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Entry version 117 (11 Dec 2019)
Sequence version 1 (11 Oct 2005)
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Protein

DDB1- and CUL4-associated factor 4-like protein 1

Gene

DCAF4L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q3SXM0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 4-like protein 1
Alternative name(s):
WD repeat-containing protein 21B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCAF4L1
Synonyms:WDR21B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000182308.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27723 DCAF4L1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q3SXM0

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000182308

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165663611

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q3SXM0 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DCAF4L1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121949049

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002889021 – 396DDB1- and CUL4-associated factor 4-like protein 1Add BLAST396

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q3SXM0

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q3SXM0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3SXM0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3SXM0

PeptideAtlas

More...
PeptideAtlasi
Q3SXM0

PRoteomics IDEntifications database

More...
PRIDEi
Q3SXM0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61816

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3SXM0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3SXM0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182308 Expressed in 68 organ(s), highest expression level in female gonad

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3SXM0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB073535

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
130110, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q3SXM0, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000327796

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3SXM0 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati268 – 307WD 1Add BLAST40
Repeati312 – 351WD 2Add BLAST40

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2695 Eukaryota
ENOG410XQIU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166990

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000065756

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3SXM0

KEGG Orthology (KO)

More...
KOi
K11799

Identification of Orthologs from Complete Genome Data

More...
OMAi
PLRVHEE

Database of Orthologous Groups

More...
OrthoDBi
1253512at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3SXM0

TreeFam database of animal gene trees

More...
TreeFami
TF332050

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3SXM0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAERLRLLE EEAKLKKVAR MGFNASSMLR KSQLGFLNVT SYSRLANELR
60 70 80 90 100
VSCMERKKVQ IRSLDPSSLA SDRFNFILAS TNSDQLFVVN QVEVEGSKYG
110 120 130 140 150
IISLRTLKIP SFHVYVLRNL YVPNRKVKSL CWASLNQLDS HVLLCFEGIT
160 170 180 190 200
DAPSCAVLLP ASRFLSVHTR VNQPGMLCSF QIPEAWSCAW SLNTRAYHCF
210 220 230 240 250
SAGLSQQVLL TSVATGHQQS FDTSSDVLAQ QFASTAPLLF NGCRSGEIFA
260 270 280 290 300
IDLRCRNRGK GWRATRLFHD SAVTSVQILQ EEQCLMASDM TGKIKLWDLR
310 320 330 340 350
ATKCVRQYEG HVNESAYLPL HVHEEEGIVV AVGQDCYTRI WSLHDAHLLR
360 370 380 390
TIPSPYSASE DDIPSVAFAS RLGGIRGAAP GLLMAVRQDL YCFPFS
Length:396
Mass (Da):44,264
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFBD7EC84C61D88A2
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH35027 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43S → Y in AAH35027 (PubMed:15489334).Curated1
Sequence conflicti195R → W in AAH52943 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK122914 mRNA Translation: BAG53795.1
CH471069 Genomic DNA Translation: EAW92995.1
BC035027 mRNA Translation: AAH35027.1 Different initiation.
BC052943 mRNA Translation: AAH52943.1
BC104224 mRNA Translation: AAI04225.1
BC104225 mRNA Translation: AAI04226.1
AL122070 mRNA Translation: CAB59246.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33978.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T34550

NCBI Reference Sequences

More...
RefSeqi
NP_001025126.2, NM_001029955.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000333141; ENSP00000327796; ENSG00000182308

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
285429

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:285429

UCSC genome browser

More...
UCSCi
uc003gwk.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122914 mRNA Translation: BAG53795.1
CH471069 Genomic DNA Translation: EAW92995.1
BC035027 mRNA Translation: AAH35027.1 Different initiation.
BC052943 mRNA Translation: AAH52943.1
BC104224 mRNA Translation: AAI04225.1
BC104225 mRNA Translation: AAI04226.1
AL122070 mRNA Translation: CAB59246.1
CCDSiCCDS33978.1
PIRiT34550
RefSeqiNP_001025126.2, NM_001029955.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi130110, 5 interactors
IntActiQ3SXM0, 3 interactors
STRINGi9606.ENSP00000327796

PTM databases

iPTMnetiQ3SXM0
PhosphoSitePlusiQ3SXM0

Polymorphism and mutation databases

BioMutaiDCAF4L1
DMDMi121949049

Proteomic databases

jPOSTiQ3SXM0
MassIVEiQ3SXM0
MaxQBiQ3SXM0
PaxDbiQ3SXM0
PeptideAtlasiQ3SXM0
PRIDEiQ3SXM0
ProteomicsDBi61816

Genome annotation databases

EnsembliENST00000333141; ENSP00000327796; ENSG00000182308
GeneIDi285429
KEGGihsa:285429
UCSCiuc003gwk.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
285429
EuPathDBiHostDB:ENSG00000182308.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DCAF4L1
HGNCiHGNC:27723 DCAF4L1
HPAiCAB073535
neXtProtiNX_Q3SXM0
OpenTargetsiENSG00000182308
PharmGKBiPA165663611

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2695 Eukaryota
ENOG410XQIU LUCA
GeneTreeiENSGT00940000166990
HOGENOMiHOG000065756
InParanoidiQ3SXM0
KOiK11799
OMAiPLRVHEE
OrthoDBi1253512at2759
PhylomeDBiQ3SXM0
TreeFamiTF332050

Enzyme and pathway databases

SignaLinkiQ3SXM0

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DCAF4L1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
285429
PharosiQ3SXM0 Tdark

Protein Ontology

More...
PROi
PR:Q3SXM0
RNActiQ3SXM0 protein

Gene expression databases

BgeeiENSG00000182308 Expressed in 68 organ(s), highest expression level in female gonad
GenevisibleiQ3SXM0 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 2 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDC4L1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3SXM0
Secondary accession number(s): B3KVI3
, Q3ZCW8, Q499Y5, Q9UFI0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2005
Last modified: December 11, 2019
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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