UniProtKB - Q3SZ57 (FETA_BOVIN)
Protein
Alpha-fetoprotein
Gene
AFP
Organism
Bos taurus (Bovine)
Status
Functioni
Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 22 | Copper or nickelBy similarity | 1 |
GO - Molecular functioni
- fatty acid binding Source: GO_Central
- zinc ion binding Source: GO_Central
GO - Biological processi
- ovulation from ovarian follicle Source: Ensembl
- progesterone metabolic process Source: Ensembl
- SMAD protein signal transduction Source: Ensembl
Keywordsi
Ligand | Copper, Metal-binding, Nickel |
Enzyme and pathway databases
Reactomei | R-BTA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-BTA-8957275, Post-translational protein phosphorylation |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-fetoproteinAlternative name(s): Alpha-1-fetoprotein Alpha-fetoglobulin |
Gene namesi | Name:AFP |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:25717, AFP |
Subcellular locationi
Extracellular region or secreted
- Secreted PROSITE-ProRule annotation
Extracellular region or secreted
- extracellular space Source: Ensembl
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | By similarityAdd BLAST | 18 | |
ChainiPRO_0000246080 | 19 – 610 | Alpha-fetoproteinBy similarityAdd BLAST | 592 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 99 ↔ 114 | PROSITE-ProRule annotation | ||
Modified residuei | 111 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 113 ↔ 124 | PROSITE-ProRule annotation | ||
Modified residuei | 115 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 148 ↔ 193 | PROSITE-ProRule annotation | ||
Disulfide bondi | 192 ↔ 201 | PROSITE-ProRule annotation | ||
Glycosylationi | 197 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 224 ↔ 270 | PROSITE-ProRule annotation | ||
Glycosylationi | 251 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 269 ↔ 277 | PROSITE-ProRule annotation | ||
Disulfide bondi | 289 ↔ 303 | PROSITE-ProRule annotation | ||
Disulfide bondi | 302 ↔ 314 | PROSITE-ProRule annotation | ||
Modified residuei | 345 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 385 ↔ 394 | PROSITE-ProRule annotation | ||
Disulfide bondi | 417 ↔ 463 | PROSITE-ProRule annotation | ||
Modified residuei | 445 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 462 ↔ 473 | PROSITE-ProRule annotation | ||
Disulfide bondi | 486 ↔ 502 | PROSITE-ProRule annotation | ||
Disulfide bondi | 501 ↔ 512 | PROSITE-ProRule annotation | ||
Disulfide bondi | 539 ↔ 584 | PROSITE-ProRule annotation | ||
Disulfide bondi | 583 ↔ 592 | PROSITE-ProRule annotation |
Post-translational modificationi
Sulfated.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, SulfationProteomic databases
PaxDbi | Q3SZ57 |
PeptideAtlasi | Q3SZ57 |
PRIDEi | Q3SZ57 |
PTM databases
UniCarbKBi | Q3SZ57 |
Expressioni
Tissue specificityi
Plasma.
Gene expression databases
Bgeei | ENSBTAG00000017131, Expressed in adult mammalian kidney and 4 other tissues |
ExpressionAtlasi | Q3SZ57, baseline |
Interactioni
Subunit structurei
Dimeric and trimeric forms have been found in addition to the monomeric form.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000022772 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 210 | Albumin 1PROSITE-ProRule annotationAdd BLAST | 192 | |
Domaini | 211 – 403 | Albumin 2PROSITE-ProRule annotationAdd BLAST | 193 | |
Domaini | 404 – 602 | Albumin 3PROSITE-ProRule annotationAdd BLAST | 199 |
Sequence similaritiesi
Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502R7EA, Eukaryota |
GeneTreei | ENSGT00390000000113 |
HOGENOMi | CLU_030161_1_0_1 |
InParanoidi | Q3SZ57 |
OMAi | HEECCRG |
OrthoDBi | 906547at2759 |
TreeFami | TF335561 |
Family and domain databases
CDDi | cd00015, ALBUMIN, 3 hits |
InterProi | View protein in InterPro IPR000264, ALB/AFP/VDB IPR020858, Serum_albumin-like IPR021177, Serum_albumin/AFP/Afamin IPR020857, Serum_albumin_CS IPR014760, Serum_albumin_N |
PANTHERi | PTHR11385, PTHR11385, 1 hit |
Pfami | View protein in Pfam PF00273, Serum_albumin, 3 hits |
PIRSFi | PIRSF002520, Serum_albumin_subgroup, 1 hit |
PRINTSi | PR00803, AFETOPROTEIN PR00802, SERUMALBUMIN |
SMARTi | View protein in SMART SM00103, ALBUMIN, 3 hits |
SUPFAMi | SSF48552, SSF48552, 3 hits |
PROSITEi | View protein in PROSITE PS00212, ALBUMIN_1, 2 hits PS51438, ALBUMIN_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q3SZ57-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKWVVSFFLL FLLNFSDSRT MHKNAYGIDS ILDSSPCSSG TNLVGLATIF
60 70 80 90 100
FAQSVQGATY EEVSQMVKDV LTIIEKPTGS KQPAGCLENQ VSAFLEEICR
110 120 130 140 150
EKEIPEKYGL SDCCSRTGEE RHDCFLAHKK AAPASIPPFP VLEPVTSCKS
160 170 180 190 200
YKENRELFIN RYIYEIARRH PVLYAPTILS VANQYNKIIP HCCKAENATE
210 220 230 240 250
CFETKVTSIT KELRESSLLN QHICAVMGKF GPRTFRAITV TKVSQKFPKA
260 270 280 290 300
NFTEIQKLVM DVAHIHEECC KGNVLECLQD GERVMSYICS QQDILSRQIA
310 320 330 340 350
ECCKLPTTLE LGHCIIHAEN DDKPEGLSPN VNRFLGDRDF NQLSSRDKDL
360 370 380 390 400
SMARFTYEYS RRHTKLAVPI ILRVAKGYQE LLEKCSQSEN PSECQDKGEE
410 420 430 440 450
ELEKYIQESQ ALAKRSCGLF QKLGEYYLQN AFLVAYTKKA PQLTSPELMA
460 470 480 490 500
LTRKMANAGA ICCHLSEDKQ LACGEGVADL IIGHLCIRHE ENPINPGVDQ
510 520 530 540 550
CCTSSYSNRR PCFSSLVVDE TYVPPPFSDD KFIFHKDLCQ VQGVPLQTMK
560 570 580 590 600
QQFLINLVKQ KPQITEEQLE TVVADFSGLL EKCCQSQEQE VCFTEEGPAL
610
ISKTRAALGV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1MIW0 | A0A3Q1MIW0_BOVIN | Alpha-fetoprotein | AFP | 601 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC103123 mRNA Translation: AAI03124.1 |
RefSeqi | NP_001029434.1, NM_001034262.2 |
Genome annotation databases
Ensembli | ENSBTAT00000022772; ENSBTAP00000022772; ENSBTAG00000017131 |
GeneIDi | 506011 |
KEGGi | bta:506011 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC103123 mRNA Translation: AAI03124.1 |
RefSeqi | NP_001029434.1, NM_001034262.2 |
3D structure databases
SMRi | Q3SZ57 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000022772 |
PTM databases
UniCarbKBi | Q3SZ57 |
Proteomic databases
PaxDbi | Q3SZ57 |
PeptideAtlasi | Q3SZ57 |
PRIDEi | Q3SZ57 |
Genome annotation databases
Ensembli | ENSBTAT00000022772; ENSBTAP00000022772; ENSBTAG00000017131 |
GeneIDi | 506011 |
KEGGi | bta:506011 |
Organism-specific databases
CTDi | 174 |
VGNCi | VGNC:25717, AFP |
Phylogenomic databases
eggNOGi | ENOG502R7EA, Eukaryota |
GeneTreei | ENSGT00390000000113 |
HOGENOMi | CLU_030161_1_0_1 |
InParanoidi | Q3SZ57 |
OMAi | HEECCRG |
OrthoDBi | 906547at2759 |
TreeFami | TF335561 |
Enzyme and pathway databases
Reactomei | R-BTA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-BTA-8957275, Post-translational protein phosphorylation |
Gene expression databases
Bgeei | ENSBTAG00000017131, Expressed in adult mammalian kidney and 4 other tissues |
ExpressionAtlasi | Q3SZ57, baseline |
Family and domain databases
CDDi | cd00015, ALBUMIN, 3 hits |
InterProi | View protein in InterPro IPR000264, ALB/AFP/VDB IPR020858, Serum_albumin-like IPR021177, Serum_albumin/AFP/Afamin IPR020857, Serum_albumin_CS IPR014760, Serum_albumin_N |
PANTHERi | PTHR11385, PTHR11385, 1 hit |
Pfami | View protein in Pfam PF00273, Serum_albumin, 3 hits |
PIRSFi | PIRSF002520, Serum_albumin_subgroup, 1 hit |
PRINTSi | PR00803, AFETOPROTEIN PR00802, SERUMALBUMIN |
SMARTi | View protein in SMART SM00103, ALBUMIN, 3 hits |
SUPFAMi | SSF48552, SSF48552, 3 hits |
PROSITEi | View protein in PROSITE PS00212, ALBUMIN_1, 2 hits PS51438, ALBUMIN_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FETA_BOVIN | |
Accessioni | Q3SZ57Primary (citable) accession number: Q3SZ57 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2006 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families