UniProtKB - Q3SXZ7 (TTLL9_HUMAN)
Probable tubulin polyglutamylase TTLL9
TTLL9
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 224 | ATPBy similarity | 1 | |
Binding sitei | 226 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 211 – 214 | ATP bindingBy similarity | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- tubulin binding Source: GO_Central
- tubulin-glutamic acid ligase activity Source: GO_Central
GO - Biological processi
- flagellated sperm motility Source: Ensembl
- microtubule cytoskeleton organization Source: GO_Central
- protein polyglutamylation Source: GO_Central
Keywordsi
Molecular function | Ligase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q3SXZ7 |
Reactomei | R-HSA-8955332, Carboxyterminal post-translational modifications of tubulin |
Names & Taxonomyi
Protein namesi | Recommended name: Probable tubulin polyglutamylase TTLL9 (EC:6.-.-.-By similarity)Alternative name(s): Tubulin--tyrosine ligase-like protein 9 |
Gene namesi | Name:TTLL9 Synonyms:C20orf125 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16118, TTLL9 |
neXtProti | NX_Q3SXZ7 |
VEuPathDBi | HostDB:ENSG00000131044.16 |
Subcellular locationi
Cytoskeleton
- cilium basal body By similarity
- cytoskeleton By similarity
Cytoskeleton
- ciliary basal body Source: Ensembl
- microtubule Source: UniProtKB-KW
Other locations
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, Cytoskeleton, MicrotubulePathology & Biotechi
Organism-specific databases
DisGeNETi | 164395 |
OpenTargetsi | ENSG00000131044 |
PharmGKBi | PA25666 |
Miscellaneous databases
Pharosi | Q3SXZ7, Tdark |
Genetic variation databases
BioMutai | TTLL9 |
DMDMi | 215274204 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000324517 | 1 – 439 | Probable tubulin polyglutamylase TTLL9Add BLAST | 439 |
Proteomic databases
MaxQBi | Q3SXZ7 |
PaxDbi | Q3SXZ7 |
PeptideAtlasi | Q3SXZ7 |
PRIDEi | Q3SXZ7 |
ProteomicsDBi | 61828 [Q3SXZ7-1] 61829 [Q3SXZ7-2] 61830 [Q3SXZ7-3] |
PTM databases
iPTMneti | Q3SXZ7 |
PhosphoSitePlusi | Q3SXZ7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000131044, Expressed in right uterine tube and 149 other tissues |
ExpressionAtlasi | Q3SXZ7, baseline and differential |
Genevisiblei | Q3SXZ7, HS |
Organism-specific databases
HPAi | ENSG00000131044, Tissue enhanced (brain, epididymis, fallopian tube, testis) |
Interactioni
GO - Molecular functioni
- tubulin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 127895, 6 interactors |
IntActi | Q3SXZ7, 5 interactors |
STRINGi | 9606.ENSP00000442515 |
Miscellaneous databases
RNActi | Q3SXZ7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 380 | TTLPROSITE-ProRule annotationAdd BLAST | 341 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2157, Eukaryota |
GeneTreei | ENSGT00940000159879 |
HOGENOMi | CLU_010131_0_1_1 |
InParanoidi | Q3SXZ7 |
OMAi | YVPLKAW |
OrthoDBi | 584228at2759 |
PhylomeDBi | Q3SXZ7 |
TreeFami | TF313087 |
Family and domain databases
Gene3Di | 3.30.1490.20, 1 hit |
InterProi | View protein in InterPro IPR013815, ATP_grasp_subdomain_1 IPR004344, TTL/TTLL_fam IPR027751, TTLL9 |
PANTHERi | PTHR12241:SF39, PTHR12241:SF39, 1 hit |
Pfami | View protein in Pfam PF03133, TTL, 1 hit |
PROSITEi | View protein in PROSITE PS51221, TTL, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVPSREALLG PGTTAIRCPK KLQNQNYKGH GLSKGKEREQ RASIRFKTTL
60 70 80 90 100
MNTLMDVLRH RPGWVEVKDE GEWDFYWCDV SWLRENFDHT YMDEHVRISH
110 120 130 140 150
FRNHYELTRK NYMVKNLKRF RKQLEREAGK LEAAKCDFFP KTFEMPCEYH
160 170 180 190 200
LFVEEFRKNP GITWIMKPVA RSQGKGIFLF RRLKDIVDWR KDTRSSDDQK
210 220 230 240 250
DDIPVENYVA QRYIENPYLI GGRKFDLRVY VLVMSVFAEC LLWSGHRRQD
260 270 280 290 300
VHLTNVAVQK TSPDYHPKKG CKWTLQRFRQ YLASKHGPEA VETLFRDIDN
310 320 330 340 350
IFVKSLQSVQ KVIISDKHCF ELYGYDILID QDLKPWLLEV NASPSLTASS
360 370 380 390 400
QEDYELKTCL LEDTLHVVDM EARLTGREKR VGGFDLMWND GPVSREEGAP
410 420 430
DLSGMGNFVT NTHLGCVNDR KKQLRQLFCS LQVQKKASS
The sequence of this isoform differs from the canonical sequence as follows:
1-50: Missing.
236-250: VFAECLLWSGHRRQD → YIPLRAWLYRDGFARFSNTRFTLNSIDDQY
374-439: LTGREKRVGGFDLMWNDGPVSREEGAPDLSGMGNFVTNTHLGCVNDRKKQLRQLFCSLQVQKKASS → SLRADSPCW
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4DZ96 | B4DZ96_HUMAN | Tubulin--tyrosine ligase-like prote... | TTLL9 | 279 | Annotation score: | ||
A0A087X135 | A0A087X135_HUMAN | Tubulin--tyrosine ligase-like prote... | TTLL9 | 341 | Annotation score: | ||
A0A087WXF5 | A0A087WXF5_HUMAN | Tubulin--tyrosine ligase-like prote... | TTLL9 | 225 | Annotation score: | ||
A0A2R8Y6A5 | A0A2R8Y6A5_HUMAN | Tubulin--tyrosine ligase-like prote... | TTLL9 | 379 | Annotation score: | ||
A0A087WWB8 | A0A087WWB8_HUMAN | Probable tubulin polyglutamylase TT... | TTLL9 | 184 | Annotation score: | ||
A0A0A0MR21 | A0A0A0MR21_HUMAN | Probable tubulin polyglutamylase TT... | TTLL9 | 105 | Annotation score: | ||
A0A2R8YD21 | A0A2R8YD21_HUMAN | Probable tubulin polyglutamylase TT... | TTLL9 | 59 | Annotation score: | ||
A0A087WYL2 | A0A087WYL2_HUMAN | Probable tubulin polyglutamylase TT... | TTLL9 | 39 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 274 | T → M in AAI04026 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039805 | 76 | Y → C. Corresponds to variant dbSNP:rs17093689Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035765 | 1 – 50 | Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 50 | |
Alternative sequenceiVSP_035766 | 169 – 191 | Missing in isoform 3. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_035767 | 236 – 250 | VFAEC…HRRQD → YIPLRAWLYRDGFARFSNTR FTLNSIDDQY in isoform 2 and isoform 3. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_035768 | 270 – 439 | GCKWT…KKASS → VAPGGQCVPITDSQQPGRL in isoform 3. 1 PublicationAdd BLAST | 170 | |
Alternative sequenceiVSP_035769 | 374 – 439 | LTGRE…KKASS → SLRADSPCW in isoform 2. 1 PublicationAdd BLAST | 66 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093491 mRNA Translation: BAG52730.1 AL031658 Genomic DNA No translation available. AL359765 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76401.1 Sequence problems. CH471077 Genomic DNA Translation: EAW76403.1 BC104024 mRNA Translation: AAI04025.1 BC104025 mRNA Translation: AAI04026.1 |
CCDSi | CCDS42863.1 [Q3SXZ7-1] |
RefSeqi | NP_001008409.1, NM_001008409.2 [Q3SXZ7-1] XP_006723787.1, XM_006723724.2 XP_011526948.1, XM_011528646.1 |
Genome annotation databases
Ensembli | ENST00000375922; ENSP00000495141; ENSG00000131044 [Q3SXZ7-2] ENST00000375938; ENSP00000365105; ENSG00000131044 [Q3SXZ7-1] ENST00000535842; ENSP00000442515; ENSG00000131044 [Q3SXZ7-1] |
GeneIDi | 164395 |
KEGGi | hsa:164395 |
UCSCi | uc002wwy.2, human [Q3SXZ7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK093491 mRNA Translation: BAG52730.1 AL031658 Genomic DNA No translation available. AL359765 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76401.1 Sequence problems. CH471077 Genomic DNA Translation: EAW76403.1 BC104024 mRNA Translation: AAI04025.1 BC104025 mRNA Translation: AAI04026.1 |
CCDSi | CCDS42863.1 [Q3SXZ7-1] |
RefSeqi | NP_001008409.1, NM_001008409.2 [Q3SXZ7-1] XP_006723787.1, XM_006723724.2 XP_011526948.1, XM_011528646.1 |
3D structure databases
SMRi | Q3SXZ7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127895, 6 interactors |
IntActi | Q3SXZ7, 5 interactors |
STRINGi | 9606.ENSP00000442515 |
PTM databases
iPTMneti | Q3SXZ7 |
PhosphoSitePlusi | Q3SXZ7 |
Genetic variation databases
BioMutai | TTLL9 |
DMDMi | 215274204 |
Proteomic databases
MaxQBi | Q3SXZ7 |
PaxDbi | Q3SXZ7 |
PeptideAtlasi | Q3SXZ7 |
PRIDEi | Q3SXZ7 |
ProteomicsDBi | 61828 [Q3SXZ7-1] 61829 [Q3SXZ7-2] 61830 [Q3SXZ7-3] |
Protocols and materials databases
Antibodypediai | 49885, 41 antibodies |
Genome annotation databases
Ensembli | ENST00000375922; ENSP00000495141; ENSG00000131044 [Q3SXZ7-2] ENST00000375938; ENSP00000365105; ENSG00000131044 [Q3SXZ7-1] ENST00000535842; ENSP00000442515; ENSG00000131044 [Q3SXZ7-1] |
GeneIDi | 164395 |
KEGGi | hsa:164395 |
UCSCi | uc002wwy.2, human [Q3SXZ7-1] |
Organism-specific databases
CTDi | 164395 |
DisGeNETi | 164395 |
GeneCardsi | TTLL9 |
HGNCi | HGNC:16118, TTLL9 |
HPAi | ENSG00000131044, Tissue enhanced (brain, epididymis, fallopian tube, testis) |
neXtProti | NX_Q3SXZ7 |
OpenTargetsi | ENSG00000131044 |
PharmGKBi | PA25666 |
VEuPathDBi | HostDB:ENSG00000131044.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2157, Eukaryota |
GeneTreei | ENSGT00940000159879 |
HOGENOMi | CLU_010131_0_1_1 |
InParanoidi | Q3SXZ7 |
OMAi | YVPLKAW |
OrthoDBi | 584228at2759 |
PhylomeDBi | Q3SXZ7 |
TreeFami | TF313087 |
Enzyme and pathway databases
PathwayCommonsi | Q3SXZ7 |
Reactomei | R-HSA-8955332, Carboxyterminal post-translational modifications of tubulin |
Miscellaneous databases
BioGRID-ORCSi | 164395, 4 hits in 852 CRISPR screens |
ChiTaRSi | TTLL9, human |
GenomeRNAii | 164395 |
Pharosi | Q3SXZ7, Tdark |
PROi | PR:Q3SXZ7 |
RNActi | Q3SXZ7, protein |
Gene expression databases
Bgeei | ENSG00000131044, Expressed in right uterine tube and 149 other tissues |
ExpressionAtlasi | Q3SXZ7, baseline and differential |
Genevisiblei | Q3SXZ7, HS |
Family and domain databases
Gene3Di | 3.30.1490.20, 1 hit |
InterProi | View protein in InterPro IPR013815, ATP_grasp_subdomain_1 IPR004344, TTL/TTLL_fam IPR027751, TTLL9 |
PANTHERi | PTHR12241:SF39, PTHR12241:SF39, 1 hit |
Pfami | View protein in Pfam PF03133, TTL, 1 hit |
PROSITEi | View protein in PROSITE PS51221, TTL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TTLL9_HUMAN | |
Accessioni | Q3SXZ7Primary (citable) accession number: Q3SXZ7 Secondary accession number(s): A6NH06 Q5JYS4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 10, 2021 | |
This is version 124 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families