UniProtKB - Q3SZI4 (1433T_BOVIN)
14-3-3 protein theta
YWHAQ
Functioni
Enzyme and pathway databases
Reactomei | R-BTA-111447, Activation of BAD and translocation to mitochondria R-BTA-5625740, RHO GTPases activate PKNs R-BTA-5628897, TP53 Regulates Metabolic Genes R-BTA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-BTA-9614399, Regulation of localization of FOXO transcription factors |
Names & Taxonomyi
Protein namesi | Recommended name: 14-3-3 protein theta |
Gene namesi | Name:YWHAQ |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:37047, YWHAQ |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058635 | 1 – 245 | 14-3-3 protein thetaAdd BLAST | 245 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 3 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 49 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 49 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 68 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 82 | 3'-nitrotyrosineBy similarity | 1 | |
Modified residuei | 92 | PhosphoserineBy similarity | 1 | |
Modified residuei | 104 | 3'-nitrotyrosineBy similarity | 1 | |
Modified residuei | 115 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 232 | Phosphoserine; by CK1By similarityCurated | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Nitration, Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | Q3SZI4 |
PeptideAtlasi | Q3SZI4 |
PRIDEi | Q3SZI4 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000002108, Expressed in spermatocyte and 18 other tissues |
ExpressionAtlasi | Q3SZI4, baseline |
Interactioni
Subunit structurei
Homodimer.
Interacts with CDK16 (By similarity).
Interacts with RGS7 (phosphorylated form).
Interacts with SSH1.
Interacts with CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm.
Interacts with GAB2.
Interacts with the 'Ser-241' phosphorylated form of PDPK1.
Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity).
Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity).
Interacts with SLITRK1 (By similarity).
Interacts with RIPOR2 (By similarity).
Interacts with INAVA; the interaction increases upon PRR (pattern recognition receptor) stimulation and is required for cellular signaling pathway activation and cytokine secretion (By similarity).
Interacts with MARK2, MARK3 and MARK4 (By similarity).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 56 | Interaction with phosphoserine on interacting proteinBy similarity | 1 | |
Sitei | 127 | Interaction with phosphoserine on interacting proteinBy similarity | 1 |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000032779 |
Structurei
Secondary structure
3D structure databases
SMRi | Q3SZI4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0841, Eukaryota |
GeneTreei | ENSGT01000000214500 |
HOGENOMi | CLU_058290_1_0_1 |
InParanoidi | Q3SZI4 |
OMAi | NGRTIEC |
OrthoDBi | 1176818at2759 |
TreeFami | TF102002 |
Family and domain databases
CDDi | cd10023, 14-3-3_theta, 1 hit |
Gene3Di | 1.20.190.20, 1 hit |
InterProi | View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain IPR042584, 14-3-3_theta |
PANTHERi | PTHR18860, PTHR18860, 1 hit |
Pfami | View protein in Pfam PF00244, 14-3-3, 1 hit |
PIRSFi | PIRSF000868, 14-3-3, 1 hit |
PRINTSi | PR00305, 1433ZETA |
SMARTi | View protein in SMART SM00101, 14_3_3, 1 hit |
SUPFAMi | SSF48445, SSF48445, 1 hit |
PROSITEi | View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MEKTELIQKA KLAEQAERYD DMATCMKAVT EQGAELSNEE RNLLSVAYKN
60 70 80 90 100
VVGGRRSAWR VISSIEQKTD TSDKKLQLIK DYREKVESEL RSICTTVLEL
110 120 130 140 150
LDKYLIANAT NPESKVFYLK MKGDYFRYLA EVACGDDRKQ TIDNSQGAYQ
160 170 180 190 200
EAFDISKKEM QPTHPIRLGL ALNFSVFYYE ILNNPELACT LAKTAFDEAI
210 220 230 240
AELDTLNEDS YKDSTLIMQL LRDNLTLWTS DSAGEECDAA EGAEN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1MQS3 | A0A3Q1MQS3_BOVIN | 14-3-3 protein theta | YWHAQ | 257 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT030749 mRNA Translation: ABS45065.1 BC102840 mRNA Translation: AAI02841.1 |
RefSeqi | NP_001071595.1, NM_001078127.2 |
Genome annotation databases
Ensembli | ENSBTAT00000032851; ENSBTAP00000032779; ENSBTAG00000002108 |
GeneIDi | 768311 |
KEGGi | bta:768311 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT030749 mRNA Translation: ABS45065.1 BC102840 mRNA Translation: AAI02841.1 |
RefSeqi | NP_001071595.1, NM_001078127.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6BCY | X-ray | 2.30 | A/B/E/F | 1-245 | [»] | |
6BD1 | X-ray | 2.35 | A/B/E/F | 1-245 | [»] | |
SMRi | Q3SZI4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000032779 |
Proteomic databases
PaxDbi | Q3SZI4 |
PeptideAtlasi | Q3SZI4 |
PRIDEi | Q3SZI4 |
Genome annotation databases
Ensembli | ENSBTAT00000032851; ENSBTAP00000032779; ENSBTAG00000002108 |
GeneIDi | 768311 |
KEGGi | bta:768311 |
Organism-specific databases
CTDi | 10971 |
VGNCi | VGNC:37047, YWHAQ |
Phylogenomic databases
eggNOGi | KOG0841, Eukaryota |
GeneTreei | ENSGT01000000214500 |
HOGENOMi | CLU_058290_1_0_1 |
InParanoidi | Q3SZI4 |
OMAi | NGRTIEC |
OrthoDBi | 1176818at2759 |
TreeFami | TF102002 |
Enzyme and pathway databases
Reactomei | R-BTA-111447, Activation of BAD and translocation to mitochondria R-BTA-5625740, RHO GTPases activate PKNs R-BTA-5628897, TP53 Regulates Metabolic Genes R-BTA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-BTA-9614399, Regulation of localization of FOXO transcription factors |
Gene expression databases
Bgeei | ENSBTAG00000002108, Expressed in spermatocyte and 18 other tissues |
ExpressionAtlasi | Q3SZI4, baseline |
Family and domain databases
CDDi | cd10023, 14-3-3_theta, 1 hit |
Gene3Di | 1.20.190.20, 1 hit |
InterProi | View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain IPR042584, 14-3-3_theta |
PANTHERi | PTHR18860, PTHR18860, 1 hit |
Pfami | View protein in Pfam PF00244, 14-3-3, 1 hit |
PIRSFi | PIRSF000868, 14-3-3, 1 hit |
PRINTSi | PR00305, 1433ZETA |
SMARTi | View protein in SMART SM00101, 14_3_3, 1 hit |
SUPFAMi | SSF48445, SSF48445, 1 hit |
PROSITEi | View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 1433T_BOVIN | |
Accessioni | Q3SZI4Primary (citable) accession number: Q3SZI4 Secondary accession number(s): A7E3X8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families