Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GrpE protein homolog 1, mitochondrial

Gene

GRPEL1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
GrpE protein homolog 1, mitochondrial
Alternative name(s):
Mt-GrpE#1
Short name:
mt-GrpE
Gene namesi
Name:GRPEL1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Organism-specific databases

VGNCiVGNC:29665 GRPEL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27Mitochondrion1 PublicationAdd BLAST27
ChainiPRO_000024534528 – 217GrpE protein homolog 1, mitochondrialAdd BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94N6-acetyllysine; alternateBy similarity1
Modified residuei94N6-succinyllysine; alternateBy similarity1
Modified residuei100N6-acetyllysineBy similarity1
Modified residuei120N6-succinyllysineBy similarity1
Modified residuei215N6-acetyllysine; alternateBy similarity1
Modified residuei215N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3SZC1
PeptideAtlasiQ3SZC1
PRIDEiQ3SZC1

Expressioni

Gene expression databases

BgeeiENSBTAG00000010181

Interactioni

Subunit structurei

Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, GRPEL1 or GRPEL2, TIMM44, TIMM16/PAM16 and TIMM14/DNAJC19. Binds to HSP70, HSC70 and HSJ1B (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013431

Structurei

3D structure databases

ProteinModelPortaliQ3SZC1
SMRiQ3SZC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3003 Eukaryota
COG0576 LUCA
GeneTreeiENSGT00390000005589
HOGENOMiHOG000252083
HOVERGENiHBG051846
InParanoidiQ3SZC1
KOiK03687
OMAiYAYEKIA
OrthoDBiEOG091G0O5D
TreeFamiTF105284

Family and domain databases

CDDicd00446 GrpE, 1 hit
Gene3Di2.30.22.10, 1 hit
3.90.20.20, 1 hit
HAMAPiMF_01151 GrpE, 1 hit
InterProiView protein in InterPro
IPR000740 GrpE
IPR013805 GrpE_coiled_coil
IPR009012 GrpE_head
PANTHERiPTHR21237 PTHR21237, 1 hit
PfamiView protein in Pfam
PF01025 GrpE, 1 hit
PRINTSiPR00773 GRPEPROTEIN
SUPFAMiSSF51064 SSF51064, 1 hit
SSF58014 SSF58014, 1 hit
PROSITEiView protein in PROSITE
PS01071 GRPE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SZC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARCVRLAR GSLPAFALSL RSSPRLLCTA AKQKNNGQNL EEDAGQNEQK
60 70 80 90 100
TDLPSTEKTL MEEKVKLEEQ LKETMEKYKR ALADTENLRQ RSQKLVEEAK
110 120 130 140 150
LYGIQGFCKD LLEVADILEK ATQCVPQEEI RDDNPHLKSL YEGLVMTEVQ
160 170 180 190 200
IQKVFTKHGL LRLNPLGAKF DPYEHEALFH TPVEGKEPGT VALVNKVGYK
210
LHGRTLRPAL VGVVKGA
Length:217
Mass (Da):24,306
Last modified:October 11, 2005 - v1
Checksum:i4BC6FB43FC049FF5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28C → S AA sequence (PubMed:7711059).Curated1
Sequence conflicti36N → D AA sequence (PubMed:7711059).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102964 mRNA Translation: AAI02965.1
RefSeqiNP_001029673.1, NM_001034501.2
UniGeneiBt.48938

Genome annotation databases

EnsembliENSBTAT00000013431; ENSBTAP00000013431; ENSBTAG00000010181
GeneIDi515580
KEGGibta:515580

Similar proteinsi

Entry informationi

Entry nameiGRPE1_BOVIN
AccessioniPrimary (citable) accession number: Q3SZC1
Secondary accession number(s): Q9T2U7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health