSRASSL SLEQESERAV
1410 1420 1430 1440 1450
KRVTKRAIST PEKSISNVTF GAGVSYIGTP ATSFFTKEKP EEAQEEGNDI
1460 1470 1480 1490
LCLSLLDKRP PQSPQWNVKS PARSQDNPRS GRRSLRKAPL KTAN
Length:1,494
Mass (Da):168,490
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7128F9351D435566
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC101928 mRNA Translation: AAI01929.1

NCBI Reference Sequences

More...
RefSeqi
NP_001029172.1, NM_001034000.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
315508

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:315508

UCSC genome browser

More...
UCSCi
RGD:1562176, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC101928 mRNA Translation: AAI01929.1
RefSeqiNP_001029172.1, NM_001034000.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

iPTMnetiQ3T1H0
PhosphoSitePlusiQ3T1H0

Genome annotation databases

GeneIDi315508
KEGGirno:315508
UCSCiRGD:1562176, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23310
RGDi1562176, Ncapd3

Phylogenomic databases

HOGENOMiCLU_002301_0_0_1
PhylomeDBiQ3T1H0

Gene expression databases

BgeeiENSRNOG00000008932, Expressed in thymus and 20 other tissues

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR026971, CND1/NCAPD3
IPR032682, Cnd1_C
IPR012371, NCAPD3
PANTHERiPTHR14222, PTHR14222, 1 hit
PfamiView protein in Pfam
PF12717, Cnd1, 1 hit
PIRSFiPIRSF036508, Condns_HCP-6, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3T1H0_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3T1H0
Secondary accession number(s): F1LMD2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: December 2, 2020
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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