Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

3-ketoacyl-CoA thiolase, mitochondrial

Gene

ACAA2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Abolishes BNIP3-mediated apoptosis and mitochondrial damage.By similarity

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.

Pathwayi: fatty acid metabolism

This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei92Acyl-thioester intermediateBy similarity1
Active sitei352Proton acceptorPROSITE-ProRule annotation1
Active sitei382Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-BTA-77289 Mitochondrial Fatty Acid Beta-Oxidation
SABIO-RKiQ3T0R7
UniPathwayi
UPA00199

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolase, mitochondrial (EC:2.3.1.16)
Alternative name(s):
Acetyl-CoA acyltransferase
Beta-ketothiolase
Mitochondrial 3-oxoacyl-CoA thiolase
Gene namesi
Name:ACAA2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 24

Organism-specific databases

VGNCiVGNC:25518 ACAA2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002704981 – 3973-ketoacyl-CoA thiolase, mitochondrialAdd BLAST397
Transit peptidei1 – 16Mitochondrion; not cleavedBy similarityAdd BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25N6-acetyllysine; alternateBy similarity1
Modified residuei25N6-succinyllysine; alternateBy similarity1
Modified residuei119PhosphothreonineBy similarity1
Modified residuei121PhosphoserineBy similarity1
Modified residuei127PhosphotyrosineBy similarity1
Modified residuei136PhosphothreonineBy similarity1
Modified residuei137N6-acetyllysine; alternateBy similarity1
Modified residuei137N6-succinyllysine; alternateBy similarity1
Modified residuei140PhosphoserineBy similarity1
Modified residuei143N6-acetyllysine; alternateBy similarity1
Modified residuei143N6-succinyllysine; alternateBy similarity1
Modified residuei171N6-acetyllysine; alternateBy similarity1
Modified residuei171N6-succinyllysine; alternateBy similarity1
Modified residuei191N6-acetyllysine; alternateBy similarity1
Modified residuei191N6-succinyllysine; alternateBy similarity1
Modified residuei209N6-acetyllysine; alternateBy similarity1
Modified residuei209N6-succinyllysine; alternateBy similarity1
Modified residuei212N6-succinyllysineBy similarity1
Modified residuei214N6-succinyllysineBy similarity1
Modified residuei234N6-acetyllysine; alternateBy similarity1
Modified residuei234N6-succinyllysine; alternateBy similarity1
Modified residuei240N6-succinyllysineBy similarity1
Modified residuei241N6-acetyllysineBy similarity1
Modified residuei269N6-acetyllysineBy similarity1
Modified residuei270N6-acetyllysineBy similarity1
Modified residuei305N6-acetyllysine; alternateBy similarity1
Modified residuei305N6-succinyllysine; alternateBy similarity1
Modified residuei310PhosphoserineBy similarity1
Modified residuei312N6-acetyllysine; alternateBy similarity1
Modified residuei312N6-succinyllysine; alternateBy similarity1
Modified residuei333PhosphoserineBy similarity1
Modified residuei340N6-acetyllysineBy similarity1
Modified residuei375N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ3T0R7
PeptideAtlasiQ3T0R7
PRIDEiQ3T0R7

Expressioni

Gene expression databases

BgeeiENSBTAG00000002863 Expressed in 9 organ(s), highest expression level in adult mammalian kidney

Interactioni

Subunit structurei

Homotetramer. Interacts with BNIP3 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ3T0R7, 1 interactor
STRINGi9913.ENSBTAP00000003716

Structurei

3D structure databases

ProteinModelPortaliQ3T0R7
SMRiQ3T0R7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1391 Eukaryota
COG0183 LUCA
GeneTreeiENSGT00390000009412
HOGENOMiHOG000012238
HOVERGENiHBG003112
InParanoidiQ3T0R7
KOiK07508
OMAiCGGTESM
OrthoDBiEOG091G09C6
TreeFamiTF105696

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.10, 4 hits
InterProiView protein in InterPro
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020610 Thiolase_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit
PS00099 THIOLASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q3T0R7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLRGVFIV AAKRTPFGAY GGLLKDFTPT DMAEFAARAA LSAGRVSPET
60 70 80 90 100
VDSVVVGNVM QSSSDAIYLA RHVGLRVGIP KETPAITINR LCGSGFQSIV
110 120 130 140 150
SGCQEICSRD SEVVLCGGTE SMSQAPYCVR NIRFGTKLGS ELKLEDTLWT
160 170 180 190 200
GLTDTHVQMP MAITAENLAV KHQISREDCD RYALQSQQRW KTANDAGYFD
210 220 230 240 250
NEMAPVEVKT RKGKQTMQVD EHPRPQTTME QLNKLPPVFK KEGTVTAGNA
260 270 280 290 300
SGVSDGAGAV IIASEDAVKK HNFTPLARIV GYFVSGCDPT IMGIGPVPAI
310 320 330 340 350
SGALKKTGLS LKDMDLVEVN EAFAPQYLAV EKSLNLDPSK TNVNGGAIAL
360 370 380 390
GHPLAGSGSR ITAHLVHELR RRGGKYAVGS ACIGGGQGIA VIIENTA
Length:397
Mass (Da):42,131
Last modified:October 11, 2005 - v1
Checksum:iD1AFAAA509594E11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF583004 mRNA Translation: ABU62844.1
EF583005 Genomic DNA Translation: ABU62845.1
BT025480 mRNA Translation: ABF57436.1
BC102287 mRNA Translation: AAI02288.1
RefSeqiNP_001030419.1, NM_001035342.2
UniGeneiBt.48847

Genome annotation databases

EnsembliENSBTAT00000003716; ENSBTAP00000003716; ENSBTAG00000002863
GeneIDi522006
KEGGibta:522006

Similar proteinsi

Entry informationi

Entry nameiTHIM_BOVIN
AccessioniPrimary (citable) accession number: Q3T0R7
Secondary accession number(s): B4X9P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 11, 2005
Last modified: September 12, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again