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Protein

2-acylglycerol O-acyltransferase 2

Gene

MOGAT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.1 Publication

Catalytic activityi

Acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.

Enzyme regulationi

Inhibited by oleic acid and sphingosine, while it is stimulated by phosphatidylcholine, phosphatidylserine and phosphatidic acid.By similarity

Kineticsi

  1. KM=45 µM for sn-1-monooleoylglycerol1 Publication

    Pathwayi: triacylglycerol biosynthesis

    This protein is involved in the pathway triacylglycerol biosynthesis, which is part of Glycerolipid metabolism.
    View all proteins of this organism that are known to be involved in the pathway triacylglycerol biosynthesis and in Glycerolipid metabolism.

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Molecular functionAcyltransferase, Transferase
    Biological processGlycerol metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BRENDAi2.3.1.22 2681
    ReactomeiR-HSA-75109 Triglyceride biosynthesis
    UniPathwayiUPA00282

    Chemistry databases

    SwissLipidsiSLP:000000299

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-acylglycerol O-acyltransferase 2 (EC:2.3.1.22)
    Alternative name(s):
    Acyl-CoA:monoacylglycerol acyltransferase 2
    Short name:
    MGAT2
    Short name:
    hMGAT2
    Diacylglycerol O-acyltransferase candidate 5
    Short name:
    hDC5
    Diacylglycerol acyltransferase 2-like protein 5
    Monoacylglycerol O-acyltransferase 2
    Gene namesi
    Name:MOGAT2
    Synonyms:DC5, DGAT2L5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 11

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000166391.14
    HGNCiHGNC:23248 MOGAT2
    MIMi610270 gene
    neXtProtiNX_Q3SYC2

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Transmembranei23 – 37HelicalSequence analysisAdd BLAST15
    Transmembranei38 – 59HelicalSequence analysisAdd BLAST22
    Transmembranei103 – 123HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi80168
    OpenTargetsiENSG00000166391
    PharmGKBiPA134936582

    Chemistry databases

    ChEMBLiCHEMBL2439944

    Polymorphism and mutation databases

    BioMutaiMOGAT2
    DMDMi114150036

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002490621 – 3342-acylglycerol O-acyltransferase 2Add BLAST334

    Proteomic databases

    PaxDbiQ3SYC2
    PeptideAtlasiQ3SYC2
    PRIDEiQ3SYC2
    ProteomicsDBi61855
    61856 [Q3SYC2-2]
    61857 [Q3SYC2-3]

    PTM databases

    iPTMnetiQ3SYC2
    PhosphoSitePlusiQ3SYC2

    Expressioni

    Tissue specificityi

    Highly expressed in liver, small intestine, colon, stomach and kidney.2 Publications

    Gene expression databases

    BgeeiENSG00000166391
    CleanExiHS_MOGAT2
    GenevisibleiQ3SYC2 HS

    Organism-specific databases

    HPAiHPA028834

    Interactioni

    Protein-protein interaction databases

    BioGridi123154, 2 interactors
    STRINGi9606.ENSP00000198801

    Chemistry databases

    BindingDBiQ3SYC2

    Structurei

    3D structure databases

    ProteinModelPortaliQ3SYC2
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0831 Eukaryota
    ENOG410XTG3 LUCA
    GeneTreeiENSGT00750000117391
    HOGENOMiHOG000179738
    HOVERGENiHBG065791
    InParanoidiQ3SYC2
    KOiK14457
    OMAiRLGFIKI
    OrthoDBiEOG091G0BGQ
    PhylomeDBiQ3SYC2
    TreeFamiTF314707

    Family and domain databases

    InterProiView protein in InterPro
    IPR007130 DAGAT
    PfamiView protein in Pfam
    PF03982 DAGAT, 1 hit

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q3SYC2-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MVEFAPLFMP WERRLQTLAV LQFVFSFLAL AEICTVGFIA LLFTRFWLLT
    60 70 80 90 100
    VLYAAWWYLD RDKPRQGGRH IQAIRCWTIW KYMKDYFPIS LVKTAELDPS
    110 120 130 140 150
    RNYIAGFHPH GVLAVGAFAN LCTESTGFSS IFPGIRPHLM MLTLWFRAPF
    160 170 180 190 200
    FRDYIMSAGL VTSEKESAAH ILNRKGGGNL LGIIVGGAQE ALDARPGSFT
    210 220 230 240 250
    LLLRNRKGFV RLALTHGAPL VPIFSFGEND LFDQIPNSSG SWLRYIQNRL
    260 270 280 290 300
    QKIMGISLPL FHGRGVFQYS FGLIPYRRPI TTVVGKPIEV QKTLHPSEEE
    310 320 330
    VNQLHQRYIK ELCNLFEAHK LKFNIPADQH LEFC
    Length:334
    Mass (Da):38,196
    Last modified:September 5, 2006 - v2
    Checksum:i57C4A964BAFA76BD
    GO
    Isoform 2 (identifier: Q3SYC2-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-82: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:252
    Mass (Da):28,283
    Checksum:i902B6B67B2E8CC02
    GO
    Isoform 3 (identifier: Q3SYC2-3) [UniParc]FASTAAdd to basket
    Also known as: MGAT2V, Trunc

    The sequence of this isoform differs from the canonical sequence as follows:
         218-284: APLVPIFSFG...PYRRPITTVV → YQASGKSTLG...PQRRLSDLRN
         285-334: Missing.

    Show »
    Length:284
    Mass (Da):32,298
    Checksum:iE56F74332AF8D2DE
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti142L → P in BAB15436 (PubMed:14702039).Curated1
    Sequence conflicti267F → L in BAC87534 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_0273909M → V1 PublicationCorresponds to variant dbSNP:rs554202Ensembl.1
    Natural variantiVAR_048857196P → H. Corresponds to variant dbSNP:rs34582952Ensembl.1
    Natural variantiVAR_027391313C → Y. Corresponds to variant dbSNP:rs12281468Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0203581 – 82Missing in isoform 2. 1 PublicationAdd BLAST82
    Alternative sequenceiVSP_020359218 – 284APLVP…ITTVV → YQASGKSTLGSVGNWQGFYF GGKMAETNADSILVEIFSPF TIKIIFWCLMPKYLEKFPQR RLSDLRN in isoform 3. 1 PublicationAdd BLAST67
    Alternative sequenceiVSP_020360285 – 334Missing in isoform 3. 1 PublicationAdd BLAST50

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY157608 mRNA Translation: AAO23672.1
    AK026297 mRNA Translation: BAB15436.1
    AK128620 mRNA Translation: BAC87534.1
    AK291998 mRNA Translation: BAF84687.1
    CH471076 Genomic DNA Translation: EAW74983.1
    BC103876 mRNA Translation: AAI03877.1
    BC103877 mRNA Translation: AAI03878.1
    BC103878 mRNA Translation: AAI03879.1
    CCDSiCCDS8240.1 [Q3SYC2-1]
    RefSeqiNP_079374.2, NM_025098.3 [Q3SYC2-1]
    UniGeneiHs.288568

    Genome annotation databases

    EnsembliENST00000198801; ENSP00000198801; ENSG00000166391 [Q3SYC2-1]
    ENST00000525093; ENSP00000436537; ENSG00000166391 [Q3SYC2-3]
    ENST00000526712; ENSP00000436283; ENSG00000166391 [Q3SYC2-2]
    GeneIDi80168
    KEGGihsa:80168
    UCSCiuc010rru.3 human [Q3SYC2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Similar proteinsi

    Entry informationi

    Entry nameiMOGT2_HUMAN
    AccessioniPrimary (citable) accession number: Q3SYC2
    Secondary accession number(s): A8K7I3
    , Q3SYC1, Q6ZQZ2, Q86UH6, Q9H630
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: June 20, 2018
    This is version 101 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

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