FOXD4L6

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	108 – 202	Fork-headPROSITE-ProRule annotationAdd BLAST		95

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
sequence-specific DNA binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anatomical structure morphogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Forkhead box protein D4-like 6 Short name: FOXD4-like 6
Gene namesⁱ	Name:FOXD4L6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000273514.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:31986 FOXD4L6
neXtProtⁱ	NX_Q3SYB3

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000273514
PharmGKBⁱ	PA162388805

Polymorphism and mutation databases

BioMutaⁱ	FOXD4L6
DMDMⁱ	166214939

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000301979	1 – 417	Forkhead box protein D4-like 6Add BLAST		417

Proteomic databases

PaxDbⁱ	Q3SYB3
PeptideAtlas More...PeptideAtlasⁱ	Q3SYB3
PRIDEⁱ	Q3SYB3
ProteomicsDBⁱ	61853

PTM databases

iPTMnetⁱ	Q3SYB3
PhosphoSitePlusⁱ	Q3SYB3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000273514 Expressed in 18 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExⁱ	HS_FOXD4L6

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA012836

HPAⁱ

HPA012836

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MDFI	Q99750	5	EBI-6425864,EBI-724076

With

Entry

#Exp.

IntAct

Notes

MDFI

Q99750

5

EBI-6425864,EBI-724076

Protein-protein interaction databases

BioGridⁱ	575756, 20 interactors
IntActⁱ	Q3SYB3, 11 interactors
STRINGⁱ	9606.ENSP00000366693

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3SYB3
SMRⁱ	Q3SYB3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	211 – 267	Pro-richAdd BLAST		57

Phylogenomic databases

eggNOGⁱ	KOG2294 Eukaryota COG5025 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118904
HOGENOMⁱ	HOG000231285
HOVERGENⁱ	HBG051641
InParanoidⁱ	Q3SYB3
KEGG Orthology (KO) More...KOⁱ	K09397
OMAⁱ	RPCALLH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HW9
PhylomeDBⁱ	Q3SYB3
TreeFamⁱ	TF316127

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00059 FH, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR001766 Fork_head_dom IPR018122 TF_fork_head_CS_1 IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00250 Forkhead, 1 hit
PRINTSⁱ	PR00053 FORKHEAD
SMARTⁱ	View protein in SMART SM00339 FH, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00657 FORK_HEAD_1, 1 hit PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3SYB3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNLPRAERLR STPQRSLRDS DGEDGKIDVL GEEEDEDEVE DEEEAASQQF 
        60         70         80         90        100
LEQSLQPGLQ VARWGGVALP REHIEGGGGP SDPSEFGTKF RAPPRSAAAS 
       110        120        130        140        150
EDARQPAKPP YSYIALITMA ILQNPHKRLT LSGICAFISG RFPYYRRKFP 
       160        170        180        190        200
AWQNSIRHNL SLNDCFVKIP REPGHPGKGN YWSLDPASQD MFDNGSFLRR 
       210        220        230        240        250
RKRFKRHQLT PGAHLPHPFP LPAAHAALHN PHPGPLLGAP APPQPVPGAY 
       260        270        280        290        300
PNTAPGRRPY ALLHPHPLRY LLLSAPVYAG APKKAEGAAL ATPAPFPCCS 
       310        320        330        340        350
PHLVLSLGRR ARVWRRHREA DASLSALRVL CKGSGERVQG LRRVCPRPRG 
       360        370        380        390        400
ATATCSSDHQ ACCIPRPLPL CCKCPPPPLL GQFCSNSSSI RRRTAPTAAL 
       410 
PPRARCWAGT CRPRRPC

Length:417

Mass (Da):45,787

Last modified:January 15, 2008 - v2

Checksum:ⁱ0A21FCC4EC1D66CE

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	416	P → R in CAI94919 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX255923 Genomic DNA Translation: CAI94919.1 BC103887 mRNA Translation: AAI03888.1 BC137365 mRNA Translation: AAI37366.1 BC137366 mRNA Translation: AAI37367.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43826.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001078945.1, NM_001085476.1
UniGeneⁱ	Hs.652377

Genome annotation databases

Ensemblⁱ	ENST00000622588; ENSP00000484875; ENSG00000273514
GeneIDⁱ	653404
KEGGⁱ	hsa:653404
UCSC genome browser More...UCSCⁱ	uc004afi.3 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q3SYB3	Forkhead box protein D4-like 4		HUMAN		416	UniRef90_Q8WXT5
FOXD4		PANTR		417
FOXD4		western gorilla		417
Forkhead box protein D4-like 3		HUMAN		417
Forkhead box protein D4-like 5		HUMAN		416
+7

Protein	Similar proteins		Species	Score	Length	Source
Q3SYB3	Forkhead box protein D4		MOUSE		444	UniRef50_Q60688
Forkhead box protein D4-like 1		HUMAN		408
Forkhead box protein D4-like 1		PTEAL		416
Forkhead box D4 like 1		BOVIN		447
Uncharacterized protein		ICTTR		436
+116

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX255923 Genomic DNA Translation: CAI94919.1 BC103887 mRNA Translation: AAI03888.1 BC137365 mRNA Translation: AAI37366.1 BC137366 mRNA Translation: AAI37367.1
CCDSⁱ	CCDS43826.1
RefSeqⁱ	NP_001078945.1, NM_001085476.1
UniGeneⁱ	Hs.652377

3D structure databases

ProteinModelPortalⁱ	Q3SYB3
SMRⁱ	Q3SYB3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	575756, 20 interactors
IntActⁱ	Q3SYB3, 11 interactors
STRINGⁱ	9606.ENSP00000366693

PTM databases

iPTMnetⁱ	Q3SYB3
PhosphoSitePlusⁱ	Q3SYB3

Polymorphism and mutation databases

BioMutaⁱ	FOXD4L6
DMDMⁱ	166214939

Proteomic databases

PaxDbⁱ	Q3SYB3
PeptideAtlasⁱ	Q3SYB3
PRIDEⁱ	Q3SYB3
ProteomicsDBⁱ	61853

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000622588; ENSP00000484875; ENSG00000273514
GeneIDⁱ	653404
KEGGⁱ	hsa:653404
UCSCⁱ	uc004afi.3 human

Organism-specific databases

CTDⁱ	653404
EuPathDBⁱ	HostDB:ENSG00000273514.1
GeneCardsⁱ	FOXD4L6
HGNCⁱ	HGNC:31986 FOXD4L6
HPAⁱ	HPA012836
neXtProtⁱ	NX_Q3SYB3
OpenTargetsⁱ	ENSG00000273514
PharmGKBⁱ	PA162388805
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2294 Eukaryota COG5025 LUCA
GeneTreeⁱ	ENSGT00760000118904
HOGENOMⁱ	HOG000231285
HOVERGENⁱ	HBG051641
InParanoidⁱ	Q3SYB3
KOⁱ	K09397
OMAⁱ	RPCALLH
OrthoDBⁱ	EOG091G0HW9
PhylomeDBⁱ	Q3SYB3
TreeFamⁱ	TF316127

Miscellaneous databases

GenomeRNAiⁱ	653404
Protein Ontology More...PROⁱ	PR:Q3SYB3

Gene expression databases

Bgeeⁱ	ENSG00000273514 Expressed in 18 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExⁱ	HS_FOXD4L6

Family and domain databases

CDDⁱ	cd00059 FH, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR001766 Fork_head_dom IPR018122 TF_fork_head_CS_1 IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00250 Forkhead, 1 hit
PRINTSⁱ	PR00053 FORKHEAD
SMARTⁱ	View protein in SMART SM00339 FH, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00657 FORK_HEAD_1, 1 hit PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FX4L6_HUMAN
Accessionⁱ	Q3SYB3Primary (citable) accession number: Q3SYB3 Secondary accession number(s): B2RPC4, Q4V336
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
	Last sequence update:	January 15, 2008
	Last modified:	November 7, 2018
	This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3SYB3 (FX4L6_HUMAN)

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Forkhead box protein D4-like 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ