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Protein

Zinc finger protein interacting with ribonucleoprotein K

Gene

ZIK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a transcriptional repressor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri239 – 261C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri267 – 289C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein interacting with ribonucleoprotein K
Alternative name(s):
Zinc finger protein 762
Gene namesi
Name:ZIK1
Synonyms:ZNF762
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171649.11
HGNCiHGNC:33104 ZIK1
neXtProtiNX_Q3SY52

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171649
PharmGKBiPA162409747

Polymorphism and mutation databases

BioMutaiZIK1
DMDMi121942960

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002867931 – 487Zinc finger protein interacting with ribonucleoprotein KAdd BLAST487

Proteomic databases

EPDiQ3SY52
MaxQBiQ3SY52
PaxDbiQ3SY52
PeptideAtlasiQ3SY52
PRIDEiQ3SY52
ProteomicsDBi61838
61839 [Q3SY52-2]
61840 [Q3SY52-3]

PTM databases

iPTMnetiQ3SY52
PhosphoSitePlusiQ3SY52

Expressioni

Tissue specificityi

Expressed at high levels in gastric glands, and at low levels in colon and small intestine. Silenced through promoter methylation in gastric glands with intestinal metaplasia.1 Publication

Gene expression databases

BgeeiENSG00000171649 Expressed in 126 organ(s), highest expression level in kidney
CleanExiHS_ZIK1
ExpressionAtlasiQ3SY52 baseline and differential
GenevisibleiQ3SY52 HS

Organism-specific databases

HPAiHPA059975

Interactioni

Subunit structurei

Interacts with HNRPK.By similarity

Protein-protein interaction databases

BioGridi129823, 1 interactor
STRINGi9606.ENSP00000472867

Structurei

3D structure databases

ProteinModelPortaliQ3SY52
SMRiQ3SY52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 136KRABPROSITE-ProRule annotationAdd BLAST110

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri239 – 261C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri267 – 289C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ3SY52
KOiK09228
OMAiSPETHMD
OrthoDBiEOG091G02KC
PhylomeDBiQ3SY52
TreeFamiTF342033

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3SY52-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAALRAPT QVTVSPETHM DLTKGCVTFE DIAIYFSQDE WGLLDEAQRL
60 70 80 90 100
LYLEVMLENF ALVASLGCGH GTEDEETPSD QNVSVGVSQS KAGSSTQKTQ
110 120 130 140 150
SCEMCVPVLK DILHLADLPG QKPYLVGECT NHHQHQKHHS AKKSLKRDMD
160 170 180 190 200
RASYVKCCLF CMSLKPFRKW EVGKDLPAML RLLRSLVFPG GKKPGTITEC
210 220 230 240 250
GEDIRSQKSH YKSGECGKAS RHKHTPVYHP RVYTGKKLYE CSKCGKAFRG
260 270 280 290 300
KYSLVQHQRV HTGERPWECN ECGKFFSQTS HLNDHRRIHT GERPYECSEC
310 320 330 340 350
GKLFRQNSSL VDHQKIHTGA RPYECSQCGK SFSQKATLVK HQRVHTGERP
360 370 380 390 400
YKCGECGNSF SQSAILNQHR RIHTGAKPYE CGQCGKSFSQ KATLIKHQRV
410 420 430 440 450
HTGERPYKCG DCGKSFSQSS ILIQHRRIHT GARPYECGQC GKSFSQKSGL
460 470 480
IQHQVVHTGE RPYECNKCGN SFSQCSSLIH HQKCHNT
Length:487
Mass (Da):54,786
Last modified:October 11, 2005 - v1
Checksum:i3D03318613E832E4
GO
Isoform 2 (identifier: Q3SY52-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.

Show »
Length:432
Mass (Da):48,645
Checksum:iC4CF3ABC2927A635
GO
Isoform 3 (identifier: Q3SY52-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Show »
Length:384
Mass (Da):43,718
Checksum:iF92987FA624D51E5
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H435F5H435_HUMAN
Zinc finger protein-interacting wit...
ZIK1
474Annotation score:
M0QYP0M0QYP0_HUMAN
Zinc finger protein-interacting wit...
ZIK1
107Annotation score:
M0R1S7M0R1S7_HUMAN
Zinc finger protein-interacting wit...
ZIK1
110Annotation score:
M0QYQ8M0QYQ8_HUMAN
Zinc finger protein-interacting wit...
ZIK1
30Annotation score:
X6R413X6R413_HUMAN
Zinc finger protein-interacting wit...
ZIK1
29Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti207Q → K in AAI03960 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0251481 – 103Missing in isoform 3. 1 PublicationAdd BLAST103
Alternative sequenceiVSP_0251471 – 55Missing in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003682 Genomic DNA Translation: AAC24608.1
BC103957 mRNA Translation: AAI03958.1
BC103958 mRNA Translation: AAI03959.1
BC103959 mRNA Translation: AAI03960.1
CCDSiCCDS33135.1 [Q3SY52-1]
CCDS82408.1 [Q3SY52-2]
RefSeqiNP_001010879.2, NM_001010879.3 [Q3SY52-1]
NP_001308074.1, NM_001321145.1
NP_001308075.1, NM_001321146.1 [Q3SY52-2]
NP_001308076.1, NM_001321147.1 [Q3SY52-3]
XP_011525068.1, XM_011526766.2 [Q3SY52-2]
XP_011525069.1, XM_011526767.2 [Q3SY52-3]
UniGeneiHs.454830

Genome annotation databases

EnsembliENST00000597850; ENSP00000472867; ENSG00000171649 [Q3SY52-1]
ENST00000599456; ENSP00000468937; ENSG00000171649 [Q3SY52-2]
GeneIDi284307
KEGGihsa:284307
UCSCiuc002qpg.4 human [Q3SY52-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003682 Genomic DNA Translation: AAC24608.1
BC103957 mRNA Translation: AAI03958.1
BC103958 mRNA Translation: AAI03959.1
BC103959 mRNA Translation: AAI03960.1
CCDSiCCDS33135.1 [Q3SY52-1]
CCDS82408.1 [Q3SY52-2]
RefSeqiNP_001010879.2, NM_001010879.3 [Q3SY52-1]
NP_001308074.1, NM_001321145.1
NP_001308075.1, NM_001321146.1 [Q3SY52-2]
NP_001308076.1, NM_001321147.1 [Q3SY52-3]
XP_011525068.1, XM_011526766.2 [Q3SY52-2]
XP_011525069.1, XM_011526767.2 [Q3SY52-3]
UniGeneiHs.454830

3D structure databases

ProteinModelPortaliQ3SY52
SMRiQ3SY52
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129823, 1 interactor
STRINGi9606.ENSP00000472867

PTM databases

iPTMnetiQ3SY52
PhosphoSitePlusiQ3SY52

Polymorphism and mutation databases

BioMutaiZIK1
DMDMi121942960

Proteomic databases

EPDiQ3SY52
MaxQBiQ3SY52
PaxDbiQ3SY52
PeptideAtlasiQ3SY52
PRIDEiQ3SY52
ProteomicsDBi61838
61839 [Q3SY52-2]
61840 [Q3SY52-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000597850; ENSP00000472867; ENSG00000171649 [Q3SY52-1]
ENST00000599456; ENSP00000468937; ENSG00000171649 [Q3SY52-2]
GeneIDi284307
KEGGihsa:284307
UCSCiuc002qpg.4 human [Q3SY52-1]

Organism-specific databases

CTDi284307
EuPathDBiHostDB:ENSG00000171649.11
GeneCardsiZIK1
HGNCiHGNC:33104 ZIK1
HPAiHPA059975
neXtProtiNX_Q3SY52
OpenTargetsiENSG00000171649
PharmGKBiPA162409747
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119107
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ3SY52
KOiK09228
OMAiSPETHMD
OrthoDBiEOG091G02KC
PhylomeDBiQ3SY52
TreeFamiTF342033

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

GenomeRNAii284307
PROiPR:Q3SY52

Gene expression databases

BgeeiENSG00000171649 Expressed in 126 organ(s), highest expression level in kidney
CleanExiHS_ZIK1
ExpressionAtlasiQ3SY52 baseline and differential
GenevisibleiQ3SY52 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZIK1_HUMAN
AccessioniPrimary (citable) accession number: Q3SY52
Secondary accession number(s): O43339, Q3SY51, Q3SY53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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