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UniProtKB - Q3SZI0 (MPI_BOVIN)
Protein
Mannose-6-phosphate isomerase
Gene
MPI
Organism
Bos taurus (Bovine)
Status
Functioni
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
By similarityCatalytic activityi
- EC:5.3.1.8
Cofactori
Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity
: GDP-alpha-D-mannose biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate. This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 110 | ZincBy similarity | 1 | |
Metal bindingi | 112 | ZincBy similarity | 1 | |
Metal bindingi | 137 | ZincBy similarity | 1 | |
Metal bindingi | 276 | ZincBy similarity | 1 | |
Active sitei | 295 | By similarity | 1 |
GO - Molecular functioni
- mannose-6-phosphate isomerase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- GDP-mannose biosynthetic process Source: GO_Central
- mannose to fructose-6-phosphate metabolic process Source: Ensembl
- protein glycosylation Source: GO_Central
Keywordsi
Molecular function | Isomerase |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
UniPathwayi | UPA00126;UER00423 |
Names & Taxonomyi
Protein namesi | Recommended name: Mannose-6-phosphate isomerase (EC:5.3.1.8)Alternative name(s): Phosphohexomutase Phosphomannose isomerase Short name: PMI |
Gene namesi | Name:MPI |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000005845 |
VGNCi | VGNC:50218, MPI |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Cytosol
- cytosol Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000245030 | 2 – 423 | Mannose-6-phosphate isomeraseAdd BLAST | 422 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 102 | PhosphoserineBy similarity | 1 | |
Modified residuei | 108 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PRIDEi | Q3SZI0 |
Family & Domainsi
Sequence similaritiesi
Belongs to the mannose-6-phosphate isomerase type 1 family.Curated
Phylogenomic databases
eggNOGi | KOG2757, Eukaryota |
GeneTreei | ENSGT00390000016075 |
InParanoidi | Q3SZI0 |
OMAi | MEEVRVF |
OrthoDBi | 1043197at2759 |
Family and domain databases
Gene3Di | 2.60.120.10, 2 hits |
InterProi | View protein in InterPro IPR001250, Man6P_Isoase-1 IPR016305, Mannose-6-P_Isomerase IPR018050, Pmannose_isomerase-type1_CS IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
PANTHERi | PTHR10309, PTHR10309, 1 hit |
Pfami | View protein in Pfam PF01238, PMI_typeI, 1 hit |
PIRSFi | PIRSF001480, Mannose-6-phosphate_isomerase, 1 hit |
PRINTSi | PR00714, MAN6PISMRASE |
SUPFAMi | SSF51182, SSF51182, 1 hit |
TIGRFAMsi | TIGR00218, manA, 1 hit |
PROSITEi | View protein in PROSITE PS00965, PMI_I_1, 1 hit PS00966, PMI_I_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q3SZI0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAQRVFPLS CVVQQYAWGK MGSNSEVARL LASSDPLAQI SEDRPYAELW
60 70 80 90 100
MGTHPRGDAK ILDNRISQKT LGQWIADNQD SLGSKVKDTF NGKLPFLFKV
110 120 130 140 150
LSVETALSIQ AHPNKELAEK LHLQAPQHYP DANHKPEMAI ALTPFQGLCG
160 170 180 190 200
FRPVEEIVTF LTKVPEFQFL IGDNAAAQLK QSLSQDSEAV TSALRSCFSH
210 220 230 240 250
LMKSEKKVVV EQLNLLVKRI SQQVAAGNNM EDICGELLLQ LHQQYPGDIG
260 270 280 290 300
CFAIYFLNLL TLKPGEAMFL EANVPHAYLK GDCVECMACS DNTVRAGLTP
310 320 330 340 350
KFIDVPTLCE MLSYTPSPSQ DRLFPPARSP EDPYLSIYDP PVPDFTVMKV
360 370 380 390 400
EVPGSVTEYK VLALDSASIL LVVQGTVTAS SPTAQAAIPL KRGGVLFIGA
410 420
NESVSLKLTV PKDLLMFRAC CLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC102844 mRNA Translation: AAI02845.1 |
RefSeqi | NP_001030361.1, NM_001035284.1 |
Genome annotation databases
Ensembli | ENSBTAT00000007684; ENSBTAP00000007684; ENSBTAG00000005845 |
GeneIDi | 513586 |
KEGGi | bta:513586 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC102844 mRNA Translation: AAI02845.1 |
RefSeqi | NP_001030361.1, NM_001035284.1 |
3D structure databases
SMRi | Q3SZI0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000007684 |
Proteomic databases
PRIDEi | Q3SZI0 |
Genome annotation databases
Ensembli | ENSBTAT00000007684; ENSBTAP00000007684; ENSBTAG00000005845 |
GeneIDi | 513586 |
KEGGi | bta:513586 |
Organism-specific databases
CTDi | 4351 |
VEuPathDBi | HostDB:ENSBTAG00000005845 |
VGNCi | VGNC:50218, MPI |
Phylogenomic databases
eggNOGi | KOG2757, Eukaryota |
GeneTreei | ENSGT00390000016075 |
InParanoidi | Q3SZI0 |
OMAi | MEEVRVF |
OrthoDBi | 1043197at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00126;UER00423 |
Gene expression databases
ExpressionAtlasi | Q3SZI0, baseline and differential |
Family and domain databases
Gene3Di | 2.60.120.10, 2 hits |
InterProi | View protein in InterPro IPR001250, Man6P_Isoase-1 IPR016305, Mannose-6-P_Isomerase IPR018050, Pmannose_isomerase-type1_CS IPR014710, RmlC-like_jellyroll IPR011051, RmlC_Cupin_sf |
PANTHERi | PTHR10309, PTHR10309, 1 hit |
Pfami | View protein in Pfam PF01238, PMI_typeI, 1 hit |
PIRSFi | PIRSF001480, Mannose-6-phosphate_isomerase, 1 hit |
PRINTSi | PR00714, MAN6PISMRASE |
SUPFAMi | SSF51182, SSF51182, 1 hit |
TIGRFAMsi | TIGR00218, manA, 1 hit |
PROSITEi | View protein in PROSITE PS00965, PMI_I_1, 1 hit PS00966, PMI_I_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MPI_BOVIN | |
Accessioni | Q3SZI0Primary (citable) accession number: Q3SZI0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2006 |
Last sequence update: | January 23, 2007 | |
Last modified: | September 29, 2021 | |
This is version 105 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families