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Protein

Solute carrier family 25 member 52

Gene

SLC25A52

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.29.2.12 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 52
Alternative name(s):
Mitochondrial carrier triple repeat protein 2
Gene namesi
Name:SLC25A52
Synonyms:MCART2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:23324 SLC25A52
MIMi616153 gene
neXtProtiNX_Q3SY17

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei34 – 51Helical; Name=1Sequence analysisAdd BLAST18
Transmembranei85 – 105Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei118 – 138Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei179 – 199Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei215 – 235Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei268 – 289Helical; Name=6Sequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi147407
PharmGKBiPA25306

Polymorphism and mutation databases

BioMutaiSLC25A52
DMDMi296436436

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002717901 – 297Solute carrier family 25 member 52Add BLAST297

Proteomic databases

EPDiQ3SY17
MaxQBiQ3SY17
PaxDbiQ3SY17
PeptideAtlasiQ3SY17
PRIDEiQ3SY17
ProteomicsDBi61835

PTM databases

iPTMnetiQ3SY17
PhosphoSitePlusiQ3SY17

Expressioni

Gene expression databases

CleanExiHS_MCART2

Organism-specific databases

HPAiHPA046388
HPA058261

Interactioni

Protein-protein interaction databases

BioGridi127058, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ3SY17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati28 – 108Solcar 1Add BLAST81
Repeati116 – 200Solcar 2Add BLAST85
Repeati209 – 296Solcar 3Add BLAST88

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1519 Eukaryota
ENOG410XNWT LUCA
HOVERGENiHBG052423
InParanoidiQ3SY17
PhylomeDBiQ3SY17
TreeFamiTF314192

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q3SY17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDSEAHEKR PPILTSSKQD ISPHITNVGE MKHYLCGCCA AFNNVAITYP
60 70 80 90 100
IQKVLFRQQL YGIKTRDAVL QLRRDGFRNL YRGILPPLMQ KTTTLALMFG
110 120 130 140 150
LYEDLSCLLR KHVRAPEFAT HGVAAVLAGT AEAIFTPLER VQTLLQNHKH
160 170 180 190 200
HDKFTNTYQA FKALKCHGIG EYYRGLVPIL FRNGLSNVLF FGLRGPIKEH
210 220 230 240 250
LPTATTHSAH LVNDFIGGGL LGAMLGFLCF PINVVKTRLQ SQIGGEFQSF
260 270 280 290
PKVFQKIWLE RDRKLINLFR GAHLNYHRSL ISWGIINATY EFLLKFI
Length:297
Mass (Da):33,721
Last modified:May 18, 2010 - v2
Checksum:i8BA8EFEABA74E2FC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060299239L → I1 PublicationCorresponds to variant dbSNP:rs3859364Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022960 Genomic DNA No translation available.
BC103999 mRNA Translation: AAI04000.1
BC104000 mRNA Translation: AAI04001.1
BC104001 mRNA Translation: AAI04002.1
RefSeqiNP_001029344.3, NM_001034172.2
UniGeneiHs.567708

Genome annotation databases

EnsembliENST00000579441; ENSP00000462754; ENSG00000141437
GeneIDi147407
KEGGihsa:147407

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS2552_HUMAN
AccessioniPrimary (citable) accession number: Q3SY17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 18, 2010
Last modified: July 18, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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