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Protein

Recombining binding protein suppressor of hairless

Gene

RBPJ

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi45 – 52By similarity8
DNA bindingi179 – 188By similarity10
DNA bindingi252 – 284By similarityAdd BLAST33

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processNotch signaling pathway, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-BTA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-BTA-2197563 NOTCH2 intracellular domain regulates transcription
R-BTA-350054 Notch-HLH transcription pathway
R-BTA-8941856 RUNX3 regulates NOTCH signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Recombining binding protein suppressor of hairless
Alternative name(s):
J kappa-recombination signal-binding protein
RBP-J kappa
Gene namesi
Name:RBPJ
Synonyms:RBPSUH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Organism-specific databases

VGNCiVGNC:53775 RBPJ

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002600761 – 487Recombining binding protein suppressor of hairlessAdd BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ3SZ41
PRIDEiQ3SZ41

Expressioni

Gene expression databases

BgeeiENSBTAG00000003602 Expressed in 10 organ(s), highest expression level in spleen

Interactioni

Subunit structurei

Interacts with activated NOTCH1, NOTCH2 or NOTCH3. Interacts with MINT/SHARP. This interaction may mediate the recruitment of large corepressor complexes containing proteins such as HDAC1, HDAC2, NCOR2, SAP30, FHL1/KYOT2 and CIR1. Interacts with EP300, MAML1 and PTF1A. Interacts with RITA1, leading to nuclear export, prevent the interaction between RBPJ and NICD product and subsequent down-regulation of the Notch signaling pathway. Interacts with SNW1. Interacts with CHCHD2 and CXXC5. Interacts with BEND6 (via BEN domain). Interacts with NKAPL. Interacts with ZMIZ1. Interacts with RBM15.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004696

Structurei

3D structure databases

ProteinModelPortaliQ3SZ41
SMRiQ3SZ41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini342 – 432IPT/TIGAdd BLAST91

Sequence similaritiesi

Belongs to the Su(H) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3743 Eukaryota
ENOG410XV7K LUCA
GeneTreeiENSGT00390000005197
HOGENOMiHOG000253907
HOVERGENiHBG006618
InParanoidiQ3SZ41
KOiK06053
OMAiDMPHFGL
OrthoDBiEOG091G057S
TreeFamiTF314117

Family and domain databases

CDDicd01176 IPT_RBP-Jkappa, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.1450, 1 hit
InterProiView protein in InterPro
IPR015350 Beta-trefoil_DNA-bd_dom
IPR036358 BTD_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR008967 p53-like_TF_DNA-bd
IPR015351 RBP-J/Cbf11/Cbf12_DNA-bd
IPR037095 RBP-J/Cbf11/Cbf12_DNA-bd_sf
IPR038007 RBP-Jkappa_IPT
PfamiView protein in Pfam
PF09270 BTD, 1 hit
PF09271 LAG1-DNAbind, 1 hit
SMARTiView protein in SMART
SM01268 BTD, 1 hit
SM01267 LAG1_DNAbind, 1 hit
SUPFAMiSSF110217 SSF110217, 1 hit
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

Q3SZ41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPVVTGKFG ERPPPKRLTR EAMRNYLKER GDQTVLILHA KVAQKSYGNE
60 70 80 90 100
KRFFCPPPCV YLMGSGWKKK KEQMERDGCS EQESQPCAFI GIGNSDQEMQ
110 120 130 140 150
QLNLEGKNYC TAKTLYISDS DKRKHFMLSV KMFYGNSDDI GVFLSKRIKV
160 170 180 190 200
ISKPSKKKQS LKNADLCIAS GTKVALFNRL RSQTVSTRYL HVEGGNFHAS
210 220 230 240 250
SQQWGAFYIH LLDDDESEGE EFTVRDGYIH YGQTVKLVCS VTGMALPRLI
260 270 280 290 300
IRKVDKQTAL LDADDPVSQL HKCAFYLKDT ERMYLCLSQE RIIQFQATPC
310 320 330 340 350
PKEPNKEMIN DGASWTIIST DKAEYTFYEG MGPVLAPVTP VPVVESLQLN
360 370 380 390 400
GGGDVAMLEL TGQNFTPNLR VWFGDVEAET MYRCGESMLC VVPDISAFRE
410 420 430 440 450
GWRWVRQPVQ VPVTLVRNDG IIYSTSLTFT YTPEPGPRPH CSAAGAILRA
460 470 480
NSSQVPPNES NTNSEGSYTN VSTNSTSVTS STATVVS
Length:487
Mass (Da):54,341
Last modified:October 11, 2005 - v1
Checksum:i0EA722EED8647942
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103164 mRNA Translation: AAI03165.1
RefSeqiNP_001070469.1, NM_001077001.2
UniGeneiBt.48972

Genome annotation databases

EnsembliENSBTAT00000004696; ENSBTAP00000004696; ENSBTAG00000003602
GeneIDi767928
KEGGibta:767928

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103164 mRNA Translation: AAI03165.1
RefSeqiNP_001070469.1, NM_001077001.2
UniGeneiBt.48972

3D structure databases

ProteinModelPortaliQ3SZ41
SMRiQ3SZ41
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004696

Proteomic databases

PaxDbiQ3SZ41
PRIDEiQ3SZ41

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000004696; ENSBTAP00000004696; ENSBTAG00000003602
GeneIDi767928
KEGGibta:767928

Organism-specific databases

CTDi3516
VGNCiVGNC:53775 RBPJ

Phylogenomic databases

eggNOGiKOG3743 Eukaryota
ENOG410XV7K LUCA
GeneTreeiENSGT00390000005197
HOGENOMiHOG000253907
HOVERGENiHBG006618
InParanoidiQ3SZ41
KOiK06053
OMAiDMPHFGL
OrthoDBiEOG091G057S
TreeFamiTF314117

Enzyme and pathway databases

ReactomeiR-BTA-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-BTA-2197563 NOTCH2 intracellular domain regulates transcription
R-BTA-350054 Notch-HLH transcription pathway
R-BTA-8941856 RUNX3 regulates NOTCH signaling

Gene expression databases

BgeeiENSBTAG00000003602 Expressed in 10 organ(s), highest expression level in spleen

Family and domain databases

CDDicd01176 IPT_RBP-Jkappa, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.1450, 1 hit
InterProiView protein in InterPro
IPR015350 Beta-trefoil_DNA-bd_dom
IPR036358 BTD_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR008967 p53-like_TF_DNA-bd
IPR015351 RBP-J/Cbf11/Cbf12_DNA-bd
IPR037095 RBP-J/Cbf11/Cbf12_DNA-bd_sf
IPR038007 RBP-Jkappa_IPT
PfamiView protein in Pfam
PF09270 BTD, 1 hit
PF09271 LAG1-DNAbind, 1 hit
SMARTiView protein in SMART
SM01268 BTD, 1 hit
SM01267 LAG1_DNAbind, 1 hit
SUPFAMiSSF110217 SSF110217, 1 hit
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSUH_BOVIN
AccessioniPrimary (citable) accession number: Q3SZ41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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