SLC25A52

Functionⁱ

Keywordsⁱ

Biological process	Transport

Biological process

Protein family/group databases

TCDBⁱ	2.A.29.2.12 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.2.12 the mitochondrial carrier (mc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Solute carrier family 25 member 52 Alternative name(s): Mitochondrial carrier triple repeat protein 2
Gene namesⁱ	Name:SLC25A52 Synonyms:MCART2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Unplaced

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23324 SLC25A52
MIMⁱ	616153 gene
neXtProtⁱ	NX_Q3SY17

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	34 – 51	Helical; Name=1Sequence analysisAdd BLAST	18
Transmembraneⁱ	85 – 105	Helical; Name=2Sequence analysisAdd BLAST	21
Transmembraneⁱ	118 – 138	Helical; Name=3Sequence analysisAdd BLAST	21
Transmembraneⁱ	179 – 199	Helical; Name=4Sequence analysisAdd BLAST	21
Transmembraneⁱ	215 – 235	Helical; Name=5Sequence analysisAdd BLAST	21
Transmembraneⁱ	268 – 289	Helical; Name=6Sequence analysisAdd BLAST	22

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	147407
PharmGKBⁱ	PA25306

Polymorphism and mutation databases

BioMutaⁱ	SLC25A52
DMDMⁱ	296436436

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000271790	1 – 297	Solute carrier family 25 member 52Add BLAST		297

Proteomic databases

EPDⁱ	Q3SY17
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3SY17
PaxDbⁱ	Q3SY17
PeptideAtlas More...PeptideAtlasⁱ	Q3SY17
PRIDEⁱ	Q3SY17
ProteomicsDBⁱ	61835

PTM databases

iPTMnetⁱ	Q3SY17
PhosphoSitePlusⁱ	Q3SY17

Expressionⁱ

Gene expression databases

CleanExⁱ	HS_MCART2

CleanExⁱ

HS_MCART2

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046388 HPA058261

HPAⁱ

HPA046388
HPA058261

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	127058, 1 interactor

BioGridⁱ

127058, 1 interactor

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3SY17
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	28 – 108	Solcar 1Add BLAST	81
Repeatⁱ	116 – 200	Solcar 2Add BLAST	85
Repeatⁱ	209 – 296	Solcar 3Add BLAST	88

Sequence similaritiesⁱ

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1519 Eukaryota ENOG410XNWT LUCA
HOVERGENⁱ	HBG052423
InParanoidⁱ	Q3SY17
PhylomeDBⁱ	Q3SY17
TreeFamⁱ	TF314192

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR040062 Mitochondrial_carrier_protein IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
PANTHERⁱ	PTHR24089 PTHR24089, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q3SY17-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIDSEAHEKR PPILTSSKQD ISPHITNVGE MKHYLCGCCA AFNNVAITYP 
        60         70         80         90        100
IQKVLFRQQL YGIKTRDAVL QLRRDGFRNL YRGILPPLMQ KTTTLALMFG 
       110        120        130        140        150
LYEDLSCLLR KHVRAPEFAT HGVAAVLAGT AEAIFTPLER VQTLLQNHKH 
       160        170        180        190        200
HDKFTNTYQA FKALKCHGIG EYYRGLVPIL FRNGLSNVLF FGLRGPIKEH 
       210        220        230        240        250
LPTATTHSAH LVNDFIGGGL LGAMLGFLCF PINVVKTRLQ SQIGGEFQSF 
       260        270        280        290 
PKVFQKIWLE RDRKLINLFR GAHLNYHRSL ISWGIINATY EFLLKFI

Length:297

Mass (Da):33,721

Last modified:May 18, 2010 - v2

Checksum:ⁱ8BA8EFEABA74E2FC

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	I3L0B8	I3L0B8_HUMAN		Solute carrier family 25 member 52 Solute carrier family 25 member 52	SLC25A52	307	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_060299	239	L → I1 PublicationCorresponds to variant dbSNP:rs3859364Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC022960 Genomic DNA No translation available. BC103999 mRNA Translation: AAI04000.1 BC104000 mRNA Translation: AAI04001.1 BC104001 mRNA Translation: AAI04002.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001029344.3, NM_001034172.2
UniGeneⁱ	Hs.567708

Genome annotation databases

Ensemblⁱ	ENST00000579441; ENSP00000462754; ENSG00000141437
GeneIDⁱ	147407
KEGGⁱ	hsa:147407

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q3SY17	Solute carrier family 25 member 52		HUMAN		307	UniRef100_Q3SY17

Protein	Similar proteins		Species	Score	Length	Source
Q3SY17	Solute carrier family 25 member 52		HUMAN		307	UniRef90_Q3SY17
Solute carrier family 25 member 52		GORGO		308
Uncharacterized protein		MACFA		304
Uncharacterized protein		PANPA		298
Uncharacterized protein		RHIBE		286
+13

Protein	Similar proteins		Species	Score	Length	Source
Q3SY17	Solute carrier family 25 member 52		HUMAN		307	UniRef50_Q3SY17
Solute carrier family 25 member 52		GORGO		308
Uncharacterized protein		MACFA		304
Uncharacterized protein		PANPA		298
Uncharacterized protein		RHIBE		286
+102

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC022960 Genomic DNA No translation available. BC103999 mRNA Translation: AAI04000.1 BC104000 mRNA Translation: AAI04001.1 BC104001 mRNA Translation: AAI04002.1
RefSeqⁱ	NP_001029344.3, NM_001034172.2
UniGeneⁱ	Hs.567708

3D structure databases

ProteinModelPortalⁱ	Q3SY17
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127058, 1 interactor

BioGridⁱ

127058, 1 interactor

Protein family/group databases

TCDBⁱ	2.A.29.2.12 the mitochondrial carrier (mc) family

TCDBⁱ

2.A.29.2.12 the mitochondrial carrier (mc) family

PTM databases

iPTMnetⁱ	Q3SY17
PhosphoSitePlusⁱ	Q3SY17

Polymorphism and mutation databases

BioMutaⁱ	SLC25A52
DMDMⁱ	296436436

Proteomic databases

EPDⁱ	Q3SY17
MaxQBⁱ	Q3SY17
PaxDbⁱ	Q3SY17
PeptideAtlasⁱ	Q3SY17
PRIDEⁱ	Q3SY17
ProteomicsDBⁱ	61835

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000579441; ENSP00000462754; ENSG00000141437
GeneIDⁱ	147407
KEGGⁱ	hsa:147407

Organism-specific databases

CTDⁱ	147407
DisGeNETⁱ	147407
GeneCardsⁱ	SLC25A52
H-InvDBⁱ	HIX0059795
HGNCⁱ	HGNC:23324 SLC25A52
HPAⁱ	HPA046388 HPA058261
MIMⁱ	616153 gene
neXtProtⁱ	NX_Q3SY17
PharmGKBⁱ	PA25306
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1519 Eukaryota ENOG410XNWT LUCA
HOVERGENⁱ	HBG052423
InParanoidⁱ	Q3SY17
PhylomeDBⁱ	Q3SY17
TreeFamⁱ	TF314192

Miscellaneous databases

GenomeRNAiⁱ	147407
Protein Ontology More...PROⁱ	PR:Q3SY17
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	HS_MCART2

CleanExⁱ

HS_MCART2

Family and domain databases

Gene3Dⁱ	1.50.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR040062 Mitochondrial_carrier_protein IPR018108 Mitochondrial_sb/sol_carrier IPR023395 Mt_carrier_dom_sf
PANTHERⁱ	PTHR24089 PTHR24089, 1 hit
Pfamⁱ	View protein in Pfam PF00153 Mito_carr, 3 hits
SUPFAMⁱ	SSF103506 SSF103506, 1 hit
PROSITEⁱ	View protein in PROSITE PS50920 SOLCAR, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	S2552_HUMAN
Accessionⁱ	Q3SY17Primary (citable) accession number: Q3SY17
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3SY17 (S2552_HUMAN)

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Solute carrier family 25 member 52

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ