We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q3SZP5 (ACOX1_BOVIN)
Protein
Peroxisomal acyl-coenzyme A oxidase 1
Gene
ACOX1
Organism
Bos taurus (Bovine)
Status
Functioni
Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs.
By similarityCatalytic activityi
- EC:1.3.3.6By similarityThis reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
- This reaction proceeds in the forwardBy similarity direction.
Cofactori
FADBy similarity
: peroxisomal fatty acid beta-oxidation Pathwayi
This protein is involved in the pathway peroxisomal fatty acid beta-oxidation, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway peroxisomal fatty acid beta-oxidation and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 139 | FADBy similarity | 1 | |
Binding sitei | 178 | FAD; via amide nitrogenBy similarity | 1 | |
Active sitei | 421 | Proton acceptorBy similarity | 1 |
GO - Molecular functioni
- acyl-CoA oxidase activity Source: UniProtKB
- FAD binding Source: InterPro
- fatty acid binding Source: GO_Central
- flavin adenine dinucleotide binding Source: GO_Central
- palmitoyl-CoA oxidase activity Source: GO_Central
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- fatty acid beta-oxidation using acyl-CoA oxidase Source: GO_Central
- fatty acid catabolic process Source: UniProtKB
- fatty acid oxidation Source: UniProtKB
- generation of precursor metabolites and energy Source: UniProtKB
- hydrogen peroxide biosynthetic process Source: UniProtKB
- lipid homeostasis Source: GO_Central
- lipid metabolic process Source: UniProtKB
- prostaglandin metabolic process Source: UniProtKB
- very long-chain fatty acid beta-oxidation Source: UniProtKB
- very long-chain fatty acid metabolic process Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
UniPathwayi | UPA00661 |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxisomal acyl-coenzyme A oxidase 1By similarity (EC:1.3.3.6By similarity)Short name: AOXBy similarity Alternative name(s): Palmitoyl-CoA oxidase1 Publication Cleaved into the following 3 chains: Peroxisomal acyl-CoA oxidase 1, A chainBy similarity Peroxisomal acyl-CoA oxidase 1, B chainBy similarity Peroxisomal acyl-CoA oxidase 1, C chainBy similarity |
Gene namesi | Name:ACOX1By similarity |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000030174 |
VGNCi | VGNC:25552, ACOX1 |
Subcellular locationi
Peroxisome
- Peroxisome By similarity
Peroxisome
- peroxisome Source: UniProtKB
Keywords - Cellular componenti
PeroxisomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000281996 | 1 – 660 | Peroxisomal acyl-CoA oxidase 1, A chainAdd BLAST | 660 | |
ChainiPRO_0000447496 | 1 – 438 | Peroxisomal acyl-CoA oxidase 1, B chainBy similarityAdd BLAST | 438 | |
ChainiPRO_0000447497 | 439 – 660 | Peroxisomal acyl-CoA oxidase 1, C chainBy similarityAdd BLAST | 222 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 26 | PhosphoserineBy similarity | 1 | |
Modified residuei | 65 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 89 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 90 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 216 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 241 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 255 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 267 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 272 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 349 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 437 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 437 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 446 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 446 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 500 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 512 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 512 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 542 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 637 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 637 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 643 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 649 | PhosphoserineBy similarity | 1 | |
Modified residuei | 651 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 654 | N6-succinyllysineBy similarity | 1 |
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 468 – 469 | CleavageBy similarity | 2 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | Q3SZP5 |
PeptideAtlasi | Q3SZP5 |
PRIDEi | Q3SZP5 |
Interactioni
Subunit structurei
Homodimer (By similarity).
Interacts with LONP2 (By similarity).
By similarityGO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000029362 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 658 – 660 | Microbody targeting signalBy similarity | 3 |
Sequence similaritiesi
Belongs to the acyl-CoA oxidase family.Curated
Phylogenomic databases
eggNOGi | KOG0136, Eukaryota |
GeneTreei | ENSGT00940000157287 |
InParanoidi | Q3SZP5 |
OMAi | TKWWIGA |
OrthoDBi | 416859at2759 |
Family and domain databases
CDDi | cd01150, AXO, 1 hit |
Gene3Di | 1.10.540.10, 1 hit |
InterProi | View protein in InterPro IPR034171, ACO IPR029320, Acyl-CoA_ox_N IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR012258, Acyl-CoA_oxidase IPR002655, Acyl-CoA_oxidase_C IPR036250, AcylCo_DH-like_C IPR037069, AcylCoA_DH/ox_N_sf IPR009100, AcylCoA_DH/oxidase_NM_dom |
PANTHERi | PTHR10909, PTHR10909, 1 hit |
Pfami | View protein in Pfam PF01756, ACOX, 1 hit PF02770, Acyl-CoA_dh_M, 1 hit PF14749, Acyl-CoA_ox_N, 1 hit |
PIRSFi | PIRSF000168, Acyl-CoA_oxidase, 1 hit |
SUPFAMi | SSF47203, SSF47203, 2 hits SSF56645, SSF56645, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q3SZP5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNPDLQKERA GASFNPELLT NVLDGSPENT RRRREIENLI LNDPDFQHEN
60 70 80 90 100
LNFLSRSQRY EVAVKKSAIM VQKMRKFGIA DPAEIMWFKK LHLVNFVEPV
110 120 130 140 150
GLNYSMFIPT LLNQGTTAQQ EKWLHSSKGL EIIGTYAQTE MGHGTHLRGL
160 170 180 190 200
ETTATYDPET QEFILNSPTV TSIKWWPGGL GKTSNHAIVL AQLFTQGKCY
210 220 230 240 250
GLHAFIVPIR ELGTHKPLPG ITVGDIGPKF GYDEMDNGYL KMDNYRIPRE
260 270 280 290 300
NMLMKHAQVK PDGTYVKPLN NKLTYGTMVF IRSFLVGESA RSLSKACTIA
310 320 330 340 350
VRYSAVRHQS EINPGEPEPQ ILDYQTQQYK LFPLLATAYA FQFVGAYMKE
360 370 380 390 400
TYLRINEDIG HGDLSELPEL HALTAGLKAF TSWTTNTAIE ACRMACGGHG
410 420 430 440 450
YSHCSGLPNI YVTFTPTCTF EGENTVMMLQ TARFLMKSYD QVHSGKLVCG
460 470 480 490 500
MVSYLNDLPS QRIQPQQVAV WPTMVDINSP DSLTEAYKLR AARLVEIAAK
510 520 530 540 550
NLQTEVIHRK SKEVAWNLTS IDLVRASEAH CHYVVVKLFT EKVLQIQEKS
560 570 580 590 600
IQAVLRRLCL LYSLYGISQN AGDFLQGSIM TESQITQVNG RIKELLTAIR
610 620 630 640 650
PDAVALVDAF DFQDVTLGSV LGRYDGNVYE NLFEWAKKSP LNKTEVHESY
660
KHLKSLQSKL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1MI26 | A0A3Q1MI26_BOVIN | Acyl-coenzyme A oxidase | ACOX1 | 660 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC102761 mRNA Translation: AAI02762.1 |
RefSeqi | NP_001030366.1, NM_001035289.3 |
Genome annotation databases
Ensembli | ENSBTAT00000029362; ENSBTAP00000029362; ENSBTAG00000030174 |
GeneIDi | 513996 |
KEGGi | bta:513996 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC102761 mRNA Translation: AAI02762.1 |
RefSeqi | NP_001030366.1, NM_001035289.3 |
3D structure databases
SMRi | Q3SZP5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000029362 |
Proteomic databases
PaxDbi | Q3SZP5 |
PeptideAtlasi | Q3SZP5 |
PRIDEi | Q3SZP5 |
Genome annotation databases
Ensembli | ENSBTAT00000029362; ENSBTAP00000029362; ENSBTAG00000030174 |
GeneIDi | 513996 |
KEGGi | bta:513996 |
Organism-specific databases
CTDi | 51 |
VEuPathDBi | HostDB:ENSBTAG00000030174 |
VGNCi | VGNC:25552, ACOX1 |
Phylogenomic databases
eggNOGi | KOG0136, Eukaryota |
GeneTreei | ENSGT00940000157287 |
InParanoidi | Q3SZP5 |
OMAi | TKWWIGA |
OrthoDBi | 416859at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00661 |
Gene expression databases
ExpressionAtlasi | Q3SZP5, baseline and differential |
Family and domain databases
CDDi | cd01150, AXO, 1 hit |
Gene3Di | 1.10.540.10, 1 hit |
InterProi | View protein in InterPro IPR034171, ACO IPR029320, Acyl-CoA_ox_N IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR012258, Acyl-CoA_oxidase IPR002655, Acyl-CoA_oxidase_C IPR036250, AcylCo_DH-like_C IPR037069, AcylCoA_DH/ox_N_sf IPR009100, AcylCoA_DH/oxidase_NM_dom |
PANTHERi | PTHR10909, PTHR10909, 1 hit |
Pfami | View protein in Pfam PF01756, ACOX, 1 hit PF02770, Acyl-CoA_dh_M, 1 hit PF14749, Acyl-CoA_ox_N, 1 hit |
PIRSFi | PIRSF000168, Acyl-CoA_oxidase, 1 hit |
SUPFAMi | SSF47203, SSF47203, 2 hits SSF56645, SSF56645, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACOX1_BOVIN | |
Accessioni | Q3SZP5Primary (citable) accession number: Q3SZP5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 3, 2007 |
Last sequence update: | October 11, 2005 | |
Last modified: | September 29, 2021 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families