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UniProtKB - Q3T0Z7 (DHPR_BOVIN)
Protein
Dihydropteridine reductase
Gene
QDPR
Organism
Bos taurus (Bovine)
Status
Functioni
Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.
By similarityCatalytic activityi
- EC:1.5.1.34By similarityThis reaction proceeds in the backwardBy similarity direction.
- EC:1.5.1.34By similarityThis reaction proceeds in the backwardBy similarity direction.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 148 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 12 – 36 | NADPBy similarityAdd BLAST | 25 |
GO - Molecular functioni
- 6,7-dihydropteridine reductase activity Source: UniProtKB
- NADH binding Source: GO_Central
- NADPH binding Source: GO_Central
GO - Biological processi
- L-phenylalanine catabolic process Source: GO_Central
- tetrahydrobiopterin biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Tetrahydrobiopterin biosynthesis |
Ligand | NADP |
Names & Taxonomyi
Protein namesi | Recommended name: Dihydropteridine reductase (EC:1.5.1.34By similarity)Alternative name(s): HDHPR Quinoid dihydropteridine reductase |
Gene namesi | Name:QDPR |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000040333 |
VGNCi | VGNC:33596, QDPR |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284384 | 1 – 242 | Dihydropteridine reductaseAdd BLAST | 242 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 71 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 77 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 94 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 100 | N6-succinyllysineBy similarity | 1 |
Proteomic databases
PaxDbi | Q3T0Z7 |
PeptideAtlasi | Q3T0Z7 |
PRIDEi | Q3T0Z7 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000040333, Expressed in kidney and 95 other tissues |
ExpressionAtlasi | Q3T0Z7, baseline and differential |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000049659 |
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated
Phylogenomic databases
eggNOGi | KOG4022, Eukaryota |
GeneTreei | ENSGT00390000000470 |
HOGENOMi | CLU_010194_22_0_1 |
InParanoidi | Q3T0Z7 |
OMAi | DWWVASI |
OrthoDBi | 1585354at2759 |
TreeFami | TF105932 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q3T0Z7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAAGEARR VLVYGGRGAL GSRCVQAFRA RNWWVASIDV QENEEASANV
60 70 80 90 100
VVKMTDSFTE QADQVTAEVG KLLGTEKVDA ILCVAGGWAG GNAKSKSLFK
110 120 130 140 150
NCDLMWKQSV WTSTISSHLA TKHLKEGGLL TLAGARAALD GTPGMIGYGM
160 170 180 190 200
AKAAVHQLCQ SLAGKSSGLP PGAAAVALLP VTLDTPVNRK SMPEADFSSW
210 220 230 240
TPLEFLVETF HDWITEKNRP SSGSLIQVVT TEGKTELTAA SP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1LU13 | A0A3Q1LU13_BOVIN | Dihydropteridine reductase | QDPR | 227 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC102193 mRNA Translation: AAI02194.1 |
RefSeqi | NP_001069960.1, NM_001076492.2 |
Genome annotation databases
Ensembli | ENSBTAT00000055681; ENSBTAP00000049659; ENSBTAG00000040333 |
GeneIDi | 618084 |
KEGGi | bta:618084 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC102193 mRNA Translation: AAI02194.1 |
RefSeqi | NP_001069960.1, NM_001076492.2 |
3D structure databases
AlphaFoldDBi | Q3T0Z7 |
SMRi | Q3T0Z7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000049659 |
Proteomic databases
PaxDbi | Q3T0Z7 |
PeptideAtlasi | Q3T0Z7 |
PRIDEi | Q3T0Z7 |
Genome annotation databases
Ensembli | ENSBTAT00000055681; ENSBTAP00000049659; ENSBTAG00000040333 |
GeneIDi | 618084 |
KEGGi | bta:618084 |
Organism-specific databases
CTDi | 5860 |
VEuPathDBi | HostDB:ENSBTAG00000040333 |
VGNCi | VGNC:33596, QDPR |
Phylogenomic databases
eggNOGi | KOG4022, Eukaryota |
GeneTreei | ENSGT00390000000470 |
HOGENOMi | CLU_010194_22_0_1 |
InParanoidi | Q3T0Z7 |
OMAi | DWWVASI |
OrthoDBi | 1585354at2759 |
TreeFami | TF105932 |
Gene expression databases
Bgeei | ENSBTAG00000040333, Expressed in kidney and 95 other tissues |
ExpressionAtlasi | Q3T0Z7, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DHPR_BOVIN | |
Accessioni | Q3T0Z7Primary (citable) accession number: Q3T0Z7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | October 11, 2005 | |
Last modified: | May 25, 2022 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families