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Protein

UDP-glucuronosyltransferase 3A2

Gene

UGT3A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).By similarity

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • glucuronosyltransferase activity Source: GO_Central
  • UDP-glycosyltransferase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-HSA-156588 Glucuronidation

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 3A2 (EC:2.4.1.17)
Short name:
UDPGT 3A2
Gene namesi
Name:UGT3A2
ORF Names:PSEC0073, UNQ842/PRO1780
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000168671.9
HGNCiHGNC:27266 UGT3A2
MIMi616384 gene
neXtProtiNX_Q3SY77

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 483ExtracellularSequence analysisAdd BLAST461
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 523CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi167127
OpenTargetsiENSG00000168671
PharmGKBiPA142670643

Polymorphism and mutation databases

BioMutaiUGT3A2
DMDMi121942966

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000029915323 – 523UDP-glucuronosyltransferase 3A2Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ3SY77
PaxDbiQ3SY77
PeptideAtlasiQ3SY77
PRIDEiQ3SY77
ProteomicsDBi61846

PTM databases

iPTMnetiQ3SY77
PhosphoSitePlusiQ3SY77

Expressioni

Gene expression databases

BgeeiENSG00000168671 Expressed in 44 organ(s), highest expression level in prostate gland
CleanExiHS_UGT3A2
ExpressionAtlasiQ3SY77 baseline and differential

Organism-specific databases

HPAiHPA059475

Interactioni

Protein-protein interaction databases

BioGridi127942, 10 interactors
STRINGi9606.ENSP00000282507

Structurei

3D structure databases

ProteinModelPortaliQ3SY77
SMRiQ3SY77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220831
HOVERGENiHBG106370
InParanoidiQ3SY77
OMAiDLVIVEM
OrthoDBiEOG091G06JC
PhylomeDBiQ3SY77
TreeFamiTF315472

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3SY77-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGQRVLLLV GFLLPGVLLS EAAKILTIST VGGSHYLLMD RVSQILQDHG
60 70 80 90 100
HNVTMLNHKR GPFMPDFKKE EKSYQVISWL APEDHQREFK KSFDFFLEET
110 120 130 140 150
LGGRGKFENL LNVLEYLALQ CSHFLNRKDI MDSLKNENFD MVIVETFDYC
160 170 180 190 200
PFLIAEKLGK PFVAILSTSF GSLEFGLPIP LSYVPVFRSL LTDHMDFWGR
210 220 230 240 250
VKNFLMFFSF CRRQQHMQST FDNTIKEHFT EGSRPVLSHL LLKAELWFIN
260 270 280 290 300
SDFAFDFARP LLPNTVYVGG LMEKPIKPVP QDLENFIAKF GDSGFVLVTL
310 320 330 340 350
GSMVNTCQNP EIFKEMNNAF AHLPQGVIWK CQCSHWPKDV HLAANVKIVD
360 370 380 390 400
WLPQSDLLAH PSIRLFVTHG GQNSIMEAIQ HGVPMVGIPL FGDQPENMVR
410 420 430 440 450
VEAKKFGVSI QLKKLKAETL ALKMKQIMED KRYKSAAVAA SVILRSHPLS
460 470 480 490 500
PTQRLVGWID HVLQTGGATH LKPYVFQQPW HEQYLLDVFV FLLGLTLGTL
510 520
WLCGKLLGMA VWWLRGARKV KET
Length:523
Mass (Da):59,547
Last modified:October 11, 2005 - v1
Checksum:iDFE9CD92D1F5AF6F
GO
Isoform 2 (identifier: Q3SY77-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-65: Missing.

Note: No experimental confirmation available.
Show »
Length:489
Mass (Da):55,677
Checksum:i3D091C66AD084274
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RDU1D6RDU1_HUMAN
UDP-glucuronosyltransferase 3A2
UGT3A2
138Annotation score:
D6RHY1D6RHY1_HUMAN
UDP-glucuronosyltransferase 3A2
UGT3A2
120Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti291G → E in BAC11583 (PubMed:16303743).Curated1
Sequence conflicti311E → G in BAG62419 (PubMed:14702039).Curated1
Sequence conflicti486L → F in AAQ88782 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05732974Y → N. Corresponds to variant dbSNP:rs2197514Ensembl.1
Natural variantiVAR_036036515R → H in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs138640717Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04609932 – 65Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358416 mRNA Translation: AAQ88782.1
AK300751 mRNA Translation: BAG62419.1
AK075383 mRNA Translation: BAC11583.1
AC016612 Genomic DNA No translation available.
BC103924 mRNA Translation: AAI03925.1
BC103925 mRNA Translation: AAI03926.1
CCDSiCCDS3914.1 [Q3SY77-1]
CCDS54842.1 [Q3SY77-2]
RefSeqiNP_001161788.1, NM_001168316.1 [Q3SY77-2]
NP_777574.2, NM_174914.3 [Q3SY77-1]
UniGeneiHs.348941

Genome annotation databases

EnsembliENST00000282507; ENSP00000282507; ENSG00000168671 [Q3SY77-1]
ENST00000513300; ENSP00000427404; ENSG00000168671 [Q3SY77-2]
GeneIDi167127
KEGGihsa:167127
UCSCiuc003jjz.3 human [Q3SY77-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358416 mRNA Translation: AAQ88782.1
AK300751 mRNA Translation: BAG62419.1
AK075383 mRNA Translation: BAC11583.1
AC016612 Genomic DNA No translation available.
BC103924 mRNA Translation: AAI03925.1
BC103925 mRNA Translation: AAI03926.1
CCDSiCCDS3914.1 [Q3SY77-1]
CCDS54842.1 [Q3SY77-2]
RefSeqiNP_001161788.1, NM_001168316.1 [Q3SY77-2]
NP_777574.2, NM_174914.3 [Q3SY77-1]
UniGeneiHs.348941

3D structure databases

ProteinModelPortaliQ3SY77
SMRiQ3SY77
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127942, 10 interactors
STRINGi9606.ENSP00000282507

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

PTM databases

iPTMnetiQ3SY77
PhosphoSitePlusiQ3SY77

Polymorphism and mutation databases

BioMutaiUGT3A2
DMDMi121942966

Proteomic databases

EPDiQ3SY77
PaxDbiQ3SY77
PeptideAtlasiQ3SY77
PRIDEiQ3SY77
ProteomicsDBi61846

Protocols and materials databases

DNASUi167127
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282507; ENSP00000282507; ENSG00000168671 [Q3SY77-1]
ENST00000513300; ENSP00000427404; ENSG00000168671 [Q3SY77-2]
GeneIDi167127
KEGGihsa:167127
UCSCiuc003jjz.3 human [Q3SY77-1]

Organism-specific databases

CTDi167127
DisGeNETi167127
EuPathDBiHostDB:ENSG00000168671.9
GeneCardsiUGT3A2
H-InvDBiHIX0032013
HGNCiHGNC:27266 UGT3A2
HPAiHPA059475
MIMi616384 gene
neXtProtiNX_Q3SY77
OpenTargetsiENSG00000168671
PharmGKBiPA142670643
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220831
HOVERGENiHBG106370
InParanoidiQ3SY77
OMAiDLVIVEM
OrthoDBiEOG091G06JC
PhylomeDBiQ3SY77
TreeFamiTF315472

Enzyme and pathway databases

ReactomeiR-HSA-156588 Glucuronidation

Miscellaneous databases

ChiTaRSiUGT3A2 human
GenomeRNAii167127
PROiPR:Q3SY77
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168671 Expressed in 44 organ(s), highest expression level in prostate gland
CleanExiHS_UGT3A2
ExpressionAtlasiQ3SY77 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUD3A2_HUMAN
AccessioniPrimary (citable) accession number: Q3SY77
Secondary accession number(s): B4DUQ7
, E9PFK7, Q6UXC4, Q8NBP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 11, 2005
Last modified: September 12, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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