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Protein

Forkhead box protein D4-like 6

Gene

FOXD4L6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi108 – 202Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: GO_Central
  • cell differentiation Source: GO_Central
  • regulation of transcription by RNA polymerase II Source: GO_Central

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D4-like 6
Short name:
FOXD4-like 6
Gene namesi
Name:FOXD4L6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000273514.1
HGNCiHGNC:31986 FOXD4L6
neXtProtiNX_Q3SYB3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000273514
PharmGKBiPA162388805

Polymorphism and mutation databases

BioMutaiFOXD4L6
DMDMi166214939

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003019791 – 417Forkhead box protein D4-like 6Add BLAST417

Proteomic databases

PaxDbiQ3SYB3
PeptideAtlasiQ3SYB3
PRIDEiQ3SYB3
ProteomicsDBi61853

PTM databases

iPTMnetiQ3SYB3
PhosphoSitePlusiQ3SYB3

Expressioni

Gene expression databases

BgeeiENSG00000273514 Expressed in 18 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_FOXD4L6

Organism-specific databases

HPAiHPA012836

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MDFIQ997505EBI-6425864,EBI-724076

Protein-protein interaction databases

BioGridi575756, 20 interactors
IntActiQ3SYB3, 11 interactors
STRINGi9606.ENSP00000366693

Structurei

3D structure databases

ProteinModelPortaliQ3SYB3
SMRiQ3SYB3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi211 – 267Pro-richAdd BLAST57

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOGENOMiHOG000231285
HOVERGENiHBG051641
InParanoidiQ3SYB3
KOiK09397
OMAiRPCALLH
OrthoDBiEOG091G0HW9
PhylomeDBiQ3SYB3
TreeFamiTF316127

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q3SYB3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF
60 70 80 90 100
LEQSLQPGLQ VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS
110 120 130 140 150
EDARQPAKPP YSYIALITMA ILQNPHKRLT LSGICAFISG RFPYYRRKFP
160 170 180 190 200
AWQNSIRHNL SLNDCFVKIP REPGHPGKGN YWSLDPASQD MFDNGSFLRR
210 220 230 240 250
RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP APPQPVPGAY
260 270 280 290 300
PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS
310 320 330 340 350
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG
360 370 380 390 400
ATATCSSDHQ ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL
410
PPRARCWAGT CRPRRPC
Length:417
Mass (Da):45,787
Last modified:January 15, 2008 - v2
Checksum:i0A21FCC4EC1D66CE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti416P → R in CAI94919 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255923 Genomic DNA Translation: CAI94919.1
BC103887 mRNA Translation: AAI03888.1
BC137365 mRNA Translation: AAI37366.1
BC137366 mRNA Translation: AAI37367.1
CCDSiCCDS43826.1
RefSeqiNP_001078945.1, NM_001085476.1
UniGeneiHs.652377

Genome annotation databases

EnsembliENST00000622588; ENSP00000484875; ENSG00000273514
GeneIDi653404
KEGGihsa:653404
UCSCiuc004afi.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255923 Genomic DNA Translation: CAI94919.1
BC103887 mRNA Translation: AAI03888.1
BC137365 mRNA Translation: AAI37366.1
BC137366 mRNA Translation: AAI37367.1
CCDSiCCDS43826.1
RefSeqiNP_001078945.1, NM_001085476.1
UniGeneiHs.652377

3D structure databases

ProteinModelPortaliQ3SYB3
SMRiQ3SYB3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi575756, 20 interactors
IntActiQ3SYB3, 11 interactors
STRINGi9606.ENSP00000366693

PTM databases

iPTMnetiQ3SYB3
PhosphoSitePlusiQ3SYB3

Polymorphism and mutation databases

BioMutaiFOXD4L6
DMDMi166214939

Proteomic databases

PaxDbiQ3SYB3
PeptideAtlasiQ3SYB3
PRIDEiQ3SYB3
ProteomicsDBi61853

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000622588; ENSP00000484875; ENSG00000273514
GeneIDi653404
KEGGihsa:653404
UCSCiuc004afi.3 human

Organism-specific databases

CTDi653404
EuPathDBiHostDB:ENSG00000273514.1
GeneCardsiFOXD4L6
HGNCiHGNC:31986 FOXD4L6
HPAiHPA012836
neXtProtiNX_Q3SYB3
OpenTargetsiENSG00000273514
PharmGKBiPA162388805
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOGENOMiHOG000231285
HOVERGENiHBG051641
InParanoidiQ3SYB3
KOiK09397
OMAiRPCALLH
OrthoDBiEOG091G0HW9
PhylomeDBiQ3SYB3
TreeFamiTF316127

Miscellaneous databases

GenomeRNAii653404
PROiPR:Q3SYB3

Gene expression databases

BgeeiENSG00000273514 Expressed in 18 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_FOXD4L6

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFX4L6_HUMAN
AccessioniPrimary (citable) accession number: Q3SYB3
Secondary accession number(s): B2RPC4, Q4V336
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 15, 2008
Last modified: November 7, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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