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Protein

Trans-L-3-hydroxyproline dehydratase

Gene

L3HYPDH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta1-pyrroline-2-carboxylate (Pyr2C).By similarity

Miscellaneous

In contrast to the T.cruzi proline racemase enzyme, lacks the conserved Cys at position 273 which is replaced by a Thr residue, transforming the racemase activity into dehydratase activity.By similarity

Catalytic activityi

Trans-3-hydroxy-L-proline = 1-pyrroline 2-carboxylate + H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei104Proton acceptorBy similarity1
Binding sitei269SubstrateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionLyase

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-L-3-hydroxyproline dehydratase (EC:4.2.1.77)
Alternative name(s):
Trans-3-hydroxy-L-proline dehydratase
Gene namesi
Name:L3HYPDH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:30762 L3HYPDH

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002889481 – 354Trans-L-3-hydroxyproline dehydrataseAdd BLAST354

Proteomic databases

PaxDbiQ3SX04
PRIDEiQ3SX04

Expressioni

Gene expression databases

BgeeiENSBTAG00000030824

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004371

Structurei

3D structure databases

ProteinModelPortaliQ3SX04
SMRiQ3SX04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni105 – 106Substrate bindingBy similarity2
Regioni274 – 275Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the proline racemase family.Curated

Phylogenomic databases

eggNOGiENOG410IIC6 Eukaryota
COG3938 LUCA
GeneTreeiENSGT00390000002032
HOGENOMiHOG000084336
HOVERGENiHBG057443
InParanoidiQ3SX04
KOiK18384
OMAiRHAMAIH
OrthoDBiEOG091G0CI6
TreeFamiTF329167

Family and domain databases

InterProiView protein in InterPro
IPR008794 Pro_racemase_fam
PANTHERiPTHR33442 PTHR33442, 1 hit
PfamiView protein in Pfam
PF05544 Pro_racemase, 1 hit
PIRSFiPIRSF029792 Pro_racemase, 1 hit
SFLDiSFLDS00028 Proline_Racemase, 1 hit

Sequencei

Sequence statusi: Complete.

Q3SX04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPLTVPWM PPHDPGTPAL SVVDMHTGGE PLRIVLAGCP EVVGPTLLAK
60 70 80 90 100
RRYMRQHLDH VRRRLMFEPR GHRDMYGAVL VPSELPDAHL GVLFLNNEGY
110 120 130 140 150
SSMCGHAVLA LGRFALDFGL VPAPPSDAQE ALVNIHCPCG LVAAFVECEG
160 170 180 190 200
CRSRGPVRFH SVPAFVLATD FLVDVPGRGK VVVDIAYGGA FYAFVSAEKL
210 220 230 240 250
GLDVCSAKMG DLVAAASAVT EAVKAQFKIS HPDSEDLAFL YGTILTDGKD
260 270 280 290 300
TYNEEPTTNI CVFADEQVDR SPTGSGVTAR IALQYHKGLL ELNQTRAFKS
310 320 330 340 350
SATGSVFTGK AVREAKCGDF KAVIVEVSGQ AHYTGTASFI VEDDDPLRDG

FLLK
Length:354
Mass (Da):37,957
Last modified:October 11, 2005 - v1
Checksum:i997C31A237A82510
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC104573 mRNA Translation: AAI04574.1
RefSeqiNP_001029558.1, NM_001034386.1
UniGeneiBt.30092

Genome annotation databases

EnsembliENSBTAT00000004371; ENSBTAP00000004371; ENSBTAG00000030824
GeneIDi510525
KEGGibta:510525

Similar proteinsi

Entry informationi

Entry nameiT3HPD_BOVIN
AccessioniPrimary (citable) accession number: Q3SX04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2005
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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