Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

AP-1 complex subunit mu-2

Gene

AP1M2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.By similarity1 Publication

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-2132295 MHC class II antigen presentation
R-BTA-432720 Lysosome Vesicle Biogenesis
R-BTA-432722 Golgi Associated Vesicle Biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit mu-2
Alternative name(s):
AP-mu chain family member mu1B
Adaptor protein complex AP-1 subunit mu-2
Adaptor-related protein complex 1 subunit mu-2
Clathrin assembly protein complex 1 mu-2 medium chain 2
Golgi adaptor HA1/AP1 adaptin mu-2 subunit
Mu-adaptin 2
Mu1B-adaptin
Gene namesi
Name:AP1M2By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:25980 AP1M2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002405911 – 423AP-1 complex subunit mu-2Add BLAST423

Post-translational modificationi

Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3SYW1
PeptideAtlasiQ3SYW1
PRIDEiQ3SYW1

Expressioni

Gene expression databases

BgeeiENSBTAG00000021160

Interactioni

Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043007

Structurei

3D structure databases

ProteinModelPortaliQ3SYW1
SMRiQ3SYW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 421MHDPROSITE-ProRule annotationAdd BLAST254

Sequence similaritiesi

Belongs to the adaptor complexes medium subunit family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0937 Eukaryota
ENOG410XPFS LUCA
GeneTreeiENSGT00530000062779
HOGENOMiHOG000173247
HOVERGENiHBG050516
InParanoidiQ3SYW1
KOiK12393
OMAiITQQGNK
OrthoDBiEOG091G06XI
TreeFamiTF300393

Family and domain databases

InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR022775 AP_mu_sigma_su
IPR001392 Clathrin_mu
IPR018240 Clathrin_mu_CS
IPR011012 Longin-like_dom_sf
IPR028565 MHD
PfamiView protein in Pfam
PF00928 Adap_comp_sub, 1 hit
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF005992 Clathrin_mu, 1 hit
PRINTSiPR00314 CLATHRINADPT
SUPFAMiSSF49447 SSF49447, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00990 CLAT_ADAPTOR_M_1, 1 hit
PS00991 CLAT_ADAPTOR_M_2, 1 hit
PS51072 MHD, 1 hit

Sequencei

Sequence statusi: Complete.

Q3SYW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASAVFILD VKGKPLISRN YKGDVAMSEI DHFMPLLMQR EEEGALTPLL
60 70 80 90 100
SHGRVHFLWI KYSNLYLVAT TLKNANASLV YSFLYKIVEV FSEYFKELEE
110 120 130 140 150
ESIRDNFVIV YELLDELMDF GFPQTTDSKI LQEYITQQGN KLETGKSRVP
160 170 180 190 200
PTVTNAVSWR SEGIKYKKNE VFIDVIESVN LLVNANGSVL LSEIVGSIKL
210 220 230 240 250
KVFLSGMPEL RLGLNDRVLF ELTGRSKNKS VELEDVKFHQ CVRLSRFDND
260 270 280 290 300
RTISFIPPDG DFELMSYRLS TQVKPLIWIE SVIEKFSHSR VEIMVKAKGQ
310 320 330 340 350
FKKQSVANGV EISVPVPSDA DSPRFKTSVG SAKYVPEKNT VIWSIKSFPG
360 370 380 390 400
GKEYLMRAHF GLPSVEKEEV EGRPPIGVKF EIPYFTVSGI QVRYMKIIEK
410 420
SGYQALPWVR YITQSGDYQL RTS
Length:423
Mass (Da):48,150
Last modified:January 23, 2007 - v3
Checksum:iD86D5545582E361F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103358 mRNA Translation: AAI03359.1
RefSeqiNP_001029683.1, NM_001034511.1
UniGeneiBt.38351

Genome annotation databases

EnsembliENSBTAT00000045632; ENSBTAP00000043007; ENSBTAG00000021160
GeneIDi515766
KEGGibta:515766

Similar proteinsi

Entry informationi

Entry nameiAP1M2_BOVIN
AccessioniPrimary (citable) accession number: Q3SYW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 89 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health