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UniProtKB - Q3SY17 (S2552_HUMAN)
Protein
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A52
Gene
SLC25A52
Organism
Homo sapiens (Human)
Status
Functioni
Mitochondrial membrane carrier protein that mediates the import of NAD+ into mitochondria (PubMed:32906142).
Compared to SLC25A51, SLC25A52-mediated transport is not essential for the import of NAD+ in mitochondria (PubMed:32906142).
1 PublicationGO - Molecular functioni
- NAD transmembrane transporter activity Source: UniProtKB
GO - Biological processi
- mitochondrial NAD transmembrane transport Source: UniProtKB
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q3SY17 |
SignaLinki | Q3SY17 |
Protein family/group databases
TCDBi | 2.A.29.2.12, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A52CuratedAlternative name(s): Mitochondrial NAD(+) transporter SLC25A52Curated Mitochondrial carrier triple repeat protein 2Curated Solute carrier family 25 member 521 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23324, SLC25A52 |
MIMi | 616153, gene |
neXtProti | NX_Q3SY17 |
VEuPathDBi | HostDB:ENSG00000141437 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 34 – 51 | Helical; Name=1Sequence analysisAdd BLAST | 18 | |
Transmembranei | 85 – 105 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 118 – 138 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 179 – 199 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 215 – 235 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 268 – 289 | Helical; Name=6Sequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 147407 |
OpenTargetsi | ENSG00000141437 |
PharmGKBi | PA25306 |
Miscellaneous databases
Pharosi | Q3SY17, Tdark |
Genetic variation databases
BioMutai | SLC25A52 |
DMDMi | 296436436 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000271790 | 1 – 297 | Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A52Add BLAST | 297 |
Proteomic databases
EPDi | Q3SY17 |
jPOSTi | Q3SY17 |
MassIVEi | Q3SY17 |
MaxQBi | Q3SY17 |
PaxDbi | Q3SY17 |
PeptideAtlasi | Q3SY17 |
PRIDEi | Q3SY17 |
ProteomicsDBi | 61835 |
PTM databases
iPTMneti | Q3SY17 |
PhosphoSitePlusi | Q3SY17 |
Expressioni
Gene expression databases
ExpressionAtlasi | Q3SY17, baseline and differential |
Organism-specific databases
HPAi | ENSG00000141437, Tissue enriched (testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127058, 9 interactors |
IntActi | Q3SY17, 2 interactors |
STRINGi | 9606.ENSP00000372612 |
Miscellaneous databases
RNActi | Q3SY17, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 28 – 108 | Solcar 1Sequence analysisAdd BLAST | 81 | |
Repeati | 116 – 200 | Solcar 2Sequence analysisAdd BLAST | 85 | |
Repeati | 209 – 296 | Solcar 3Sequence analysisAdd BLAST | 88 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1519, Eukaryota |
GeneTreei | ENSGT01040000240890 |
InParanoidi | Q3SY17 |
OrthoDBi | 966424at2759 |
PhylomeDBi | Q3SY17 |
TreeFami | TF314192 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q3SY17-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIDSEAHEKR PPILTSSKQD ISPHITNVGE MKHYLCGCCA AFNNVAITYP
60 70 80 90 100
IQKVLFRQQL YGIKTRDAVL QLRRDGFRNL YRGILPPLMQ KTTTLALMFG
110 120 130 140 150
LYEDLSCLLR KHVRAPEFAT HGVAAVLAGT AEAIFTPLER VQTLLQNHKH
160 170 180 190 200
HDKFTNTYQA FKALKCHGIG EYYRGLVPIL FRNGLSNVLF FGLRGPIKEH
210 220 230 240 250
LPTATTHSAH LVNDFIGGGL LGAMLGFLCF PINVVKTRLQ SQIGGEFQSF
260 270 280 290
PKVFQKIWLE RDRKLINLFR GAHLNYHRSL ISWGIINATY EFLLKFI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketI3L0B8 | I3L0B8_HUMAN | Mitochondrial nicotinamide adenine ... | SLC25A52 | 307 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060299 | 239 | L → I1 PublicationCorresponds to variant dbSNP:rs3859364Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC022960 Genomic DNA No translation available. BC103999 mRNA Translation: AAI04000.1 BC104000 mRNA Translation: AAI04001.1 BC104001 mRNA Translation: AAI04002.1 |
CCDSi | CCDS32812.2 |
RefSeqi | NP_001029344.3, NM_001034172.2 |
Genome annotation databases
Ensembli | ENST00000269205.7; ENSP00000372612.4; ENSG00000141437.10 |
GeneIDi | 147407 |
KEGGi | hsa:147407 |
MANE-Selecti | ENST00000269205.7; ENSP00000372612.4; NM_001034172.4; NP_001029344.4 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC022960 Genomic DNA No translation available. BC103999 mRNA Translation: AAI04000.1 BC104000 mRNA Translation: AAI04001.1 BC104001 mRNA Translation: AAI04002.1 |
CCDSi | CCDS32812.2 |
RefSeqi | NP_001029344.3, NM_001034172.2 |
3D structure databases
AlphaFoldDBi | Q3SY17 |
SMRi | Q3SY17 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127058, 9 interactors |
IntActi | Q3SY17, 2 interactors |
STRINGi | 9606.ENSP00000372612 |
Protein family/group databases
TCDBi | 2.A.29.2.12, the mitochondrial carrier (mc) family |
PTM databases
iPTMneti | Q3SY17 |
PhosphoSitePlusi | Q3SY17 |
Genetic variation databases
BioMutai | SLC25A52 |
DMDMi | 296436436 |
Proteomic databases
EPDi | Q3SY17 |
jPOSTi | Q3SY17 |
MassIVEi | Q3SY17 |
MaxQBi | Q3SY17 |
PaxDbi | Q3SY17 |
PeptideAtlasi | Q3SY17 |
PRIDEi | Q3SY17 |
ProteomicsDBi | 61835 |
Protocols and materials databases
Antibodypediai | 54450, 85 antibodies from 16 providers |
DNASUi | 147407 |
Genome annotation databases
Ensembli | ENST00000269205.7; ENSP00000372612.4; ENSG00000141437.10 |
GeneIDi | 147407 |
KEGGi | hsa:147407 |
MANE-Selecti | ENST00000269205.7; ENSP00000372612.4; NM_001034172.4; NP_001029344.4 |
Organism-specific databases
CTDi | 147407 |
DisGeNETi | 147407 |
GeneCardsi | SLC25A52 |
HGNCi | HGNC:23324, SLC25A52 |
HPAi | ENSG00000141437, Tissue enriched (testis) |
MIMi | 616153, gene |
neXtProti | NX_Q3SY17 |
OpenTargetsi | ENSG00000141437 |
PharmGKBi | PA25306 |
VEuPathDBi | HostDB:ENSG00000141437 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1519, Eukaryota |
GeneTreei | ENSGT01040000240890 |
InParanoidi | Q3SY17 |
OrthoDBi | 966424at2759 |
PhylomeDBi | Q3SY17 |
TreeFami | TF314192 |
Enzyme and pathway databases
PathwayCommonsi | Q3SY17 |
SignaLinki | Q3SY17 |
Miscellaneous databases
BioGRID-ORCSi | 147407, 6 hits in 1008 CRISPR screens |
GenomeRNAii | 147407 |
Pharosi | Q3SY17, Tdark |
PROi | PR:Q3SY17 |
RNActi | Q3SY17, protein |
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | Q3SY17, baseline and differential |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | S2552_HUMAN | |
Accessioni | Q3SY17Primary (citable) accession number: Q3SY17 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | May 25, 2022 | |
This is version 126 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families