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UniProtKB - Q3SZV8 (ROMO1_BOVIN)
Protein
Reactive oxygen species modulator 1
Gene
ROMO1
Organism
Bos taurus (Bovine)
Status
Functioni
Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage (By similarity).
By similarityInduces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation (By similarity).
By similarityGO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: Ensembl
- cellular response to reactive oxygen species Source: UniProtKB
- cytolysis by host of symbiont cells Source: Ensembl
- defense response to Gram-negative bacterium Source: Ensembl
- defense response to Gram-positive bacterium Source: Ensembl
- killing of cells of another organism Source: Ensembl
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of reactive oxygen species metabolic process Source: UniProtKB
- protein import into mitochondrial matrix Source: GO_Central
- protein insertion into mitochondrial inner membrane Source: GO_Central
- replicative senescence Source: UniProtKB
Keywordsi
Molecular function | Antibiotic, Antimicrobial |
Names & Taxonomyi
Protein namesi | Recommended name: Reactive oxygen species modulator 1Short name: ROS modulator 1 Alternative name(s): Protein MGR2 homolog |
Gene namesi | Name:ROMO1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000027361 |
VGNCi | VGNC:34085, ROMO1 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Single-pass membrane protein By similarity
Mitochondrion
- mitochondrion Source: UniProtKB
- TIM23 mitochondrial import inner membrane translocase complex Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 22 – 44 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000294146 | 1 – 79 | Reactive oxygen species modulator 1Add BLAST | 79 |
Proteomic databases
PaxDbi | Q3SZV8 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000027361, Expressed in kidney and 97 other tissues |
Structurei
3D structure databases
AlphaFoldDBi | Q3SZV8 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 42 – 60 | Sufficient for antibacterial activityBy similarityAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the MGR2 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4096, Eukaryota |
GeneTreei | ENSGT00390000005315 |
HOGENOMi | CLU_142435_2_0_1 |
InParanoidi | Q3SZV8 |
OMAi | FMIGFCV |
OrthoDBi | 1635599at2759 |
TreeFami | TF300273 |
Family and domain databases
InterProi | View protein in InterPro IPR018450, Romo1/Mgr2 |
PANTHERi | PTHR28525, PTHR28525, 1 hit |
Pfami | View protein in Pfam PF10247, Romo1, 1 hit |
SMARTi | View protein in SMART SM01378, Romo1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3SZV8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPVAVGPYGQ SQPSCFDRVK MGFVMGCAVG MAAGALFGTF SCLRIGMRGR
60 70
ELMGGIGKTM MQSGGTFGTF MAIGMGIRC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC102685 mRNA Translation: AAI02686.1 |
RefSeqi | NP_001108000.1, NM_001114528.2 XP_005214932.1, XM_005214875.3 |
Genome annotation databases
Ensembli | ENSBTAT00000039245; ENSBTAP00000039044; ENSBTAG00000027361 |
GeneIDi | 618530 |
KEGGi | bta:618530 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC102685 mRNA Translation: AAI02686.1 |
RefSeqi | NP_001108000.1, NM_001114528.2 XP_005214932.1, XM_005214875.3 |
3D structure databases
AlphaFoldDBi | Q3SZV8 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000039044 |
Proteomic databases
PaxDbi | Q3SZV8 |
Genome annotation databases
Ensembli | ENSBTAT00000039245; ENSBTAP00000039044; ENSBTAG00000027361 |
GeneIDi | 618530 |
KEGGi | bta:618530 |
Organism-specific databases
CTDi | 140823 |
VEuPathDBi | HostDB:ENSBTAG00000027361 |
VGNCi | VGNC:34085, ROMO1 |
Phylogenomic databases
eggNOGi | KOG4096, Eukaryota |
GeneTreei | ENSGT00390000005315 |
HOGENOMi | CLU_142435_2_0_1 |
InParanoidi | Q3SZV8 |
OMAi | FMIGFCV |
OrthoDBi | 1635599at2759 |
TreeFami | TF300273 |
Gene expression databases
Bgeei | ENSBTAG00000027361, Expressed in kidney and 97 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR018450, Romo1/Mgr2 |
PANTHERi | PTHR28525, PTHR28525, 1 hit |
Pfami | View protein in Pfam PF10247, Romo1, 1 hit |
SMARTi | View protein in SMART SM01378, Romo1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ROMO1_BOVIN | |
Accessioni | Q3SZV8Primary (citable) accession number: Q3SZV8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 10, 2007 |
Last sequence update: | October 11, 2005 | |
Last modified: | May 25, 2022 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families