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Protein

Transcription factor Sp6

Gene

SP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Promotes cell proliferation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 278C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri284 – 308C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri314 – 336C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • regulation of odontogenesis Source: Ensembl
  • regulation of transcription by RNA polymerase II Source: GO_Central

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp6
Alternative name(s):
Krueppel-like factor 14
Gene namesi
Name:SP6
Synonyms:KLF14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000189120.4
HGNCiHGNC:14530 SP6
MIMi608613 gene
neXtProtiNX_Q3SY56

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi80320
OpenTargetsiENSG00000189120
PharmGKBiPA37892

Polymorphism and mutation databases

BioMutaiSP6
DMDMi82582258

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471481 – 376Transcription factor Sp6Add BLAST376

Proteomic databases

EPDiQ3SY56
MaxQBiQ3SY56
PaxDbiQ3SY56
PeptideAtlasiQ3SY56
PRIDEiQ3SY56
ProteomicsDBi61841

PTM databases

iPTMnetiQ3SY56
PhosphoSitePlusiQ3SY56

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000189120 Expressed in 90 organ(s), highest expression level in placenta
CleanExiHS_KLF14
HS_SP6
GenevisibleiQ3SY56 HS

Organism-specific databases

HPAiHPA024516
HPA044469

Interactioni

Protein-protein interaction databases

BioGridi123233, 8 interactors
IntActiQ3SY56, 4 interactors
STRINGi9606.ENSP00000340799

Structurei

3D structure databases

ProteinModelPortaliQ3SY56
SMRiQ3SY56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri254 – 278C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri284 – 308C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri314 – 336C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000231067
HOVERGENiHBG102037
InParanoidiQ3SY56
KOiK09196
OMAiHPGTEDG
OrthoDBiEOG091G0HX6
PhylomeDBiQ3SY56
TreeFamiTF315506

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q3SY56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTAVCGSLG SQHTEAPHAS PPRLDLQPLQ TYQGHTSPEA GDYPSPLQPG
60 70 80 90 100
ELQSLPLGPE VDFSQGYELP GASSRVTCED LESDSPLAPG PFSKLLQPDM
110 120 130 140 150
SHHYESWFRP THPGAEDGSW WDLHPGTSWM DLPHTQGALT SPGHPGALQA
160 170 180 190 200
GLGGYVGDHQ LCAPPPHPHA HHLLPAAGGQ HLLGPPDGAK ALEVAAPESQ
210 220 230 240 250
GLDSSLDGAA RPKGSRRSVP RSSGQTVCRC PNCLEAERLG APCGPDGGKK
260 270 280 290 300
KHLHNCHIPG CGKAYAKTSH LKAHLRWHSG DRPFVCNWLF CGKRFTRSDE
310 320 330 340 350
LQRHLQTHTG TKKFPCAVCS RVFMRSDHLA KHMKTHEGAK EEAAGAASGE
360 370
GKAGGAVEPP GGKGKREAEG SVAPSN
Length:376
Mass (Da):39,840
Last modified:October 11, 2005 - v1
Checksum:i1F4355CFB75206E8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052714156V → I. Corresponds to variant dbSNP:rs34309518Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127850 mRNA Translation: BAG54586.1
CH471109 Genomic DNA Translation: EAW94789.1
BC103951 mRNA Translation: AAI03952.1
BC103952 mRNA Translation: AAI03953.1
BC103953 mRNA Translation: AAI03954.1
BC103954 mRNA Translation: AAI03955.1
CCDSiCCDS11520.1
RefSeqiNP_001245177.1, NM_001258248.1
NP_954871.1, NM_199262.2
XP_006722178.1, XM_006722115.3
UniGeneiHs.253603

Genome annotation databases

EnsembliENST00000342234; ENSP00000340799; ENSG00000189120
ENST00000536300; ENSP00000438209; ENSG00000189120
GeneIDi80320
KEGGihsa:80320
UCSCiuc002img.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127850 mRNA Translation: BAG54586.1
CH471109 Genomic DNA Translation: EAW94789.1
BC103951 mRNA Translation: AAI03952.1
BC103952 mRNA Translation: AAI03953.1
BC103953 mRNA Translation: AAI03954.1
BC103954 mRNA Translation: AAI03955.1
CCDSiCCDS11520.1
RefSeqiNP_001245177.1, NM_001258248.1
NP_954871.1, NM_199262.2
XP_006722178.1, XM_006722115.3
UniGeneiHs.253603

3D structure databases

ProteinModelPortaliQ3SY56
SMRiQ3SY56
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123233, 8 interactors
IntActiQ3SY56, 4 interactors
STRINGi9606.ENSP00000340799

PTM databases

iPTMnetiQ3SY56
PhosphoSitePlusiQ3SY56

Polymorphism and mutation databases

BioMutaiSP6
DMDMi82582258

Proteomic databases

EPDiQ3SY56
MaxQBiQ3SY56
PaxDbiQ3SY56
PeptideAtlasiQ3SY56
PRIDEiQ3SY56
ProteomicsDBi61841

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342234; ENSP00000340799; ENSG00000189120
ENST00000536300; ENSP00000438209; ENSG00000189120
GeneIDi80320
KEGGihsa:80320
UCSCiuc002img.3 human

Organism-specific databases

CTDi80320
DisGeNETi80320
EuPathDBiHostDB:ENSG00000189120.4
GeneCardsiSP6
HGNCiHGNC:14530 SP6
HPAiHPA024516
HPA044469
MIMi608613 gene
neXtProtiNX_Q3SY56
OpenTargetsiENSG00000189120
PharmGKBiPA37892
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000231067
HOVERGENiHBG102037
InParanoidiQ3SY56
KOiK09196
OMAiHPGTEDG
OrthoDBiEOG091G0HX6
PhylomeDBiQ3SY56
TreeFamiTF315506

Miscellaneous databases

ChiTaRSiSP6 human
GenomeRNAii80320
PROiPR:Q3SY56
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000189120 Expressed in 90 organ(s), highest expression level in placenta
CleanExiHS_KLF14
HS_SP6
GenevisibleiQ3SY56 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSP6_HUMAN
AccessioniPrimary (citable) accession number: Q3SY56
Secondary accession number(s): B3KXS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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