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Protein

Cellular nucleic acid-binding protein

Gene

CNBP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 21CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri45 – 62CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri65 – 82CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri89 – 106CCHC-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri110 – 127CCHC-type 5PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri128 – 145CCHC-type 6PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri149 – 166CCHC-type 7PROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular nucleic acid-binding protein
Short name:
CNBP
Alternative name(s):
Zinc finger protein 9
Gene namesi
Name:CNBP
Synonyms:ZNF9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 22

Organism-specific databases

VGNCiVGNC:27492 CNBP

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002470132 – 170Cellular nucleic acid-binding proteinAdd BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei8N6-acetyllysineBy similarity1
Modified residuei25Omega-N-methylarginine; by PRMT1By similarity1
Modified residuei27Omega-N-methylarginine; by PRMT1By similarity1
Modified residuei42PhosphoserineBy similarity1
Modified residuei72Omega-N-methylarginineBy similarity1

Post-translational modificationi

Arginine methylation by PRMT1 in the Arg/Gly-rich region impedes RNA binding.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ3T0Q6
PRIDEiQ3T0Q6

Expressioni

Gene expression databases

BgeeiENSBTAG00000012159

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016130

Structurei

3D structure databases

ProteinModelPortaliQ3T0Q6
SMRiQ3T0Q6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 42Arg/Gly-richAdd BLAST21

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri4 – 21CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri45 – 62CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri65 – 82CCHC-type 3PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri89 – 106CCHC-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri110 – 127CCHC-type 5PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri128 – 145CCHC-type 6PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri149 – 166CCHC-type 7PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4400 Eukaryota
COG5082 LUCA
GeneTreeiENSGT00510000047065
HOGENOMiHOG000186262
HOVERGENiHBG000397
InParanoidiQ3T0Q6
KOiK09250
OMAiRRECDEK
OrthoDBiEOG091G0LZK
TreeFamiTF316974

Family and domain databases

InterProiView protein in InterPro
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00098 zf-CCHC, 7 hits
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 7 hits
SUPFAMiSSF57756 SSF57756, 4 hits
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 7 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3T0Q6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSNECFKCG RSGHWARECP TGGGRGRGMR SRGRGFQFVS SSLPDICYRC
60 70 80 90 100
GESGHLAKDC DLQEDACYNC GRGGHIAKDC KEPKREREQC CYNCGKPGHL
110 120 130 140 150
ARDCDHADEQ KCYSCGEFGH IQKDCTKVKC YRCGETGHVA INCSKTSEVN
160 170
CYRCGESGHL ARECTIEATA
Length:170
Mass (Da):18,742
Last modified:October 11, 2005 - v1
Checksum:i152BEC42881358E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102298 mRNA Translation: AAI02299.1
RefSeqiNP_001029396.1, NM_001034224.1
UniGeneiBt.9541

Genome annotation databases

EnsembliENSBTAT00000016130; ENSBTAP00000016130; ENSBTAG00000012159
GeneIDi504831
KEGGibta:504831

Similar proteinsi

Entry informationi

Entry nameiCNBP_BOVIN
AccessioniPrimary (citable) accession number: Q3T0Q6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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