Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 95 (22 Apr 2020)
Sequence version 2 (09 Jul 2014)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Testis-specific protein 10-interacting protein

Gene

TSGA10IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cilium organization Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Testis-specific protein 10-interacting protein
Alternative name(s):
Tsga10-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26555 TSGA10IP

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3SY00

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000175513

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134983361

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q3SY00 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TSGA10IP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121942943

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003314211 – 556Testis-specific protein 10-interacting proteinAdd BLAST556

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q3SY00

PeptideAtlas

More...
PeptideAtlasi
Q3SY00

PRoteomics IDEntifications database

More...
PRIDEi
Q3SY00

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61831 [Q3SY00-1]
61832 [Q3SY00-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3SY00

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3SY00

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000175513 Expressed in testis and 32 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3SY00 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3SY00 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000175513 Group enriched (blood, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q3SY00
With#Exp.IntAct
AKAP8L [Q9ULX6]3EBI-10241197,EBI-357530
AMOTL2 [Q9Y2J4]3EBI-10241197,EBI-746752
AP1B1 - isoform C [Q10567-3]3EBI-10241197,EBI-11978055
ARHGEF9 [O43307]3EBI-10241197,EBI-3447299
BHLHB9 [Q6PI77]3EBI-10241197,EBI-11519926
BICD2 - isoform 2 [Q8TD16-2]3EBI-10241197,EBI-11975051
BICDL2 [A1A5D9]3EBI-10241197,EBI-10171799
BIRC7 [Q96CA5]3EBI-10241197,EBI-517623
C1orf109 [Q9NX04]3EBI-10241197,EBI-8643161
CALCOCO2 [Q13137]3EBI-10241197,EBI-739580
CARD9 - isoform 2 [Q9H257-2]6EBI-10241197,EBI-11530605
CAVIN1 [Q6NZI2]3EBI-10241197,EBI-2559016
CCDC102B [Q68D86]3EBI-10241197,EBI-10171570
CCDC120 [Q96HB5]3EBI-10241197,EBI-744556
CCDC125 [Q86Z20]3EBI-10241197,EBI-11977221
CCDC13 [Q8IYE1]3EBI-10241197,EBI-10961312
CCDC57 [Q2TAC2]3EBI-10241197,EBI-2808286
CCDC57 - isoform 2 [Q2TAC2-2]3EBI-10241197,EBI-10961624
CCDC88B [A6NC98]3EBI-10241197,EBI-347573
CDKN2D [P55273]3EBI-10241197,EBI-745859
CDR2 [Q01850]3EBI-10241197,EBI-1181367
CDR2L [Q86X02]6EBI-10241197,EBI-11063830
CEP63 - isoform 3 [Q96MT8-3]3EBI-10241197,EBI-11522539
CEP70 [Q8NHQ1]7EBI-10241197,EBI-739624
CIB1 [Q99828]3EBI-10241197,EBI-372594
CRACR2B - isoform 3 [Q8N4Y2-3]3EBI-10241197,EBI-11982645
CTAG1B [P78358]3EBI-10241197,EBI-1188472
CYSRT1 [A8MQ03]3EBI-10241197,EBI-3867333
DMAP1 [Q9NPF5]3EBI-10241197,EBI-399105
DYDC1 [Q8WWB3]3EBI-10241197,EBI-740680
EFHC1 [Q5JVL4]3EBI-10241197,EBI-743105
FCHSD2 - isoform 3 [O94868-3]3EBI-10241197,EBI-11958845
FHL3 [Q13643]5EBI-10241197,EBI-741101
FRS3 [O43559]3EBI-10241197,EBI-725515
FSD2 [A1L4K1]3EBI-10241197,EBI-5661036
GAS8 [O95995]3EBI-10241197,EBI-1052570
GOLGA2 [Q08379]3EBI-10241197,EBI-618309
GOLGA6A [Q9NYA3]3EBI-10241197,EBI-11163335
GOLGA6L9 [A6NEM1]3EBI-10241197,EBI-5916454
GRIPAP1 [Q4V328]3EBI-10241197,EBI-717919
HMBOX1 [Q6NT76]3EBI-10241197,EBI-2549423
HOOK2 - isoform 2 [Q96ED9-2]3EBI-10241197,EBI-10961706
HSF2BP [O75031]3EBI-10241197,EBI-7116203
IKZF3 [Q9UKT9]3EBI-10241197,EBI-747204
JAKMIP1 [Q96N16]3EBI-10241197,EBI-2680803
KANK2 [Q63ZY3]3EBI-10241197,EBI-2556193
KHDRBS3 [O75525]3EBI-10241197,EBI-722504
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-10241197,EBI-14069005
KRT24 [Q2M2I5]3EBI-10241197,EBI-2952736
KRT36 - isoform 2 [O76013-2]3EBI-10241197,EBI-11958506
KRT40 [Q6A162]3EBI-10241197,EBI-10171697
KRT86 [O43790]3EBI-10241197,EBI-9996498
KRTAP12-2 [P59991]3EBI-10241197,EBI-10176379
KRTAP6-2 [Q3LI66]3EBI-10241197,EBI-11962084
LCA5L [O95447]3EBI-10241197,EBI-8473670
LDOC1 [O95751]3EBI-10241197,EBI-740738
LIPE [Q05469]3EBI-10241197,EBI-721601
LMNB2 [Q03252]3EBI-10241197,EBI-2830427
LMO2 - isoform 3 [P25791-3]3EBI-10241197,EBI-11959475
LZTS1 [Q9Y250]3EBI-10241197,EBI-1216080
MAGED1 [Q9Y5V3]3EBI-10241197,EBI-716006
MBD3L1 [Q8WWY6]3EBI-10241197,EBI-12516603
MDFI [Q99750]3EBI-10241197,EBI-724076
MEIS3 - isoform 3 [Q99687-3]3EBI-10241197,EBI-18582591
MEOX2 [Q6FHY5]3EBI-10241197,EBI-16439278
MIPOL1 [Q8TD10]3EBI-10241197,EBI-2548751
MIS18A [Q9NYP9]3EBI-10241197,EBI-1104552
MKRN3 [Q13064]3EBI-10241197,EBI-2340269
MSS51 [Q4VC12]3EBI-10241197,EBI-11599933
MTUS2 [Q5JR59]4EBI-10241197,EBI-742948
MTUS2 - isoform 2 [Q5JR59-3]4EBI-10241197,EBI-11522433
NAB2 [Q15742]3EBI-10241197,EBI-8641936
PARVG [Q9HBI0]3EBI-10241197,EBI-3921217
PDLIM7 [Q9NR12]3EBI-10241197,EBI-350517
PICK1 [Q9NRD5]3EBI-10241197,EBI-79165
PRDM6 [Q9NQX0]3EBI-10241197,EBI-11320284
PRKAR1B [P31321]3EBI-10241197,EBI-2805516
PSTPIP1 [O43586]3EBI-10241197,EBI-1050964
RASGEF1B - isoform 3 [Q0VAM2-3]3EBI-10241197,EBI-12013954
RBM4B [Q9BQ04]3EBI-10241197,EBI-715531
RBPMS - isoform C [Q93062-3]3EBI-10241197,EBI-740343
ROPN1 [Q9HAT0]3EBI-10241197,EBI-1378139
RORB - isoform 1 [Q92753-1]3EBI-10241197,EBI-18560266
RUNDC3A - isoform 3 [Q59EK9-3]3EBI-10241197,EBI-11957366
SORBS3 [O60504]3EBI-10241197,EBI-741237
SPERT - isoform 2 [Q8NA61-2]3EBI-10241197,EBI-11524851
SPG21 [Q9NZD8]3EBI-10241197,EBI-742688
SSX2IP [Q9Y2D8]3EBI-10241197,EBI-2212028
STX11 [O75558]3EBI-10241197,EBI-714135
STX1A [Q16623]3EBI-10241197,EBI-712466
TBC1D1 [Q86TI0]3EBI-10241197,EBI-1644036
TEKT1 [Q969V4]3EBI-10241197,EBI-10180409
TFIP11 [Q9UBB9]3EBI-10241197,EBI-1105213
TLE5 - isoform 2 [Q08117-2]3EBI-10241197,EBI-11741437
TRAF2 [Q12933]3EBI-10241197,EBI-355744
TRAF4 [Q9BUZ4]3EBI-10241197,EBI-3650647
TRIM27 [P14373]3EBI-10241197,EBI-719493
TRIM5 - isoform Gamma [Q9C035-3]3EBI-10241197,EBI-12840050
TRIM50 [Q86XT4]3EBI-10241197,EBI-9867283
TRIP6 [Q15654]3EBI-10241197,EBI-742327
TSC1 [Q86WV8]3EBI-10241197,EBI-12806590
TTC23 - isoform 3 [Q5W5X9-3]3EBI-10241197,EBI-9090990
TTC23L [Q6PF05]3EBI-10241197,EBI-8656864
UHMK1 - isoform 2 [Q8TAS1-2]3EBI-10241197,EBI-12157345
WWOX - isoform 5 [Q9NZC7-5]5EBI-10241197,EBI-12040603
YES1 [P07947]3EBI-10241197,EBI-515331
ZRANB1 [Q9UGI0]3EBI-10241197,EBI-527853

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
129021, 17 interactors

Protein interaction database and analysis system

More...
IntActi
Q3SY00, 114 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000484252

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3SY00 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3SY00

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili379 – 464Sequence analysisAdd BLAST86

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008351

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_037959_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3SY00

Identification of Orthologs from Complete Genome Data

More...
OMAi
DCGPQKQ

Database of Orthologous Groups

More...
OrthoDBi
1171000at2759

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3SY00-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGQDTDMLNT YQQLVRTPSV RPGQDVRLQA PGTRTGLLKL LSTVSQDKQG
60 70 80 90 100
CLGSGDGVPN QDLQQRSQSS RQTAKKDRKP RGQSKKGQGS EESEDHFPLL
110 120 130 140 150
PRKPSFPFQW AWESIATDVR AVLQPSSPTP GHQALPMPSS FSQRQSRRKS
160 170 180 190 200
TANLPEAHGC CWKTEAQNLK ARQQLGAWGG VSIPTGKGEL GSEPPSGLQL
210 220 230 240 250
PGRRPGSGSA SDKQVQLQSL GAEEAERGLS SGVLPQRPRR GSISEEEQFS
260 270 280 290 300
EATEEAEEGE HRTPCRRRAG CQRKGQISGE EASDEGEVQG QSQGSSPSFN
310 320 330 340 350
NLRRRQWRKT RAKELQGPWD LEKLHRQLQR DLDCGPQKLP WKTLRAAFQA
360 370 380 390 400
SKRNGKAYAS GYDETFVSAN LPNRTFHKRQ EATRSLLQAW ERQRQEERQQ
410 420 430 440 450
AELRRARTQH VQRQVAHCLA AYAPRGSRGP GAAQRKLEEL RRQERQRFAE
460 470 480 490 500
YQAELQGIQH RVQARPFLFQ QAMQANARLT VTRRFSQVLS ALGLDEEQLL
510 520 530 540 550
SEAGKVDREG TPRKPRSHRS MGVRMEHSPQ RPPRTEPTGS QPDRHYNPSL

DPECSP
Length:556
Mass (Da):62,381
Last modified:July 9, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA676754C093FDA61
GO
Isoform 2 (identifier: Q3SY00-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     336-404: PQKLPWKTLR...QEERQQAELR → SHQEPAAGLG...AEAPGATALC
     405-556: Missing.

Show »
Length:403
Mass (Da):42,887
Checksum:i33CEDFE052DA823A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZG0A0A087WZG0_HUMAN
Testis-specific protein 10-interact...
TSGA10IP
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0H3A0A087X0H3_HUMAN
Testis-specific protein 10-interact...
TSGA10IP
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti67S → P in BAB71488 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042855210A → V. Corresponds to variant dbSNP:rs565921Ensembl.1
Natural variantiVAR_042856237R → S. Corresponds to variant dbSNP:rs7927388Ensembl.1
Natural variantiVAR_042857292S → N. Corresponds to variant dbSNP:rs7927826Ensembl.1
Natural variantiVAR_042858305R → P. Corresponds to variant dbSNP:rs7927841Ensembl.1
Natural variantiVAR_042859521M → V1 PublicationCorresponds to variant dbSNP:rs491973Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033196336 – 404PQKLP…QAELR → SHQEPAAGLGAAAAGGAAAG RAAAGPDTACTAAGGPLPGS LRTQREPGPWGGPAQAGGAE APGATALC in isoform 2. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_033197405 – 556Missing in isoform 2. 1 PublicationAdd BLAST152

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK057442 mRNA Translation: BAB71488.1
AP006287 Genomic DNA No translation available.
BC104022 mRNA Translation: AAI04023.1
BC104023 mRNA Translation: AAI04024.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS66138.1 [Q3SY00-1]

NCBI Reference Sequences

More...
RefSeqi
NP_689975.2, NM_152762.2 [Q3SY00-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000532620; ENSP00000484252; ENSG00000175513 [Q3SY00-1]
ENST00000608857; ENSP00000477317; ENSG00000175513 [Q3SY00-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
254187

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:254187

UCSC genome browser

More...
UCSCi
uc009yqw.2 human [Q3SY00-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057442 mRNA Translation: BAB71488.1
AP006287 Genomic DNA No translation available.
BC104022 mRNA Translation: AAI04023.1
BC104023 mRNA Translation: AAI04024.1
CCDSiCCDS66138.1 [Q3SY00-1]
RefSeqiNP_689975.2, NM_152762.2 [Q3SY00-1]

3D structure databases

SMRiQ3SY00
ModBaseiSearch...

Protein-protein interaction databases

BioGridi129021, 17 interactors
IntActiQ3SY00, 114 interactors
STRINGi9606.ENSP00000484252

PTM databases

iPTMnetiQ3SY00
PhosphoSitePlusiQ3SY00

Polymorphism and mutation databases

BioMutaiTSGA10IP
DMDMi121942943

Proteomic databases

MassIVEiQ3SY00
PeptideAtlasiQ3SY00
PRIDEiQ3SY00
ProteomicsDBi61831 [Q3SY00-1]
61832 [Q3SY00-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
72461 92 antibodies

Genome annotation databases

EnsembliENST00000532620; ENSP00000484252; ENSG00000175513 [Q3SY00-1]
ENST00000608857; ENSP00000477317; ENSG00000175513 [Q3SY00-2]
GeneIDi254187
KEGGihsa:254187
UCSCiuc009yqw.2 human [Q3SY00-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
254187

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TSGA10IP
HGNCiHGNC:26555 TSGA10IP
HPAiENSG00000175513 Group enriched (blood, testis)
neXtProtiNX_Q3SY00
OpenTargetsiENSG00000175513
PharmGKBiPA134983361

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00390000008351
HOGENOMiCLU_037959_0_0_1
InParanoidiQ3SY00
OMAiDCGPQKQ
OrthoDBi1171000at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TSGA10IP human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
254187
PharosiQ3SY00 Tdark

Protein Ontology

More...
PROi
PR:Q3SY00
RNActiQ3SY00 protein

Gene expression databases

BgeeiENSG00000175513 Expressed in testis and 32 other tissues
ExpressionAtlasiQ3SY00 baseline and differential
GenevisibleiQ3SY00 HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT10IP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3SY00
Secondary accession number(s): Q3SXZ9, Q3SY01, Q96M26
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 9, 2014
Last modified: April 22, 2020
This is version 95 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again