Platelet endothelial cell adhesion molecule

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• protein homodimerization activity Source: RGD
• protein phosphatase binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31)."
    Sagawa K., Kimura T., Swieter M., Siraganian R.P.
    J Biol Chem 272:31086-31091(1997) [PubMed] [Europe PMC] [Abstract]
• transmembrane signaling receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• angiogenesis Source: RGD
• bicellular tight junction assembly Source: RGD
• cell adhesion Source: RGD
• cell-cell adhesion Source: RGD
• cell-cell adhesion via plasma-membrane adhesion molecules Source: RGD
• cell surface receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to interferon-gamma Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Decrease of PECAM-1-gene-expression induced by proinflammatory cytokines IFN-gamma and IFN-alpha is reversed by TGF-beta in sinusoidal endothelial cells and hepatic mononuclear phagocytes."
    Neubauer K., Lindhorst A., Tron K., Ramadori G., Saile B.
    BMC Physiol 8:9-9(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to organic cyclic compound Source: RGDInferred from expression patternⁱ
  • "Effects of chlorogenic acid on neutrophil locomotion functions in response to inflammatory stimulus."
    Hebeda C.B., Bolonheis S.M., Nakasato A., Belinati K., Souza P.D., Gouvea D.R., Lopes N.P., Farsky S.H.
    J Ethnopharmacol 135:261-269(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to transforming growth factor beta stimulus Source: RGDInferred from expression patternⁱ
  • "Decrease of PECAM-1-gene-expression induced by proinflammatory cytokines IFN-gamma and IFN-alpha is reversed by TGF-beta in sinusoidal endothelial cells and hepatic mononuclear phagocytes."
    Neubauer K., Lindhorst A., Tron K., Ramadori G., Saile B.
    BMC Physiol 8:9-9(2008) [PubMed] [Europe PMC] [Abstract]
• diapedesis Source: RGD
• endothelial cell-matrix adhesion Source: RGD
• endothelial cell migration Source: RGD
• endothelial cell morphogenesis Source: RGD
• establishment of endothelial barrier Source: RGD
• glomerular endothelium development Source: RGD
• homophilic cell adhesion via plasma membrane adhesion molecules Source: RGD
• leukocyte cell-cell adhesion Source: RGD
• monocyte extravasation Source: RGD
• negative regulation of actin filament polymerization Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells."
    Couty J.P., Rampon C., Leveque M., Laran-Chich M.P., Bourdoulous S., Greenwood J., Couraud P.O.
    J Neurochem 103:793-801(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of GTPase activity Source: RGDInferred from direct assayⁱ
  • "PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells."
    Couty J.P., Rampon C., Leveque M., Laran-Chich M.P., Bourdoulous S., Greenwood J., Couraud P.O.
    J Neurochem 103:793-801(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of peptidyl-tyrosine phosphorylation Source: RGDInferred from direct assayⁱ
  • "PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells."
    Couty J.P., Rampon C., Leveque M., Laran-Chich M.P., Bourdoulous S., Greenwood J., Couraud P.O.
    J Neurochem 103:793-801(2007) [PubMed] [Europe PMC] [Abstract]
• neutrophil extravasation Source: RGD
• phagocytosis Source: RGD
• positive regulation of cell migration Source: RGD
• positive regulation of cellular extravasation Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Divergent effects of platelet-endothelial cell adhesion molecule-1 and beta 3 integrin blockade on leukocyte transmigration in vivo."
    Thompson R.D., Wakelin M.W., Larbi K.Y., Dewar A., Asimakopoulos G., Horton M.A., Nakada M.T., Nourshargh S.
    J Immunol 165:426-434(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of leukocyte migration Source: RGDInferred from mutant phenotypeⁱ
  • "Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo."
    Vaporciyan A.A., DeLisser H.M., Yan H.C., Mendiguren I.I., Thom S.R., Jones M.L., Ward P.A., Albelda S.M.
    Science 262:1580-1582(1993) [PubMed] [Europe PMC] [Abstract]
• positive regulation of peptidyl-tyrosine phosphorylation Source: RGD
• positive regulation of protein localization to cell-cell junction Source: RGD
• positive regulation of protein phosphorylation Source: RGD
• positive regulation of tyrosine phosphorylation of STAT protein Source: RGD
• regulation of cell migration Source: RGD
• Rho protein signal transduction Source: RGD
• wound healing Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• protein homodimerization activity Source: RGD
• protein phosphatase binding Source: RGDInferred from physical interactionⁱ
  • "The protein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31)."
    Sagawa K., Kimura T., Swieter M., Siraganian R.P.
    J Biol Chem 272:31086-31091(1997) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Motif

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MLLALLLTML LYASLQAQEN SFTINSIHME SRPSWEVSNG QKLTLQCLVD 
        60         70         80         90        100
ISTTSKSRPQ HQVLFYKDDA LVYNVSSSEH TESFVIPQSR VFHAGKYKCT 
       110        120        130        140        150
VILNSKEKTT IEYQLTVNGV PMPEVTVDKK EVTEGGIVTV NCSMQEEKPP 
       160        170        180        190        200
IYFKIEKVEL GTKNVKLSRE KTSNMNFVLI EFPIEEQDHL LVFRCQAGVL 
       210        220        230        240        250
SGIKMQTSEF IRSEYVTVQE FFSTPKFQIQ PPEMIIEGNQ LHIKCSVQVA 
       260        270        280        290        300
HLAQEFPEII IQKDKAIVAT SKQSKEAVYS VMALVEHSGH YTCKVESNRI 
       310        320        330        340        350
SKASSILVNI TELFPRPKLE LSSSRLDQGE MLDLSCSVSG APVANFTIQK 
       360        370        380        390        400
EETVLSQYQN FSKIAEERDS GLYSCTAGIG KVVKRSNLVP VQVCEMLSKP 
       410        420        430        440        450
RIFHDAKFEI IKGQIIGISC QSVNGTAPIT YRLLRAKSNF QTVQKNSNDP 
       460        470        480        490        500
VTFTDKPTRD MEYQCIVDNC HSHPEVRSEI LRVKVIAPVD EVTISILSGN 
       510        520        530        540        550
DVQSGDEMVL RCSVKEGTGP VTFQFYKEKE GRPFHEETVN DTQVFWHHEQ 
       560        570        580        590        600
TSKEQEGQYY CTAFNRASIV TSLRSGPLTV RVFLAPWKKG LIAVVVIGVV 
       610        620        630        640        650
IAALIVAAKY YFLRKAKAKQ KPVEMSRPAV PLLNSNSEKV SEPSVETNSH 
       660        670 
YDSQNMDVEY TEVEVSSLEP HQENGRLP                         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ