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Protein

Zinc finger protein 718

Gene

ZNF718

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri171 – 193C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 718
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF718
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000250312.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26889 ZNF718

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3SXZ3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
255403

Open Targets

More...
OpenTargetsi
ENSG00000250312

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485682

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF718

Domain mapping of disease mutations (DMDM)

More...
DMDMi
94730683

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002332861 – 478Zinc finger protein 718Add BLAST478

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3SXZ3

PeptideAtlas

More...
PeptideAtlasi
Q3SXZ3

PRoteomics IDEntifications database

More...
PRIDEi
Q3SXZ3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61826
61827 [Q3SXZ3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3SXZ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3SXZ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000250312 Expressed in 140 organ(s), highest expression level in forebrain

CleanEx database of gene expression profiles

More...
CleanExi
HS_ZNF718

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
129101, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q3SXZ3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3SXZ3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 193C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri199 – 221C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri227 – 249C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 277C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri283 – 305C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri311 – 333C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri339 – 361C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri367 – 389C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri423 – 445C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri451 – 473C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161765

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG018163

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3SXZ3

KEGG Orthology (KO)

More...
KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
HEKRGHE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02KC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3SXZ3

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3SXZ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELLTFKDVA IEFSPEEWKC LDTSQQNLYR DVMLENYRNL VSLGVSISNP
60 70 80 90 100
DLVTSLEQRK EPYNLKIHET AARPPAVCSH FTQNLWTVQG IEDSFHKLIP
110 120 130 140 150
KGHEKRGHEN LRKTCKSINE CKVQKGGYNR INQCLLTTQK KTIQSNICVK
160 170 180 190 200
VFHKFSNSNK DKIRYTGDKT FKCKECGKSF HVLSRLTQHK RIHTGENPYT
210 220 230 240 250
CEECGKAFNW SSILTKHKRI HAREKFYKCE ECGKGFTRSS HLTKHKRIHT
260 270 280 290 300
GEKPYICEKC GKAFNQSSTL NLHKRIHSAQ KYYKCEECGK AFKWSSSLNE
310 320 330 340 350
HKRIHAGEKP FSCEECGNVF TTSSDFAKHK RIHTGEKPYK CEECGKSFNR
360 370 380 390 400
STTLTTHKRI HTGEKPYTCE ECGKAFNWSS TLNVHKRIHS GKNPYKCEDC
410 420 430 440 450
GKAFKVFANL HNHKKIHTGE KPYICKQCGK AFKQSSHLNK HKKIHTVDKP
460 470
YKCKECGKAF KQYSNLPQHK RTHTGGKF
Length:478
Mass (Da):55,359
Last modified:March 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8362FA9A3A982FFD
GO
Isoform 2 (identifier: Q3SXZ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Show »
Length:446
Mass (Da):51,528
Checksum:i36A78A02B03AE38C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y4V3A0A2R8Y4V3_HUMAN
Zinc finger protein 718
ZNF718
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti23T → I in AAI04030 (PubMed:15489334).Curated1
Sequence conflicti46S → T in AAI04027 (PubMed:15489334).Curated1
Sequence conflicti46S → T in AAI04029 (PubMed:15489334).Curated1
Sequence conflicti46S → T in AAI04030 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059933140K → N. Corresponds to variant dbSNP:rs9684215Ensembl.1
Natural variantiVAR_059934140K → R. Corresponds to variant dbSNP:rs9684214Ensembl.1
Natural variantiVAR_059935297S → Y. Corresponds to variant dbSNP:rs7677201Ensembl.1
Natural variantiVAR_059936413H → R1 PublicationCorresponds to variant dbSNP:rs7440274Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0181101 – 32Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC253576 Genomic DNA No translation available.
BC104026 mRNA Translation: AAI04027.1
BC104027 mRNA Translation: AAI04028.1
BC104028 mRNA Translation: AAI04029.1
BC104029 mRNA Translation: AAI04030.1
BC154406 mRNA Translation: AAI54407.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS75078.1 [Q3SXZ3-1]
CCDS75079.1 [Q3SXZ3-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001034216.2, NM_001039127.5 [Q3SXZ3-1]
NP_001276859.1, NM_001289930.1 [Q3SXZ3-2]
NP_001276860.1, NM_001289931.1 [Q3SXZ3-2]
XP_016863468.1, XM_017007979.1 [Q3SXZ3-2]
XP_016863469.1, XM_017007980.1 [Q3SXZ3-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.636638
Hs.724954
Hs.745062
Hs.745417

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000510175; ENSP00000480556; ENSG00000250312 [Q3SXZ3-1]
ENST00000609714; ENSP00000476435; ENSG00000250312 [Q3SXZ3-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
255403

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:255403

UCSC genome browser

More...
UCSCi
uc032tae.2 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC253576 Genomic DNA No translation available.
BC104026 mRNA Translation: AAI04027.1
BC104027 mRNA Translation: AAI04028.1
BC104028 mRNA Translation: AAI04029.1
BC104029 mRNA Translation: AAI04030.1
BC154406 mRNA Translation: AAI54407.1
CCDSiCCDS75078.1 [Q3SXZ3-1]
CCDS75079.1 [Q3SXZ3-2]
RefSeqiNP_001034216.2, NM_001039127.5 [Q3SXZ3-1]
NP_001276859.1, NM_001289930.1 [Q3SXZ3-2]
NP_001276860.1, NM_001289931.1 [Q3SXZ3-2]
XP_016863468.1, XM_017007979.1 [Q3SXZ3-2]
XP_016863469.1, XM_017007980.1 [Q3SXZ3-2]
UniGeneiHs.636638
Hs.724954
Hs.745062
Hs.745417

3D structure databases

ProteinModelPortaliQ3SXZ3
SMRiQ3SXZ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129101, 1 interactor

PTM databases

iPTMnetiQ3SXZ3
PhosphoSitePlusiQ3SXZ3

Polymorphism and mutation databases

BioMutaiZNF718
DMDMi94730683

Proteomic databases

EPDiQ3SXZ3
PeptideAtlasiQ3SXZ3
PRIDEiQ3SXZ3
ProteomicsDBi61826
61827 [Q3SXZ3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000510175; ENSP00000480556; ENSG00000250312 [Q3SXZ3-1]
ENST00000609714; ENSP00000476435; ENSG00000250312 [Q3SXZ3-2]
GeneIDi255403
KEGGihsa:255403
UCSCiuc032tae.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
255403
DisGeNETi255403
EuPathDBiHostDB:ENSG00000250312.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF718
HGNCiHGNC:26889 ZNF718
neXtProtiNX_Q3SXZ3
OpenTargetsiENSG00000250312
PharmGKBiPA143485682

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000161765
HOVERGENiHBG018163
InParanoidiQ3SXZ3
KOiK09228
OMAiHEKRGHE
OrthoDBiEOG091G02KC
PhylomeDBiQ3SXZ3

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF718 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
255403

Protein Ontology

More...
PROi
PR:Q3SXZ3

Gene expression databases

BgeeiENSG00000250312 Expressed in 140 organ(s), highest expression level in forebrain
CleanExiHS_ZNF718

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN718_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3SXZ3
Secondary accession number(s): A0A075B7G5
, A8WFQ3, Q3SXZ4, Q3SXZ5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 28, 2018
Last modified: December 5, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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