UniProtKB - Q3T0C9 (SYJ2B_BOVIN)
Protein
Synaptojanin-2-binding protein
Gene
SYNJ2BP
Organism
Bos taurus (Bovine)
Status
Functioni
Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction.By similarity
GO - Biological processi
- cell-cell adhesion Source: GO_Central
- chemical synaptic transmission Source: GO_Central
- endocytosis Source: UniProtKB-KW
- establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
- negative regulation of angiogenesis Source: UniProtKB
- negative regulation of endothelial cell migration Source: UniProtKB
- negative regulation of endothelial cell proliferation Source: UniProtKB
- negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
- negative regulation of sprouting angiogenesis Source: UniProtKB
- receptor clustering Source: GO_Central
- receptor localization to synapse Source: GO_Central
- regulation of Notch signaling pathway Source: UniProtKB
Keywordsi
Biological process | Endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptojanin-2-binding proteinBy similarityImportedAlternative name(s): Activin receptor-interacting protein 2By similarity Mitochondrial outer membrane protein 25By similarity |
Gene namesi | Name:SYNJ2BPImported Synonyms:ARIP2By similarity, OMP25By similarity |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane By similarity; Single-pass type IV membrane protein By similarity; Cytoplasmic side By similarity
Other locations
- perinuclear region By similarity
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB-SubCell
Plasma Membrane
- basolateral plasma membrane Source: GO_Central
- postsynaptic density membrane Source: GO_Central
Other locations
- cell junction Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
- neuromuscular junction Source: GO_Central
- neuron projection Source: GO_Central
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 117 | CytoplasmicSequence analysisAdd BLAST | 117 | |
Transmembranei | 118 – 138 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 139 – 145 | Mitochondrial intermembraneSequence analysis | 7 |
Keywords - Cellular componenti
Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000375981 | 1 – 145 | Synaptojanin-2-binding proteinAdd BLAST | 145 |
Proteomic databases
PaxDbi | Q3T0C9 |
PRIDEi | Q3T0C9 |
Interactioni
Subunit structurei
Binds (via the PDZ domain) to isoform 2A of SYNJ2 (via the unique motif in the C-terminus) (By similarity).
Interacts (via C-terminus) with RALBP1.
Interacts (via PDZ domain) with ACVR2A (via C-terminus) and ACVR2B (via C-terminus).
Forms a ternary complex with ACVR2A and RALBP1 (By similarity).
Interacts with MAPK12 (By similarity).
Interacts with DLL1; enhances DLL1 protein stability, and promotes notch signaling in endothelial cells (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000020908 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 13 – 100 | PDZPROSITE-ProRule annotationAdd BLAST | 88 |
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3528, Eukaryota |
InParanoidi | Q3T0C9 |
OrthoDBi | 1502481at2759 |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3T0C9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNGRVDYLVT EEEINLTRGP SGLGFNIVGG TDQQYVSNDS GIFVSRIKEN
60 70 80 90 100
GAAALDGRLQ EGDKILSVNG QDLKNLLHQD AVDLFRNAGY AVSLRVQHRL
110 120 130 140
QVQNGPIGPQ GEGEPSGIPI AMVLVPVFAL TMVAAWAFMR YRQRL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC102451 mRNA Translation: AAI02452.1 |
RefSeqi | NP_001030432.1, NM_001035355.2 |
Genome annotation databases
GeneIDi | 525107 |
KEGGi | bta:525107 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC102451 mRNA Translation: AAI02452.1 |
RefSeqi | NP_001030432.1, NM_001035355.2 |
3D structure databases
SMRi | Q3T0C9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000020908 |
Proteomic databases
PaxDbi | Q3T0C9 |
PRIDEi | Q3T0C9 |
Genome annotation databases
GeneIDi | 525107 |
KEGGi | bta:525107 |
Organism-specific databases
CTDi | 55333 |
Phylogenomic databases
eggNOGi | KOG3528, Eukaryota |
InParanoidi | Q3T0C9 |
OrthoDBi | 1502481at2759 |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYJ2B_BOVIN | |
Accessioni | Q3T0C9Primary (citable) accession number: Q3T0C9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 26, 2009 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |