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Protein

Cyclic AMP-responsive element-binding protein 3-like protein 3

Gene

CREB3L3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds the cAMP response element (CRE). Activates transcription through box-B element and CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Unfolded protein response

Enzyme and pathway databases

ReactomeiR-BTA-8874211 CREB3 factors activate genes

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-responsive element-binding protein 3-like protein 3
Short name:
cAMP-responsive element-binding protein 3-like protein 3
Cleaved into the following chain:
Gene namesi
Name:CREB3L3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:27696 CREB3L3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 317CytoplasmicSequence analysisAdd BLAST317
Transmembranei318 – 338Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini339 – 456LumenalSequence analysisAdd BLAST118

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002880731 – 456Cyclic AMP-responsive element-binding protein 3-like protein 3Add BLAST456
ChainiPRO_00002962151 – ?Processed cyclic AMP-responsive element-binding protein 3-like protein 3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi408N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi415N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2) (By similarity).By similarity
N-glycosylation is required for optimal proteolytic activation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei358 – 359Cleavage; by PS1By similarity2

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3SYZ3
PRIDEiQ3SYZ3

Expressioni

Gene expression databases

BgeeiENSBTAG00000010215 Expressed in 3 organ(s), highest expression level in liver

Interactioni

Subunit structurei

Binds DNA as a dimer. Probably homodimerizes. Probably forms a heterodimer with ATF6. Interacts with ATF6 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013478

Structurei

3D structure databases

ProteinModelPortaliQ3SYZ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini238 – 301bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni240 – 269Basic motifPROSITE-ProRule annotationAdd BLAST30
Regioni280 – 301Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi181 – 184Poly-Ser4

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0709 Eukaryota
ENOG410ZZQM LUCA
GeneTreeiENSGT00520000055538
HOGENOMiHOG000059566
HOVERGENiHBG090496
InParanoidiQ3SYZ3
KOiK09048
OMAiDLEMWSP
OrthoDBiEOG091G07QR
TreeFamiTF316079

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR029806 CREBH
PANTHERiPTHR22952:SF98 PTHR22952:SF98, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3SYZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGDLAIGKM ASSTSPMGPI DSLELLDLLF DRQDGVLRHV ELGEDWGHGE
60 70 80 90 100
DQVLPGADSD DFLNSILGSG DSDSPTWSPA ASDSGISEDL PSDTQDTPPH
110 120 130 140 150
GGVPATPAGC HSVESGKGPC PSYHPGPTCP ARHLGPVAPR LETSVAIDLE
160 170 180 190 200
MWSPGVYAEE QTDLADSPSR YNLTVKDLLL SSSSGDLQQH HLAAPHLLRP
210 220 230 240 250
GTGHCQELVL TEDEKKLLAK EGITLPTQLP LTKYEERMLK KIRRKIRNKQ
260 270 280 290 300
SAQESRKKKK EYIDGLETRM SACTAQNQEL QRKVLHLEKQ NLSLLEQLKK
310 320 330 340 350
LQAIVVQSTS KSAQTGTCIA VLLFSFALIV LPSISPFASN RAESPGDFAP
360 370 380 390 400
VRVFSRTLHN DAASRVAPDT APGSEAPGPG PNTGALQERS PGSPPGEWES
410 420 430 440 450
QDTRALDNST EDLDNSTLVQ GNSVKELDQA TLLDCAPPEP AVSPGHVGLE

AAGGEL
Length:456
Mass (Da):48,689
Last modified:October 11, 2005 - v1
Checksum:i7EB1705FA08DEBF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103320 mRNA Translation: AAI03321.1
RefSeqiNP_001029604.1, NM_001034432.2
UniGeneiBt.18871

Genome annotation databases

EnsembliENSBTAT00000013478; ENSBTAP00000013478; ENSBTAG00000010215
GeneIDi513010
KEGGibta:513010

Similar proteinsi

Entry informationi

Entry nameiCR3L3_BOVIN
AccessioniPrimary (citable) accession number: Q3SYZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2005
Last modified: September 12, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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