UniProtKB - Q3SXP7 (SHSL1_HUMAN)
Protein
Protein shisa-like-1
Gene
SHISAL1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Protein shisa-like-1Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000138944.7 |
HGNCi | HGNC:29335, SHISAL1 |
neXtProti | NX_Q3SXP7 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 97 | ExtracellularSequence analysisAdd BLAST | 72 | |
Transmembranei | 98 – 118 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 119 – 199 | CytoplasmicSequence analysisAdd BLAST | 81 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 85352 |
OpenTargetsi | ENSG00000138944 |
PharmGKBi | PA164721896 |
Miscellaneous databases
Pharosi | Q3SXP7, Tdark |
Polymorphism and mutation databases
BioMutai | KIAA1644 |
DMDMi | 172044643 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000318951 | 26 – 199 | Protein shisa-like-1Add BLAST | 174 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 53 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 95 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q3SXP7 |
PeptideAtlasi | Q3SXP7 |
PRIDEi | Q3SXP7 |
ProteomicsDBi | 61819 |
PTM databases
GlyGeni | Q3SXP7, 2 sites |
Expressioni
Gene expression databases
Bgeei | ENSG00000138944, Expressed in lateral nuclear group of thalamus and 163 other tissues |
Genevisiblei | Q3SXP7, HS |
Organism-specific databases
HPAi | ENSG00000138944, Tissue enhanced (cervix, uterine, endometrium, smooth muscle) |
Interactioni
Binary interactionsi
Hide detailsQ3SXP7
Protein-protein interaction databases
BioGRIDi | 124484, 30 interactors |
IntActi | Q3SXP7, 28 interactors |
STRINGi | 9606.ENSP00000370568 |
Miscellaneous databases
RNActi | Q3SXP7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the shisa family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502R0N8, Eukaryota |
GeneTreei | ENSGT00390000006791 |
HOGENOMi | CLU_089343_0_0_1 |
InParanoidi | Q3SXP7 |
OMAi | WHRSMPE |
OrthoDBi | 1351441at2759 |
PhylomeDBi | Q3SXP7 |
TreeFami | TF331539 |
Family and domain databases
InterProi | View protein in InterPro IPR026910, Shisa |
PANTHERi | PTHR31395, PTHR31395, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q3SXP7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSCGQQSLN VLAVLFSLLF SAVLSAHFRV CEPYTDHKGR YHFGFHCPRL
60 70 80 90 100
SDNKTFILCC HHNNTVFKYC CNETEFQAVM QANLTASSEG YMHNNYTALL
110 120 130 140 150
GVWIYGFFVL MLLVLDLLYY SAMNYDICKV YLARWGIQGR WMKQDPRRWG
160 170 180 190
NPARAPRPGQ RAPQPQPPPG PLPQAPQAVH TLRGDAHSPP LMTFQSSSA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 197 | S → L in AAI04185 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL022339 Genomic DNA No translation available. AL591914 Genomic DNA No translation available. BC104183 mRNA Translation: AAI04184.1 BC104184 mRNA Translation: AAI04185.1 AB051431 mRNA Translation: BAB33314.1 |
CCDSi | CCDS43025.1 |
RefSeqi | NP_001092764.1, NM_001099294.1 XP_005261847.1, XM_005261790.3 |
Genome annotation databases
Ensembli | ENST00000381176; ENSP00000370568; ENSG00000138944 |
GeneIDi | 85352 |
KEGGi | hsa:85352 |
UCSCi | uc003bet.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL022339 Genomic DNA No translation available. AL591914 Genomic DNA No translation available. BC104183 mRNA Translation: AAI04184.1 BC104184 mRNA Translation: AAI04185.1 AB051431 mRNA Translation: BAB33314.1 |
CCDSi | CCDS43025.1 |
RefSeqi | NP_001092764.1, NM_001099294.1 XP_005261847.1, XM_005261790.3 |
3D structure databases
SMRi | Q3SXP7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124484, 30 interactors |
IntActi | Q3SXP7, 28 interactors |
STRINGi | 9606.ENSP00000370568 |
PTM databases
GlyGeni | Q3SXP7, 2 sites |
Polymorphism and mutation databases
BioMutai | KIAA1644 |
DMDMi | 172044643 |
Proteomic databases
PaxDbi | Q3SXP7 |
PeptideAtlasi | Q3SXP7 |
PRIDEi | Q3SXP7 |
ProteomicsDBi | 61819 |
Protocols and materials databases
Antibodypediai | 53815, 63 antibodies |
Genome annotation databases
Ensembli | ENST00000381176; ENSP00000370568; ENSG00000138944 |
GeneIDi | 85352 |
KEGGi | hsa:85352 |
UCSCi | uc003bet.3, human |
Organism-specific databases
CTDi | 85352 |
DisGeNETi | 85352 |
EuPathDBi | HostDB:ENSG00000138944.7 |
GeneCardsi | SHISAL1 |
HGNCi | HGNC:29335, SHISAL1 |
HPAi | ENSG00000138944, Tissue enhanced (cervix, uterine, endometrium, smooth muscle) |
neXtProti | NX_Q3SXP7 |
OpenTargetsi | ENSG00000138944 |
PharmGKBi | PA164721896 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502R0N8, Eukaryota |
GeneTreei | ENSGT00390000006791 |
HOGENOMi | CLU_089343_0_0_1 |
InParanoidi | Q3SXP7 |
OMAi | WHRSMPE |
OrthoDBi | 1351441at2759 |
PhylomeDBi | Q3SXP7 |
TreeFami | TF331539 |
Enzyme and pathway databases
PathwayCommonsi | Q3SXP7 |
Miscellaneous databases
BioGRID-ORCSi | 85352, 6 hits in 845 CRISPR screens |
ChiTaRSi | KIAA1644, human |
GenomeRNAii | 85352 |
Pharosi | Q3SXP7, Tdark |
PROi | PR:Q3SXP7 |
RNActi | Q3SXP7, protein |
Gene expression databases
Bgeei | ENSG00000138944, Expressed in lateral nuclear group of thalamus and 163 other tissues |
Genevisiblei | Q3SXP7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026910, Shisa |
PANTHERi | PTHR31395, PTHR31395, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SHSL1_HUMAN | |
Accessioni | Q3SXP7Primary (citable) accession number: Q3SXP7 Secondary accession number(s): A6NHP0 Q9BYB5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | December 2, 2020 | |
This is version 94 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM