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Protein

Chymotrypsin-C

Gene

Ctrc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has chymotrypsin-type protease activity and hypocalcemic activity.By similarity

Catalytic activityi

Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74Charge relay systemBy similarity1
Active sitei121Charge relay systemBy similarity1
Active sitei216Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.157

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-C (EC:3.4.21.2)
Gene namesi
Name:Ctrc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1923951 Ctrc

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000028861617 – 29Activation peptideBy similarityAdd BLAST13
ChainiPRO_000028861730 – 268Chymotrypsin-CAdd BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi17 ↔ 141PROSITE-ProRule annotation
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi59 ↔ 75PROSITE-ProRule annotation
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi155 ↔ 222PROSITE-ProRule annotation
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi186 ↔ 202PROSITE-ProRule annotation
Disulfide bondi212 ↔ 243PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ3SYP2
PRIDEiQ3SYP2

Expressioni

Gene expression databases

CleanExiMM_CTRC

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039879

Structurei

3D structure databases

ProteinModelPortaliQ3SYP2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 267Peptidase S1PROSITE-ProRule annotationAdd BLAST238

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ3SYP2
KOiK01311
PhylomeDBiQ3SYP2

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q3SYP2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGITVLAAI LACASSCGDP TFPPNLSARV VGGEDAVPNS WPWQVSLQYL
60 70 80 90 100
RDDTWRHTCG GSLITTSHVL TAAHCINTNL TYRVGLGKYN LTVEDEEGSV
110 120 130 140 150
YAEVDTIYVH EKWNRLLLWN DIAIIKLAEP VELSDTIQVA CIPEQDSLLP
160 170 180 190 200
GDYPCYVTGW GRLWTNGPIA EVLQQGLQPI VNHTTCSRLD WWFIKVRETM
210 220 230 240 250
VCAGGDGVIS ACNGDSGGPL NCPVEDGLWQ VHGIVSFGSS RGCNTYKKPV
260
VFTRVSAYID WIKEKIQL
Length:268
Mass (Da):29,470
Last modified:October 11, 2005 - v1
Checksum:iF5B813882E5F93C4
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QL79E9QL79_MOUSE
Chymotrypsin-C
Ctrc
267Annotation score:
A2AAC0A2AAC0_MOUSE
Chymotrypsin-C
Ctrc
235Annotation score:
H3BLM3H3BLM3_MOUSE
Chymotrypsin-C
Ctrc
78Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103715 mRNA Translation: AAI03716.1
BC115516 mRNA Translation: AAI15517.1
BC115517 mRNA Translation: AAI15518.1
RefSeqiNP_001029047.1, NM_001033875.2
UniGeneiMm.489680

Genome annotation databases

GeneIDi76701
KEGGimmu:76701
UCSCiuc008vpk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC103715 mRNA Translation: AAI03716.1
BC115516 mRNA Translation: AAI15517.1
BC115517 mRNA Translation: AAI15518.1
RefSeqiNP_001029047.1, NM_001033875.2
UniGeneiMm.489680

3D structure databases

ProteinModelPortaliQ3SYP2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039879

Protein family/group databases

MEROPSiS01.157

Proteomic databases

PaxDbiQ3SYP2
PRIDEiQ3SYP2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi76701
KEGGimmu:76701
UCSCiuc008vpk.1 mouse

Organism-specific databases

CTDi11330
MGIiMGI:1923951 Ctrc

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ3SYP2
KOiK01311
PhylomeDBiQ3SYP2

Miscellaneous databases

ChiTaRSiCtrc mouse
PROiPR:Q3SYP2
SOURCEiSearch...

Gene expression databases

CleanExiMM_CTRC

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTRC_MOUSE
AccessioniPrimary (citable) accession number: Q3SYP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2005
Last modified: May 10, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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