UniProtKB - Q3T149 (HSPB1_BOVIN)
Heat shock protein beta-1
HSPB1
Functioni
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins.
By similarityGO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein folding chaperone Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein kinase C binding Source: Ensembl
- protein kinase C inhibitor activity Source: Ensembl
- RNA polymerase II-specific DNA-binding transcription factor binding Source: Ensembl
GO - Biological processi
- anterograde axonal protein transport Source: UniProtKB
- chaperone-mediated protein folding Source: UniProtKB
- intracellular signal transduction Source: Ensembl
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Source: Ensembl
- negative regulation of protein kinase activity Source: Ensembl
- positive regulation of angiogenesis Source: Ensembl
- positive regulation of blood vessel endothelial cell migration Source: Ensembl
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway Source: Ensembl
- positive regulation of interleukin-1 beta production Source: Ensembl
- positive regulation of tumor necrosis factor production Source: Ensembl
- regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- regulation of protein phosphorylation Source: UniProtKB
- response to virus Source: Ensembl
Keywordsi
Molecular function | Chaperone |
Biological process | Stress response |
Names & Taxonomyi
Protein namesi | Recommended name: Heat shock protein beta-1Short name: HspB1 Alternative name(s): Heat shock 27 kDa protein Short name: HSP 27 |
Gene namesi | Name:HSPB1 Synonyms:HSP27 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000011969 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytoskeleton
- spindle By similarity
Nucleus
- Nucleus By similarity
Note: Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.By similarity
Cytoskeleton
- spindle Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- axon cytoplasm Source: GOC
- cytoplasm Source: UniProtKB
- Z disc Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125924 | 1 – 201 | Heat shock protein beta-1Add BLAST | 201 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 12 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 15 | Phosphoserine; by MAPKAPK2 and MAPKAPK3By similarity | 1 | |
Modified residuei | 27 | PhosphoserineBy similarity | 1 | |
Modified residuei | 74 | Phosphoserine; by MAPKAPK2, MAPKAPK3 and MAPKAPK5By similarity | 1 | |
Modified residuei | 78 | Phosphoserine; by MAPKAPK2, MAPKAPK3 and MAPKAPK5By similarity | 1 | |
Modified residuei | 79 | PhosphoserineBy similarity | 1 | |
Modified residuei | 82 | PhosphoserineBy similarity | 1 | |
Modified residuei | 94 | PhosphoserineBy similarity | 1 | |
Modified residuei | 119 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 170 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 172 | PhosphoserineBy similarity | 1 | |
Modified residuei | 195 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Methylation, PhosphoproteinProteomic databases
PaxDbi | Q3T149 |
PeptideAtlasi | Q3T149 |
PRIDEi | Q3T149 |
PTM databases
iPTMneti | Q3T149 |
Interactioni
Subunit structurei
Homooligomer. Homodimer; becomes monomeric upon activation. Heterooligomer; with HSPB6. Associates with alpha- and beta-tubulin.
Interacts with TGFB1I1.
Interacts with CRYAB.
Interacts with HSPB8.
Interacts with HSPBAP1.
By similarityGO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein kinase C binding Source: Ensembl
- RNA polymerase II-specific DNA-binding transcription factor binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 72 – 180 | sHSPPROSITE-ProRule annotationAdd BLAST | 109 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 68 – 201 | Interaction with TGFB1I1By similarityAdd BLAST | 134 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3591, Eukaryota |
GeneTreei | ENSGT00940000155882 |
InParanoidi | Q3T149 |
OMAi | EEWAQWF |
OrthoDBi | 1187096at2759 |
Family and domain databases
CDDi | cd06475, ACD_HspB1_like, 1 hit |
Gene3Di | 2.60.40.790, 1 hit |
InterProi | View protein in InterPro IPR002068, A-crystallin/Hsp20_dom IPR037876, ACD_HspB1 IPR001436, Alpha-crystallin/sHSP_animal IPR008978, HSP20-like_chaperone |
PANTHERi | PTHR45640, PTHR45640, 1 hit |
Pfami | View protein in Pfam PF00011, HSP20, 1 hit |
PRINTSi | PR00299, ACRYSTALLIN |
SUPFAMi | SSF49764, SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS01031, SHSP, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAERRVPFSL LRGPSWDPFR DWYPAHSRLF DQAFGLPRLP EEWSQWLSHS
60 70 80 90 100
GWPGYVRALP AAAIEGPAYN RALSRQLSSG VSEIQQTADR WRVSLDVNHF
110 120 130 140 150
APEELTVKTK DGVVEITGKH EERQDEHGYI SRCFTRKYTL PPGVDPTLVS
160 170 180 190 200
SSLSPEGTLT VEAPLPKSAT QSAEITIPVT FQARAQLGGP EAGKSEQPEN
K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC102129 mRNA Translation: AAI02130.1 |
RefSeqi | XP_005225172.1, XM_005225115.1 |
Genome annotation databases
Ensembli | ENSBTAT00000044397; ENSBTAP00000041898; ENSBTAG00000011969 |
GeneIDi | 516099 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC102129 mRNA Translation: AAI02130.1 |
RefSeqi | XP_005225172.1, XM_005225115.1 |
3D structure databases
SMRi | Q3T149 |
ModBasei | Search... |
PTM databases
iPTMneti | Q3T149 |
Proteomic databases
PaxDbi | Q3T149 |
PeptideAtlasi | Q3T149 |
PRIDEi | Q3T149 |
Genome annotation databases
Ensembli | ENSBTAT00000044397; ENSBTAP00000041898; ENSBTAG00000011969 |
GeneIDi | 516099 |
Organism-specific databases
CTDi | 3315 |
VEuPathDBi | HostDB:ENSBTAG00000011969 |
Phylogenomic databases
eggNOGi | KOG3591, Eukaryota |
GeneTreei | ENSGT00940000155882 |
InParanoidi | Q3T149 |
OMAi | EEWAQWF |
OrthoDBi | 1187096at2759 |
Gene expression databases
ExpressionAtlasi | Q3T149, baseline and differential |
Family and domain databases
CDDi | cd06475, ACD_HspB1_like, 1 hit |
Gene3Di | 2.60.40.790, 1 hit |
InterProi | View protein in InterPro IPR002068, A-crystallin/Hsp20_dom IPR037876, ACD_HspB1 IPR001436, Alpha-crystallin/sHSP_animal IPR008978, HSP20-like_chaperone |
PANTHERi | PTHR45640, PTHR45640, 1 hit |
Pfami | View protein in Pfam PF00011, HSP20, 1 hit |
PRINTSi | PR00299, ACRYSTALLIN |
SUPFAMi | SSF49764, SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS01031, SHSP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HSPB1_BOVIN | |
Accessioni | Q3T149Primary (citable) accession number: Q3T149 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2006 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 23, 2022 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families